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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review

Author(s): Wen-Zhe Nie, Qing-Kun Shen, Zhe-Shan Quan*, Hong-Yan Guo* and Ya-Mei Li*

Volume 24, Issue 14, 2024

Published on: 23 January, 2024

Page: [1368 - 1384] Pages: 17

DOI: 10.2174/0113895575277085231123165546

Price: $65

Abstract

Usnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value. In this paper, the structural modification, biological activity and structure-activity relationship of usnic acid were reviewed to provide reference for the development of usnic acid derivatives.

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