Using Electrospray Ionisation Mass Spectrometry to Study Non-Covalent Interactions

Title: Using Electrospray Ionisation Mass Spectrometry to Study Non-Covalent Interactions

Volume: 12 Issue: 2

Author(s): Bryan J. McCullough and Simon J. Gaskell

Affiliation:

Keywords: Mass Spectrometry, Electrospray Ionisation, Non-Covalent Interactions, ESI mass spectrum, PROTEIN-LIGAND INTERACTIONS

Abstract: The key strengths of electrospray over any other ionisation techniques are its soft nature and its ability to produce multiply charged ions. This combination is ideal for the study of non-covalent interactions. In this review article, we cover the basics of studying non-covalent interactions by mass spectrometry - illustrated with examples from our own and other labs - and discuss the current mass spectrometry based methods used for understanding and characterising noncovalent protein complexes.

Cite this article as:

McCullough J. Bryan and Gaskell J. Simon, Using Electrospray Ionisation Mass Spectrometry to Study Non-Covalent Interactions, Combinatorial Chemistry & High Throughput Screening 2009; 12 (2) . https://dx.doi.org/10.2174/138620709787315463

DOI https://dx.doi.org/10.2174/138620709787315463	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402