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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review

Author(s): Lim Joe Siang, Harish Rajak and Veerasamy Ravichandran*

Volume 24, Issue 15, 2024

Published on: 18 April, 2024

Page: [1279 - 1290] Pages: 12

DOI: 10.2174/0115680266300963240408051156

Price: $65

Abstract

The multifaceted benefits of Lepisanthes fruticosa position it is not only as a promising agricultural commodity but also as a versatile resource with implications for health, biodiversity, and economic growth. Lepisanthes fruticosa has a rich history of traditional use for treating various ailments such as fever and diarrhea. Beyond its traditional uses, the plant's antioxidant properties suggest potential applications in combating oxidative stress-related conditions. Its antihyperglycemic properties indicate promise in managing elevated blood sugar levels, while its antibacterial and antiviral attributes hint at potential applications in infectious disease control. Furthermore, the plant's anticancer properties add to its appeal as a valuable resource in the realm of medical research. The plant also exhibits considerable potential in addressing a range of health concerns, including non-communicable diseases and infections, antidiarrheal, and antiviral properties. In essence, Lepisanthes fruticose emerges as more than just an agricultural asset. Its unique combination of nutritional richness, health benefits, and economic viability underscores its potential to become a valuable asset both locally and on the global stage. In this current review, we are discussed about the ethnopharmacology, nutritional value, therapeutic effects, phytochemistry, and toxicology of Lepisanthes fruticose.

