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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Approaches Towards Better Immunosuppressive Agents

Author(s): Juliusz Walczak, Dorota Iwaszkiewicz-Grześ and Grzegorz Cholewiński*

Volume 24, Issue 14, 2024

Published on: 29 March, 2024

Page: [1230 - 1263] Pages: 34

DOI: 10.2174/0115680266292661240322072908

Price: $65

Abstract

Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophenolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility and therapeutic properties. In this review article, we present the synthesis of the designed chemical structures based on recent literature reports concerning novel compounds as promising immunosuppressive drugs. Moreover, some of the discussed derivers revealed also other types of activities with prospective medicinal potential.

Graphical Abstract

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