Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

The Association between Diet and Multiple Sclerosis

Author(s): Vahid Asgharzadeh, Seyyed Amin Seyyed Rezaei, Behroz Mahdavi Poor, Mohammad Asgharzadeh, Hossein Jalaei Nobari, Zahra Taghinejad, Abdolhassan Kazemi and Jalil Rashedi*

Volume 24, Issue 8, 2024

Published on: 06 November, 2023

Page: [909 - 917] Pages: 9

DOI: 10.2174/0118715303247891231023070031

Price: $65

Abstract

Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the Central Nervous System (CNS) that affects individuals between the ages of 20 and 40 years, with a higher prevalence among women. Prevalence of this disease has increased significantly in recent decades in different geographical areas. There is evidence to suggest that both genetic and environmental factors play a role in the development of MS.

Objective: This study aims to investigate the potential relationship between diet and MS in the Azeri population of the East Azerbaijan province of Iran.

Methods: 467 MS patients and 260 non-related healthy individuals under the age of 15 completed a dietary demographic questionnaire. The relationship between food consumption and MS was evaluated using the obtained data.

Results: MS patients had a significantly higher consumption of fat, high-fat dairy, fast food, soybean, sausages and kielbasa, pickles, and leftover food (p-value=0.0001), while healthy individuals had a higher consumption of fruit (p-value=0.0001). Consumption of Meat, sweets, and fizzy drinks was also found to be higher in MS patients (p-value<0.05). There was no significant difference in the consumption of vegetables, cakes biscuits, and spices between the two groups (p-value>0.05).

Conclusion: The results suggest that fruit consumption under the age of 15 may be a protective factor against MS, while the consumption of fat, high-fat dairy, fast food, soybean, sausages and kielbasa, pickles, leftover food, meat, sweets, sauce, and fizzy drinks under the age of 15, maybe risk factors for MS.

