Recent Developments in Asymmetric Nazarov Reactions

Hélène      Pellissier
doi:10.2174/0113852728296619240321060646
Abstract

The Nazarov reaction involves the cyclization of divinyl ketones into cyclopentenones under the influence of strong acids. The prevalence of five-membered carbocycles in a multitude of natural and bioactive products has triggered an intense development of efficient methods for their construction. In particular, asymmetric versions of the Nazarov reaction are achieved by using either a chiral auxiliary or a chiral catalyst, which can be an organocatalyst, a metal catalyst, or a multicatalytic system. This review aims to update the field of asymmetric Nazarov reactions published since 2017. It is divided into four sections, dealing successively with Nazarov reactions of chiral auxiliaries, organocatalytic enantioselective Nazarov reactions, metal/boron-catalyzed enantioselective Nazarov reactions, and multicatalytic enantioselective Nazarov reactions. Each section of the review is subdivided into simple asymmetric Nazarov reactions and Nazarov-based domino/tandem reactions, which have allowed numerous more complex functionalized chiral molecules to be synthesized in one-pot procedures.
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DOI https://dx.doi.org/10.2174/0113852728296619240321060646	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

Recent Developments in Asymmetric Nazarov Reactions

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

Current Organic Chemistry

Recent Developments in Asymmetric Nazarov Reactions

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

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