Abstract
This paper provides a review on ring closure reactions proceeding via intermediate nitrene formation published during the past 15 years. These cyclisations are classified according to the reaction types taking place. These are nitrene aromatic C-H insertions to form indoles, pyridine rings, nitrene – alicyclic CH insertions to fused oxazolidones, various other insertions on CH bonds in diverse saturated ring and aliphatic chains, nitrene insertion on a methoxy group, addition of the nitrene to a double bond, reactions with intermediate ring formation and subsequent transformation, N-N bond formation by addition of an electrophilic nitrene, and 1,3-dipolar cycloaddition of acyl nitrenes and C=C double bonds.
Keywords: Ring Closures, Heterocycles, Nitrenes, indoles, pyridine rings, N-N bond formation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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