The Relationship between SNAP25 and Some Common Human Neurological Syndromes

Title:The Relationship between SNAP25 and Some Common Human Neurological Syndromes

Volume: 30 Issue: 30

Author(s): Jie Shu, Fan Peng, Jing Li, Yuhang Liu, Xiaolan Li*Chengfu Yuan*

Affiliation:

• College of Basic Medicine, The Second People’s Hospital of China Three Gorges University, Yichang 443002, China
• Department of Gynecology, The Second People’s Hospital of Yichang, Hubei, China

• Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China
• College of Basic Medical Science, China Three Gorges University, Yichang 443002, China
• Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China

Abstract: Over the years, research on the pathogenesis of neurological diseases has progressed slowly worldwide. However, as the incidence rate continues to increase and the disease gradually develops, early diagnosis and treatment have become a top priority. SANP25, a protein present on the presynaptic membrane and involved in neurotransmitter release, is closely related to the loss or abnormal expression of synapses and neurons. SNAP25 deficiency can lead to synaptic disorders and inhibit neurotransmitter release. Therefore, a large amount of literature believes that SNAP25 gene mutation is a risk factor for many neurological diseases. This review used advanced search on PubMed to conduct extensive article searches for relevant literature. The search keywords included SNAP25 and Alzheimer's disease, SNAP25 and Parkinson's disease, and so on. After reading and summarizing the previous papers, the corresponding conclusions were obtained to achieve the purpose of the review. The deficiency or variation of SNAP25 might be related to the onset of schizophrenia, epilepsy, attention deficit/hypoactivity disorder, bipolar disorder effective disorder, and autism. SNAP25 has been found to be used as a neuropathological marker for neurological diseases, which could be the target of diagnosis or treatment of Alzheimer’s disease and Parkinson’s disease. Cerebrospinal Fluid (CSF) or blood has been found to enable more effective drug development.

Cite this article as:

Shu Jie, Peng Fan, Li Jing, Liu Yuhang, Li Xiaolan*, Yuan Chengfu*, The Relationship between SNAP25 and Some Common Human Neurological Syndromes, Current Pharmaceutical Design 2024; 30 (30) . https://dx.doi.org/10.2174/0113816128305683240621060024