Abstract
A variety of biomolecules known as enzymes are found in honey and originated from bees and plant nectars. The plant yields nectar that aids bees in producing honey. Diastases, invertases, glucosidases, glucose oxidases and proteases are the common enzymes present in honey and highly sensitive toward UV-vis light, heat, and microwave energy. Among all enzymes, invertase and diastase have been used for assessing the freshness of honey. The enzyme's capacity to transform amylose into glucose enhances the sweetness and flavor of honey. The role of enzymatic reactions in two types of honey, based upon bee sting morphology, namely honey from honey bees (HB) and stingless bees (SB) are discussed in this review. Enzymes that act as the main ingredient in honey production are comprehensively discussed for their significance in producing good quality and therapeutic properties of honey.
Graphical Abstract
[http://dx.doi.org/10.1080/87559129.2020.1810701]
[http://dx.doi.org/10.1080/00218839.2020.1738135]
[http://dx.doi.org/10.1016/j.wndm.2018.09.005]
[http://dx.doi.org/10.1159/000458416] [PMID: 28291965]
[http://dx.doi.org/10.3390/antibiotics10050551] [PMID: 34065141]
[http://dx.doi.org/10.3390/insects13030308] [PMID: 35323606]
[http://dx.doi.org/10.1002/iub.578] [PMID: 22095907]
[http://dx.doi.org/10.1186/0717-6287-48-4] [PMID: 25654191]
[http://dx.doi.org/10.1002/jev2.12069] [PMID: 33613874]
[http://dx.doi.org/10.1002/ptr.7066] [PMID: 33751689]
[http://dx.doi.org/10.1007/s13592-015-0400-z]
[http://dx.doi.org/10.12980/APJTB.4.2014APJTB-2013-0039] [PMID: 25183275]
[http://dx.doi.org/10.1007/s42250-020-00203-x]
[http://dx.doi.org/10.1016/S2221-1691(11)60016-6] [PMID: 23569748]
[http://dx.doi.org/10.1016/j.jprot.2012.04.029] [PMID: 22571915]
[http://dx.doi.org/10.1186/s12906-020-03170-5] [PMID: 33441127]
[http://dx.doi.org/10.1051/apido:2006034]
[http://dx.doi.org/10.3329/pa.v30i1.42219]
[http://dx.doi.org/10.13057/biodiv/d211021]
[http://dx.doi.org/10.1051/apido:2004047]
[http://dx.doi.org/10.1016/j.foodchem.2009.07.057]
[http://dx.doi.org/10.3390/antiox10111700] [PMID: 34829570]
[http://dx.doi.org/10.3390/foods9111538] [PMID: 33114468]
[http://dx.doi.org/10.2754/avb201483S10S85]
[http://dx.doi.org/10.18689/mjft-1000124]
[http://dx.doi.org/10.3390/antibiotics8040251] [PMID: 31817375]
[http://dx.doi.org/10.17576/jsm-2020-4908-08]
[http://dx.doi.org/10.1007/s13592-021-00895-1]
[http://dx.doi.org/10.1146/annurev-ento-040320-074933] [PMID: 32806934]
[http://dx.doi.org/10.31436/imjm.v17i1.1030]
[http://dx.doi.org/10.3389/finsc.2022.829869]
[http://dx.doi.org/10.3896/IBRA.1.53.3.03]
[http://dx.doi.org/10.1371/journal.pone.0156584] [PMID: 27272274]
[http://dx.doi.org/10.3390/molecules26123770] [PMID: 34205731]
[PMID: 28013383]
[http://dx.doi.org/10.1016/j.lwt.2022.114183]
[http://dx.doi.org/10.1007/s13197-018-3341-5] [PMID: 30228384]
[http://dx.doi.org/10.1080/10942910600981708]
[http://dx.doi.org/10.1080/01140671.2010.520164]
[http://dx.doi.org/10.3896/IBRA.1.49.3.09]
[http://dx.doi.org/10.1080/00218839.2017.1357940]
[http://dx.doi.org/10.1016/S0308-8146(00)00162-X]
[http://dx.doi.org/10.11113/jt.v81.13105]
[http://dx.doi.org/10.1016/j.jksus.2021.101608]
[http://dx.doi.org/10.3390/foods10050997] [PMID: 34063246]
[http://dx.doi.org/10.1080/0005772X.1999.11099429]
[http://dx.doi.org/10.3390/vetsci7040168] [PMID: 33142815]
[http://dx.doi.org/10.1080/00218839.2020.1714193]
[http://dx.doi.org/10.1021/ed084p1643]
