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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

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ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

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Review Article

Flavonoids as Potential Natural Compounds for the Prevention and Treatment of Eczema

Author(s): Javed Khan, Shikha Yadav*, Divya Bhardwaj, Abhishek Kumar and Moshood Ummuani Okanlawon

Volume 23, Issue 2, 2024

Published on: 08 May, 2024

Page: [71 - 84] Pages: 14

DOI: 10.2174/0118715230299752240310171954

Price: $65

Abstract

Eczema is a systemic autoimmune disease characterized by inflammation and skin manifestation with a range of comorbidities that include physical and psychological disorders. Despite recent advancements in understanding the mechanisms involved in atopic dermatitis, current marketed products have shown varying results with more side effects. The present objective of the research studies is to develop new agents for eczema that cut down the cost of the novel drugs available and also improve the efficacy with the least adverse effects. Natural compounds and medicinal plants have been traditionally used since ancient civilizations. Nowadays, research in the herbal field is at its peak. One such natural compound, flavonoid, was found to be beneficial for the treatment of eczema. This review describes the use of certain flavonoid products to prepare preparations suitable for the treatment of prophylaxis or eczema. This is especially true for prophylaxis or atopic eczema treatment. These compounds exhibit anti-inflammatory, anti-inflammatory, anti-inflammatory, and anti-inflammatory properties and are, therefore, used in treatments to prevent allergies, inflammation, and irritation to the skin. We also dock the flavonoid derivatives used with the protein associated with the inhibition of eczema for better lead optimization. These preparations appear to be used for cosmetic, dermatological, or herbal remedies as a local application.

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[1]
Gębka, N.; Adamczyk, J.; Gębka-Kępińska, B.; Mizgała-Izworska, E. The role of flavonoids in prevention and treatment of selected skin diseases. J Pre Clin Clin Res., 2022, 16(3), 99-107.
[http://dx.doi.org/10.26444/jpccr/152551]
[2]
Eichenfield, L.F.; Tom, W.L.; Chamlin, S.L.; Feldman, S.R.; Hanifin, J.M.; Simpson, E.L.; Berger, T.G.; Bergman, J.N.; Cohen, D.E.; Cooper, K.D.; Cordoro, K.M.; Davis, D.M.; Krol, A.; Margolis, D.J.; Paller, A.S.; Schwarzenberger, K.; Silverman, R.A.; Williams, H.C.; Elmets, C.A.; Block, J.; Harrod, C.G.; Smith Begolka, W.; Sidbury, R. Guidelines of care for the management of atopic dermatitis. J. Am. Acad. Dermatol., 2014, 70(2), 338-351.
[http://dx.doi.org/10.1016/j.jaad.2013.10.010] [PMID: 24290431]
[3]
Rodenbeck, D.L.; Silverberg, J.I.; Silverberg, N.B. Phototherapy for atopic dermatitis. Clin. Dermatol., 2016, 34(5), 607-613.
[http://dx.doi.org/10.1016/j.clindermatol.2016.05.011] [PMID: 27638440]
[4]
Ellis, B.C.; Garnsworthy, R.K. A review of techniques for the assessment of hand. Text. Res. J., 1980, 50(4), 231-238.
[http://dx.doi.org/10.1177/004051758005000406]
[5]
Leung, D.Y.M.; Boguniewicz, M.; Howell, M.D.; Nomura, I.; Hamid, Q.A. New insights into atopic dermatitis. J. Clin. Invest., 2004, 113(5), 651-657.
[http://dx.doi.org/10.1172/JCI21060] [PMID: 14991059]
[6]
Harvey, L.H. Eragrostis in North and Middle America; University of Michigan, 1948.
[7]
Hwang, H.Y.; Iwasa, Y.; Kawasaki, M.; Keimer, B.; Nagaosa, N.; Tokura, Y. Emergent phenomena at oxide interfaces. Nat. Mater., 2012, 11(2), 103-113.
[http://dx.doi.org/10.1038/nmat3223] [PMID: 22270825]
[8]
Paller, A.S.; Tom, W.L.; Lebwohl, M.G.; Blumenthal, R.L.; Boguniewicz, M.; Call, R.S.; Eichenfield, L.F.; Forsha, D.W.; Rees, W.C.; Simpson, E.L.; Spellman, M.C.; Stein Gold, L.F.; Zaenglein, A.L.; Hughes, M.H.; Zane, L.T.; Hebert, A.A. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J. Am. Acad. Dermatol., 2016, 75(3), 494-503.e6.
[http://dx.doi.org/10.1016/j.jaad.2016.05.046] [PMID: 27417017]
[9]
Vonk-Herwig, I. Sensory Stimulus Processing and the Connection with Relationships with other Children and the Teacher and Personality Characteristics in Primary School Children from 8 to 12 years.,
[10]
Joseph, J.; Cinque, P.; Colosi, D.; Dravid, A.; Ene, L.; Fox, H.; Gabuzda, D.; Gisslen, M.; Beth Joseph, S.; Letendre, S.; Mukerji, S.S.; Nath, A.; Perez-Valero, I.; Persaud, D.; Price, R.W.; Rao, V.R.; Sacktor, N.; Swanstrom, R.; Winston, A.; Wojna, V.; Wright, E.; Spudich, S. Highlights of the global HIV-1 CSF escape consortium meeting, 9 June 2016, Bethesda, MD, USA. J. Virus Erad., 2016, 2(4), 243-250.
[http://dx.doi.org/10.1016/S2055-6640(20)30879-7] [PMID: 27781109]
[11]
Heiat, F.; Heiat, M.; Shojaeifard, M. Changes in mitochondrial biogenesis and fatty liver indicators in rat following continuous and high intensity interval training. J. Sports Med. Phys. Fitness, 2021, 61(10), 1416-1422.
[http://dx.doi.org/10.23736/S0022-4707.20.11693-1] [PMID: 34652089]
[12]
Vogler, B.K.; Ernst, E. Aloe vera: A systematic review of its clinical effectiveness. Br. J. Gen. Pract., 1999, 49(447), 823-828.
[PMID: 10885091]
[13]
Hultsch, T.; Kapp, A.; Spergel, J. Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis. Dermatology, 2005, 211(2), 174-187.
[http://dx.doi.org/10.1159/000086739] [PMID: 16088174]
[14]
Shadi, I.T.; Chowdhry, B.Z.; Snowden, M.J.; Withnall, R. Analysis of the conversion of indigo into indigo carmine dye using SERRS. Chem. Commun., 2004, (12), 1436-1437.
[http://dx.doi.org/10.1039/b403601h] [PMID: 15179502]
[15]
Nemoto-Hasebe, I.; Akiyama, M.; Nomura, T.; Sandilands, A.; Irwin McLean, W.H.; Shimizu, H. Clinical severity correlates with impaired barrier in filaggrin-related eczema. J. Invest. Dermatol., 2009, 129(3), 682-689.
[http://dx.doi.org/10.1038/jid.2008.280] [PMID: 18818676]
[16]
Kral, Q.; Krivov, A.V.; Defrère, D.; van Lieshout, R.; Bonsor, A.; Augereau, J.C.; Thébault, P.; Ertel, S.; Lebreton, J.; Absil, O. Exozodiacal clouds: Hot and warm dust around main sequence stars. Astronomical Review, 2017, 13(2), 69-111.
[http://dx.doi.org/10.1080/21672857.2017.1353202]
[17]
Wishart, D.S.; Tzur, D.; Knox, C.; Eisner, R.; Guo, A.C.; Young, N.; Cheng, D.; Jewell, K.; Arndt, D.; Sawhney, S.; Fung, C.; Nikolai, L.; Lewis, M.; Coutouly, M.A.; Forsythe, I.; Tang, P.; Shrivastava, S.; Jeroncic, K.; Stothard, P.; Amegbey, G.; Block, D.; Hau, D.D.; Wagner, J.; Miniaci, J.; Clements, M.; Gebremedhin, M.; Guo, N.; Zhang, Y.; Duggan, G.E.; MacInnis, G.D.; Weljie, A.M.; Dowlatabadi, R.; Bamforth, F.; Clive, D.; Greiner, R.; Li, L.; Marrie, T.; Sykes, B.D.; Vogel, H.J.; Querengesser, L. HMDB: The human metabolome database. Nucleic Acids Res., 2007, 35(Database)(Suppl. 1), D521-D526.
[http://dx.doi.org/10.1093/nar/gkl923] [PMID: 17202168]
[18]
Um, J.W.; Choii, G.; Park, D.; Kim, D.; Jeon, S.; Kang, H.; Mori, T.; Papadopoulos, T.; Yoo, T.; Lee, Y.; Kim, E.; Tabuchi, K.; Ko, J. IQ motif and SEC7 domain-containing protein 3 (IQSEC3) interacts with gephyrin to promote inhibitory synapse formation. J. Biol. Chem., 2016, 291(19), 10119-10130.
[http://dx.doi.org/10.1074/jbc.M115.712893] [PMID: 27002143]
[19]
Qian, W.; Jia, Y.; Ren, S.X.; He, Y.Q.; Feng, J.X.; Lu, L.F.; Sun, Q.; Ying, G.; Tang, D.J.; Tang, H.; Wu, W.; Hao, P.; Wang, L.; Jiang, B.L.; Zeng, S.; Gu, W.Y.; Lu, G.; Rong, L.; Tian, Y.; Yao, Z.; Fu, G.; Chen, B.; Fang, R.; Qiang, B.; Chen, Z.; Zhao, G.P.; Tang, J.L.; He, C. Comparative and functional genomic analyses of the pathogenicity of phytopathogen Xanthomonas campestris pv. campestris. Genome Res., 2005, 15(6), 757-767.
[http://dx.doi.org/10.1101/gr.3378705] [PMID: 15899963]
[20]
Calderón-Montaño, J.M.; Burgos-Morón, E.; Orta, M.L.; Maldonado-Navas, D.; García-Domínguez, I.; López-Lázaro, M. Evaluating the cancer therapeutic potential of cardiac glycosides. BioMed Res. Int., 2014, 2014, 1-9.
[http://dx.doi.org/10.1155/2014/794930] [PMID: 24895612]
[21]
Abdel-Monaim, M.F.; Morsy, M. K.; Zyan, A.H.M. efficacy of some organic compounds in controlling fusarium wilt disease, growth, and yield parameters in chickpea plants. Egypt. J. Agric. Res., 2018, 96(2), 351-364.
[http://dx.doi.org/10.21608/ejar.2018.132936]
[22]
Dubey, S.; Biswas, P.; Ghosh, R.; Chatterjee, S.; Dubey, M.J.; Chatterjee, S.; Lahiri, D.; Lavie, C.J. Psychosocial impact of COVID-19. Diabetes Metab. Syndr., 2020, 14(5), 779-788.
[http://dx.doi.org/10.1016/j.dsx.2020.05.035] [PMID: 32526627]
[23]
Manay, P.; Satoskar, R.; Karthik, V.; Prajapati, R. Studying morbidity and predicting mortality in patients with blunt chest trauma using a novel clinical score. J. Emerg. Trauma Shock, 2017, 10(3), 128-133.
[http://dx.doi.org/10.4103/JETS.JETS_131_16] [PMID: 28855775]
[24]
Aggarwal, B.B.; Sundaram, C.; Prasad, S.; Kannappan, R. Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases. Biochem. Pharmacol., 2010, 80(11), 1613-1631.
[http://dx.doi.org/10.1016/j.bcp.2010.07.043] [PMID: 20696139]
[25]
Khilji, S.E. Editor’s perspective. South Asian J. Glob. Bus. Res., 2012, 1(1), 8-21.
[http://dx.doi.org/10.1108/20454451211205914]
[26]
Kashchenko, N.I.; Olennikov, D.N.; Chirikova, N.K. Phytohormones and elicitors enhanced the ecdysteroid and glycosylflavone content and antioxidant activity of silene repens. Appl. Sci., 2021, 11(23), 11099.
[http://dx.doi.org/10.3390/app112311099]
[27]
Rügge, S.D.; Nielsen, M.; Jacobsen, A.S.; Vang, O.; Jemec, G.B. Evidence of dermatological effects of chamomile. Ugeskr. Laeger, 2010, 172(50), 3492-3496.
[PMID: 21156115]
[28]
Blumenthal, M.N.; Zhong, W.; Miller, M.; Wendt, C.; Connett, J.E.; Pei, D. Serum metalloproteinase leukolysin (MMP‐25/MT‐6): A potential metabolic marker for atopy‐associated inflammation. Clin. Exp. Allergy, 2010, 40(6), 859-866.
[http://dx.doi.org/10.1111/j.1365-2222.2010.03475.x] [PMID: 20337648]
[29]
Frankel, H.C.; Qureshi, A.A. Comparative effectiveness of topical calcineurin inhibitors in adult patients with atopic dermatitis. Am. J. Clin. Dermatol., 2012, 13(2), 113-123.
[http://dx.doi.org/10.2165/11597780-000000000-00000] [PMID: 22263704]
[30]
Hanifin, J.; Tofte, S. Update on therapy of atopic dermatitis. J. Allergy Clin. Immunol., 1999, 104(3), S123-S125.
[http://dx.doi.org/10.1016/S0091-6749(99)70054-0] [PMID: 10482863]
[31]
Nadeau, K.C.; Schneider, L.C.; Hoyte, L.; Borras, I.; Umetsu, D.T. Rapid oral desensitization in combination with omalizumab therapy in patients with cow’s milk allergy. J. Allergy Clin. Immunol., 2011, 127(6), 1622-1624.
[http://dx.doi.org/10.1016/j.jaci.2011.04.009] [PMID: 21546071]
[32]
Chan, L.S.; Vanderlugt, C.J.; Hashimoto, T.; Nishikawa, T.; Zone, J.J.; Black, M.M.; Wojnarowska, F.; Stevens, S.R.; Chen, M.; Fairley, J.A.; Woodley, D.T.; Miller, S.D.; Gordon, K.B. Epitope spreading: Lessons from autoimmune skin diseases. J. Invest. Dermatol., 1998, 110(2), 103-109.
[http://dx.doi.org/10.1046/j.1523-1747.1998.00107.x] [PMID: 9457902]
[33]
Aertgeerts, P.; Albring, M.; Klaschka, F.; Nasemann, T.; Patzelt-Wenczler, R.; Rauhut, K.; Weigl, B. [Comparative testing of Kamillosan cream and steroidal (0.25% hydrocortisone, 0.75% fluocortin butyl ester) and non-steroidal (5% bufexamac) dermatologic agents in maintenance therapy of eczematous diseases]. Z. Hautkr., 1985, 60(3), 270-277.
[PMID: 3158124]
[34]
Aggarwal, B.B.; Bhardwaj, A.; Aggarwal, R.S.; Seeram, N.P.; Shishodia, S.; Takada, Y. Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Res., 2004, 24(5A), 2783-2840.
[PMID: 15517885]
[35]
Barcroft, J.; Haldane, J.S. A method of estimating the oxygen and carbonic acid in small quantities of blood. J. Physiol., 1902, 28(3), 232-240.
[http://dx.doi.org/10.1113/jphysiol.1902.sp000912] [PMID: 16992619]
[36]
Blumenthal, M.S.; Clark, D.D. Rethinking the design of the Internet. ACM Trans. Internet Technol., 2001, 1(1), 70-109.
[http://dx.doi.org/10.1145/383034.383037]
[37]
Brown, D.J.; Schermerhorn, M.L.; Powell, R.J.; Fillinger, M.F.; Rzucidlo, E.M.; Walsh, D.B.; Wyers, M.C.; Zwolak, R.M.; Cronenwett, J.L. Mesenteric stenting for chronic mesenteric ischemia. J. Vasc. Surg., 2005, 42(2), 268-274.
[http://dx.doi.org/10.1016/j.jvs.2005.03.054] [PMID: 16102625]
[38]
Bunyapraphatsara, N.; Yongchaiyudha, S.; Rungpitarangsi, V.; Chokechaijaroenporn, O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine, 1996, 3(3), 245-248.
[http://dx.doi.org/10.1016/S0944-7113(96)80061-4] [PMID: 23195078]
[39]
Calapai, G.; Casciaro, M.; Miroddi, M.; Calapai, F.; Navarra, M.; Gangemi, S. Montelukast-induced adverse drug reactions: A review of case reports in the literature. Pharmacology, 2014, 94(1-2), 60-70.
[http://dx.doi.org/10.1159/000366164] [PMID: 25196099]
[40]
Krakowski, A.C.; Eichenfield, L.F.; Dohil, M.A. Management of atopic dermatitis in the pediatric population. Pediatrics, 2008, 122(4), 812-824.
[http://dx.doi.org/10.1542/peds.2007-2232] [PMID: 18829806]
[41]
Carr, W.W.; Ratner, P.; Munzel, U.; Murray, R.; Price, D.; Canonica, G.W.; Mullol, J.; Virchow, J.C.; Lieberman, P.; Meltzer, E.; Bachert, C. Comparison of intranasal azelastine to intranasal fluticasone propionate for symptom control in moderate-to-severe seasonal allergic rhinitis. Allergy Asthma Proc., 2012, 33(6), 450-458.
[http://dx.doi.org/10.2500/aap.2012.33.3626] [PMID: 23127291]
[42]
Chattopadhyay, S.; Sen, G.C. dsRNA-activation of TLR3 and RLR signaling: Gene induction-dependent and independent effects. J. Interferon Cytokine Res., 2014, 34(6), 427-436.
[http://dx.doi.org/10.1089/jir.2014.0034] [PMID: 24905199]
[43]
Chaturvedi, T. Allergy related to dental implant and its clinical significance. Clin. Cosmet. Investig. Dent., 2013, 5, 57-61.
[http://dx.doi.org/10.2147/CCIDE.S35170] [PMID: 23990733]
[44]
Xiong, X.; Yang, X.; Liu, Y.; Zhang, Y.; Wang, P.; Wang, J. Chinese herbal formulas for treating hypertension in traditional Chinese medicine: Perspective of modern science. Hypertens. Res., 2013, 36(7), 570-579.
[http://dx.doi.org/10.1038/hr.2013.18] [PMID: 23552514]
[45]
Daur, I. Study of commercial effective microorganism on composting and dynamics of plant essential metal micronutrients. J. Environ. Biol., 2016, 37(5), 937-941.
[PMID: 29251850]
[46]
Dawid-Pać, R. Medicinal plants used in treatment of inflammatory skin diseases. Postepy Dermatol. Alergol., 2013, 3(3), 170-177.
[http://dx.doi.org/10.5114/pdia.2013.35620] [PMID: 24278070]
[47]
Duke, J.A. Ecosystematic data on economic plants. Q. J. Crude Drug Res., 1979, 17(3-4), 91-109.
[http://dx.doi.org/10.3109/13880207909065158]
[48]
Gamal, E.E.G.; Khalifa, S.A.K.; Gameel, A.S.; Emad, M.A. Traditional medicinal plants indigenous to Al-Rass province, Saudi Arabia. J. Med. Plants Res., 2010, 4(24), 2680-2683.
[http://dx.doi.org/10.5897/JMPR09.556]
[49]
Regnstrom, J.; Koenig, F.; Aronsson, B.; Reimer, T.; Svendsen, K.; Tsigkos, S.; Flamion, B.; Eichler, H.G.; Vamvakas, S. Factors associated with success of market authorisation applications for pharmaceutical drugs submitted to the European Medicines Agency. Eur. J. Clin. Pharmacol., 2010, 66(1), 39-48.
[http://dx.doi.org/10.1007/s00228-009-0756-y] [PMID: 19936724]
[50]
Femenia, A.; Sastre-Serrano, G.; Simal, S.; Garau, M.C.; Eim, V.S.; Rosselló, C. Effects of air-drying temperature on the cell walls of kiwifruit processed at different stages of ripening. Lebensm. Wiss. Technol., 2009, 42(1), 106-112.
[http://dx.doi.org/10.1016/j.lwt.2008.05.022]
[51]
Ferro, V.A.; Bradbury, F.; Cameron, P.; Shakir, E.; Rahman, S.R.; Stimson, W.H. In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller. Antimicrob. Agents Chemother., 2003, 47(3), 1137-1139.
[http://dx.doi.org/10.1128/AAC.47.3.1137-1139.2003] [PMID: 12604556]
[52]
Brito, V.N.; Spinola-Castro, A.M.; Kochi, C.; Kopacek, C.; Silva, P.C.A.; Guerra-Júnior, G. Central precocious puberty: Revisiting the diagnosis and therapeutic management. Arch. Endocrinol. Metab., 2016, 60(2), 163-172.
[http://dx.doi.org/10.1590/2359-3997000000144] [PMID: 27191050]
[53]
Kolodziejczyk-Czepas, J. Trifolium species-derived substances and extracts—Biological activity and prospects for medicinal applications. J. Ethnopharmacol., 2012, 143(1), 14-23.
[http://dx.doi.org/10.1016/j.jep.2012.06.048] [PMID: 22771317]
[54]
Nagpal, I.; Raj, I.; Subbarao, N.; Gourinath, S. Virtual screening, identification and in vitro testing of novel inhibitors of O-acetyl-L-serine sulfhydrylase of Entamoeba histolytica. PLoS One, 2012, 7(2), e30305.
[http://dx.doi.org/10.1371/journal.pone.0030305] [PMID: 22355310]
[55]
Nayak, S.; Lyon, L.A. Soft nanotechnology with soft nanoparticles. Angew. Chem. Int. Ed., 2005, 44(47), 7686-7708.
[http://dx.doi.org/10.1002/anie.200501321] [PMID: 16283684]
[56]
Nayak, S.K. Probiotics and immunity: A fish perspective. Fish Shellfish Immunol., 2010, 29(1), 2-14.
[http://dx.doi.org/10.1016/j.fsi.2010.02.017] [PMID: 20219683]
[57]
Ratz-łyko, A.; Arct, J.; Pytkowska, K. Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract. Indian J. Pharm. Sci., 2016, 78(1), 27-33.
[http://dx.doi.org/10.4103/0250-474X.180247] [PMID: 27168678]
[58]
Zhu, Y.; Zhang, Y.; Liu, Y.; Chu, H.; Duan, H. Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents. Molecules, 2010, 15(12), 9174-9183.
[http://dx.doi.org/10.3390/molecules15129174] [PMID: 21150832]
[59]
Le Roy, J.; Huss, B.; Creach, A.; Hawkins, S.; Neutelings, G. Glycosylation is a major regulator of phenylpropanoid availability and biological activity in plants. Front. Plant Sci., 2016, 7, 735.
[http://dx.doi.org/10.3389/fpls.2016.00735] [PMID: 27303427]
[60]
Vessal, M.; Yazdanian, M. Comparison of the effects of an aqueous extract of Physalis alkekengi fruits and/or various doses of 17-β-estradiol on rat estrous cycle and uterine glucose 6-phosphate dehydrogenase activity. Comp. Biochem. Physiol. C. Comp. Pharmacol. Toxicol., 1995, 112(2), 229-236.
[http://dx.doi.org/10.1016/0742-8413(95)02014-4] [PMID: 8788592]
[61]
Luhata, L.P.; Luhata, W.G. Tiliroside: Biosynthesis, bioactivity and structure activity relationship (SAR)-A review. Journal of Phytopharmacology, 2017, 6(6), 343-348.
[http://dx.doi.org/10.31254/phyto.2017.6607]
[62]
Arshad, M.; Frankenberger, W.T., Jr Ethylene accumulation in soil in response to organic amendments. Soil Sci. Soc. Am. J., 1990, 54(4), 1026-1031.
[http://dx.doi.org/10.2136/sssaj1990.03615995005400040016x]
[63]
Burak, M.F.; Inouye, K.E.; White, A.; Lee, A.; Tuncman, G.; Calay, E.S.; Sekiya, M.; Tirosh, A.; Eguchi, K.; Birrane, G.; Lightwood, D.; Howells, L.; Odede, G.; Hailu, H.; West, S.; Garlish, R.; Neale, H.; Doyle, C.; Moore, A.; Hotamisligil, G.S. Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes. Sci. Transl. Med., 2015, 7(319), 319ra205.
[http://dx.doi.org/10.1126/scitranslmed.aac6336] [PMID: 26702093]
[64]
Havsteen, B. Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol., 1983, 32(7), 1141-1148.
[http://dx.doi.org/10.1016/0006-2952(83)90262-9] [PMID: 6342623]
[65]
Miles, W.D. A history of the National Library of Medicine: The nation’s treasury of medical knowledge; US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, 1982.
[66]
Wang, Y.; Jia, Y.; Guan, L.; Lu, C.; Lei, G.; Wen, L.; Liu, G. Optimising hydrological conditions to sustain wintering waterbird populations in P oyang L ake N ational N atural R eserve: Implications for dam operations. Freshw. Biol., 2013, 58(11), 2366-2379.
[http://dx.doi.org/10.1111/fwb.12216]
[67]
Karpel, J.E.; Place, W.R.; Bisson, L.F. Analysis of the major hexose transporter genes in wine strains of Saccharomyces cerevisiae. Am. J. Enol. Vitic., 2008, 59(3), 265-275.
[http://dx.doi.org/10.5344/ajev.2008.59.3.265]
[68]
Kaufman, T.S.; Rúveda, E.A. The quest for quinine: Those who won the battles and those who won the war. Angew. Chem. Int. Ed., 2005, 44(6), 854-885.
[http://dx.doi.org/10.1002/anie.200400663] [PMID: 15669029]
[69]
Kaul, G.; Pattan, G.; Rafeequi, T. Eukaryotic elongation factor‐2 (eEF2): Its regulation and peptide chain elongation. Cell Biochem. Funct., 2011, 29(3), 227-234.
[http://dx.doi.org/10.1002/cbf.1740] [PMID: 21394738]
[70]
Ernst, E. Adverse effects of herbal drugs in dermatology. Br. J. Dermatol., 2000, 143(5), 923-929.
[http://dx.doi.org/10.1046/j.1365-2133.2000.03822.x] [PMID: 11069498]
[71]
Kim, J.; Basak, J.M.; Holtzman, D.M. The role of apolipoprotein E in Alzheimer’s disease. Neuron, 2009, 63(3), 287-303.
[http://dx.doi.org/10.1016/j.neuron.2009.06.026] [PMID: 19679070]
[72]
Evans, S.M.; Judy, K.D.; Dunphy, I.; Jenkins, W.T.; Nelson, P.T.; Collins, R.; Wileyto, E.P.; Jenkins, K.; Hahn, S.M.; Stevens, C.W.; Judkins, A.R.; Phillips, P.; Geoerger, B.; Koch, C.J. Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding. Cancer Res., 2004, 64(5), 1886-1892.
[http://dx.doi.org/10.1158/0008-5472.CAN-03-2424] [PMID: 14996753]
[73]
Tripathi, A.K.; Prajapati, V.; Verma, N.; Bahl, J.R.; Bansal, R.P.; Khanuja, S.P.S.; Kumar, S. Bioactivities of the leaf essential oil of Curcuma longa (var. ch-66) on three species of stored-product beetles (Coleoptera). J. Econ. Entomol., 2002, 95(1), 183-189.
[http://dx.doi.org/10.1603/0022-0493-95.1.183] [PMID: 11942755]
[74]
Langmead, L.; Rampton, D.S. Review article: Herbal treatment in gastrointestinal and liver disease—benefits and dangers. Aliment. Pharmacol. Ther., 2001, 15(9), 1239-1252.
[http://dx.doi.org/10.1046/j.1365-2036.2001.01053.x] [PMID: 11552894]
[75]
Limtrakul, P.; Chearwae, W.; Shukla, S.; Phisalphong, C.; Ambudkar, S.V. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol. Cell. Biochem., 2007, 296(1-2), 85-95.
[http://dx.doi.org/10.1007/s11010-006-9302-8] [PMID: 16960658]
[76]
McAleer, M.A.; Fitzpatrick, P.; Powell, F.C. Papulopustular rosacea: Prevalence and relationship to photodamage. J. Am. Acad. Dermatol., 2010, 63(1), 33-39.
[http://dx.doi.org/10.1016/j.jaad.2009.04.024] [PMID: 20462665]
[77]
McKay, D.L.; Blumberg, J.B. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother. Res., 2006, 20(8), 619-633.
[http://dx.doi.org/10.1002/ptr.1936] [PMID: 16767798]
[78]
McLeod, P.J.; Huang, A.R.; Tamblyn, R.M.; Gayton, D.C. Defining inappropriate practices in prescribing for elderly people: A national consensus panel. CMAJ, 1997, 156(3), 385-391.
[PMID: 9033421]
[79]
Murata, Y.; Iwasaki, H.; Sasaki, M.; Inaba, K.; Okamura, Y. Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor. Nature, 2005, 435(7046), 1239-1243.
[http://dx.doi.org/10.1038/nature03650] [PMID: 15902207]
[80]
Sood, S.; Nagpal, M. Role of curcumin in systemic and oral health: An overview. J. Nat. Sci. Biol. Med., 2013, 4(1), 3-7.
[http://dx.doi.org/10.4103/0976-9668.107253] [PMID: 23633828]
[81]
Nebus, J.A.; Smith, G.; Kurtz, E.S.; Wallo, W. Alleviating dry, ashen skin in patients with skin of color. J. Am. Acad. Dermatol., 2004, 50(3), 77.
[http://dx.doi.org/10.1016/j.jaad.2003.10.632]
[82]
Olsen, D.L.; Raub, W., Jr; Bradley, C.; Johnson, M.; Macias, J.L.; Love, V.; Markoe, A. The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol. Nurs. Forum, 2001, 28(3), 543-547.
[PMID: 11338761]
[83]
Pan, S.Y.; Zhou, S.F.; Gao, S.H.; Yu, Z.L.; Zhang, S.F.; Tang, M.K.; Sun, J.N.; Ma, D.L.; Han, Y.F.; Fong, W.F.; Ko, K.M. New perspectives on how to discover drugs from herbal medicines: CAM’s outstanding contribution to modern therapeutics. Evid. Based Complement. Alternat. Med., 2013, 2013, 627375.
[84]
Pytkowska, K.; Arct, J. Natural anti-age ingredients from the fraction of unsaponifiable vegetable oils. In: SOFW Journal - Polish Edition. 1; , 2008.
[85]
Renu, S.; Shivashangari, K.S.; Ravikumar, V. Incorporated plant extract fabricated silver/poly-D,l-lactide-co-glycolide nanocomposites for antimicrobial based wound healing. Spectrochim. Acta A Mol. Biomol. Spectrosc., 2020, 228, 117673.
[http://dx.doi.org/10.1016/j.saa.2019.117673] [PMID: 31735599]
[86]
Reynertson, K.A.; Wallace, A.M.; Adachi, S.; Gil, R.R.; Yang, H.; Basile, M.J.; D’Armiento, J.; Weinstein, I.B.; Kennelly, E.J. Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). J. Nat. Prod., 2006, 69(8), 1228-1230.
[http://dx.doi.org/10.1021/np0600999] [PMID: 16933884]
[87]
Reynolds, K.T.; Hoffmann, A.A. Male age, host effects and the weak expression or non-expression of cytoplasmic incompatibility in Drosophila strains infected by maternally transmitted Wolbachia. Genet. Res., 2002, 80(2), 79-87.
[http://dx.doi.org/10.1017/S0016672302005827] [PMID: 12534211]
[88]
Jain, S.; Mahajan, A.; Patil, P.; Bhandarkar, P.; Sarang, B.; Bains, L.; Bhandoria, G.; Khajanchi, M.; Veetil, DK.; Mohan, M.; Shah, P. Understanding the effect of COVID-19 pandemic on emergency surgical care delivery in India: A multicenter cross-sectional study. Research Square, 2022, 1-17.
[http://dx.doi.org/10.21203/rs.3.rs-1543145/v1]
[89]
Schulte-Schrepping, J.; Reusch, N.; Paclik, D.; Baßler, K.; Schlickeiser, S.; Zhang, B.; Krämer, B.; Krammer, T.; Brumhard, S.; Bonaguro, L.; De Domenico, E.; Wendisch, D.; Grasshoff, M.; Kapellos, T.S.; Beckstette, M.; Pecht, T.; Saglam, A.; Dietrich, O.; Mei, H.E.; Schulz, A.R.; Conrad, C.; Kunkel, D.; Vafadarnejad, E.; Xu, C.J.; Horne, A.; Herbert, M.; Drews, A.; Thibeault, C.; Pfeiffer, M.; Hippenstiel, S.; Hocke, A.; Müller-Redetzky, H.; Heim, K.M.; Machleidt, F.; Uhrig, A.; Bosquillon de Jarcy, L.; Jürgens, L.; Stegemann, M.; Glösenkamp, C.R.; Volk, H.D.; Goffinet, C.; Landthaler, M.; Wyler, E.; Georg, P.; Schneider, M.; Dang-Heine, C.; Neuwinger, N.; Kappert, K.; Tauber, R.; Corman, V.; Raabe, J.; Kaiser, K.M.; Vinh, M.T.; Rieke, G.; Meisel, C.; Ulas, T.; Becker, M.; Geffers, R.; Witzenrath, M.; Drosten, C.; Suttorp, N.; von Kalle, C.; Kurth, F.; Händler, K.; Schultze, J.L.; Aschenbrenner, A.C.; Li, Y.; Nattermann, J.; Sawitzki, B.; Saliba, A.E.; Sander, L.E.; Angelov, A.; Bals, R.; Bartholomäus, A.; Becker, A.; Bezdan, D.; Bonifacio, E.; Bork, P.; Clavel, T.; Colome-Tatche, M.; Diefenbach, A.; Dilthey, A.; Fischer, N.; Förstner, K.; Frick, J-S.; Gagneur, J.; Goesmann, A.; Hain, T.; Hummel, M.; Janssen, S.; Kalinowski, J.; Kallies, R.; Kehr, B.; Keller, A.; Kim-Hellmuth, S.; Klein, C.; Kohlbacher, O.; Korbel, J.O.; Kurth, I.; Landthaler, M.; Li, Y.; Ludwig, K.; Makarewicz, O.; Marz, M.; McHardy, A.; Mertes, C.; Nöthen, M.; Nürnberg, P.; Ohler, U.; Ossowski, S.; Overmann, J.; Peter, S.; Pfeffer, K.; Poetsch, A.R.; Pühler, A.; Rajewsky, N.; Ralser, M.; Rieß, O.; Ripke, S.; Nunes da Rocha, U.; Rosenstiel, P.; Saliba, A-E.; Sander, L.E.; Sawitzki, B.; Schiffer, P.; Schulte, E-C.; Schultze, J.L.; Sczyrba, A.; Stegle, O.; Stoye, J.; Theis, F.; Vehreschild, J.; Vogel, J.; von Kleist, M.; Walker, A.; Walter, J.; Wieczorek, D.; Ziebuhr, J. Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell, 2020, 182(6), 1419-1440.e23.
[http://dx.doi.org/10.1016/j.cell.2020.08.001] [PMID: 32810438]
[90]
Schürer, N.Y.; Plewig, G.; Elias, P.M. Stratum corneum lipid function. Dermatology, 1991, 183(2), 77-94.
[http://dx.doi.org/10.1159/000247644] [PMID: 1743378]
[91]
Shankar, T.N.; Sahoo, G. Cryptography with elliptic curves. Int. J. Comput. Sci. Appl., 2009, 2(1), 38-42.
[92]
Srivastava, J.K.; Shankar, E.; Gupta, S. Chamomile: A herbal medicine of the past with bright future. Mol. Med. Rep., 2010, 3(6), 895-901.
[PMID: 21132119]
[93]
Srivastava, J.; Gupta, S. Extraction, characterization, stability and biological activity of flavonoids isolated from chamomile flowers. Mol. Cell. Pharmacol., 2009, 1(3), 138-147.
[http://dx.doi.org/10.4255/mcpharmacol.09.18] [PMID: 20098626]
[94]
Díaz, S.; Settele, J.; Brondízio, E.S.; Ngo, H.T.; Agard, J.; Arneth, A.; Balvanera, P.; Brauman, K.A.; Butchart, S.H.M.; Chan, K.M.A.; Garibaldi, L.A.; Ichii, K.; Liu, J.; Subramanian, S.M.; Midgley, G.F.; Miloslavich, P.; Molnár, Z.; Obura, D.; Pfaff, A.; Polasky, S.; Purvis, A.; Razzaque, J.; Reyers, B.; Chowdhury, R.R.; Shin, Y.J.; Visseren-Hamakers, I.; Willis, K.J.; Zayas, C.N. Pervasive human-driven decline of life on Earth points to the need for transformative change. Science, 2019, 366(6471), eaax3100.
[http://dx.doi.org/10.1126/science.aax3100] [PMID: 31831642]
[95]
Sur, R.; Nigam, A.; Grote, D.; Liebel, F.; Southall, M.D. Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity. Arch. Dermatol. Res., 2008, 300(10), 569-574.
[http://dx.doi.org/10.1007/s00403-008-0858-x] [PMID: 18461339]
[96]
Syed, T.A.; Ahmad, S.A.; Holt, A.H.; Ahmad, S.A.; Ahmad, S.H.; Afzal, M. Management of psoriasis with Aloe vera extract in a hydrophilic cream: A placebo‐controlled, double‐blind study. Trop. Med. Int. Health, 1996, 1(4), 505-509.
[http://dx.doi.org/10.1046/j.1365-3156.1996.d01-91.x] [PMID: 8765459]
[97]
Tabassum, N.; Hamdani, M. Plants used to treat skin diseases. Pharmacogn. Rev., 2014, 8(15), 52-60.
[http://dx.doi.org/10.4103/0973-7847.125531] [PMID: 24600196]
[98]
Tay, Y.K.; Weston, W.L.; Morelli, J.G. Treatment of pyogenic granuloma in children with the flashlamp-pumped pulsed dye laser. Pediatrics, 1997, 99(3), 368-370.
[http://dx.doi.org/10.1542/peds.99.3.368] [PMID: 9041290]
[99]
Tayel, A.A.; El-Tras, W.F.; Abdel-Monem, O.A.; El-Sabbagh, S.M.; Alsohim, A.S.; El-Refai, E.M. Production of anticandidal cotton textiles treated with oak gall extract. Rev. Argent. Microbiol., 2013, 45(4), 271-276.
[http://dx.doi.org/10.1016/S0325-7541(13)70036-1] [PMID: 24401783]
[100]
Tayyem, R.F.; Bawadi, H.A.; Shehadah, I.; Bani-Hani, K.E.; Takruri, H.; Al-Jaberi, T.; Heath, D.D. Fast foods, sweets and beverage consumption and risk of colorectal cancer: A case-control study in Jordan. Asian Pac. J. Cancer Prev., 2018, 19(1), 261-269.
[PMID: 29374411]
[101]
Teplitsky, V.; Shoenfeld, Y.; Tanay, A. The renin-angiotensin system in lupus: Physiology, genes and practice, in animals and humans. Lupus, 2006, 15(6), 319-325.
[http://dx.doi.org/10.1191/0961203306lu2306rr] [PMID: 16830877]
[102]
Vogler, B.K.; Pittler, M.H.; Ernst, E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur. J. Clin. Pharmacol., 1999, 55(8), 567-575.
[http://dx.doi.org/10.1007/s002280050674] [PMID: 10541774]
[103]
Weiss, R.F. Determinations of carbon dioxide and methane by dual catalyst flame ionization chromatography and nitrous oxide by electron capture chromatography. J. Chromatogr. Sci., 1981, 19(12), 611-616.
[http://dx.doi.org/10.1093/chromsci/19.12.611]
[104]
Odhiambo, J.A.; Williams, H.C.; Clayton, T.O.; Robertson, C.F.; Asher, M.I. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J. Allergy Clin. Immunol., 2009, 124(6), 1251-1258.e23.
[http://dx.doi.org/10.1016/j.jaci.2009.10.009] [PMID: 20004783]
[105]
Williams, A.H.; Kim, T.H.; Wang, F.; Vyas, S.; Ryu, S.I.; Shenoy, K.V.; Schnitzer, M.; Kolda, T.G.; Ganguli, S. Unsupervised discovery of demixed, low-dimensional neural dynamics across multiple timescales through tensor component analysis. Neuron, 2018, 98(6), 1099-1115.e8.
[http://dx.doi.org/10.1016/j.neuron.2018.05.015] [PMID: 29887338]
[106]
Williams, H.C.; Ma, J.; Weiss, D.; Lassègue, B.; Sutliff, R.L.; San Martín, A. The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo. Lab. Invest., 2019, 99(3), 399-410.
[http://dx.doi.org/10.1038/s41374-018-0116-6] [PMID: 30291325]
[107]
Simoni, D.; Grisolia, G.; Giannini, G.; Roberti, M.; Rondanin, R.; Piccagli, L.; Baruchello, R.; Rossi, M.; Romagnoli, R.; Invidiata, F.P.; Grimaudo, S.; Jung, M.K.; Hamel, E.; Gebbia, N.; Crosta, L.; Abbadessa, V.; Di Cristina, A.; Dusonchet, L.; Meli, M.; Tolomeo, M. Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines. J. Med. Chem., 2005, 48(3), 723-736.
[http://dx.doi.org/10.1021/jm049622b] [PMID: 15689156]
[108]
Lane, J.E.; Kinser, K. Eds.; Multinational Colleges and Universities: Leading, Governing, and Managing International Branch Campuses: New Directions for Higher Education, Number 155; John Wiley & Sons, 2011.
[109]
Belloni, M.; Kawohl, B. A direct uniqueness proof for equations involving the p -Laplace operator. Manuscripta Math., 2002, 109(2), 229-231.
[http://dx.doi.org/10.1007/s00229-002-0305-9]

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