Abstract
Viruses are the cause of many human pathogenesis-related conditions. A serious hazard to public health has been created because of the increase in worldwide travel, fast urbanization, and infectious epidemics. At the same time, no preventative vaccines or antiviral treatments are currently available. Resources for developing new antiviral medications can be found in enhanced natural products and herbal medicines. These natural substances have aided the research on developing preventive vaccines and antiviral treatments. Based primarily on in vitro and in vivo searches, this review aims to explore the antiviral properties of plant extracts and some isolated plant natural products. Only a few antiviral medications have been given clinical approval, while numerous viruses continue to elude adequate immunization. Therefore, developing novel antiviral medicines is crucial, and natural substances make excellent sources for these new drugs. This review highlights various natural herbal drugs possessing antiviral properties.
Graphical Abstract
[http://dx.doi.org/10.1248/cpb.33.3881] [PMID: 4092287]
[http://dx.doi.org/10.1016/j.fitote.2005.03.010] [PMID: 15890472]
[http://dx.doi.org/10.1128/AAC.47.2.759-769.2003] [PMID: 12543689]
[http://dx.doi.org/10.1139/y05-029] [PMID: 15877107]
[http://dx.doi.org/10.1016/j.jep.2006.01.018] [PMID: 16504434]
[http://dx.doi.org/10.1002/1099-1573(200012)14:8<604:AID-PTR678>3.0.CO;2-L] [PMID: 11113996]
[http://dx.doi.org/10.1177/135965350300800201] [PMID: 12741619]
[http://dx.doi.org/10.1016/0006-2952(83)90262-9] [PMID: 6342623]
[http://dx.doi.org/10.1046/j.1365-2796.2001.00742.x] [PMID: 10971784]
[http://dx.doi.org/10.1016/j.jep.2005.08.053] [PMID: 16198524]
[http://dx.doi.org/10.1042/BA20100010] [PMID: 20649513]
[http://dx.doi.org/10.1016/j.indcrop.2015.03.033]
[http://dx.doi.org/10.1002/ptr.4847] [PMID: 23027684]
[http://dx.doi.org/10.1016/j.jep.2012.10.043] [PMID: 23123794]
[http://dx.doi.org/10.1016/j.phytochem.2004.06.008] [PMID: 15280001]
[http://dx.doi.org/10.1016/j.phytochem.2005.05.007] [PMID: 15996695]
[http://dx.doi.org/10.1186/1749-8546-5-17] [PMID: 20465823]
[http://dx.doi.org/10.1002/ptr.1765] [PMID: 16372376]
[http://dx.doi.org/10.1002/1099-1573(200008)14:5<333:AID-PTR584>3.0.CO;2-D] [PMID: 10925397]
[http://dx.doi.org/10.1248/bpb.31.2018] [PMID: 18981566]
[http://dx.doi.org/10.1186/1472-6882-12-3] [PMID: 22244370]
[http://dx.doi.org/10.1016/j.molstruc.2020.129489] [PMID: 33100380]
[http://dx.doi.org/10.1080/07391102.2020.1860133] [PMID: 33305988]
[http://dx.doi.org/10.3389/fchem.2021.622898] [PMID: 33889562]
[http://dx.doi.org/10.21859/isv.3.1.19]
[http://dx.doi.org/10.1007/s002530100722] [PMID: 11759674]
[http://dx.doi.org/10.2165/00044011-200222010-00007]
[PMID: 27516987]
[http://dx.doi.org/10.3390/v11121111] [PMID: 31801280]
[http://dx.doi.org/10.1055/s-2006-961504] [PMID: 1470664]
[PMID: 8389276]
[http://dx.doi.org/10.1515/pjfns-2017-0005]
[http://dx.doi.org/10.5530/pj.2019.1.25]
[PMID: 5720682]
[http://dx.doi.org/10.1021/np020365s] [PMID: 12713396]
[http://dx.doi.org/10.1007/BF02510095]
[PMID: 9282507]
[http://dx.doi.org/10.1128/AAC.41.3.551] [PMID: 9055991]
