A Complete Sojourn of Monoclonal Antibodies: AI, Rare Diseases / Disorders And Immunotoxic Effects

Title:A Complete Sojourn of Monoclonal Antibodies: AI, Rare Diseases / Disorders And Immunotoxic Effects

Volume: 21

Author(s): Sonakshi Garg, Gurisha Garg, Preeti Patel, Ghanshyam Das Gupta and Balak Das Kurmi*

Affiliation:

• Department of Pharmaceutics, ISF College Pharmacy, GT Road, Moga-142001, Punjab, India

Abstract: Monoclonal antibodies (mAbs) are magic bullets proved to be a wonder in the pharmaceutical as well as medical fields. These are produced by various methods like hybridoma technology, phage display technology, YAC technology, and transgenic animals and plants. Based on the percentage of animal origin, mAbs are divided into chimeric, murine, humanized, and fully human. This review covers the history and methods of mAb production, immunotoxicity (Immunosuppression, immunostimulant, autoimmunity, hypersensitivity) associated with mAbs, and targets of mAbs. It also compiles mAb production using AI, new modifications, and novel mAbs, with its various clinical trial information ensuring the use of mAbs in rare diseases and disorders.

Cite this article as:

Garg Sonakshi, Garg Gurisha, Patel Preeti, Gupta Ghanshyam Das and Kurmi Balak Das*, A Complete Sojourn of Monoclonal Antibodies: AI, Rare Diseases / Disorders And Immunotoxic Effects, Current Proteomics 2024; 21 () . https://dx.doi.org/10.2174/0115701646313765240610062419