« Previous Next »
Graphical Abstract

[1]
Asgharzadeh, M.; Valiallahzadeh, M.R.; Taghinejad, Z.; Poor, B.M.; Kafil, H.S.; Asgharzadeh, V.; Rashedi, J. Diagnostic biomarkers of multiple sclerosis. Rom. J. Neurol., 2021, 20(4), 418-423.
[http://dx.doi.org/10.37897/RJN.2021.4.2]
[2]
Dighriri, I.M.; Aldalbahi, A.A.; Albeladi, F.; Tahiri, A.A.; Kinani, E.M.; Almohsen, R.A.; Alamoudi, N.H.; Alanazi, A.A.; Alkhamshi, S.J.; Althomali, N.A.; Alrubaiei, S.N.; Altowairqi, F.K. An overview of the history, pathophysiology, and pharmacological interventions of multiple sclerosis. Cureus, 2023, 15(1), e33242.
[http://dx.doi.org/10.7759/cureus.33242] [PMID: 36733554]
[3]
Lublin, F.D.; Reingold, S.C.; Cohen, J.A.; Cutter, G.R.; Sørensen, P.S.; Thompson, A.J.; Wolinsky, J.S.; Balcer, L.J.; Banwell, B.; Barkhof, F.; Bebo, B., Jr; Calabresi, P.A.; Clanet, M.; Comi, G.; Fox, R.J.; Freedman, M.S.; Goodman, A.D.; Inglese, M.; Kappos, L.; Kieseier, B.C.; Lincoln, J.A.; Lubetzki, C.; Miller, A.E.; Montalban, X.; O’Connor, P.W.; Petkau, J.; Pozzilli, C.; Rudick, R.A.; Sormani, M.P.; Stüve, O.; Waubant, E.; Polman, C.H. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology, 2014, 83(3), 278-286.
[http://dx.doi.org/10.1212/WNL.0000000000000560] [PMID: 24871874]
[4]
Machcińska, M.; Kierasińska, M.; Michniowska, M.; Maruszewska-Cheruiyot, M.; Szewczak, L.; Rola, R.; Karlińska, A.; Stear, M.; Donskow-Łysoniewska, K. Reduced expression of PD-1 in circulating CD4+ and CD8+ tregs is an early feature of RRMS. Int. J. Mol. Sci., 2022, 23(6), 3185.
[http://dx.doi.org/10.3390/ijms23063185] [PMID: 35328606]
[5]
Yamout, B.I.; Assaad, W.; Tamim, H.; Mrabet, S.; Goueider, R. Epidemiology and phenotypes of multiple sclerosis in the Middle East North Africa (MENA) region. Mult. Scler. J. Exp. Transl. Clin., 2020, 6(1)
[http://dx.doi.org/10.1177/2055217319841881] [PMID: 31984137]
[6]
Eskandarieh, S.; Molazadeh, N.; Moghadasi, A.N.; Azimi, A.R.; Sahraian, M.A. The prevalence, incidence and familial recurrence of multiple sclerosis in Tehran, Iran. Mult. Scler. Relat. Disord., 2018, 25, 143.
[http://dx.doi.org/10.1016/j.msard.2018.07.023] [PMID: 30075407]
[7]
Miyazaki, Y.; Niino, M. B-cell depletion therapy for multiple sclerosis. Immunol. Med., 2022, 45(2), 54-62.
[http://dx.doi.org/10.1080/25785826.2021.1952543] [PMID: 34289331]
[8]
Pourostadi, M.; Sattarpour, S.; Poor, B.M.; Asgharzadeh, M.; Kafil, H.S.; Farhoudi, M.; Asgharzadeh, V.; Vegari, A.; Najafi-Ghalelou, N.; Rashedi, J. Vitamin D receptor gene polymorphism and the risk of multiple sclerosis in the azeri population of iran. Endocr. Metab. Immune Disord. Drug Targets, 2021, 21(7), 1306-1311.
[http://dx.doi.org/10.2174/1871530320666200910113954] [PMID: 32914731]
[9]
Asgharzadeh, M.; Sanajoo, D.; Mahdavi Poor, B.; Samadi Kafil, H.; Gholizadeh, P.; Rashedi, J. Interleukin-10 Promoter and the CCR5 Polymorphisms in Iranian Azari Population with Multiple Sclerosis. Iran. J. Immunol., 2021, 18(3), 241-248.
[PMID: 34596589]
[10]
Asgharzadeh, M.; Najafi-Ghalehlou, N.; Poor, B.M.; Asgharzadeh, V.; Pourostadi, M.; Vegari, A.; Kafil, H.S.; Fadaee, M.; Farhoudi, M.; Rashedi, J. IFN-γ and TNF-α Gene polymorphisms in multiple sclerosis patients in northwest Iran. Endocr. Metab. Immune Disord. Drug Targets, 2021, 21(3), 520-525.
[http://dx.doi.org/10.2174/1871530320666200505123443] [PMID: 32368988]
[11]
Rodríguez, M.S.; Farez, M.F.; Quintana, F.J. The immune response in multiple sclerosis. Annu. Rev. Pathol., 2022, 17(1), 121-139.
[http://dx.doi.org/10.1146/annurev-pathol-052920-040318] [PMID: 34606377]
[12]