[http://dx.doi.org/10.1177/2156587214553302] [PMID: 25305209]
[http://dx.doi.org/10.4103/0974-8490.157977] [PMID: 26130938]
[http://dx.doi.org/10.1021/jf60189a030] [PMID: 4733385]
[http://dx.doi.org/10.1007/s00705-016-3032-3] [PMID: 27581805]
[http://dx.doi.org/10.1016/j.jep.2015.10.042] [PMID: 26528588]
[PMID: 10810594]
[http://dx.doi.org/10.1016/S0378-8741(01)00395-6] [PMID: 11801392]
[http://dx.doi.org/10.29261/pakvetj/2018.005]
[http://dx.doi.org/10.1080/14786419.2015.1075527] [PMID: 26274064]
[http://dx.doi.org/10.1038/s41598-022-15930-z] [PMID: 35842458]
[http://dx.doi.org/10.1016/S0166-3542(02)00077-3] [PMID: 12206882]
[http://dx.doi.org/10.1056/NEJMsr1604338] [PMID: 27074377]
[http://dx.doi.org/10.1016/0010-7824(89)90034-6] [PMID: 2473865]
[http://dx.doi.org/10.1016/0166-3542(93)90019-F] [PMID: 8470882]
[http://dx.doi.org/10.1073/pnas.84.1.274] [PMID: 3467354]
[http://dx.doi.org/10.1089/aid.1992.8.1937] [PMID: 1283310]
[http://dx.doi.org/10.17485/ijst/2012/v5i5.20]
[http://dx.doi.org/10.1016/0378-8741(85)90078-9] [PMID: 4058035]
[http://dx.doi.org/10.2165/00126839-200304020-00003] [PMID: 12718564]
[http://dx.doi.org/10.1016/j.foodchem.2009.09.011]
[http://dx.doi.org/10.1016/j.jep.2009.08.001] [PMID: 19666102]
[http://dx.doi.org/10.1186/1472-6882-9-47] [PMID: 19930633]
[PMID: 27761420]
[http://dx.doi.org/10.1016/j.jep.2005.01.032] [PMID: 15876501]
[http://dx.doi.org/10.1016/j.jep.2012.03.024] [PMID: 22465592]
[http://dx.doi.org/10.1021/np9700679] [PMID: 9249970]
[http://dx.doi.org/10.1016/j.micres.2012.11.002] [PMID: 23218996]
[http://dx.doi.org/10.1055/s-2006-958128] [PMID: 7480202]
[http://dx.doi.org/10.1016/j.bmcl.2011.06.130] [PMID: 21824777]
[http://dx.doi.org/10.1016/j.antiviral.2008.05.002] [PMID: 18565600]
[http://dx.doi.org/10.1016/j.antiviral.2016.11.011] [PMID: 27864075]
[http://dx.doi.org/10.1016/j.antiviral.2006.03.017] [PMID: 16844239]
[http://dx.doi.org/10.1021/np990180u] [PMID: 10579862]
[PMID: 15837655]
[http://dx.doi.org/10.1016/0378-8741(95)90037-3] [PMID: 8847882]
[http://dx.doi.org/10.1016/0378-8741(95)01226-4] [PMID: 7475121]
[http://dx.doi.org/10.1016/j.jep.2008.05.033] [PMID: 18582554]
[http://dx.doi.org/10.1021/np50080a008] [PMID: 1624941]
[http://dx.doi.org/10.1016/j.jhep.2014.10.040] [PMID: 25450204]
[http://dx.doi.org/10.1186/s12985-016-0674-4] [PMID: 28081706]
[http://dx.doi.org/10.1186/1743-422X-10-245] [PMID: 23890410]
[http://dx.doi.org/10.1080/10286020500382397] [PMID: 17365191]
[http://dx.doi.org/10.1080/14756366.2016.1265519] [PMID: 28112000]
[http://dx.doi.org/10.1021/jf404310y] [PMID: 24377463]
[http://dx.doi.org/10.1016/j.antiviral.2006.01.011] [PMID: 16540181]
[http://dx.doi.org/10.1055/s-2003-43207] [PMID: 14598216]
[http://dx.doi.org/10.7314/APJCP.2015.16.10.4199] [PMID: 26028072]
[http://dx.doi.org/10.1021/np501025r] [PMID: 25927586]
[http://dx.doi.org/10.1016/j.jep.2015.05.040] [PMID: 26051832]
[http://dx.doi.org/10.1038/srep20394] [PMID: 26833261]
[http://dx.doi.org/10.1016/j.rvsc.2009.04.007] [PMID: 19435637]
[http://dx.doi.org/10.1021/np960399y] [PMID: 8864237]
[http://dx.doi.org/10.1248/cpb.53.244] [PMID: 15684529]
[http://dx.doi.org/10.1016/j.antiviral.2009.02.001] [PMID: 19428598]