[http://dx.doi.org/10.3390/molecules25215017] [PMID: 33138197]
[http://dx.doi.org/10.1016/j.sjbs.2020.10.017] [PMID: 33911935]
[http://dx.doi.org/10.1111/j.1600-0625.2009.00994.x] [PMID: 19845754]
[http://dx.doi.org/10.1186/s13104-017-2884-2] [PMID: 29110688]
[http://dx.doi.org/10.1016/j.foodchem.2015.09.051] [PMID: 26593496]
[http://dx.doi.org/10.1016/j.fct.2018.08.001] [PMID: 30077706]
[http://dx.doi.org/10.1016/j.foodres.2019.108756] [PMID: 32036884]
[http://dx.doi.org/10.1016/j.tca.2003.06.005]
[http://dx.doi.org/10.31782/IJCRR.2021.SP131]
[http://dx.doi.org/10.9734/ACSJ/2015/17547]
[http://dx.doi.org/10.1111/1462-2920.12526] [PMID: 24905222]
[http://dx.doi.org/10.3390/foods10112882] [PMID: 34829164]
[http://dx.doi.org/10.19045/bspab.2019.80109]
[http://dx.doi.org/10.1016/j.jinsphys.2010.03.007] [PMID: 20230830]
[http://dx.doi.org/10.1007/s13592-020-00802-0]
[http://dx.doi.org/10.1080/10942912.2019.1590398]
[http://dx.doi.org/10.1007/s13197-015-1760-0] [PMID: 26396418]
[http://dx.doi.org/10.1111/jfpe.13221]
[http://dx.doi.org/10.1111/jfpp.15328]
[http://dx.doi.org/10.1080/07373937.2022.2065297]
[http://dx.doi.org/10.1051/apido:2001001]
[http://dx.doi.org/10.1016/j.ifset.2021.102709]
[http://dx.doi.org/10.1080/00218839.1995.11100884]
[http://dx.doi.org/10.1080/00218839.2021.1948745]
[PMID: 16475106]
[http://dx.doi.org/10.1515/jas-2015-0001]
[http://dx.doi.org/10.1051/apido:19990107]
[http://dx.doi.org/10.3390/molecules24071244] [PMID: 30934979]
[http://dx.doi.org/10.1016/j.jksus.2022.102301]
[http://dx.doi.org/10.51248/.v41i4.1013]
[http://dx.doi.org/10.13102/sociobiology.v59i1.671]
[http://dx.doi.org/10.21608/eajbsa.2012.14827]
[http://dx.doi.org/10.1007/BF00313521]
[http://dx.doi.org/10.1038/srep21641] [PMID: 26869239]
[http://dx.doi.org/10.1016/j.bcab.2020.101599]
[http://dx.doi.org/10.1016/j.procbio.2015.04.015]
[http://dx.doi.org/10.1016/j.lwt.2021.111715]
[http://dx.doi.org/10.3390/biom12030472] [PMID: 35327664]
[http://dx.doi.org/10.1186/s13068-018-1152-6] [PMID: 29881456]
[http://dx.doi.org/10.1021/jf071062c] [PMID: 17661489]
[http://dx.doi.org/10.1080/00218839.1966.11100150]
[http://dx.doi.org/10.1080/00218839.1966.11100130]
[http://dx.doi.org/10.1080/00218839.2008.11101426]
[http://dx.doi.org/10.1016/j.bmcl.2008.03.012] [PMID: 18353640]
[PMID: 19322334]
[http://dx.doi.org/10.1083/jcb.21.2.191] [PMID: 14153481]
[http://dx.doi.org/10.1002/arch.21253] [PMID: 26314562]
[http://dx.doi.org/10.1016/j.foodres.2008.07.014]
[http://dx.doi.org/10.3390/foods11030357] [PMID: 35159507]
[http://dx.doi.org/10.3390/insects10090282] [PMID: 31480801]
[http://dx.doi.org/10.1080/0005772X.1994.11099213]
[http://dx.doi.org/10.26717/BJSTR.2020.24.004105]
[http://dx.doi.org/10.1155/2020/5398062]
[http://dx.doi.org/10.3390/molecules27154719] [PMID: 35897895]
[http://dx.doi.org/10.17306/J.AFS.2014.2.6] [PMID: 24876312]
[http://dx.doi.org/10.1111/j.1365-2621.2005.tb11439.x]
[http://dx.doi.org/10.1515/ijfe-2016-0320]
[http://dx.doi.org/10.1007/s40995-020-00936-x]
[http://dx.doi.org/10.1016/j.talanta.2012.01.063] [PMID: 22483889]
[http://dx.doi.org/10.3390/app12073661]
[http://dx.doi.org/10.1007/s00216-006-0367-8] [PMID: 16532307]
[http://dx.doi.org/10.5772/66839]
[http://dx.doi.org/10.1501/Vetfak_0000002811]
[http://dx.doi.org/10.1080/10942912.2019.1576730]
[http://dx.doi.org/10.1111/jfpe.12410]
[http://dx.doi.org/10.22271/phyto.2022.v11.i1d.14352]
[http://dx.doi.org/10.1111/j.1750-3841.2006.00215.x] [PMID: 17995872]
