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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

1,2,4-Triazole-conjugated Fluoroquinolones as Potential Candidates for New Antibacterial Agents

Author(s): Yıldız Uygun Cebeci* and Sengul Alpay Karaoglu

Volume 21, Issue 8, 2024

Published on: 24 January, 2024

Page: [669 - 676] Pages: 8

DOI: 10.2174/0115701786270260231215101046

Price: $65

Abstract

In this study, synthesis of 1,2,4 triazole-fluoroquinolone hybrid compounds was realized. 7a-d hybrid compound was obtained as a result of mannich reaction with 6a-b triazole compounds norfloxacin and ciprofloxacin. 1H-NMR, 13C-NMR, Mass Spectrometry and Elemental Analysis confirmed the structures of all synthesized compounds. The antimicrobial activities of all compounds were investigated, and it was observed that 7a-d compounds, which are mannich bases, showed excellent activity.

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