A Comprehensive Review on Phytochemistry and Pharmacology of Rosa
Species (Rosaceae)

Faheem      Fayaz; Kanwaljeet      Singh; Sumeet      Gairola; Zabeer      Ahmed; Bhahwal Ali      Shah
doi:10.2174/0115680266274385231023075011
Abstract

The Rosa L. genus is a significant plant family in the Rosaceae group, consisting of around 200 species, primarily shrubs. In India, it has 37 species, most located in the Western Himalayan region of Jammu and Kashmir and Himachal Pradesh. Roses are highly regarded for their beauty and growth and are popular worldwide for their nutritional, therapeutic, ornamental, and cosmetic value. The rose hips are utilized in creating various food and drink items, such as jams, jellies, teas, and alcoholic beverages. The Rosa species has various pharmacological activities, including anti-inflammatory, antidiabetic, hepatoprotective, antimicrobial, anti-proliferative/anticancer, anti-arthritic, neurological, and anti-obesity activity. This review aims to provide an in- -depth overview of the phytochemistry and pharmacology of the Rosa species in India, focusing on Rosa indica L., which has significant potential for future chemical and biological research.
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Graphical Abstract

[1]
Hummer, K.E.; Janick, J. Rosaceae: Taxonomy, economic importance, genomics. In: Genetics and Genomics of Rosaceae; Folta, K.M.; Gardiner, S.E., Eds.; , 2006; pp. 1-17.

[2]
Phipps, J.B. Flora of North America North of Mexico  Magnoliophyta: Picramniaceae to Rosaceae, 2014; 9.

[3]
Judd, W.S.; Campbell, C.S.; Kellogg, E.A.; Stevens, P.F. Plant Systematics: A phylogenetic approach. Ecol. Mediter.,  1999, 25, 135-146.

[4]
Phillips, R.; Rix, M. Roses; Random House: New York, USA, 1988.  224.

[5]
Ku, T.C.; Robertson, K.R. Rosa (Rosaceae). In: Flora of China; Wu, Z.Y.; Raven, P.H. , 2003; pp. 339-338.

[6]
Kevan, P.G.; Eisikowitch, D.; Ambrose, J.D.; Kemp, J.R. Cryptic dioecy and insect pollination in Rosa setigera Michx. (Rosaceae), a rare plant of Carolinian Canada. Biol. J. Linn. Soc. Lond.,  1990, 40(3), 229-243.
 [http://dx.doi.org/10.1111/j.1095-8312.1990.tb00537.x]

[7]
Kemp, J.R. Floral morphology and pollination biology of Rosa setigera Michaux,  1994.

[8]
Duthie, J.F. Flora of the upper gangetic plain: And of the adjacent Shiwalik and Sub-Himalayan tracts; International Book Distributors, 1971. 

[9]
Bamber, C.J. Plants of the Punjab, North West Frontier Province and Kashmir; Singh, B.; Singh, M., Eds.; Dehradun, 1976. 

[10]
Hooker, J.D. Flora of British India; L. Reeve & Co.: London, 1879. 

[11]
Singh, K.; Sharma, Y.P.; Gairola, S. Morphological characterization of wild Rosa L. germplasm from the Western Himalaya, India. Euphytica,  2020, 216(3), 41.
 [http://dx.doi.org/10.1007/s10681-020-2567-2]

[12]
Guimarães, R.; Barros, L.; Carvalho, A.M.; Ferreira, I.C.F.R. Studies on chemical constituents and bioactivity of Rosa micrantha: an alternative antioxidants source for food, pharmaceutical, or cosmetic applications. J. Agric. Food Chem.,  2010, 58(10), 6277-6284.
 [http://dx.doi.org/10.1021/jf101394w] [PMID: 20426454]

[13]
Grochowski, W. Ubocznaprodukcjalesna; PWN: Warszawa, Poland, 1990, pp. 379-383.

[14]
Ercisli, S. Rose (Rosa spp.) germplasm resources of Turkey. Genet. Resour. Crop Evol.,  2005, 52(6), 787-795.
 [http://dx.doi.org/10.1007/s10722-003-3467-8]

[15]
Genc, G.E.; Ozhatay, N. An ethnobotanical study in Çatalca (European part of Istanbul) II. Turk. J. Pharm. Sci,  2006, 3, 73-89.

[16]
Ayati, Z.; Amiri, M.S.; Ramezani, M.; Delshad, E.; Sahebkar, A.; Emami, S.A. Phytochemistry, traditional uses and pharmacological profile of rose hip: A review. Curr. Pharm. Des.,  2019, 24(35), 4101-4124.
 [http://dx.doi.org/10.2174/1381612824666181010151849] [PMID: 30317989]

[17]
Patel, S. Rose hip as an underutilized functional food: Evidence-based review. Trends Food Sci. Technol.,  2017, 63, 29-38.
 [http://dx.doi.org/10.1016/j.tifs.2017.03.001]

[18]
Ercisli, S. Chemical composition of fruits in some rose (Rosa spp.) species. Food Chem.,  2007, 104(4), 1379-1384.
 [http://dx.doi.org/10.1016/j.foodchem.2007.01.053]

[19]
Barros, L.; Carvalho, A.M.; Ferreira, I.C.F.R. Exotic fruits as a source of important phytochemicals: Improving the traditional use of Rosa canina fruits in Portugal. Food Res. Int.,  2011, 44(7), 2233-2236.
 [http://dx.doi.org/10.1016/j.foodres.2010.10.005]