[http://dx.doi.org/10.1016/j.foodchem.2020.128654] [PMID: 33461823]
[http://dx.doi.org/10.1007/s12161-016-0544-0]
[http://dx.doi.org/10.1016/j.jfca.2018.06.002]
[http://dx.doi.org/10.26656/fr.2017.5(3).651]
[http://dx.doi.org/10.1556/AAlim.42.2013.4.9]
[http://dx.doi.org/10.1007/s13197-017-2713-6] [PMID: 28928516]
[http://dx.doi.org/10.1016/j.foodcont.2020.107857]
[http://dx.doi.org/10.1515/pjfns-2015-0022]
[http://dx.doi.org/10.1186/s40850-021-00103-8] [PMID: 37170318]
[PMID: 29881428]
[http://dx.doi.org/10.1016/j.foodchem.2018.04.104] [PMID: 29751904]
[http://dx.doi.org/10.1016/j.foodchem.2015.06.089] [PMID: 26304332]
[http://dx.doi.org/10.1007/s11694-021-00937-3]
[http://dx.doi.org/10.22271/j.ento.2022.v10.i1d.8950]
[http://dx.doi.org/10.1093/jisesa/iev065] [PMID: 26113511]
[http://dx.doi.org/10.1080/00218839.1986.11100713]
[http://dx.doi.org/10.1016/j.jinsphys.2018.11.007] [PMID: 30472007]
[http://dx.doi.org/10.1073/pnas.1916224116] [PMID: 31776248]
[http://dx.doi.org/10.1002/arch.21406] [PMID: 28833462]
[http://dx.doi.org/10.1007/s12033-015-9892-z] [PMID: 26385478]
[http://dx.doi.org/10.1016/j.cois.2018.02.012] [PMID: 29764668]
[http://dx.doi.org/10.3390/cells10030701] [PMID: 33809924]
[http://dx.doi.org/10.1016/j.foodchem.2020.128899] [PMID: 33401089]
[http://dx.doi.org/10.1016/j.enzmictec.2006.10.011]
[http://dx.doi.org/10.1016/S0965-1748(01)00147-3] [PMID: 12020842]
[http://dx.doi.org/10.3390/antibiotics11020203] [PMID: 35203806]
[http://dx.doi.org/10.12691/jfnr-6-10-5]
[http://dx.doi.org/10.3389/fmicb.2011.00213] [PMID: 22046173]
[http://dx.doi.org/10.12944/CRNFSJ.7.1.15]
[http://dx.doi.org/10.5897/JABSD2017.0292]
[http://dx.doi.org/10.1371/journal.pone.0086923] [PMID: 24489805]
[http://dx.doi.org/10.1111/phen.12213]
[http://dx.doi.org/10.1074/jbc.R800035200] [PMID: 18650443]
[http://dx.doi.org/10.1371/journal.pone.0049164] [PMID: 23145107]
[http://dx.doi.org/10.1111/1541-4337.12326] [PMID: 33350076]
[http://dx.doi.org/10.1186/s43014-021-00052-2]
[http://dx.doi.org/10.1021/jf101583s] [PMID: 20681666]
[http://dx.doi.org/10.1007/s00216-012-6630-2] [PMID: 23292042]
[http://dx.doi.org/10.1271/bbb.100778] [PMID: 21389615]
[http://dx.doi.org/10.1021/acs.jafc.9b05190] [PMID: 31618580]
[http://dx.doi.org/10.1007/s11274-021-03036-z] [PMID: 33730214]
[http://dx.doi.org/10.1016/j.bbapap.2019.140345]
[http://dx.doi.org/10.1016/0022-1910(96)00045-5]
[http://dx.doi.org/10.1111/j.1365-2583.2006.00684.x] [PMID: 17069636]
[http://dx.doi.org/10.1007/s13592-014-0313-2]
[http://dx.doi.org/10.1016/j.foodchem.2021.130931] [PMID: 34509939]
[http://dx.doi.org/10.1016/j.toxrep.2020.04.002] [PMID: 32455119]
[http://dx.doi.org/10.1080/00032719.2014.952374]
[http://dx.doi.org/10.1016/j.foodchem.2008.08.082]
[http://dx.doi.org/10.1186/gb-2008-9-10-r156] [PMID: 18959778]
[http://dx.doi.org/10.1016/j.jinsphys.2014.10.002] [PMID: 25450567]
[http://dx.doi.org/10.1016/j.cbpc.2020.108844] [PMID: 32777468]
[http://dx.doi.org/10.1016/j.lwt.2017.12.072]
[http://dx.doi.org/10.1080/10942912.2014.962656]
[http://dx.doi.org/10.9775/kvfd.2016.16373]
[http://dx.doi.org/10.1021/acs.jafc.5b01410] [PMID: 26151590]
[http://dx.doi.org/10.1038/s41598-020-73306-7] [PMID: 33004933]
[http://dx.doi.org/10.1016/j.foodchem.2016.09.001] [PMID: 27664687]
[http://dx.doi.org/10.24263/2304-974X-2016-5-3-3]
[http://dx.doi.org/10.1111/jfpp.15438]
[http://dx.doi.org/10.1016/j.jfca.2019.04.001]
[http://dx.doi.org/10.1021/jf034777y] [PMID: 15080614]
[http://dx.doi.org/10.1021/jf100758x] [PMID: 20491475]