Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

Title: Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

Volume: 9 Issue: 3

Author(s): Sanjay K. Srivastava, Vivek Kumar, Shiv K. Agarwal, Rama Mukherjee and Anand C. Burman

Affiliation:

Abstract: In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It was found that C-4, C-6 and C-7 positions in quinazoline are appropriate sites for designing new tyrosine kinase inhibitors. This review should help the medicinal chemist in designing more effective tyrosine kinase inhibitors.

Cite this article as:

Srivastava K. Sanjay, Kumar Vivek, Agarwal K. Shiv, Mukherjee Rama and Burman C. Anand, Synthesis of Quinazolines as Tyrosine Kinase Inhibitors, Anti-Cancer Agents in Medicinal Chemistry 2009; 9 (3) . https://dx.doi.org/10.2174/1871520610909030246