Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics

Title: Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics

Volume: 12 Issue: 2

Author(s): Jessica Z. Bereszczak and Francesco L. Brancia

Affiliation:

Keywords: Liquid Chromatography, Mass Spectrometry, proteomics, MALDI, electrospray ionisation

Abstract: Hyphenation with liquid chromatography has become indispensable in mass spectrometry-based proteomics. Sample complexity together with the large variations in dynamic range can be only tackled using techniques that isolate and/or concentrate individual components prior to mass spectrometric analysis. In this review the most recent developments in micro/nanoliquid chromatography interfaced with MALDI and electrospray ionisation are discussed. Particular attention is focused on all applications related to quantitative proteomics.

Cite this article as:

Bereszczak Z. Jessica and Brancia L. Francesco, Offline and Online Liquid Chromatography Mass Spectrometry in Quantitative Proteomics, Combinatorial Chemistry & High Throughput Screening 2009; 12 (2) . https://dx.doi.org/10.2174/138620709787315418

DOI https://dx.doi.org/10.2174/138620709787315418	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402