Login Register Cart 0
Generic placeholder image

Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

An Update on Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria

Author(s): Andrea Miniello*, Rossella Casella, Teresa Loverre, Dario Aloia, Danilo Di Bona and Eustachio Nettis

Volume 24, Issue 8, 2024

Published on: 07 September, 2023

Page: [885 - 895] Pages: 11

DOI: 10.2174/1871530323666230907112453

Price: $65

Abstract

Background: Hypersensitivity reactions to non-steroidal anti-inflammatory drugs (HR-NSAIDs) are common adverse events related to the widespread use of over-the-counter NSAIDs for the treatment of a variety of inflammatory conditions. Urticaria is the most commonly reported immediate cutaneous clinical sign of HR-NSAIDs, but it can be a manifestation of pathophysiologically different clinical entities that require different therapeutic strategies. The aim of this study is to ease the identification of the correct phenotype of HR-NSAIDs in patients reporting urticaria associated with the intake of NSAIDs and provide updated information about their diagnosis and management.

Methods: The study is a narrative review conducted by collecting the most relevant and up-todate data related to the classification, pathophysiology, severity, and prognosis of NSAID hypersensitivity reactions. PubMed and Embase scientific databases were used as search engines to select relevant articles.

Results: Patients developing HR-NSAIDs can be divided into two categories: selective responders (SR), who develop reactions after the administration of a single specific NSAID due to an underlying IgE or T-cell mediated hypersensitivity mechanism, or cross-intolerant (CI), who develop reactions to more than one chemically unrelated NSAIDs due to abnormalities in the biochemical pathways related with prostaglandin metabolism, independently from an underlying immunological mechanism. Five major different categories of HR-NSAIDs have been identified: NSAIDs-exacerbated cutaneous disease (NECD), NSAIDs-induced urticaria/angioedema with/without respiratory and systemic symptoms of anaphylaxis (NIUAA), and NSAIDsexacerbated respiratory disease (NERD), which are developed by CI patients, and single NSAIDs-induced urticaria, angioedema and/ or anaphylaxis (SNIUAA) and single NSAIDsinduced delayed hypersensitivity reactions (SNIDHR), which are developed by CI patients. In vivo and in vitro diagnostic tests have rarely been shown to be reliable in all these entities and therefore are not routinely used in clinical practice. The management in SR patients consists of strict avoidance of the culprit drug, while for cross-intolerance reactions oral tolerance tests with safe alternative drugs (e.g. weak COX-1 inhibitors or selective COX-2 inhibitors) can be performed.

Conclusion: HR-NSAIDs are being observed with increasing frequency, however, the pathogenesis behind some NSAIDS-associated clinical entities is still unclear. Diagnosis is mostly based on a thorough clinical history and confirmed by a drug challenge test. Clinical management is based on strict avoidance and use of alternative tolerated medications. Overall, all therapeutic decisions depend on the correct identification of the type of reaction the patient experienced.