Olsson, T.; Barcellos, L.F.; Alfredsson, L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat. Rev. Neurol., 2017, 13(1), 25-36.
[http://dx.doi.org/10.1038/nrneurol.2016.187] [PMID: 27934854]
[13]
Langley, M.R.; Triplet, E.M.; Scarisbrick, I.A. Dietary influence on central nervous system myelin production, injury, and regeneration. Biochim. Biophys. Acta Mol. Basis Dis., 2020, 1866(7), 165779.
[http://dx.doi.org/10.1016/j.bbadis.2020.165779] [PMID: 32224154]
[14]
Jahromi, S.R.; Toghae, M.; Jahromi, M.J.R.; Aloosh, M. Dietary pattern and risk of multiple sclerosis. Iran. J. Neurol., 2012, 11(2), 47-53.
[PMID: 24250861]
[15]
Jörg, S.; Grohme, D.A.; Erzler, M.; Binsfeld, M.; Haghikia, A.; Müller, D.N.; Linker, R.A.; Kleinewietfeld, M. Environmental factors in autoimmune diseases and their role in multiple sclerosis. Cell. Mol. Life Sci., 2016, 73(24), 4611-4622.
[http://dx.doi.org/10.1007/s00018-016-2311-1] [PMID: 27491297]
[16]
Sharifi, M.H.; Keshani, P.; Salehi, A.; Jaladat, A.M.; Mirzaei, Z.; Nikseresht, A. Association between multiple sclerosis and dietary patterns based on the traditional concept of food nature: A case-control study in Iran. BMC Neurol., 2021, 21(1), 453.
[http://dx.doi.org/10.1186/s12883-021-02483-3] [PMID: 34794406]
[17]
Mirzanajafi-Zanjani, M.; Yousefi, M.; Ehsani, A. Challenges and approaches for production of a healthy and functional mayonnaise sauce. Food Sci. Nutr., 2019, 7(8), 2471-2484.
[http://dx.doi.org/10.1002/fsn3.1132] [PMID: 31428335]
[18]
Wu, C.; Yosef, N.; Thalhamer, T.; Zhu, C.; Xiao, S.; Kishi, Y.; Regev, A.; Kuchroo, V.K. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature, 2013, 496(7446), 513-517.
[http://dx.doi.org/10.1038/nature11984] [PMID: 23467085]
[19]
Forouzesh, A.; Forouzesh, F.; Samadi, F.S.; Forouzesh, A. A new method for calculating iron content and determining appropriate iron levels. , 2022. Available From: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4133519
[20]
Williams, R.; Buchheit, C.L.; Berman, N.E.J.; LeVine, S.M. Pathogenic implications of iron accumulation in multiple sclerosis. J. Neurochem., 2012, 120(1), 7-25.
[http://dx.doi.org/10.1111/j.1471-4159.2011.07536.x] [PMID: 22004421]
[21]
Günal, S.Y.; Mirza, M. Environmental risk factors in the aetiology of multiple sclerosis in Kayseri: A case control study. Epidemiol. Biostat. Public Health, 2022, 10(3)
[http://dx.doi.org/10.2427/8949]
[22]
Al Wutayd, O.; Mohamed, A.G.; Saeedi, J.; Al Otaibi, H.; Al Jumah, M. Environmental exposures and the risk of multiple sclerosis in Saudi Arabia. BMC Neurol., 2018, 18(1), 86.
[http://dx.doi.org/10.1186/s12883-018-1090-8] [PMID: 29914402]
[23]
Kleinewietfeld, M.; Manzel, A.; Titze, J.; Kvakan, H.; Yosef, N.; Linker, R.A.; Muller, D.N.; Hafler, D.A. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature, 2013, 496(7446), 518-522.
[http://dx.doi.org/10.1038/nature11868] [PMID: 23467095]
[24]
Liu, J.; Klebach, M.; Visser, M.; Hofman, Z. Amino acid availability of a dairy and vegetable protein blend compared to single casein, whey, soy, and pea proteins: A double-blind, cross-over trial. Nutrients, 2019, 11(11), 2613.
[http://dx.doi.org/10.3390/nu11112613] [PMID: 31683779]
[25]
Al Gawwam, G.; Sharquie, I.K. Serum glutamate is a predictor for the diagnosis of multiple sclerosis. Sci World J, 2017, 2017, 1-5.
[http://dx.doi.org/10.1155/2017/9320802] [PMID: 28676865]
[26]
Noormohammadi, M.; Ghorbani, Z.; Naser Moghadasi, A.; Saeedirad, Z.; Shahemi, S.; Ghanaatgar, M.; Rezaeimanesh, N.; Hekmatdoost, A.; Ghaemi, A.; Razeghi, J.S. MIND Diet adherence might be associated with a reduced odds of multiple sclerosis: Results from a case-control study. Neurol. Ther., 2022, 11(1), 397-412.