[20]
Ouerghemmi, S.; Sebei, H.; Siracusa, L.; Ruberto, G.; Saija, A.; Cimino, F.; Cristani, M. Comparative study of phenolic composition and antioxidant activity of leaf extracts from three wild Rosa species grown in different Tunisia regions: Rosa canina L., Rosa moschata Herrm. and Rosa sempervirens L. Ind. Crops Prod.,  2016, 94, 167-177.
 [http://dx.doi.org/10.1016/j.indcrop.2016.08.019]

[21]
Fascella, G.; D’Angiolillo, F.; Mammano, M.M.; Amenta, M.; Romeo, F.V.; Rapisarda, P.; Ballistreri, G. Bioactive compounds and antioxidant activity of four rose hip species from spontaneous Sicilian flora. Food Chem.,  2019, 289, 56-64.
 [http://dx.doi.org/10.1016/j.foodchem.2019.02.127] [PMID: 30955649]

[22]
Akram, M.; Riaz, M.; Munir, N.; Akhter, N.; Zafar, S.; Jabeen, F.; Ali Shariati, M.; Akhtar, N.; Riaz, Z.; Altaf, S.H.; Daniyal, M.; Zahid, R.; Said Khan, F. Chemical constituents, experimental and clinical pharmacology of Rosa damascena : A literature review. J. Pharm. Pharmacol.,  2020, 72(2), 161-174.
 [http://dx.doi.org/10.1111/jphp.13185] [PMID: 31709541]

[23]
Cunja, V.; Mikulic-Petkovsek, M.; Weber, N.; Jakopic, J.; Zupan, A.; Veberic, R.; Stampar, F.; Schmitzer, V. Fresh from the ornamental garden: Hips of selected rose cultivars rich in phytonutrients. J. Food Sci.,  2016, 81(2), C369-C379.
 [http://dx.doi.org/10.1111/1750-3841.13220] [PMID: 26773854]

[24]
Kumar, K.; Sharma, Y.P.; Manhas, R.K.; Bhatia, H. Ethnomedicinal plants of Shankaracharya Hill, Srinagar, J&K, India. J. Ethnopharmacol.,  2015, 170, 255-274.
 [http://dx.doi.org/10.1016/j.jep.2015.05.021] [PMID: 26008867]

[25]
Deliorman Orhan, D.; Hartevioğlu, A.; Küpeli, E.; Yesilada, E. in vivo anti-inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits. J. Ethnopharmacol.,  2007, 112(2), 394-400.
 [http://dx.doi.org/10.1016/j.jep.2007.03.029] [PMID: 17482395]

[26]
Singh, K.; Singh, D.; Lone, J.F.; Bhat, S.; Sharma, Y.P.; Gairola, S. Nutraceutical potential of rose hips of three wild Rosa species from Western Himalaya, India. Not. Bot. Horti Agrobot. Cluj-Napoca,  2021, 49(4), 12471.
 [http://dx.doi.org/10.15835/nbha49412471]

[27]
Hodisan, T.; Socaciu, C.; Ropan, I.; Neamtu, G. Carotenoid composition of Rosa canina fruits determined by thin-layer chromatography and high-performance liquid chromatography. J. Pharm. Biomed. Anal.,  1997, 16(3), 521-528.
 [http://dx.doi.org/10.1016/S0731-7085(97)00099-X] [PMID: 9589412]

[28]
Dubtsova, G.N.; Negmatulloeva, R.N.; Bessonov, V.V.; Baĭkov, V.G.; Sheviakova, L.V.; Makhova, N.N.; Perederiaev, O.I.; Bogachuk, M.N.; Baĭgarin, E.K. [Composition and content of biologically active substances in rose hips]. Vopr. Pitan.,  2012, 81(6), 84-88.
 [PMID: 23530442]

[29]
Patel, S. Rose hips as complementary and alternative medicine: overview of the present status and prospects. Mediterranean. J. Nutr. Metab.,  2013, 6, 89-97.

[30]
Rasheed, H.; Khan, T.; Wahid, F.; Khan, R.; Shah, A. Chemical composition and vasorelaxant and antispasmodic effects of essential oil from Rosa indica L. Petals. Evid.-based Complement. Altern. Med,  2015, 2015, 279247.

[31]
Javed, S.; Safdar, A.; Shoaib, A.; Nisar, Z. Physico-chemical characterization of essential oils of Rosa indica and its application in hand sanitizer: Rose essential oil as a potential ingredient in hand sanitizer formulation. Int. J. Biol. Chem. Sci.,  2021, 14(2), 70-81.

[32]
Bai, S.; Seasotiya, L.; Malik, A.; Bharti, P.; Dalal, S. Bioactive compounds and pharmacological potential of Rosa indica L. and Psidium guajava L. methanol extracts as antiurease and anticollagenase agents. Pharm. Lett.,  2015, 7(1), 179-184.