« Previous Next »
Graphical Abstract

[1]
Doña, I.; Blanca-López, N.; Torres, M.J.; García-Campos, J.; García-Núñez, I.; Gómez, F.; Salas, M.; Rondón, C.; Canto, M.G.; Blanca, M. Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients. J. Investig. Allergol. Clin. Immunol., 2012, 22(5), 363-371.
[PMID: 23101312]
[2]
Blanca-López, N.; Pérez-Alzate, D.; Canto, G.; Blanca, M. Practical approach to the treatment of NSAID hypersensitivity. Expert Rev. Clin. Immunol., 2017, 13(11), 1017-1027.
[http://dx.doi.org/10.1080/1744666X.2017.1377072] [PMID: 28893093]
[3]
Alves, C.; Romeira, A.M.; Abreu, C.; Carreiro-Martins, P.; Gomes, E.; Leiria-Pinto, P. Non-steroidal anti-inflammatory drug hypersensitivity in children. Allergol. Immunopathol., 2017, 45(1), 40-47.
[http://dx.doi.org/10.1016/j.aller.2016.04.004] [PMID: 27475775]
[4]
Fosbøl, E.L.; Gislason, G.H.; Jacobsen, S.; Abildstrom, S.Z.; Hansen, M.L.; Schramm, T.K.; Folke, F.; Sørensen, R.; Rasmussen, J.N.; Køber, L.; Madsen, M.; Torp-Pedersen, C. The pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) from 1997 to 2005: A nationwide study on 4.6 million people. Pharmacoepidemiol. Drug Saf., 2008, 17(8), 822-833.
[http://dx.doi.org/10.1002/pds.1592] [PMID: 18383428]
[5]
Duong, M.; Salvo, F.; Pariente, A.; Abouelfath, A.; Lassalle, R.; Droz, C.; Blin, P.; Moore, N. Usage patterns of ‘over-the-counter’ vs. prescription-strength nonsteroidal anti-inflammatory drugs in France. Br. J. Clin. Pharmacol., 2014, 77(5), 887-895.
[http://dx.doi.org/10.1111/bcp.12239] [PMID: 24102791]
[6]
Hassani, A.; Ponvert, C.; Karila, C.; Le Bourgeois, M.; De Blic, J.; Scheinmann, P. Hypersensitivity to cyclooxygenase inhibitory drugs in children: A study of 164 cases. Eur. J. Dermatol., 2008, 18(5), 561-565.
[PMID: 18693161]
[7]
Aberer, W.; Bircher, A.; Romano, A.; Blanca, M.; Campi, P.; Fernandez, J.; Brockow, K.; Pichler, W.J.; Demoly, P. Drug provocation testing in the diagnosis of drug hypersensitivity reactions: General considerations. Allergy., 2003, 58(9), 854-863.
[http://dx.doi.org/10.1034/j.1398-9995.2003.00279.x] [PMID: 12911412]
[8]
Kowalski, M.L.; Asero, R.; Bavbek, S.; Blanca, M.; Blanca-Lopez, N.; Bochenek, G.; Brockow, K.; Campo, P.; Celik, G.; Cernadas, J.; Cortellini, G.; Gomes, E.; Niżankowska-Mogilnicka, E.; Romano, A.; Szczeklik, A.; Testi, S.; Torres, M.J.; Wöhrl, S.; Makowska, J. Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy., 2013, 68(10), 1219-1232.
[http://dx.doi.org/10.1111/all.12260] [PMID: 24117484]
[9]
Nettis, E.; Marcandrea, M.; Maggio, G.D.; Ferrannini, A.; Tursi, A. Retrospective analysis of drug-induced urticaria and angioedema: A survey of 2287 patients. Immunopharmacol. Immunotoxicol., 2001, 23(4), 585-595.
[http://dx.doi.org/10.1081/IPH-100108604] [PMID: 11792017]
[10]
Ali, S.; Udrea, R.; Boustani, R.; Puiu, I.A.; Corcea, S.L.; Spiru, L. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: Does age matter? Arch. Clin. Cases., 2022, 9(2), 80-88.
[http://dx.doi.org/10.22551/2022.35.0902.10208] [PMID: 35813497]
[11]
Yuenyongviwat, A.; Chantaravisarut, N.; Phattarapongdilok, W.; Koosakulchai, V.; Jessadapakorn, W.; Sangsupawanich, P. Characteristics and contributing factors related to nonsteroidal anti-inflammatory drugs hypersensitivity. Int. Arch. Allergy Immunol., 2021, 182(2), 139-145.
[http://dx.doi.org/10.1159/000510364] [PMID: 32950992]
[12]