[http://dx.doi.org/10.1007/s40120-022-00325-z] [PMID: 35094301]
[27]
Riccio, P.; Rossano, R. Diet, gut microbiota, and vitamins D+ A in multiple sclerosis. Neurotherapeutics, 2018, 15(1), 75-91.
[http://dx.doi.org/10.1007/s13311-017-0581-4] [PMID: 29067566]
[28]
Wang, T.; Fu, X.; Chen, Q.; Patra, J.K.; Wang, D.; Wang, Z.; Gai, Z. Arachidonic acid metabolism and kidney inflammation. Int. J. Mol. Sci., 2019, 20(15), 3683.
[http://dx.doi.org/10.3390/ijms20153683] [PMID: 31357612]
[29]
Golam Kibria, A.; Khalequzzaman, M.; Khan, F.A.; Rayna, S.E.; Khan, M.M.H.; Alam, M.R. Health- compromising ingredients in fizzy drinks available in the markets of Dhaka city, Bangladesh. J. Food Sci. Nutr. Res., 2021, 4(1), 57-65.
[30]
Eweis, D.S.; Abed, F.; Stiban, J. Carbon dioxide in carbonated beverages induces ghrelin release and increased food consumption in male rats: Implications on the onset of obesity. Obes. Res. Clin. Pract., 2017, 11(5), 534-543.
[http://dx.doi.org/10.1016/j.orcp.2017.02.001] [PMID: 28228348]
[31]
Herbig, A.L.; Renard, C.M.G.C. Factors that impact the stability of vitamin C at intermediate temperatures in a food matrix. Food Chem., 2017, 220, 444-451.
[http://dx.doi.org/10.1016/j.foodchem.2016.10.012] [PMID: 27855924]
[32]
Wang, H; Li, L; Zhang, N; Zhang, T; Ma, Y Effects of pelleting and long-term high-temperature stabilization on vitamin retention in swine feed. Animals (Basel), 2022, 20(9), 41058.
[http://dx.doi.org/10.3390/ani12091058]
[33]
Nemazannikova, N.; Mikkelsen, K.; Stojanovska, L.; Blatch, G.L.; Apostolopoulos, V. Is there a link between vitamin B and multiple sclerosis? Med. Chem., 2018, 14(2), 170-180.
[PMID: 28875857]
[34]
Falahatian, M. The effects of different kinds of nutrition and functional foods on multiple sclerosis. Curr. Nutr. Food Sci., 2020, 16(5), 632-637.
[http://dx.doi.org/10.2174/1573401316666200129115858]
[35]
Koutsos, A.; Lima, M.; Conterno, L.; Gasperotti, M.; Bianchi, M.; Fava, F.; Vrhovsek, U.; Lovegrove, J.; Tuohy, K. Effects of commercial apple varieties on human gut microbiota composition and metabolic output using an in vitro colonic model. Nutrients, 2017, 9(6), 533.
[http://dx.doi.org/10.3390/nu9060533] [PMID: 28538678]
[36]
Melbye, P.; Olsson, A.; Hansen, T.H.; Søndergaard, H.B.; Bang Oturai, A. Short-chain fatty acids and gut microbiota in multiple sclerosis. Acta Neurol. Scand., 2019, 139(3), 208-219.
[http://dx.doi.org/10.1111/ane.13045] [PMID: 30427062]
[37]
Farid Hossain, M.; Akhtar, S.; Anwar, M. Nutritional value and medicinal benefits of pineapple. Int J Nutrition Food Sci, 2015, 4(1), 84-88.
[http://dx.doi.org/10.11648/j.ijnfs.20150401.22]
[38]
Khosravi-Largani, M.; Pourvali-Talatappeh, P.; Rousta, A.M.; Karimi-Kivi, M.; Noroozi, E.; Mahjoob, A.; Asaadi, Y.; Shahmohammadi, A.; Sadeghi, S.; Shakeri, S.; Ghiyasvand, K.; Tavakoli-Yaraki, M. A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis. e Neurol Sci, 2018, 10, 37-44.
[http://dx.doi.org/10.1016/j.ensci.2018.01.007] [PMID: 29736427]
[39]
Penesová, A.; Dean, Z.; Kollár, B.; Havranová, A.; Imrich, R.; Vlček, M.; Rádiková, Ž. Nutritional intervention as an essential part of multiple sclerosis treatment? Physiol. Res., 2018, 67(4), 521-533.
[http://dx.doi.org/10.33549/physiolres.933694] [PMID: 29750884]
[40]
Cuervo-Zanatta, D; Syeda, T; Sánchez-Valle, V. Dietary fiber modulates the release of gut bacterial products preventing cognitive decline in an Alzheimer’s mouse model. Cel Mol. Neurobiol., 2022, 43(4), 1595-1618.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy