The Potential Therapeutic Applications of CRISPR/Cas9 in Colorectal Cancer

Title:The Potential Therapeutic Applications of CRISPR/Cas9 in Colorectal Cancer

Volume: 31 Issue: 35

Author(s): Toktam Sahranavard, Shima Mehrabadi, Ghazaleh Pourali, Mina Maftooh, Hamed Akbarzade, Seyed Mahdi Hassanian, Majid Ghayour Mobarhan, Gordon A. Ferns, Majid Khazaei and Amir Avan*

Affiliation:

• Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
• School of Mechanical, Medical and Process Engineering, Science and Engineering Faculty, Queensland University of Technology, 2 George St, Brisbane City QLD 4000, Australia
• Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia

Abstract: The application of the CRISPR-associated nuclease 9 (Cas9) system in tumor studies has led to the discovery of several new treatment strategies for colorectal cancer (CRC), including the recognition of novel target genes, the construction of animal mass models, and the identification of genes related to chemotherapy resistance. CRISPR/Cas9 can be applied to genome therapy for CRC, particularly regarding molecular-targeted medicines and suppressors. This review summarizes some aspects of using CRISPR/- Cas9 in treating CRC. Further in-depth and systematic research is required to fully realize the potential of CRISPR/Cas9 in CRC treatment and integrate it into clinical practice.

Cite this article as:

Sahranavard Toktam, Mehrabadi Shima, Pourali Ghazaleh, Maftooh Mina, Akbarzade Hamed, Hassanian Mahdi Seyed, Mobarhan Ghayour Majid, Ferns A. Gordon, Khazaei Majid and Avan Amir*, The Potential Therapeutic Applications of CRISPR/Cas9 in Colorectal Cancer, Current Medicinal Chemistry 2024; 31 (35) . https://dx.doi.org/10.2174/0929867331666230915103707