Cladribine Efficacy in a Patient with Hairy Cell Leukemia and Severe Renal Insufficiency

Title:Cladribine Efficacy in a Patient with Hairy Cell Leukemia and Severe Renal Insufficiency

Volume: 18 Issue: 4

Author(s): Alessandro Gozzetti*, Francesca Bacchiarri, Donatella Raspadori, Anna Sicuranza, Vincenzo Sammartano and Monica Bocchia

Affiliation:

• Hematology, University of Siena, Policlinico “Santa Maria alle Scotte”, Siena, Italy;

Abstract:

Background: Hairy cell leukemia commonly presents with pancytopenia, indolent course, and predisposition as infectious complications. Current first-line therapeutic options are purine analogues, particularly cladribine, with a high percentage of complete responses and durable remissions. However, their use is poorly investigated in patients affected by severe chronic renal insufficiency.

Case Presentation: Here, we describe a case of HCL in a 68-year-old man affected by multiple comorbidities, including severe chronic renal failure. After a course of interferon-α, the patient received therapy with Cladribine every other week, obtaining a complete hematological remission and improvement of renal function.

Discussion: With a different soft schedule of cladribine, the patient was treated adequately, obtaining a complete remission.

Conclusion: Cladribine can be administered with caution, even in patients with renal failure, with good results.

Cite this article as:

Gozzetti Alessandro*, Bacchiarri Francesca, Raspadori Donatella, Sicuranza Anna, Sammartano Vincenzo and Bocchia Monica, Cladribine Efficacy in a Patient with Hairy Cell Leukemia and Severe Renal Insufficiency, Reviews on Recent Clinical Trials 2023; 18 (4) . https://dx.doi.org/10.2174/0115748871241817230919062313

DOI https://dx.doi.org/10.2174/0115748871241817230919062313	Print ISSN 1574-8871
Publisher Name Bentham Science Publisher	Online ISSN 1876-1038