Abstract
Background: Nidus Vespae (honeycomb), which is a well-known traditional Chinese medicine, is the honey-comb of Polistes japonicus Saussure, Parapolybia varia Fabricius, or Polistes olivaceus (De Geer), and it is usually harvest in winter and autumn.
Methods: Its chemical component is completely complex combining honey, pollen, royal jelly, and propolis and consequently has a significant number of bioactive components such as nitro compounds, flavonoids, and polyphenols. It has shown various pharmacological impacts, such as anti-inflammatory, anti-viral, anti-microbial, and anti-tumor effects.
Results: In this review article, all relevant papers from various scholars and researchers were searched in Science Direct, Google Scholar, PubMed, and Scopus. Honeycomb has various activities and numerous pharmacological benefits and health advantages, and it can be considered a valuable source of nutraceuticals, and an effective natural medicine and organic product.
Conclusion: In this review, we have decided to discuss the importance of traditional treatment, and the pharmacological properties of Nidus Vespae.
Graphical Abstract
[1]
Zhu M, Ling Y, Qi Q, Zhang Y, Bao Y, Liu Y. The immunomodulatory effects of Nidus vespae on human peripheral blood immune cells in vitro. Evid-Based Complemen Alter Med 2015; 2015
[2]
Cavallin T, Visentin F, Peruzzo V, et al. Metal PVD honey-combs coated with TIO2 and Al2O3via PECVD suitable for sensoring applications. Surf Coat Tech 2013; 230: 66-72.
[http://dx.doi.org/10.1016/j.surfcoat.2013.06.020]
[http://dx.doi.org/10.1016/j.surfcoat.2013.06.020]
[3]
Shunmugesh K, Raphel A, Unnikrishnan TG, Akhil KT. Finite element modelling of carbon fiber reinforced with vespel and honey-comb structure. Mater Today Proc 2023; 72(4): 2163-8.
[http://dx.doi.org/10.1016/j.matpr.2022.08.301]
[http://dx.doi.org/10.1016/j.matpr.2022.08.301]
[4]
Shahrajabian MH, Sun W, Soleymani A, Cheng Q. Traditional herbal medicines to overcome stress, anxiety and improve mental health in outbreaks of human coronaviruses. Phytother Res 2020; 2020(1): 1-11.
[PMID: 33350538]
[PMID: 33350538]
[5]
Shahrajabian MH. Medicinal herbs with anti-inflammatory activities for natural and organic healing. Curr Org Chem 2021; 25(23): 2885-901.
[http://dx.doi.org/10.2174/1385272825666211110115656]
[http://dx.doi.org/10.2174/1385272825666211110115656]
[6]
Yang B, Yu N. Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review. Brain Res Bull 2023; 204: 110800.
[http://dx.doi.org/10.1016/j.brainresbull.2023.110800] [PMID: 37913850]
[http://dx.doi.org/10.1016/j.brainresbull.2023.110800] [PMID: 37913850]
[7]
Huang M, Liu Y, Xiong K, et al. The role and advantage of traditional Chinese medicine in the prevention and treatment of COVID-19. J Integr Med 2023; 21(5): 407-12.
[http://dx.doi.org/10.1016/j.joim.2023.08.003] [PMID: 37625946]
[http://dx.doi.org/10.1016/j.joim.2023.08.003] [PMID: 37625946]
[8]
Hajibeygi R, Mirghazanfari SM, Pahlavani N, et al. Effect of a diet based on Iranian traditional medicine on inflammatory markers and clinical outcomes in COVID-19 patients: A double-blind, randomized, controlled trial. Eur J Integr Med 2022; 55: 102179.
[http://dx.doi.org/10.1016/j.eujim.2022.102179] [PMID: 36035633]
[http://dx.doi.org/10.1016/j.eujim.2022.102179] [PMID: 36035633]
[9]
Dalir N, Javadian S. Thermodynamic study for the role of functional group on the honey-comb pattern interaction between CNT and E5CN7 nematic liquid crystal. J Mol Liq 2021; 341: 117287.