Hennino, A.; Bérard, F.; Guillot, I.; Saad, N.; Rozières, A.; Nicolas, J.F. Pathophysiology of urticaria. Clin. Rev. Allergy Immunol., 2006, 30(1), 3-11.
[http://dx.doi.org/10.1385/CRIAI:30:1:003] [PMID: 16461989]
[13]
Asero, R. Single NSAID hypersensitivity is associated with atopic status. Eur. Ann. Allergy Clin. Immunol., 2015, 47(2), 48-53.
[PMID: 25781194]
[14]
Sanchez-Borges, M.; Capriles-Hulett, A. Atopy is a risk factor for non-steroidal anti-inflammatory drug sensitivity. Ann. Allergy Asthma Immunol., 2000, 84, 101e6.
[http://dx.doi.org/10.1016/S1081-1206(10)62748-2]
[15]
Zambonino, M.A.; Torres, M.J.; Muñoz, C.; Requena, G.; Mayorga, C.; Posadas, T.; Urda, A.; Blanca, M.; Corzo, J.L. Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children. Pediatr. Allergy Immunol., 2013, 24(2), 151-159.
[http://dx.doi.org/10.1111/pai.12039] [PMID: 23506290]
[16]
Hedman, J.; Kaprio, J.; Poussa, T.; Nieminen, M.M. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int. J. Epidemiol., 1999, 28, 717e22.
[http://dx.doi.org/10.1093/ije/28.4.717]
[17]
Settipane, R.A.; Constantine, H.P.; Settipane, G.A. Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review. Allergy, 1980, 35, 149e54.
[http://dx.doi.org/10.1111/j.1398-9995.1980.tb01730.x]
[18]
Jenkins, C.; Costello, J.; Hodge, L. Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice. BMJ, 2004, 328(7437), 434.
[http://dx.doi.org/10.1136/bmj.328.7437.434] [PMID: 14976098]
[19]
Doña, I.; Blanca-López, N.; Cornejo-García, J.A.; Torres, M.J.; Laguna, J.J.; Fernández, J.; Rosado, A.; Rondón, C.; Campo, P.; Agúndez, J.A.; Blanca, M.; Canto, G. Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: Patterns of response. Clin. Exp. Allergy, 2011, 41(1), 86-95.
[http://dx.doi.org/10.1111/j.1365-2222.2010.03651.x] [PMID: 21155908]
[20]
Steinke, J.W.; Negri, J.; Liu, L.; Payne, S.C.; Borish, L. Aspirin activation of eosinophils and mast cells: Implications in the pathogenesis of aspirin-exacerbated respiratory disease. J. Immunol., 2014, 193(1), 41-47.
[http://dx.doi.org/10.4049/jimmunol.1301753] [PMID: 24890720]
[21]
Blanca-López, N.; Soriano, V.; Garcia-Martin, E.; Canto, G.; Blanca, M. NSAID-induced reactions: Classification, prevalence, impact, and management strategies. J. Asthma Allergy, 2019, 12, 217-233.
[http://dx.doi.org/10.2147/JAA.S164806] [PMID: 31496752]
[22]
Szczeklik, A.; Nizankowska-Mogilnicka, E.; Sanak, M. Hypersensitivity to aspirin and non-steroidal antiinflammatory drugs. In: Middleton’s allergy princi-ples and practice; , 2009; pp. 1227-1243.
[23]
Blanca-López, N.; Doña, I.; Perkins, J.R.; Canto, G.; Cornejo-García, J.A.; Blanca, M. Multiple nonsteroidal anti-inflammatory drug-induced cutaneous disease: Relevance, natural evolution and relationship with atopy. Int. Arch. Allergy Immunol., 2014, 164(2), 147-148.
[http://dx.doi.org/10.1159/000363503] [PMID: 25012690]
[24]
Canto, M.G.; Andreu, I.; Fernandez, J.; Blanca, M. Selective immediate hypersensitivity reactions to NSAIDs. Curr. Opin. Allergy Clin. Immunol., 2009, 9(4), 293-297.
[http://dx.doi.org/10.1097/ACI.0b013e32832db943] [PMID: 19561490]
[25]
Plaza-Serón, M.D.C.; García-Martín, E.; Agúndez, J.A.; Ayuso, P. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: An update on pharmacogenetics studies. Pharmacogenomics., 2018, 19(13), 1069-1086.
[http://dx.doi.org/10.2217/pgs-2018-0079] [PMID: 30081739]
[26]
Blanca-Lopez, N.; Somoza-Alvarez, M.L.; Bellon, T.; Amo, G.; Canto, G.; Blanca, M. NSAIDs hypersensitivity: Questions not resolved. Curr. Opin. Allergy Clin. Immunol., 2018, 18(4), 291-301.
[http://dx.doi.org/10.1097/ACI.0000000000000454] [PMID: 29878898]
[27]
Posadas, S.J.; Leyva, L.; Torres, M.J.; Rodriguez, J.L.; Bravo, I.; Rosal, M.; Fernandez, J.; Juarez, C.; Blanca, M. Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction. J. Allergy Clin. Immunol., 2000, 106(4), 769-776.
[http://dx.doi.org/10.1067/mai.2000.109828] [PMID: 11031349]
[28]
Blanca, M.; Posadas, S.; Torres, M.J.; Leyva, L.; Mayorga, C.; Gonzalez, L.; Juarez, C.; Fernández, J.; Santamaria, L.F. Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions. Allergy., 2000, 55(11), 998-1004.
[http://dx.doi.org/10.1034/j.1398-9995.2000.00628.x] [PMID: 11097307]
[29]
Bellón, T.; Álvarez, L.; Mayorga, C.; Morel, E.; Torres, M.J.; Martín-Díaz, M.A.; Díaz, R.; Radial, A.; Carballo, M.; Blanca, M. Differential gene expression in drug hypersensitivity reactions: induction of alarmins in severe bullous diseases. Br. J. Dermatol., 2010, 162(5), 1014-1022.
[http://dx.doi.org/10.1111/j.1365-2133.2009.09627.x] [PMID: 20030638]
[30]
Blanca-López, N.; Pérez-Sánchez, N.; Agúndez, J.A.; García-Martin, E.; Torres, M.J.; Cornejo-García, J.A.; Perkins, J.R.; Miranda, M.A.; Andreu, I.; Mayorga, C.; Canto, G.; Blanca, M.; Doña, I. Allergic reactions to metamizole: Immediate and delayed responses. Int. Arch. Allergy Immunol., 2016, 169(4), 223-230.
[http://dx.doi.org/10.1159/000444798] [PMID: 27224978]
[31]
Koransky, R.; Ferastraoaru, D.; Jerschow, E. Single nonsteroidal anti-inflammatory drug induced serum sickness-like reaction to naproxen in a patient able to tolerate both aspirin and ibuprofen. J. Allergy Clin. Immunol. Pract., 2016, 4(1), 160-161.
[http://dx.doi.org/10.1016/j.jaip.2015.07.019] [PMID: 26342741]
[32]
Lee, S.Y.; Nam, Y.H.; Koh, Y.I.; Kim, S.H.; Kim, S.; Kang, H.R.; Kim, M.H.; Lee, J.G.; Park, J.W.; Park, H.K.; La, H.O.; Kim, M.Y.; Park, S.J.; Kwon, Y.E.; Jung, J.W.; Kim, S.H.; Kim, C.W.; Yang, M.S.; Kang, M.G.; Lee, J.Y.; Kim, J.H.; Kim, S.H.; Hur, G.Y.; Jee, Y.K.; Jin, H.J.; Park, C.S.; Jeong, Y.Y.; Ye, Y.M. Phenotypes of severe cutaneous adverse reactions caused by nonsteroidal anti-inflammatory drugs. Allergy Asthma Immunol. Res., 2019, 11(2), 212-221.
[http://dx.doi.org/10.4168/aair.2019.11.2.212] [PMID: 30661313]
[33]
Jurado-Escobar, R.; Doña, I.; Triano-Cornejo, J.; Perkins, J.R.; Pérez-Sánchez, N.; Testera-Montes, A.; Labella, M.; Bartra, J.; Laguna, J.J.; Estravís, M.; Agúndez, J.A.G.; Torres, M.J.; Cornejo-García, J.A. Genetic variants in cytosolic phospholipase A2 associated with nonsteroidal anti-inflammatory drug-induced acute urticaria/angioedema. Front. Pharmacol., 2021, 12, 667824.
[http://dx.doi.org/10.3389/fphar.2021.667824] [PMID: 33995098]
[34]
Szczeklik, A.; Gryglewski, R.J.; Czerniawska-Mysik, G. Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. BMJ, 1975, 1(5949), 67-69.
[http://dx.doi.org/10.1136/bmj.1.5949.67] [PMID: 1109660]
[35]
Haberal, I.; Corey, J.P. The role of leukotrienes in nasal allergy. Otolaryngol. Head Neck Surg., 2003, 129(3), 274-279.
[http://dx.doi.org/10.1016/S0194-5998(03)00601-6] [PMID: 12958580]
[36]
Dahlén, S.E.; Björk, J.; Hedqvist, P.; Arfors, K.E.; Hammarström, S.; Lindgren, J.A.; Samuelsson, B. Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proc. Natl. Acad. Sci., 1981, 78(6), 3887-3891.