[33]
Akhtar, N.; Ihsan-ul-Haq; Mirza, B. Phytochemical analysis and comprehensive evaluation of antimicrobial and antioxidant properties of 61 medicinal plant species. Arab. J. Chem.,  2018, 11(8), 1223-1235.
 [http://dx.doi.org/10.1016/j.arabjc.2015.01.013]

[34]
Bieski, I.G.C.; Leonti, M.; Arnason, J.T.; Ferrier, J.; Rapinski, M.; Violante, I.M.P.; Balogun, S.O.; Pereira, J.F.C.A.; Figueiredo, R.C.F.; Lopes, C.R.A.S.; da Silva, D.R.; Pacini, A.; Albuquerque, U.P.; Martins, D.T.O. Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil. J. Ethnopharmacol.,  2015, 173, 383-423.
 [http://dx.doi.org/10.1016/j.jep.2015.07.025] [PMID: 26234177]

[35]
Ribeiro, R.V.; Bieski, I.G.C.; Balogun, S.O.; Martins, D.T.O. Ethnobotanical study of medicinal plants used by Ribeirinhos in the North Araguaia microregion, Mato Grosso, Brazil. J. Ethnopharmacol.,  2017, 205, 69-102.
 [http://dx.doi.org/10.1016/j.jep.2017.04.023] [PMID: 28476677]

[36]
Amiri, M.S.; Joharchi, M.R. Ethnobotanical investigation of traditional medicinal plants commercialized in the markets of Mashhad, Iran. Avicenna J. Phytomed.,  2013, 3(3), 254-271.
 [PMID: 25050282]

[37]
Rivera, D.; Obon, C.; Inocencio, C.; Heinrich, M.; Verde, A.; Fajardo, J.; Llorach, R. The ethnobotanical study of local Mediterranean food plants as medicinal resources in Southern Spain. J. Physiol. Pharmacol.,  2005, 56(Suppl. 1), 97-114.
 [PMID: 15800388]

[38]
Tuttolomondo, T.; Licata, M.; Leto, C.; Savo, V.; Bonsangue, G.; Letizia Gargano, M.; Venturella, G.; La Bella, S. Ethnobotanical investigation on wild medicinal plants in the Monti Sicani Regional Park (Sicily, Italy). J. Ethnopharmacol.,  2014, 153(3), 568-586.
 [http://dx.doi.org/10.1016/j.jep.2014.02.032] [PMID: 24632020]

[39]
Vitalini, S.; Iriti, M.; Puricelli, C.; Ciuchi, D.; Segale, A.; Fico, G. Traditional knowledge on medicinal and food plants used in Val San Giacomo (Sondrio, Italy)—An alpine ethnobotanical study. J. Ethnopharmacol.,  2013, 145(2), 517-529.
 [http://dx.doi.org/10.1016/j.jep.2012.11.024] [PMID: 23220197]

[40]
Cakilcioglu, U.; Sengun, M.T.; Turkoglu, I. An ethnobotanical survey of medicinal plants of Yazikonak and Yurtbaşi districts of Elazig province, Turkey. J. Med. Plants Res.,  2010, 4, 567-572.

[41]
Baser, K.H.C.; Altintas, A.; Kurkcuoglu, M. Turkish rose: A review of the history, ethnobotany, and modern uses of rose petals, rose oil, rose water, and other rose products. HerbalGram,  2012, 96, 40-53.

[42]
Nadiroglu, M.; Behcet, L.; Cakilcioglu, U. An ethnobotanical survey of medicinal plants in Karliova (Bingol-Turkey). Indian J. Tradit. Knowl.,  2019, 18, 76-87.

[43]
Hong, L.; Guo, Z.; Huang, K.; Wei, S.; Liu, B.; Meng, S.; Long, C. Ethnobotanical study on medicinal plants used by Maonan people in China. J. Ethnobiol. Ethnomed.,  2015, 11(1), 32.
 [http://dx.doi.org/10.1186/s13002-015-0019-1] [PMID: 25925830]

[44]
Chaudhary, M.I.; He, Q.; Cheng, Y.Y.; Xiao, P.G. Ethnobotany of medicinal plants from tian Mu Shan biosphere reserve, Zhejiang-province, China. Asian J. Plant Sci.,  2006, 5, 646-653.
 [http://dx.doi.org/10.3923/ajps.2006.646.653]

[45]
Singh, K.; Sharma, Y.P.; Gairola, S. Distribution and ethnomedicinal importance of genus Rosa L. (Rosaceae) in India. Ethnobot. Res. Appl.,  2023, 25, 1-22.
 [http://dx.doi.org/10.32859/era.25.51.1-22]

[46]
Yanishlieva, N.V.; Marinova, E.; Pokorný, J. Natural antioxidants from herbs and spices. Eur. J. Lipid Sci. Technol.,  2006, 108(9), 776-793.
 [http://dx.doi.org/10.1002/ejlt.200600127]

[47]
Czyzowska, A.; Klewicka, E.; Pogorzelski, E.; Nowak, A. Polyphenols, vitamin C and antioxidant activity in wines from Rosa canina L. and Rosa rugosa Thunb. J. Food Compos. Anal.,  2015, 39, 62-68.
 [http://dx.doi.org/10.1016/j.jfca.2014.11.009]

[48]
Bhave, A.; Schulzova, V.; Chmelarova, H.; Mrnka, L.; Hajslova, J. Assessment of rosehips based on the content of their biologically active compounds. Yao Wu Shi Pin Fen Xi,  2017, 25(3), 681-690.
 [PMID: 28911653]

[49]
Shameh, S.; Alirezalu, A.; Hosseini, B.; Maleki, R. Fruit phytochemical composition and color parameters of 21 accessions of five Rosa species grown in North West Iran. J. Sci. Food Agric.,  2019, 99(13), 5740-5751.
 [http://dx.doi.org/10.1002/jsfa.9842] [PMID: 31166009]

[50]
Park, Y.S.; Namiesnik, J.; Vearasilp, K.; Leontowicz, H.; Leontowicz, M.; Barasch, D.; Nemirovski, A.; Trakhtenberg, S.; Gorinstein, S. Bioactive compounds and the antioxidant capacity in new kiwi fruit cultivars. Food Chem.,  2014, 165, 354-361.
 [http://dx.doi.org/10.1016/j.foodchem.2014.05.114] [PMID: 25038687]

[51]
Fenglin, H.; Ruili, L.; bao, H.; Liang, M. Free radical scavenging activity of extracts prepared from fresh leaves of selected Chinese medicinal plants. Fitoterapia,  2004, 75(1), 14-23.
 [http://dx.doi.org/10.1016/j.fitote.2003.07.003] [PMID: 14693215]

[52]
Charan, A.A.; Gupta, P. Comparative analysis of antibacterial, antioxidant and photosynthetic activity of Azadirachta indica, Rosa indica and Moringa oliefera cultivars. Int. J. Curr. Res.,  2013, 53, 556-561.

[53]
Zahid, K.; Ahmed, M.; Khan, F. Phytochemical screening, antioxidant activity, total phenolic and total flavonoid contents of seven local varieties of Rosa indica L. Nat. Prod. Res.,  2018, 32(10), 1239-1243.
 [http://dx.doi.org/10.1080/14786419.2017.1331228] [PMID: 28539055]

[54]
Marques-Rocha, J.L.; Samblas, M.; Milagro, F.I.; Bressan, J.; Martínez, J.A.; Marti, A. Noncoding RNAs, cytokines, and inflammation-related diseases. FASEB J.,  2015, 29(9), 3595-3611.
 [http://dx.doi.org/10.1096/fj.14-260323] [PMID: 26065857]

[55]
Kharazmi, A.; Winther, K. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo. Inflammopharmacology,  1999, 7(4), 377-386.
 [http://dx.doi.org/10.1007/s10787-999-0031-y] [PMID: 17657440]

[56]
Christensen, L. Galactolipids as potential health promoting compounds in vegetable foods. Recent Pat. Food Nutr. Agric.,  2009, 1(1), 50-58.
 [http://dx.doi.org/10.2174/2212798410901010050] [PMID: 20653526]

[57]
Yeşilada, E.; Üstün, O.; Sezik, E.; Takaishi, Y.; Ono, Y.; Honda, G. Inhibitory effects of Turkish folk remedies on inflammatory cytokines: interleukin-1α, interleukin-1β and tumor necrosis factor α. J. Ethnopharmacol.,  1997, 58(1), 59-73.
 [http://dx.doi.org/10.1016/S0378-8741(97)00076-7] [PMID: 9324006]

[58]
Lee, S.H.; Choi, S.H.; Lee, I.S.; Kim, Y.; An, E.J.; Jang, H.J. Anti-inflammatory effect of Rosa laevigata extract on in vitro and in vivo model of allergic asthma via the suppression of IgE and related cytokines. Mol. Cell. Toxicol.,  2020, 16(2), 119-127.
 [http://dx.doi.org/10.1007/s13273-019-00063-8]

[59]
Yan, M.; Zhu, Y.; Zhang, H.J.; Jiao, W.H.; Han, B.N.; Liu, Z.X.; Qiu, F.; Chen, W.S.; Lin, H.W. Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata. Bioorg. Med. Chem.,  2013, 21(11), 3290-3297.
 [http://dx.doi.org/10.1016/j.bmc.2013.03.018] [PMID: 23632365]

[60]
Ko, H. M.; Choi, S. H.; Kim, Y.; An, E. J.; Lee, S. H.; Kim, K.; Jung, H. J.; Jang, H. J. Effect of Rosa laevigata on PM10-induced inflammatory response of human lung epithelial cells. Evid.-based Complement. Altern. Med.,  2020, 2893609.
 [http://dx.doi.org/10.1155/2020/2893609]

[61]
Jiang, H.; Han, H.; Man, W.J.; Hou, A.J.; Guo, X.Y.; Xing, X.D.; Yan, M.L.; Yang, L.; Yang, L. Ursane-type triterpenoids from the roots of Rosa multiflora with their anti-inflammatory activity. J. Asian Nat. Prod. Res.,  2020, 22(2), 131-137.
 [http://dx.doi.org/10.1080/10286020.2018.1541135] [PMID: 30526062]

[62]
Manikandan, R.; Manikandan, B.; Raman, T.; Arunagirinathan, K.; Prabhu, N.M.; Jothi Basu, M.; Perumal, M.; Palanisamy, S.; Munusamy, A. Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities. Spectrochim. Acta A Mol. Biomol. Spectrosc.,  2015, 138, 120-129.
 [http://dx.doi.org/10.1016/j.saa.2014.10.043] [PMID: 25481491]

[63]
Gochev, V.; Dobreva, A.; Girova, T.; Stoyanova, A. Antimicrobial activity of essential oil from Rosa alba. Biotechnol. Biotechnol. Equip.,  2010, 24(sup1), 512-515.
 [http://dx.doi.org/10.1080/13102818.2010.10817892]

[64]
Mileva, M.; Kusovski, V.K.; Krastev, D.S.; Dobreva, A.M.; Galabov, A.S. Chemical composition, in vitro antiradical and antimicrobial activities of Bulgarian Rosa alba L. essential oil against some oral pathogens. Int. J. Curr. Microbiol. Appl. Sci.,  2014, 3, 11-20.

[65]
Frey, F.M.; Meyers, R. Antibacterial activity of traditional medicinal plants used by Haudenosaunee peoples of New York State. BMC Complement. Altern. Med.,  2010, 10(1), 64.
 [http://dx.doi.org/10.1186/1472-6882-10-64] [PMID: 21054887]

[66]
Bitis, L.; Sen, A.; Ozsoy, N.; Birteksoz-Tan, S.; Kultur, S.; Melikoglu, G. Flavonoids and biological activities of various extracts from Rosa sempervirens leaves. Biotechnol. Biotechnol. Equip.,  2017, 31(2), 299-303.
 [http://dx.doi.org/10.1080/13102818.2016.1277956]

[67]
Kumarasamy, Y.; Cox, P.J.; Jaspars, M.; Rashid, M.A.; Sarker, S.D. Bioactive flavonoid glycosides from the seeds of Rosa canina. Pharm. Biol.,  2003, 41(4), 237-242.
 [http://dx.doi.org/10.1076/phbi.41.4.237.15663]

[68]
Rovná, K.; Ivanišová, E.; Žiarovská, J.; Ferus, P.; Terentjeva, M.; Kowalczewski, P.Ł.; Kačániová, M. Characterization of Rosa canina fruits collected in urban areas of Slovakia. Genome size, iPBS profiles and antioxidant and antimicrobial activities. Molecules,  2020, 25(8), 1888.
 [http://dx.doi.org/10.3390/molecules25081888] [PMID: 32325812]

[69]
Dave, K.; Shah, H.G.; Patel, K. Antibacterial activity and phytochemical analysis of methanolic and acetonic extracts from Moringa oleifera, Vitex negundo and Rosa indica. Int. J. Curr. Microbiol. Appl. Sci.,  2018, 7, 3718-3727.
 [http://dx.doi.org/10.20546/ijcmas.2018.707.430]

[70]
Pathak, D.; Dave, K.M.; Aliasgar, L. Antimicrobial properties of Rosa indica (A new start with nature). Biosci. Biotechnol. Res. Asia,  2019, 16(2), 403-409.
 [http://dx.doi.org/10.13005/bbra/2755]

[71]
Mishra, R.P.; Arshad, M.; Sami, A. Antibacterial properties of Rosa indica (L.) stem, leaves and flowers. J. Pharm. Biomed. Anal.,  2011, 12, 1-3.

[72]
Ishaque, M.; Bibi, Y.; Qayyum, A. Fruits of Rosa brunonii Lindle: An ethnomedicinal plant from foothills of Himalaya with antibacterial, antitumor and cytotoxic properties. Arab. J. Sci. Eng.,  2021, 47(3), 1-9.

[73]
Blair, M. Diabetes Mellitus review. Urol. Nurs.,  2016, 36(1), 27-36.
 [http://dx.doi.org/10.7257/1053-816X.2016.36.1.27] [PMID: 27093761]

[74]
Patel, D.K.; Prasad, S.K.; Kumar, R.; Hemalatha, S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac. J. Trop. Biomed.,  2012, 2(4), 320-330.
 [http://dx.doi.org/10.1016/S2221-1691(12)60032-X] [PMID: 23569923]

[75]
Taghizadeh, M.; Rashidi, A.A.; Taherian, A.A.; Vakili, Z.; Sajad Sajadian, M.; Ghardashi, M. Antidiabetic and antihyperlipidemic effects of ethanol extract of Rosa canina L. fruit on diabetic rats: An experimental study with histopathological evaluations. J. Evid. Based Complementary Altern. Med.,  2016, 21(4), NP25-NP30.
 [http://dx.doi.org/10.1177/2156587215612626] [PMID: 26498488]

[76]
Fattahi, A.; Niyazi, F.; Shahbazi, B.; Farzaei, M.H.; Bahrami, G. Antidiabetic mechanisms of Rosa canina fruits: An in vitro evaluation. J. Evid. Based Complementary Altern. Med.,  2017, 22(1), 127-133.
 [http://dx.doi.org/10.1177/2156587216655263] [PMID: 27352916]

[77]
Miraghaee, S.S.; Bahrami, G.; Mohammadi, B.; Bahrami, M.; Taheripak, G.; Keshavarzi, S.; Babaei, A.; Sajadimajd, S.; Hatami, R. Molecular mechanism of the anti-diabetic activity of an identified oligosaccharide from Rosa canina. Res. Pharm. Sci.,  2020, 15(1), 36-47.
 [http://dx.doi.org/10.4103/1735-5362.278713] [PMID: 32180815]

[78]
Gholamhoseinian, A.; Fallah, H.; Sharifi far, F. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on α-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine,  2009, 16(10), 935-941.
 [http://dx.doi.org/10.1016/j.phymed.2009.02.020] [PMID: 19380218]

[79]
Liu, Y.T.; Lu, B.N.; Xu, L.N.; Yin, L.H.; Wang, X.N.; Peng, J.Y.; Liu, K.X. The antioxidant activity and hypolipidemic activity of the total flavonoids from the fruit of Rosa laevigata  Michx. Nat. Sci.,  2010, 2, 175-183.

[80]
Yu, C.H.; Dai, X.Y.; Chen, Q.; Zang, J.N.; Deng, L.L.; Liu, Y.H.; Ying, H.Z. Hypolipidemic and antioxidant activities of polysaccharides from Rosae laevigatae Fructus in rats. Carbohydr. Polym.,  2013, 94(1), 56-62.
 [http://dx.doi.org/10.1016/j.carbpol.2013.01.006] [PMID: 23544509]

[81]
Siddiqui, M.A.; Rasheed, S.; Saquib, Q.; Al-Khedhairy, A.A.; Al-Said, M.S.; Musarrat, J.; Choudhary, M.I. in-vitro dual inhibition of protein glycation, and oxidation by some Arabian plants. BMC Complement. Altern. Med.,  2016, 16(1), 276.
 [http://dx.doi.org/10.1186/s12906-016-1225-7] [PMID: 27495289]

[82]
Cagle, P.; Idassi, O.; Carpenter, J.; Minor, R.; Goktepe, I.; Martin, P. Effect of Rose-hip (Rosa canina) extracts on human brain tumor cell proliferation and apoptosis. J. Cancer Ther.,  2012, 3(5), 534-545.
 [http://dx.doi.org/10.4236/jct.2012.35069]

[83]
Sui, C.G.; Meng, F.D.; Li, Y.; Jiang, Y. Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells. Phytomedicine,  2015, 22(9), 796-806.
 [http://dx.doi.org/10.1016/j.phymed.2015.05.004] [PMID: 26220626]

[84]
Chandragopal, S.; Kumar, S.; Archana, B. Evaluation of antiulcer activity of Rosa centifolia (Linn.) flowers in experimental rats. J. Nat. Rem.,  2012, 2, 20-29.

[85]
Zarei, O.; Yaghoobi, M.M. Cytotoxic and anti-proliferative effects of Rosa beggeriana Schrenk extracts on human liver and breast cancer cells. Avicenna J. Phytomed.,  2019, 9(4), 386-395.
 [PMID: 31309076]

[86]
Ganduri, K.; Rama, V.S.; Bodaiah, B.; Usha, M.; Vijayalakshmi, M.; Rao, S.K.; Poda, S. Green synthesis, characterization and biological activities of silver nanoparticles using Wrightia tomentosa leaves. J. Chem. Pharm. Res.,  2016, 10, 266-278.

[87]
Sadeghi, H.; Hosseinzadeh, S.; Akbartabar Touri, M.; Ghavamzadeh, M.; Jafari Barmak, M.; Sayahi, M.; Sadeghi, H. Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat. Avicenna J. Phytomed.,  2016, 6(2), 181-188.
 [PMID: 27222831]

[88]
Rao, K.U.M.; Reddy, R.V.R.; Vangoori, Y.; Sundharam, J.M. Evaluation of hepatoprotective (preventive & curative) activity of leaves extract of Rosa centifolia on experimental animal models. Asian J. Pharm. Clin. Res.,  2014, 7, 105-107.

[89]
Achuthan, C.R.; Babu, B.H.; Padikkala, J. Antioxidant and hepatoprotective effects of Rosa damascena. Pharm. Biol.,  2003, 41(5), 357-361.
 [http://dx.doi.org/10.1076/phbi.41.5.357.15945]

[90]
Alam, M. A.; Nyeem, M. A. B.; Awal, M. A.; Mostofa, M.; Alam, M. S.; Subhan, N.; Rahman, M. M. Antioxidant and hepatoprotective action of the crude ethanolic extract of the flowering top of Rosa damascena. Adv. trad. med.,  2008, 8, 164-170.

[91]
Saxena, M.; Shakya, A.K.; Sharma, N.; Shrivastava, S.; Shukla, S. Therapeutic efficacy of Rosa damascena Mill. on acetaminophen-induced oxidative stress in albino rats. J. Environ. Pathol. Toxicol. Oncol.,  2012, 31(3), 193-201.
 [http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.v31.i3.10] [PMID: 23339694]

[92]
Shafiuddin, M.; Abdullah, K.; Sadath, A. Evaluation of hepatoprotective activity of traditional herbal formulation. Int. J. Chem. Sci.,  2009, 7, 617-624.

[93]
Liu, Y.; Lu, B.; Peng, J. Hepatoprotective activity of the total flavonoids from Rosa laevigata Michx fruit in mice treated by paracetamol. Food Chem.,  2011, 125(2), 719-725.
 [http://dx.doi.org/10.1016/j.foodchem.2010.09.080]

[94]
Zhang, S.; Lu, B.; Han, X.; Xu, L.; Qi, Y.; Yin, L.; Xu, Y.; Zhao, Y.; Liu, K.; Peng, J. Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice. Food Chem. Toxicol.,  2013, 55, 60-69.
 [http://dx.doi.org/10.1016/j.fct.2012.12.041] [PMID: 23279844]

[95]
Dong, D.; Xu, L.; Han, X.; Qi, Y.; Xu, Y.; Yin, L.; Liu, K.; Peng, J. Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis. Molecules,  2014, 19(6), 7189-7206.
 [http://dx.doi.org/10.3390/molecules19067189] [PMID: 24886943]

[96]
Naikwade, N.; Mule, S.; Adnaik, R.; Magdum, C. Memory-enhancing activity of Rose alba in mice. Int J Green Pharm,  2009, 3(3), 239-242.
 [http://dx.doi.org/10.4103/0973-8258.56283]

[97]
Nemati, Z.; Komaki, A.; Shahidi, S.; Sarihi, A. Effect of a hydroalcoholic extract of Rosa canina flowers on anxiety in rats. Neurophysiology,  2015, 47(2), 133-137.
 [http://dx.doi.org/10.1007/s11062-015-9509-y]

[98]
Daneshmand, P.; Saliminejad, K.; Dehghan Shasaltaneh, M.; Kamali, K.; Riazi, G.H.; Nazari, R.; Azimzadeh, P.; Khorram Khorshid, H.R. Neuroprotective effects of herbal extract (Rosa canina, Tanacetum vulgare and Urtica dioica) on rat model of sporadic Alzheimer’s disease. Avicenna J. Med. Biotechnol.,  2016, 8(3), 120-125.
 [PMID: 27563424]

