Targeted Delivery of Anti-Inflammatory Agents to Tumors

Title: Targeted Delivery of Anti-Inflammatory Agents to Tumors

Volume: 15 Issue: 16

Author(s): Maria Coimbra, Sylvia A. Kuijpers, Sebastiaan P. van Seters, Gert Storm and Raymond M. Schiffelers

Affiliation:

Abstract: Inflammation is considered a hallmark of cancer. The chronic inflammatory process is driven by the interaction of cells, proteins, cytokines, transcription factors, and lipid mediators within the tumor microenvironment giving rise to complex pro-inflammatory cascades. These can be inhibited by a variety of different anti-inflammatory compounds, like non-steroidal anti-inflammatory drugs, glucocorticoids, anti-inflammatory biologicals, phytotherapeutics (mainly polyphenols), and drugs with pleiotropic anti-inflammatory effects. In general, it appears that the anti-tumor activity of these compounds occurs at higher doses than the doses used in conventional anti-inflammatory therapy. To optimally take advantage of the anti-tumor activity and at the same time limit side effects, targeted delivery of anti-inflammatory drugs appears an attractive approach.

Cite this article as:

Coimbra Maria, Kuijpers A. Sylvia, van Seters P. Sebastiaan, Storm Gert and Schiffelers M. Raymond, Targeted Delivery of Anti-Inflammatory Agents to Tumors, Current Pharmaceutical Design 2009; 15 (16) . https://dx.doi.org/10.2174/138161209788453220