Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A
Recent Update

Shivangi      Jaiswal; Jaya      Dwivedi; Dharma      Kishore; Swapnil      Sharma
doi:10.2174/0113852728283721240109092312
Abstract

Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved drugs have been marketed globally for the management of various diseases. In spite of many remarkable and consistent efforts having been made by the chemists towards the development of greener and sustainable strategies for the synthesis of tetrazole derivatives, this approach still needs more attention. The present review focuses on the green synthetic approach for the preparation of tetrazole derivatives from different starting materials such as nitrile, isonitrile, carbonyl, amine, amide, oxime and terminal alkyne functions. The mechanism of tetrazole synthesis from different substrates is discussed. In addition to this, a four component Ugi-azide reaction to the tetrazole synthesis is also described. Of note, the present articles exploited several water-mediated and solvent-free methodologies for tetrazole synthesis. The important key features of tetrazole synthesis were pinpointing in each synthetic scheme which provides excellent guide to those searching for selective procedure to achieve the desired transformation. This review seeks to present a timely account (2011-2023) on the splendid array of ecofriendly procedures of synthesis known today for the preparation of tetrazole derivatives from different starting materials. The rational of this review is to enlighten recent advancements in the synthesis of tetrazole derivatives from different substrates.
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DOI https://dx.doi.org/10.2174/0113852728283721240109092312	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

Current Organic Chemistry

Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update

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Catalytic C-H bond activation as a tool for functionalization of heterocycles

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