Role of miRNAs in Brain Development

Title:Role of miRNAs in Brain Development

Volume: 13 Issue: 2

Author(s): Himanshu Sharma, Monika Kaushik, Priyanka Goswami, Sanakattula Sreevani, Ananya Chakraborty, Sumel Ashique*Radheshyam Pal

Affiliation:

• Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, India

Abstract: Non-coding RNAs that are small in size, called microRNAs (miRNAs), exert a consequence in neutralizing gene activity after transcription. The nervous system is a massively expressed organ, and an expanding body of research reveals the vital functions that miRNAs play in the brain's growth and neural activity. The significant benefit of miRNAs on the development of the central nervous system is currently shown through new scientific methods that concentrate on targeting and eradicating vital miRNA biogenesis pathways the elements involving Dicer and DGCR8. Modulation of miRNA has been associated with numerous essential cellular processes on neural progenitors, like differentiation, proliferation, and destiny determination. Current research discoveries that emphasize the significance of miRNAs in the complex process of brain development are included in this book. The miRNA pathway plays a major role in brain development, its operational dynamics, and even diseases. Recent studies on miRNA-mediated gene regulation within neural discrepancy, the circadian period and synaptic remodeling are signs of this. We also discussed how these discoveries may affect our comprehension of the fundamental processes behind brain diseases, highlighting the novel therapeutic opportunities miRNAs provide for treating various human illnesses.

Cite this article as:

Sharma Himanshu, Kaushik Monika, Goswami Priyanka, Sreevani Sanakattula, Chakraborty Ananya, Ashique Sumel*, Pal Radheshyam, Role of miRNAs in Brain Development, MicroRNA 2024; 13 (2) . https://dx.doi.org/10.2174/0122115366287127240322054519