[http://dx.doi.org/10.1016/j.molliq.2021.117287]
[http://dx.doi.org/10.1016/j.molliq.2021.117287]
[10]
Shahrajabian MH, Sun W. Mechanism of action of collagen and epidermal growth factor: A review on theory and research methods. Mini Rev Med Chem 2023.
[PMID: 37587815]
[PMID: 37587815]
[11]
Li P, Yu G, Liu F. Meta-analysis of the traditional Chinese medicine care model in relieving postoperative pain in patients with anorectal diseases. Heliyon 2023; 9(11): e22310.
[http://dx.doi.org/10.1016/j.heliyon.2023.e22310] [PMID: 38053898]
[http://dx.doi.org/10.1016/j.heliyon.2023.e22310] [PMID: 38053898]
[12]
Shahrajabian MH, Sun W. Study of different types of fermentation in wine-making process and considering aromatic substances and organic acid. Curr Org Synth 2023; 20: 20.
[http://dx.doi.org/10.2174/1570179420666230803102253] [PMID: 37534487]
[http://dx.doi.org/10.2174/1570179420666230803102253] [PMID: 37534487]
[13]
Zhang H, Jin B, You X, et al. Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke. Chin Herb Med 2023; 15(4): 496-508.
[http://dx.doi.org/10.1016/j.chmed.2023.09.003] [PMID: 38094018]
[http://dx.doi.org/10.1016/j.chmed.2023.09.003] [PMID: 38094018]
[14]
Kong Y, Zhu X, Zhang X, et al. Traditional Chinese medicine combined with radiofrequency ablation improves primary liver cancer outcomes: A systematic review with meta-analysis. Heliyon 2023; 9(8): e18591.
[http://dx.doi.org/10.1016/j.heliyon.2023.e18591] [PMID: 37554780]
[http://dx.doi.org/10.1016/j.heliyon.2023.e18591] [PMID: 37554780]
[15]
Sun W, Shahrajabian MH. The application of arbuscular mycorrhizal fungi as microbial biostimulant, sustainable approaches in modern agriculture. Plants 2023; 12(17): 3101.
[http://dx.doi.org/10.3390/plants12173101] [PMID: 37687348]
[http://dx.doi.org/10.3390/plants12173101] [PMID: 37687348]
[16]
Duan Y, Xu Z, Zhao P, Chen J, Ma Y, Yu L. A cross-sectional study of reporting guidelines for clinical studies in Traditional Chinese Medicine. Eur J Integr Med 2023; 64: 102315.
[http://dx.doi.org/10.1016/j.eujim.2023.102315]
[http://dx.doi.org/10.1016/j.eujim.2023.102315]
[17]
Zhu M, Han W, Ling Y, et al. Preliminary study on the in vitro antitumor effects of Nidus vespae on gastric cancer. Evid Based Complement Alternat Med 2021; 2021: 1-9.
[http://dx.doi.org/10.1155/2021/1549359] [PMID: 34194516]
[http://dx.doi.org/10.1155/2021/1549359] [PMID: 34194516]
[18]
Cui H, Shahrajabian MH, Kuang Y, Zhang HY, Sun W. Heterologous expression and function of cholesterol oxidase: A review. Protein Pept Lett 2023; 30(7): 531-40.
[http://dx.doi.org/10.2174/0929866530666230525162545] [PMID: 37231716]
[http://dx.doi.org/10.2174/0929866530666230525162545] [PMID: 37231716]
[19]
Zhao H, Zhu M, Wang K, et al. Identification and quantitation of bioactive components from honeycomb (Nidus vespae). Food Chem 2020; 314: 126052.
[http://dx.doi.org/10.1016/j.foodchem.2019.126052] [PMID: 31982855]
[http://dx.doi.org/10.1016/j.foodchem.2019.126052] [PMID: 31982855]
[20]
Choi MB, Martin SJ, Lee JW. Distribution, spread, and impact of the invasive hornet Vespa velutina in South Korea. J Asia Pac Entomol 2012; 15(3): 473-7.