[http://dx.doi.org/10.1016/S0166-3542(01)00125-5] [PMID: 11428243]
[http://dx.doi.org/10.1021/np200855d] [PMID: 22148316]
[http://dx.doi.org/10.1111/j.1365-2893.2011.01507.x] [PMID: 22239530]
[http://dx.doi.org/10.1093/jac/dkh136] [PMID: 14998984]
[PMID: 19454510]
[http://dx.doi.org/10.4314/tjpr.v15i4.13]
[PMID: 16514891]
[http://dx.doi.org/10.1021/np50073a012] [PMID: 1710653]
[http://dx.doi.org/10.1016/j.fitote.2011.11.014] [PMID: 22155188]
[PMID: 15850358]
[http://dx.doi.org/10.1080/14786419.2010.528758] [PMID: 21294043]
[PMID: 28650322]
[http://dx.doi.org/10.1016/S0166-3542(03)00030-5] [PMID: 12834859]
[PMID: 24520776]
[http://dx.doi.org/10.1016/j.jep.2004.07.010] [PMID: 15507347]
[http://dx.doi.org/10.1186/1743-422X-9-310] [PMID: 23244491]
[http://dx.doi.org/10.1016/j.jep.2008.03.018] [PMID: 18479853]
[http://dx.doi.org/10.1038/srep45723] [PMID: 28393840]
[http://dx.doi.org/10.1016/j.virusres.2014.07.015] [PMID: 25150190]
[http://dx.doi.org/10.1016/j.antiviral.2005.02.007] [PMID: 15885816]
[http://dx.doi.org/10.1016/j.ejps.2011.08.030] [PMID: 21914477]
[http://dx.doi.org/10.1128/AAC.46.9.2854-2864.2002] [PMID: 12183238]
[http://dx.doi.org/10.1055/s-2004-827239] [PMID: 15386196]
[http://dx.doi.org/10.1016/j.nbt.2009.08.005] [PMID: 19703599]
[http://dx.doi.org/10.1016/j.antiviral.2010.11.010] [PMID: 21095205]
[http://dx.doi.org/10.1186/1743-422X-9-98] [PMID: 22624581]
[http://dx.doi.org/10.3390/v7092852] [PMID: 26378567]
[http://dx.doi.org/10.1159/000335590] [PMID: 22377592]
[PMID: 29043989]
[http://dx.doi.org/10.3390/molecules25081876] [PMID: 32325742]
[http://dx.doi.org/10.1371/journal.pone.0139338] [PMID: 26405764]
[http://dx.doi.org/10.1002/ptr.3663] [PMID: 22131154]
[http://dx.doi.org/10.1016/j.antiviral.2006.04.006] [PMID: 16720052]
[http://dx.doi.org/10.1016/j.bmcl.2013.01.118] [PMID: 23434420]
[http://dx.doi.org/10.1016/S0378-8741(99)00050-1] [PMID: 10624889]
[http://dx.doi.org/10.1021/jo5004604] [PMID: 24824117]
[http://dx.doi.org/10.1016/j.phytochem.2015.06.001] [PMID: 26074492]
[http://dx.doi.org/10.1177/2156587216676421] [PMID: 27899436]
[http://dx.doi.org/10.1186/1743-422X-8-188] [PMID: 21513560]
[http://dx.doi.org/10.1186/1743-422X-10-303] [PMID: 24103432]
[http://dx.doi.org/10.1016/j.fitote.2014.10.011] [PMID: 25454460]
[http://dx.doi.org/10.1016/j.phymed.2016.08.001] [PMID: 27765358]
[http://dx.doi.org/10.3390/v8060157] [PMID: 27275830]
[PMID: 20103835]
[http://dx.doi.org/10.1016/j.antiviral.2007.06.001] [PMID: 17624450]
[http://dx.doi.org/10.1016/j.antiviral.2012.10.006] [PMID: 23153834]
[PMID: 26339261]
[http://dx.doi.org/10.3389/fimmu.2016.00115] [PMID: 27066007]
[http://dx.doi.org/10.1007/s13346-019-00691-6] [PMID: 31788762]
[http://dx.doi.org/10.1016/j.bmcl.2012.04.081] [PMID: 22578462]
[http://dx.doi.org/10.3390/biom10030366] [PMID: 32120929]
[http://dx.doi.org/10.1016/j.virusres.2019.197767] [PMID: 31560964]
[http://dx.doi.org/10.1016/j.bmc.2010.09.035] [PMID: 20934345]
[http://dx.doi.org/10.1074/jbc.M109.004945] [PMID: 19531480]
[http://dx.doi.org/10.1021/np020379y] [PMID: 12608862]
[http://dx.doi.org/10.22207/JPAM.14.1.66]
[http://dx.doi.org/10.5958/0974-4576.2022.00099.8]