Abstract
Lung cancer has emerged as one of the most often reported illnesses and leading causes of mortality worldwide. Inefficient, lack of safety, low therapeutic index, unpleasant effects, and excessive cost have led to a loss of trust in synthetic medications, limiting their use. Natural compounds have good anticancer potential without unwanted toxic effects. Among them, flavonoids are the most important compounds. Flavonoids are polyphenolic chemical compounds abundant in fruits and vegetables and are essential in preventing lung cancer. Their potent anticancer effects are said to be based on a wide range of biological actions, such as antioxidants, anti-mutagenesis, anti-inflammation, and differentiation induction, preventing cancer cell proliferation through regulating signal transduction pathways, triggering cell cycle arrest, and activating apoptosis or autophagy; anti-invasion; anti-metastasis, altering cancer cell drug resistance and increasing sensitization to chemotherapy. This review illustrates the most recent advancements in flavonoids in lung cancer and their associated molecular mechanisms using information from scientific research studies like in vitro and in vivo clinical trials. It takes these data into theory and practice.
Graphical Abstract