[http://dx.doi.org/10.1016/j.aspen.2011.11.004]
[http://dx.doi.org/10.1016/j.aspen.2011.11.004]
[21]
Choi MB, Kim TG, Kwon O. Recent trends in wasp nest removal and hymenoptera stings in South Korea. J Med Entomol 2019; 56(1): 254-60.
[http://dx.doi.org/10.1093/jme/tjy144] [PMID: 30137561]
[http://dx.doi.org/10.1093/jme/tjy144] [PMID: 30137561]
[22]
Cini A, Cappa F, Petrocelli I, Pepiciello I, Bortolotti L, Cervo R. Competition between the native and the introduced hornetsVespa crabro and Vespa velutina : A comparison of potentially relevant life-history traits. Ecol Entomol 2018; 43(3): 351-62.
[http://dx.doi.org/10.1111/een.12507]
[http://dx.doi.org/10.1111/een.12507]
[23]
Monceau K, Maher N, Bonnard O, Thiéry D. Evaluation of competition between a native and an invasive hornet species: Do seasonal phenologies overlap? Bull Entomol Res 2015; 105(4): 462-9.
[http://dx.doi.org/10.1017/S0007485315000280] [PMID: 25895505]
[http://dx.doi.org/10.1017/S0007485315000280] [PMID: 25895505]
[24]
Yamasaki K, Takahashi R, Harada R, Matsuo Y, Nakamura M, Takahashi J. Reproductive interference by alien hornet Vespa velutina threatens the native populations of Vespa simillima in Japan. Naturwissenschaften 2019; 106(5-6): 15.
[http://dx.doi.org/10.1007/s00114-019-1609-x] [PMID: 30989338]
[http://dx.doi.org/10.1007/s00114-019-1609-x] [PMID: 30989338]
[25]
Monceau K, Bonnard O, Thiéry D. Vespa velutina: A new invasive predator of honeybees in Europe. J Pest Sci 2014; 87(1): 1-16.
[http://dx.doi.org/10.1007/s10340-013-0537-3]
[http://dx.doi.org/10.1007/s10340-013-0537-3]
[26]
Turchi L, Derijard B. Options for the biological and physical control of Vespa velutina nigrithorax (Hym.: Vespidae) in Europe: A review. J Appl Entomol 2018; 142(6): 553-62.
[http://dx.doi.org/10.1111/jen.12515]
[http://dx.doi.org/10.1111/jen.12515]
[27]
Sun W, Shahrajabian MH. Therapeutic potential of phenolic compounds in medicinal plants-natural health products for human health. Molecules 2023; 28(4): 1845.
[http://dx.doi.org/10.3390/molecules28041845] [PMID: 36838831]
[http://dx.doi.org/10.3390/molecules28041845] [PMID: 36838831]
[28]
Sun W, Shahrajabian MH, Petropoulos SA, Shahrajabian N. Developing sustainable agriculture systems in medicinal and aromatic plant production by using chitosan and chitin-based biostimulants. Plants 2023; 12(13): 2469.
[http://dx.doi.org/10.3390/plants12132469] [PMID: 37447031]
[http://dx.doi.org/10.3390/plants12132469] [PMID: 37447031]
[29]
Marmitt DJ, Shahrajabian MH. Plant species used in Brazil and Asia regions with toxic properties. Phytother Res 2021; 35(9): 4703-26.
[http://dx.doi.org/10.1002/ptr.7100] [PMID: 33793002]
[http://dx.doi.org/10.1002/ptr.7100] [PMID: 33793002]
[30]
Shahrajabian MH, Sun W. Importance of thymoquinone, sulforaphane, phloretin, and epigallocatechin and their health benefits. Lett Drug Des Discov 2023; 19.
[31]
Chen Y, Huang G, Qin T, et al. Ferroptosis: A new view on the prevention and treatment of diabetic kidney disease with traditional Chinese medicine. Biomed Pharmacother 2024; 170: 115952.
[http://dx.doi.org/10.1016/j.biopha.2023.115952] [PMID: 38056233]
[http://dx.doi.org/10.1016/j.biopha.2023.115952] [PMID: 38056233]
[32]
Shahrajabian MH, Sun W. Various techniques for molecular and rapid detection of infectious and epidemic diseases. Lett Org Chem 2023; 20(9): 779-801.
[http://dx.doi.org/10.2174/1570178620666230331095720]
[http://dx.doi.org/10.2174/1570178620666230331095720]
[33]
Liu B, Kou Z, Chen B. Effects and mechanisms of traditional Chinese medicines on functional dyspepsia: A review. Chin Herb Med 2023; 15(4): 516-25.
[http://dx.doi.org/10.1016/j.chmed.2023.06.001] [PMID: 38094020]
[http://dx.doi.org/10.1016/j.chmed.2023.06.001] [PMID: 38094020]
[34]
Wang B, Zhang C-G, Gao P-F. Chemical composition and clinical application of hive as traditional Chinese medicine: Research advances. J Int Pharm Res 2014; 41(2): 184-9.
[35]
Li ZQ, Wang YF. Clinical application and progress of the Nidue Vespae. Lishizhen. Med Mater Med Res 2005; 16(11): 1081-2.
[36]
Tan HK, Nguyen QNP, Le LTH, Nguyen DTH, Le LB. Association between traditional medicine body constiution types and body mass index of students at the university of medicine and pharmacy at Ho Chi Ming city. Obes Med 2023; 43: 100513.
[37]
Jeong H, Kim JM, Kim B, Nam JO, Hahn D, Choi MB. Nutritional value of the larvae of the alien invasive wasp Vespa velutina nigrithorax and amino acid composition of the larval saliva. Foods 2020; 9(7): 885.
[http://dx.doi.org/10.3390/foods9070885] [PMID: 32640612]
[http://dx.doi.org/10.3390/foods9070885] [PMID: 32640612]
[38]
Ueno T. Establishment of the invasive hornet Vespa velutina (Hymenoptera: Vespidae) in Japan. Int J Chem Environ Biol Sci 2014; 2: 3.
[39]
Turillazzi S, Meriggi N, Cavalieri D. Mutualistic relationships between microorganisms and eusocial wasps (Hymenoptera, Vespidae). Microorganisms 2023; 11(5): 1340.
[http://dx.doi.org/10.3390/microorganisms11051340] [PMID: 37317314]
[http://dx.doi.org/10.3390/microorganisms11051340] [PMID: 37317314]
[40]
Zeng Y, Nikitkova A, Abdelsalam H, Li J, Xiao J. Activity of quercetin and kaemferol against Streptococcus mutans biofilm. Arch Oral Biol 2019; 98: 9-16.
[http://dx.doi.org/10.1016/j.archoralbio.2018.11.005] [PMID: 30419487]
[http://dx.doi.org/10.1016/j.archoralbio.2018.11.005] [PMID: 30419487]
[41]
Zhang Z-J, Wu W-Y, Hou J-J, Zhang L-L, Li F-F, Gao L. Active constituents and mechanisms of respiratory Detox Shot, a traditional Chinese medicine presceiption for COVID-19 control and prevention: Network-molecular docking-LC-MSE analysis. J Integr Med 2020; 18(3): 229-41.
[http://dx.doi.org/10.1016/j.joim.2020.03.004] [PMID: 32307268]
[http://dx.doi.org/10.1016/j.joim.2020.03.004] [PMID: 32307268]
[42]
Choi MB, Kwon O. Occurrence of Hymenoptera (wasps and bees) and their foraging in the southwestern part of Jirisan National Park, South Korea. J Ecol Environ 2015; 38(3): 367-74.
[http://dx.doi.org/10.5141/ecoenv.2015.038]
[http://dx.doi.org/10.5141/ecoenv.2015.038]
[43]
Shah FA, Shah TA. Vespa velutina, a serious pest of honey bees in Kashmir. Bee World 1991; 72(4): 161-4.
[http://dx.doi.org/10.1080/0005772X.1991.11099099]
[http://dx.doi.org/10.1080/0005772X.1991.11099099]
[44]
Arbol D. Ecology, behavior and management of social wasp Vespa velutina Smith (Hymenoptera: Vespidae), attacking honeybee colonies. Korean J Apic 1994; 9: 5-10.
[45]
Kim J, Kim M, Lee M, et al. Antibacterial potential of Nidus vespae built by invasive alien hornet, Vespa velutina nigrithorax, against food-borne pathogenic bacteria. Entomol Res 2020; 50(1): 28-33.
[http://dx.doi.org/10.1111/1748-5967.12405]
[http://dx.doi.org/10.1111/1748-5967.12405]
[46]
Xiao J, Zuo Y, Liu Y, Li J, Hao Y, Zhou X. Effects of Nidus Vespae extract and chemical fractions on glucosyltransferases, adherence and biofilm formation of Streptococcus mutans. Arch Oral Biol 2007; 52(9): 869-75.
[http://dx.doi.org/10.1016/j.archoralbio.2007.02.009] [PMID: 17382894]
[http://dx.doi.org/10.1016/j.archoralbio.2007.02.009] [PMID: 17382894]
[47]
Yan L, Huo Y, Shi J, Dong Y, Tan H. Traditional Chinese medicine for the prevention and treatment of presbycusis. Heliyon 2023; 9(12): e22422.
[http://dx.doi.org/10.1016/j.heliyon.2023.e22422] [PMID: 38076135]
[http://dx.doi.org/10.1016/j.heliyon.2023.e22422] [PMID: 38076135]
[48]
Shahrajabian MH, Petropoulos SA, Sun W. Survey of the influences of microbial biostimulants on horticultural crops: Case studies and successful paradigms. Horticulturae 2023; 9(2): 193.
[http://dx.doi.org/10.3390/horticulturae9020193]
[http://dx.doi.org/10.3390/horticulturae9020193]
[49]
Xiao J, Liu Y, Zuo YL, Li JY, Ye L, Zhou XD. Effects of Nidus Vespae extract and chemical fractions on the growth and acidogenicity of oral microorganisms. Arch Oral Biol 2006; 51(9): 804-13.
[http://dx.doi.org/10.1016/j.archoralbio.2006.03.014] [PMID: 16723116]
[http://dx.doi.org/10.1016/j.archoralbio.2006.03.014] [PMID: 16723116]
[50]
Guan X, Zhou Y, Liang X, Xiao J, He L, Li J. Effects of compounds found in Nidus Vespae on the growth and cariogenic virulence factors of Streptococcus mutans. Microbiol Res 2012; 167(2): 61-8.
[http://dx.doi.org/10.1016/j.micres.2011.03.002] [PMID: 21498060]
[http://dx.doi.org/10.1016/j.micres.2011.03.002] [PMID: 21498060]
[51]
Li ZQ, Wang YF. Clinical application and progress of the Nidus Vespae. Lishizehn Med Materia Medica Res 2005; 16(11): 1081-2.
[52]
Chauhan L, Aggarwal N. Honey-comb lungs in langerhans cell histiocytosis. J Pediatr 2016; 168: 248-248.e1.
[http://dx.doi.org/10.1016/j.jpeds.2015.09.070] [PMID: 26526366]
[http://dx.doi.org/10.1016/j.jpeds.2015.09.070] [PMID: 26526366]
[53]
da Silva J, Lautenschläger F, Sivaniah E, Guck JR. The cavity-to-cavity migration of leukaemic cells through 3D honey-combed hydrogels with adjustable internal dimension and stiffness. Biomaterials 2010; 31(8): 2201-8.
[http://dx.doi.org/10.1016/j.biomaterials.2009.11.105] [PMID: 20015545]
[http://dx.doi.org/10.1016/j.biomaterials.2009.11.105] [PMID: 20015545]
[54]
Yadav AA, Lokhande AC, Pujari RB, Kim JH, Lokhande CD. The synthesis of multifunctional porous honey comb-like La2O3 thin film for supercapacitor and gas sensor applications. J Colloid Interface Sci 2016; 484: 51-9.
[http://dx.doi.org/10.1016/j.jcis.2016.08.056] [PMID: 27586000]
[http://dx.doi.org/10.1016/j.jcis.2016.08.056] [PMID: 27586000]
[55]
Wilson KC, Basheer AM. Surface modification of cadmium sulfide thin film honey comb nanostructures: Effect of in situ tin doping using chemical bath deposition. Appl Surf Sci 2016; 361: 277-82.
[http://dx.doi.org/10.1016/j.apsusc.2015.11.184]
[http://dx.doi.org/10.1016/j.apsusc.2015.11.184]
[56]
Podrižnik B, Božič J. Maturation and stratification of antibacterial activity and total phenolic content of bee bread in honey comb cells. J Apic Res 2015; 54(2): 81-92.
[http://dx.doi.org/10.1080/00218839.2015.1090774]
[http://dx.doi.org/10.1080/00218839.2015.1090774]
[57]
Xin XG, Zhang SM, Zhang CY, Shi Y, Wu HJ. Effect of the protein from Nidus Vespae on the ultrastructure of bone marrow mono-nuclear cells in acute myeloid leukemia patients. J Chin Electron Microscopy Soc 2005; 24: 65-8.
[58]
Smolinske SC, Smolinske PD. Herbal product contamination and toxicity. J Pharm Pract 2005; 18(3): 188-208.
[http://dx.doi.org/10.1177/0897190005277217]
[http://dx.doi.org/10.1177/0897190005277217]
[59]
Wang C, Chen P, Jin H, et al. Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest. Acta Biochim Biophys Sin 2008; 40(11): 970-8.
[http://dx.doi.org/10.1111/j.1745-7270.2008.00476.x] [PMID: 18989579]
[http://dx.doi.org/10.1111/j.1745-7270.2008.00476.x] [PMID: 18989579]
[60]
Paul M, Tsukamoto T, Ghosh AR, et al. The significance of enteroaggregative Escherichia coli in the etiology of hospitalized diarrhoea in Calcutta, India and the demonstration of a new honey-combed pattern of aggregative adherence. FEMS Microbiol Lett 1994; 117(3): 319-25.
[http://dx.doi.org/10.1111/j.1574-6968.1994.tb06786.x] [PMID: 8200507]
[http://dx.doi.org/10.1111/j.1574-6968.1994.tb06786.x] [PMID: 8200507]
[61]
Lee SG, Kim DS, Chae J, et al. Nidus vespae built by an invasive alien hornet, Vespa velutina nigrithorax, inhibits adipose tissue expansion in high-fat diet-indued obese mice. Biology 2022; 11(7): 1013.
[http://dx.doi.org/10.3390/biology11071013] [PMID: 36101393]
[http://dx.doi.org/10.3390/biology11071013] [PMID: 36101393]
[62]
Mulugeta M, Belay A. Comb honey and processed honey of Croton macrostachyus and Schefflera abyssinica honey differentiated by enzymes and antioxidant properties, and botanical origin. Heliyon 2022; 8(5): e09512.
[http://dx.doi.org/10.1016/j.heliyon.2022.e09512] [PMID: 35647353]
[http://dx.doi.org/10.1016/j.heliyon.2022.e09512] [PMID: 35647353]
[63]
Park JH, Nho YC, Kang MG. Dye-sensitized solar cells containing polymer film with honey-comb like morphology. J Photochem Photobiol Chem 2009; 203(2-3): 151-4.
[http://dx.doi.org/10.1016/j.jphotochem.2009.01.010]
[http://dx.doi.org/10.1016/j.jphotochem.2009.01.010]
[64]
Xiao J, Zhou XD, Feng J, Hao YQ, Li JY. Activity of Nidus Vespae extract and chemical fractions against Streptococcus mutans biofilms. Lett Appl Microbiol 2007; 45(5): 547-52.
[http://dx.doi.org/10.1111/j.1472-765X.2007.02230.x] [PMID: 17916132]
[http://dx.doi.org/10.1111/j.1472-765X.2007.02230.x] [PMID: 17916132]