[99]
Homayoun, M.; Seghatoleslam, M.; Pourzaki, M.; Shafieian, R.; Hosseini, M.; Ebrahimzadeh Bideskan, A. Anticonvulsant and neuroprotective effects of Rosa damascena hydro-alcoholic extract on rat hippocampus. Avicenna J. Phytomed.,  2015, 5(3), 260-270.
 [PMID: 26101759]

[100]
Mohammadpour, T.; Hosseini, M.; Naderi, A.; Karami, R.; Sadeghnia, H.R.; Soukhtanloo, M.; Vafaee, F. Protection against brain tissues oxidative damage as a possible mechanism for the beneficial effects of Rosa damascena hydroalcoholic extract on scopolamine induced memory impairment in rats. Nutr. Neurosci.,  2015, 18(7), 329-336.
 [http://dx.doi.org/10.1179/1476830514Y.0000000137] [PMID: 24974980]

[101]
Esfandiary, E.; Karimipour, M.; Mardani, M.; Alaei, H.; Ghannadian, M.; Kazemi, M.; Mohammadnejad, D.; Hosseini, N.; Esmaeili, A. Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer’s disease. J. Neurosci. Res.,  2014, 92(4), 517-530.
 [http://dx.doi.org/10.1002/jnr.23319] [PMID: 24395280]

[102]
Mizuno, D.; Konoha-Mizuno, K.; Mori, M.; Yamazaki, K.; Haneda, T.; Koyama, H.; Kawahara, M. An in vitro system comprising immortalized hypothalamic neuronal cells (GT1–7 Cells) for evaluation of the neuroendocrine effects of essential oils. Evid.-based Complement. Altern. Med,  2015, 1-7.

[103]
Rakhshandah, H.; Hosseini, M.; Dolati, K. Hypnotic Effect of Rosa damascena in Mice. Iran. J. Pharm. Res.,  2004, 3, 181-185.

[104]
Awale, S.; Tohda, C.; Tezuka, Y.; Miyazaki, M.; Kadota, S. Protective effects of Rosa damascena and its active constituent on Aβ (25–35)-induced neuritic atrophy. Evid.-based Complement. Altern. Med.,  2011, 2011, 131042.
 [http://dx.doi.org/10.1093/ecam/nep149]

[105]
Firdous, A.; Sarwar, S.; Shah, F.A.; Tabasum, S.; Zeb, A.; Nadeem, H.; Alamro, A.; Alghamdi, A.A.; Alvi, A.M.; Naeem, K.; Khalid, M.S. Contribution of attenuation of TNF-α and NF-κB in the anti-epileptic, anti-apoptotic and neuroprotective potential of Rosa webbiana fruit and its Chitosan encapsulation. Molecules,  2021, 26(8), 2347.
 [http://dx.doi.org/10.3390/molecules26082347] [PMID: 33920713]

[106]
Warholm, O.; Skaar, S.; Hedman, E.; Mølmen, H.M.; Eik, L. The effects of a standardized herbal remedy made from a subtype of Rosa canina in patients with osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial. Curr. Ther. Res. Clin. Exp.,  2003, 64(1), 21-31.
 [http://dx.doi.org/10.1016/S0011-393X(03)00004-3] [PMID: 24944354]

[107]
Winther, K.; Apel, K.; Thamsborg, G. A powder made from seeds and shells of a rose-hip subspecies ( Rosa canina ) reduces symptoms of knee and hip osteoarthritis: A randomized, double-blind, placebo-controlled clinical trial. Scand. J. Rheumatol.,  2005, 34(4), 302-308.
 [http://dx.doi.org/10.1080/03009740510018624] [PMID: 16195164]

[108]
Rein, E.; Kharazmi, A.; Winther, K. A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis—a double-blind, placebo-controlled, randomised trial. Phytomedicine,  2004, 11(5), 383-391.
 [http://dx.doi.org/10.1016/j.phymed.2004.01.001] [PMID: 15330493]

[109]
Willich, S.N.; Rossnagel, K.; Roll, S.; Wagner, A.; Mune, O.; Erlendson, J.; Kharazmi, A.; Sörensen, H.; Winther, K. Rose hip herbal remedy in patients with rheumatoid arthritis – a randomised controlled trial. Phytomedicine,  2010, 17(2), 87-93.
 [http://dx.doi.org/10.1016/j.phymed.2009.09.003] [PMID: 19818588]

[110]
Kirkeskov, B.; Christensen, R.; Bügel, S.; Bliddal, H.; Danneskiold-Samsøe, B.; Christensen, L.P.; Andersen, J.R. The effects of rose hip (Rosa canina) on plasma antioxidative activity and C-reactive protein in patients with rheumatoid arthritis and normal controls: A prospective cohort study. Phytomedicine,  2011, 18(11), 953-958.
 [http://dx.doi.org/10.1016/j.phymed.2011.02.008] [PMID: 21420288]

[111]
Schwager, J.; Hoeller, U.; Wolfram, S.; Richard, N. Rose hip and its constituent galactolipids confer cartilage protection by modulating cytokine, and chemokine expression. BMC Complement. Altern. Med.,  2011, 11(1), 105.
 [http://dx.doi.org/10.1186/1472-6882-11-105] [PMID: 22051322]

