Abstract
This work presents the main methods of synthesis for [4.n]cyclophanes and reveals the possibilities to use common methods or peculiar ones in order to obtain more efficient access to different cyclophanes which exhibit a four membered bridge. The conformational behavior of [4.n]cyclophanes involving the flexibility of the bridges and the rotational behavior of the aromatic rings is discussed in correlation with the length of the bridges and with the nature of the aromatic rings. The complexation ability of the named cyclophanes, their reactivity and applications are also discussed.
Keywords: cyclophanes, synthesis, aromatic rings, cyclophenylenealkane, Heterophanes, Aliphanes
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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