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[1]
Ikram, E.H.K.; Eng, K.H.; Jalil, A.M.M.; Ismail, A.; Idris, S.; Azlan, A.; Nazri, H.S.M.; Diton, N.A.M.; Mokhtar, R.A.M. Antioxidant capacity and total phenolic content of Malaysian underutilized fruits. J. Food Compos. Anal., 2009, 22(5), 388-393.
[http://dx.doi.org/10.1016/j.jfca.2009.04.001]
[2]
Kalsum, H.U.; Mirfat, A.H. Proximate composition of Malaysian underutilised fruits. J. Trop. Agric. Food Sci., 2014, 42(1), 63-72.
[3]
Aman, R. Buah-buahan nadir Semenanjung Malaysia Dewan Bahasa dan Pustaka, Kementerian Pendidikan Malaysia, 2006. Available from: https://books.google.com.pk/books/about/Buah_buahan_nadir_Semenanjung_Malaysia.html?id=NEMNKBO5q6kC&redir_esc=y (Accessed Dec 18, 2023).
[4]
Sabeetha, S.; Tun Norbrilinda, M.; Hadijah, H.; Mohd Firdaus, S. Dietary fiber content in ceri Terengganu seed and pulp powder, presented at the National Food Technology Seminar, 9-10 March, 2021, Selangor, Malaysia: MARDI. (Accessed Dec 18, 2023).
[5]
Salahuddin, M.; Othman, Z.; Ying, J.; Noor, E.; Idris, S. Antioxidant activity and phytochemical content of fresh and freeze-dried Lepisanthes fruticosa fruits at different maturity stages. J. Agric. Sci., 2017, 9, 147-153.
[6]
Lim, T.K. Edible Medicinal and Non-Medicinal Plants: Fruits; Springer: Dordrecht: The Netherlands, 2013, 6, pp. 656-768.
[7]
Pennington, T.D.; Adema, F.; Leenhouts, P.W.; van Welzen, P.C. Sapindaceae. Flora Malesiana Ser. 1: Spermatophyta. Vol. 11 Part 3: 1994. Kew Bull., 1995, 50(3), 659.
[http://dx.doi.org/10.2307/4110342]
[8]
Buerki, S.; Forest, F.; Alvarez, N.; Nylander, J.A.A.; Arrigo, N.; Sanmartín, I. An evaluation of new parsimony-based versus parametric inference methods in biogeography: a case study using the globally distributed plant family Sapindaceae. J. Biogeogr., 2011, 38(3), 531-550.
[http://dx.doi.org/10.1111/j.1365-2699.2010.02432.x]
[9]
Vijaya Kumar Reddy, C.; Sreeramulu, D.; Raghunath, M. Antioxidant activity of fresh and dry fruits commonly consumed in India. Food Res. Int., 2010, 43(1), 285-288.
[http://dx.doi.org/10.1016/j.foodres.2009.10.006]
[10]
So easy to preserve. Available from: https://extension.uga.edu/publications/detail.html?number=B989&title=so-easy-to-preserve (Accessed Dec 19, 2023).
[11]
Doymaz, İ.; Özdemir, Ö. Effect of air temperature, slice thickness and pretreatment on drying and rehydration of tomato. Int. J. Food Sci. Technol., 2014, 49(2), 558-564.
[http://dx.doi.org/10.1111/ijfs.12337]
[12]
Madaleno, R.O. Effect of pre-treatments and post-treatments on drying products; Doctoral Thesis, 2015.
[13]
Tun, Norbrillinda, M.; Norra, I.; Hasri, H.; Helmi, M.M.A. The effects of pretreatment and ripening stage on nutrient content and antioxidant properties of Lepisanthes fruticosa whole fruit powder. Food Res., 2020, 4(S6), 70-78.
[http://dx.doi.org/10.26656/fr.2017.4(S6).010]
[14]
Alvindia, D.; Mangoba, M.A. Bioactivities of Allium longicuspis regel against anthracnose of mango caused by Colletotrichum gloeosporioides (Penz.). Sci. Rep., 2020, 10.
[15]
Haireen, M.R.R.; Mohd Shukri, M.A.; Mohd Norfaizal, G.; Razali, M.; Nur Diyana, A.; Koh, S.P.; Nurhazwani, M.; Nurul Ain, A. The potential of γ-aminobutryic acid (gaba) as defence metabolite against Colletrotrichum gloeosporioides in Lepisanthes fruticosa. Trans. Malaysian Soc. Plant Physiol, 2022, 29, 109-112.
[16]
Eswani, N.; Abd Kudus, K.; Nazre, M.; Awang Noor, A.G.; Ali, M. Medicinal plant diversity and vegetation analysis of logged over hill forest of Tekai Tembeling forest reserve, Jerantut, Pahang. J. Agric. Sci., 2010, 2, 189-210.
[17]
Haque, M.M.; Choudhury, M.S.; Hossain, M.S.; Haque, M.A.; Seraj, S.; Rahmatullah, M. Ethnographic information and medicinal formulations of a Mro community of Gazalia union in the Bandarbans district of Bangladesh. Am. J. Sustain. Agric., 2012, 6, 162-171.
[18]
Gunasekaran, M.; Balasubramanian, P. Ethnomedicinal uses of sthalavrikshas (temple trees) in tamil nadu, southern india. Ethnobot. Res. Appl., 2012, 10, 253-268.
[http://dx.doi.org/10.17348/era.10.0.253-268]
[19]
Lomchid, P.; Nasomjai, P.; Kanokmedhakul, S.; Boonmak, J.; Youngme, S.; Kanokmedhakul, K. Bioactive lupane and hopane triterpenes from Lepisanthes Senegalensis. Planta Med., 2017, 83(3-04), 334-340.
[PMID: 27617903]
[20]
Sarker, B.; Akther, F.; Ayman, U.; Sifa, R.; Jahan, I.; Sarker, M.; Chakma, S.K.; Podder, P.K.; Khatun, Z.; Rahmatullah, M. Ethnomedicinal investigations among the sigibe clan of the khumi tribe of thanchi sub-district in bandarban district of bangladesh. Am. J. Sustain. Agric., 2012, 6, 378-386.
[21]
Fall, A.D.; Bagla, V.P.; Bassene, E.; Eloff, J.N. Phytochemical screening, antimicrobial and cytotoxicity studies of ethanol leave extract of Aphania senegalensis (Sapindaceae). Afr. J. Tradit. Complement. Altern. Med., 2017, 14(4), 135-139.
[http://dx.doi.org/10.21010/ajtcam.v14i4.16] [PMID: 28638876]
[22]
Salahuddin, M.A.H.; Ismail, A.; Kassim, N.K.; Hamid, M.; Ali, M.S.M. Phenolic profiling and evaluation of in vitro antioxidant, α-glucosidase and α-amylase inhibitory activities of Lepisanthes fruticosa (Roxb) Leenh fruit extracts. Food Chem., 2020, 331, 127240.
[http://dx.doi.org/10.1016/j.foodchem.2020.127240] [PMID: 32585546]
[23]
Kuspradini, H.; Susanto, D.; Ritmaleni; Mitsunaga, T. Phytochemical and comparative study of antimicrobial activity of Lepisanthes amoena leaves extract. J. biol. agric. healthc., 2012, 2(11), 80-87.
[24]
Awang, N.A.; Mat, N.; Mahmud, K. Traditional knowledge and botanical description of edible bitter plants from Besut, Terengganu, Malaysia. J. Agrobiotechnol., 2020, 11(1), 32-47.
[http://dx.doi.org/10.37231/jab.2020.11.1.180]
[25]
Islam, A.R.; Das, S.; Alam, M.; Rahman, A. Documentation of wild edible minor fruits used by the local people of Barishal, Bangladesh with emphasis on traditional medicinal values. J. Biosci., 2019, 27, 69-81.
[26]
Matius, P.; Diana, R. Sutedjo inventarisasi tumbuhan berhasiat obat yang dimanfaatkan suku dayak benuaq di desa muara nilik. J. Tengkawang, 2021, 11, 106-116.
[27]
Karunamoorthi, K.; Jegajeevanram, K.; Vijayalakshmi, J.; Mengistie, E. Traditional medicinal plants: A source of phytotherapeutic modality in resource-constrained health care settings. J. Evid. Based Complementary Altern. Med., 2013, 18(1), 67-74.
[http://dx.doi.org/10.1177/2156587212460241]
[28]
Zulkifli, S.Z.; Ghani, N.A.; Ismail, N.H.; Bihud, N.V.; Rasol, N.E. Phytochemistry and pharmacological activities of Lepisanthes genus: A Review. Tropi. J. Natur. Prod. Res., 2021, 5(6), 994-1005.
[http://dx.doi.org/10.26538/tjnpr/v5i6.2]
[29]
Lepisanthes fruticosa., Available from: https://asianplant.net/Sapindaceae/Lepisanthes_fruticosa.htm (Accessed Dec 18, 2023).
[30]
Buah ceri Terengganu yang masak ranum. Institut Penyelidikan Perhutanan Malaysia 2023. Available from: https://www.frim.gov.my/ms/quicklinks/buah-ceri-terengganu-yang-masak-ranum/ (Accessed Dec 18, 2023).
[31]
Boonsuk, B.; Chantaranothai, P. A new record of Lepisanthes Blume for Thailand and lectotypification of two names in Otophora Blume (Sapindaceae). Thai For. Bull., 2016, 44, 22-25.
[http://dx.doi.org/10.20531/tfb.2016.44.1.05]
[32]
Zhang, Y.; Wong, A.I.C.; Wu, J.; Abdul Karim, N.B.; Huang, D. Lepisanthes alata (Malay cherry) leaves are potent inhibitors of starch hydrolases due to proanthocyanidins with high degree of polymerization. J. Funct. Foods, 2016, 25, 568-578.
[http://dx.doi.org/10.1016/j.jff.2016.06.035]
[33]
Wallace, T.C.; Giusti, M.M. Anthocyanins. Adv. Nutr., 2015, 6(5), 620-622.
[http://dx.doi.org/10.3945/an.115.009233] [PMID: 26374184]
[34]
Kaisongkram, T.; Laovitthayanggoon, S.; Iamsub, K.; Chuennangchee, V.; Srithong, P.; Bangchonglikitkul, C. Comparative studies on antioxidant activities, total phenolics and anthocyanin content of four native fruits. Thaiphesatchasan, 2013, 38, 33-36.
[35]
Laleh, G.H.; Frydoonfar, H.; Heidary, R.; Jamei, P.; Zare, S. The Effect of light, temperature, pH and species on stability of anthocyanin pigments in four berberis species. Pak. J. Nutr., 2006, 5, 90-92.
[36]
Jung, H.; Kwak, H.K.; Hwang, K.T. Antioxidant and antiinflammatory activities of cyanidin-3-glucoside and cyanidin-3-rutinoside in hydrogen peroxide and lipopolysaccharide-treated RAW264.7 cells. Food Sci. Biotechnol., 2014, 23(6), 2053-2062.
[http://dx.doi.org/10.1007/s10068-014-0279-x]
[37]
Supian, S.; Devan, C.; Ahmad, M.; Rozano, L.; Mat Ali, M.S.; Simoh, S. Metabolite profiling and in vitro evaluation of Lepisanthes fruticosa fruit pulp extract as inhibitor against dengue and west nile virus NS2B-NS3 proteases. Pharmacogn. Mag., 2021, 17, 636-642.
[38]
Nabavi, S.F.; Braidy, N.; Gortzi, O.; Sobarzo-Sanchez, E.; Daglia, M.; Skalicka-Woźniak, K.; Nabavi, S.M. Luteolin as an anti-inflammatory and neuroprotective agent: A brief review. Brain Res. Bull., 2015, 119(Pt A), 1-11.
[http://dx.doi.org/10.1016/j.brainresbull.2015.09.002] [PMID: 26361743]
[39]
Ndawula, J.; Kabasa, J.D.; Byaruhanga, Y.B. Alterations in fruit and vegetable β-carotene and vitamin C content caused by open- sun drying, visqueen-covered and polyethylene-covered solar-dryers. African Health Service, 2004, 4(2), 125-130.
[PMID: 15477192]
[40]
Martínez, S.; López, M.; González-Raurich, M.; Bernardo Alvarez The effects of ripening stage and processing systems on vitamin C content in sweet peppers ( Capsicum annuum L.). Int. J. Food Sci. Nutr., 2005, 56(1), 45-51.
[http://dx.doi.org/10.1080/09637480500081936] [PMID: 16019314]
[41]
Garba, U.; Kaur, S. Effect of drying and pretreatment on anthocyanins, flavanoids and ascorbic acid content of black carrot (Daucus carrota l.). J. Global Biosci, 2014, 3(4), 772777.
[42]
Rahmadi, A.; Puspita, Y.; Nursayekti, D.; Sintia Sinaga, I.; Oktalina, R.; Setiawan, H.; Murdianto, W. Analisis proksimat, senyawa fenolik, sifat antioksidan dan antibakteri kulit buah Lepisanthes alata. J. Teknol. Ind. Pangan, 2016, 27(2), 115-122.
[http://dx.doi.org/10.6066/jtip.2016.27.2.115]
[43]
Shehzad, A.; Rehman, G.; Lee, Y.S. Curcumin in inflammatory diseases. Biofactors, 2013, 39(1), 69-77.
[http://dx.doi.org/10.1002/biof.1066] [PMID: 23281076]
[44]
Basu, A.; Rhone, M.; Lyons, T.J. Berries: emerging impact on cardiovascular health. Nutr. Rev., 2010, 68(3), 168-177.
[http://dx.doi.org/10.1111/j.1753-4887.2010.00273.x] [PMID: 20384847]
[45]
Hsu, S.P.; Wu, M.S.; Yang, C.C.; Huang, K.C.; Liou, S.Y.; Hsu, S.M. Chronic green tea extract supplementation reduces hemodialysis-enhanced production of hydrogen peroxide and hypochlorous acid, atherosclerotic factors, and proinflammatory cytokines. Am. J. Clin. Nutr., 2005, 81(5), 1157-1165.
[PMID: 17991670]
[46]
Josling, P. Preventing the common cold with a garlic supplement: A double-blind, placebo-controlled survey. Adv. Ther., 2001, 18(4), 189-193.
[http://dx.doi.org/10.1007/BF02850113] [PMID: 11697022]
[47]
Al-Waili, N.S.; Salom, K.; Al-Ghamdi, A.A.; Ansari, M.J. Antibiotic, pesticide, and microbial contaminants of honey: human health hazards. ScientificWorldJournal, 2011, 11, 1632-1645.
[PMID: 23097637]
[48]
Kumar, S.; Sharma, S.; Vasudeva, N. Review on antioxidants and evaluation procedures. Chin. J. Integr. Med., 2017, 1-12.
[PMID: 28986809]
[49]
Hasan, M.M.; Hossain, A.; Shamim, A.; Rahman, M.M. Phytochemical and pharmacological evaluation of ethanolic extract of Lepisanthes rubiginosa L. leaves. BMC Complement. Altern. Med., 2017, 17(1), 496.
[http://dx.doi.org/10.1186/s12906-017-2010-y] [PMID: 29166935]
[50]
Dontha, S. A review on antioxidant methods. Asian J. Pharm. Clin. Res., 2016, 14-32.
[51]
Hadijah, H.; Razali, M.; Aishah, R.; Shukri, M. Potential use of Ceri Terengganu for functional food: A preliminary study on its cytotoxicity aspect. Int. J. Agr. Forestry and Plant., 2020, 10, 216-223.
[52]
Charoenteeraboon, J.; Limmatvapirat, C.; Phaechamud, T. Antioxidant activities of some thai and exotic fruits cultivated in Thailand. Res. J. Pharm. Biol. Chem. Sci., 2012, 3, 12-21.
[53]
Alqahtani, A.S.; Hidayathulla, S.; Rehman, M.T.; ElGamal, A.A.; Al-Massarani, S.; Razmovski-Naumovski, V.; Alqahtani, M.S.; El Dib, R.A.; AlAjmi, M.F. Alpha-amylase and alpha-glucosidase enzyme inhibition and antioxidant potential of 3-oxolupenal and katononic acid isolated from Nuxia oppositifolia. Biomolecules, 2019, 10(1), 61.
[http://dx.doi.org/10.3390/biom10010061] [PMID: 31905962]
[54]
Mirfat, A.H.S.; Amin, I.; Mohd Shukri, M.A.; Muhajir, H.; Nur Kartinee, K.; Syahida, M.; Razali, M. Antidiabetic and antioxidative effects of Lepisanthes fruticosa fruit seed extractin type 2 diabetic experimental rats. Food Res., 2023, 6, 191-201.
[http://dx.doi.org/10.26656/fr.2017.6(S2).016]
[55]
Hadijah, H.; Musaalbakri, A.M.; Syahida, M.; Rosliza, J.; Mohd Shukri, M.A. Potential of fermented kuini and Ceri Terengganu beverages in enhancing insulin secretion in pancreatic cells. Food Res., 2023, 6, 292-302.
[http://dx.doi.org/10.26656/fr.2017.6(S2).28]
[56]
Felipe, E.T.; Maestri, J.S.; Kanunfre, C.C.; Curi, R.; Newsholme, P.; Carpinelli, A.R.; Oliveira-Emilio, H.R. Cytotoxicity and cytoprotective effects of citrus flavonoids on insulin-secreting cells BRIN-BD11: beneficial synergic effects. Nat. Prod. Res., 2013, 27(10), 925-928.
[http://dx.doi.org/10.1080/14786419.2012.671315] [PMID: 22443082]
[57]
Arulselvan, P.; Ghofar, H.A.A.; Karthivashan, G.; Halim, M.F.A.; Ghafar, M.S.A.; Fakurazi, S. Antidiabetic therapeutics from natural source: A systematic review. Biomedi. & Preven. Nutri., 2014, 4(4), 607-617.
[http://dx.doi.org/10.1016/j.bionut.2014.07.009]
[58]
Orhan, N.; Aslan, M.; Şüküroğlu, M.; Deliorman Orhan, D. in vivo and in vitro antidiabetic effect of Cistus laurifolius L. and detection of major phenolic compounds by UPLC–TOF-MS analysis. J. Ethnopharmacol., 2013, 146(3), 859-865.
[http://dx.doi.org/10.1016/j.jep.2013.02.016] [PMID: 23462413]
[59]
Irondi, E.A.; Oboh, G.; Akindahunsi, A.A.; Boligon, A.A.; Athayde, M.L. Phenolics composition and antidiabetic property of Brachystegia eurycoma seed flour in high-fat diet, low-dose streptozotocin-induced type 2 diabetes in rats. Asian Pac. J. Trop. Dis., 2015, 5(S1), S159-S165.
[http://dx.doi.org/10.1016/S2222-1808(15)60880-5]
[60]
Manan, M.; Abd Rashid, N.Y.; Lazim, M.; Abd Razak, D.; Ghazalli, M.N.; Md Sah, M.; Mohmad Sabdin, Z.H.; Hassan, H.; Mat Ali, M.S. Prebiotic properties of fermented Ceri Terengganu (Lepisanthes fruticosa) beverage by survival of lactic acid bacteria and its antibacterial activity. Food Research, 2023, 6, 171-181.
[http://dx.doi.org/10.26656/fr.2017.6(S2).029]
[61]
Burstein, H.J.; Schwartz, R.S. Molecular origins of cancer. N. Engl. J. Med., 2008, 358(5), 527.
[http://dx.doi.org/10.1056/NEJMe0800065] [PMID: 18234758]
[62]
Syahida, M.; Hadijah, H.; Razali, M.; Mohd Shukri, M.A. Safety assessment of Lepisanthes fruticosa extract. Food Res., 2023, 6(Suppl. 2), 116-121.
[http://dx.doi.org/10.26656/fr.2017.6(S2).034]

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