[112]
Saaby, L.; Jäger, A.K.; Moesby, L.; Hansen, E.W.; Christensen, S.B. Isolation of immunomodulatory triterpene acids from a standardized rose hip powder ( Rosa canina L.). Phytother. Res.,  2011, 25(2), 195-201.
 [http://dx.doi.org/10.1002/ptr.3241] [PMID: 20632303]

[113]
Petcharat, A.; Wongsuphasawat, K. The efficacy of a standardized Rose-hip powder containing seeds and shells compared with glucosamine sulfate in patients with osteoarthritis of the knee - a blinded, parallel, randomized study. Osteoarthritis Cartilage,  2013, 21, S216.
 [http://dx.doi.org/10.1016/j.joca.2013.02.446]

[114]
Wu, J.; Liu, X.; Chan, C.; Mok, D.K.W.; Chan, S.; Yu, Z.; Chen, S. Petroleum ether extractive of the hips of Rosa multiflora ameliorates collagen-induced arthritis in rats. J. Ethnopharmacol.,  2014, 157, 45-54.
 [http://dx.doi.org/10.1016/j.jep.2014.09.026] [PMID: 25256690]

[115]
Nanda, S.; Das, P.K. Medicinal Efficacy of Rose Plant: A Mini Review. PharmaTutor,  2015, 3(10), 23-26.

[116]
Rose Tea: Is It Good for You?  Available from: https://www.webmd.com/diet/rose-tea-good-for-you (Accessed: Feb 22, 2024).

[117]
Ahmad, E.; Jahangir, M.; Akhtar, Z.M.; Ishtiaq, S.; Mukhtar, H.; Haider, H.M.F.; Bukhari, N.I. Rosa brunonii Lindely fruit as a new protective agent evaluated against Rif/INH induced toxicity in rats. Pak. J. Pharm. Sci.,  2020, 33(2(Supplementary)), 805-814.
 [PMID: 32863255]

[118]
Ninomiya, K.; Matsuda, H.; Kubo, M.; Morikawa, T.; Nishida, N.; Yoshikawa, M. Potent anti-obese principle from Rosa canina: Structural requirements and mode of action of trans-tiliroside. Bioorg. Med. Chem. Lett.,  2007, 17(11), 3059-3064.
 [http://dx.doi.org/10.1016/j.bmcl.2007.03.051] [PMID: 17400451]

[119]
Fetni, S.; Bertella, N.; Ouahab, A. LC–DAD/ESI–MS/MS characterization of phenolic constituents in Rosa canina L. and its protective effect in cells. Biomed. Chromatogr.,  2020, 34(12), e4961.
 [http://dx.doi.org/10.1002/bmc.4961] [PMID: 32737906]

[120]
Khojasteh, S.; Basirat, E.; Sheikhzadeh, F.; Ozy, S.; Dehghan, G.; Hatami, H.; Farsad, N. Effects of the ethanolic extract of Rosa canina on some serum biochemical factors in diabetic adult male rats. Trakia J. Sci. Ser. Biomed. Sci.,  2015, 13(2), 143-148.
 [http://dx.doi.org/10.15547/tjs.2015.02.006]

[121]
Dunnick, J.; Hailey, J.R. Toxicity and carcinogenicity studies of quercetin, a natural component of foods. Fundam. Appl. Toxicol.,  1992, 19(3), 423-431.
 [http://dx.doi.org/10.1016/0272-0590(92)90181-G] [PMID: 1459373]

[122]
Cuevas, E.; Limón, D.; Pérez-Severiano, F.; Díaz, A.; Ortega, L.; Zenteno, E.; Guevara, J. Antioxidant effects of Epicatechin on the hippocampal toxicity caused by Amyloid-beta 25-35 in rats. Eur. J. Pharmacol.,  2009, 616(1-3), 122-127.
 [http://dx.doi.org/10.1016/j.ejphar.2009.06.013] [PMID: 19540227]

[123]
Zhang, S.; Zheng, L.; Xu, L.; Sun, H.; Li, H.; Yao, J.; Liu, K.; Peng, J. Subchronic toxicity study of the total flavonoids from Rosa laevigata Michx fruit in rats. Regul. Toxicol. Pharmacol.,  2012, 62(2), 221-230.
 [http://dx.doi.org/10.1016/j.yrtph.2011.12.009] [PMID: 22226919]

[124]
Fasinu, P.S.; Bouic, P.J.; Rosenkranz, B.; Rosenkranz, B. An overview of the evidence and mechanisms of herb-drug interactions. Front. Pharmacol.,  2012, 3, 69.
 [http://dx.doi.org/10.3389/fphar.2012.00069] [PMID: 22557968]

[125]
Surana, A.R.; Agrawal, S.P.; Kumbhare, M.R.; Gaikwad, S.B. Current perspectives in herbal and conventional drug interactions based on clinical manifestations. Fut. J. Pharm. Sci.,  2021, 7(1), 103.
 [http://dx.doi.org/10.1186/s43094-021-00256-w]

[126]
Obika, P.; Beamon, J.; Ali, S.; Kakar, N.; Analla, A.; Moudden, R.; Shihadeh, L.; Patel, S.; Hudson, B.; Khan, F.; Weening, M.P.; Basist, P.; Ahmad, S.; Shahid, M. Herbal medicines for the treatment of metabolic syndrome. Herb. Med.,  2022, 139-191.
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DOI https://dx.doi.org/10.2174/0115680266274385231023075011	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294
Current Topics in Medicinal Chemistry

A Comprehensive Review on Phytochemistry and Pharmacology of Rosa Species (Rosaceae)

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