[http://dx.doi.org/10.1073/pnas.78.6.3887] [PMID: 6267608]
[37]
Joris, I.; Majno, G.; Corey, E.J.; Lewis, R.A. The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction. Am. J. Pathol., 1987, 126(1), 19-24.
[PMID: 3028143]
[38]
Hay, D.W.P.; Torphy, T.J.; Undem, B.J. Cysteinyl leukotrienes in asthma: Old mediators up to new tricks. Trends Pharmacol. Sci., 1995, 16(9), 304-309.
[http://dx.doi.org/10.1016/S0165-6147(00)89059-8] [PMID: 7482995]
[39]
Sanak, M. Eicosanoid mediators in the airway inflammation of asthmatic patients: What is new? Allergy Asthma Immunol. Res., 2016, 8(6), 481-490.
[http://dx.doi.org/10.4168/aair.2016.8.6.481] [PMID: 27582398]
[40]
Doña, I.; Jurado-Escobar, R.; Perkins, J.R.; Ayuso, P.; Plaza-Serón, M.C.; Pérez-Sánchez, N.; Campo, P.; Bogas-Herrera, G.; Bartra, J.; Torres, M.J.; Sanak, M.; Cornejo-García, J.A. Eicosanoid mediator profiles in different phenotypes of nonsteroidal anti-inflammatory drug-induced urticaria. Allergy, 2019, 74(6), 1135-1144.
[PMID: 30667070]
[41]
Blanca, M.; Perez, E.; Garcia, J.J.; Miranda, A.; Terrados, S.; Vega, J.M.; Suau, R. Angioedema and IgE antibodies to aspirin: A case report. Ann. Allergy, 1989, 62(4), 295-298.
[PMID: 2468301]
[42]
Nettis, E.; Napoli, G.; Ferrannini, A.; Tursi, A. IgE-mediated allergy to bromelain. Allergy, 2001, 56(3), 257-258.
[http://dx.doi.org/10.1034/j.1398-9995.2001.056003257.x] [PMID: 11251415]
[43]
Himly, M.; Jahn-Schmid, B.; Pittertschatscher, K.; Bohle, B.; Grubmayr, K.; Ferreira, F.; Ebner, H.; Ebner, C. IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. J. Allergy Clin. Immunol., 2003, 111(4), 882-888.
[http://dx.doi.org/10.1067/mai.2003.163] [PMID: 12704373]
[44]
Kinaciyan, T.; Riemer, A.; Hemmer, V. Multimeric drug conjugates facilitates diagnosis of immediate type drug allergy. Allergy, 2007, 62, 35.
[45]
Herdeg, C.; Hilt, F.; Büchtemann, A.; Bianchi, L.; Klein, R. Allergic cholestatic hepatitis and exanthema induced by metamizole: Verification by lymphocyte transformation test. Liver, 2002, 22(6), 507-513.
[http://dx.doi.org/10.1034/j.1600-0676.2002.01718.x] [PMID: 12445177]
[46]
Gómez, E.; Blanca-Lopez, N.; Salas, M.; Canto, G.; Campo, P.; Torres, M.J.; Mayorga, C.; Blanca, M. Induction of accelerated reactions to amoxicillin by T-cell effector mechanisms. Ann. Allergy Asthma Immunol., 2013, 110(4), 267-273.
[http://dx.doi.org/10.1016/j.anai.2013.01.003] [PMID: 23535091]
[47]
Sánchez, J.; Sánchez, A.; Cardona, R. Prevalence of drugs as triggers of exacerbations in chronic urticaria. J. Investig. Allergol. Clin. Immunol., 2019, 29(2), 112-117.
[http://dx.doi.org/10.18176/jiaci.0287] [PMID: 29956666]
[48]
Zuberbier, T.; Abdul Latiff, A.H.; Abuzakouk, M.; Aquilina, S.; Asero, R.; Baker, D.; Ballmer-Weber, B.; Bangert, C.; Ben-Shoshan, M.; Bernstein, J.A.; Bindslev-Jensen, C.; Brockow, K.; Brzoza, Z.; Chong Neto, H.J.; Church, M.K.; Criado, P.R.; Danilycheva, I.V.; Dressler, C.; Ensina, L.F.; Fonacier, L.; Gaskins, M.; Gáspár, K.; Gelincik, A.; Giménez-Arnau, A.; Godse, K.; Gonçalo, M.; Grattan, C.; Grosber, M.; Hamelmann, E.; Hébert, J.; Hide, M.; Kaplan, A.; Kapp, A.; Kessel, A.; Kocatürk, E.; Kulthanan, K.; Larenas-Linnemann, D.; Lauerma, A.; Leslie, T.A.; Magerl, M.; Makris, M.; Meshkova, R.Y.; Metz, M.; Micallef, D.; Mortz, C.G.; Nast, A.; Oude-Elberink, H.; Pawankar, R.; Pigatto, P.D.; Ratti Sisa, H.; Rojo Gutiérrez, M.I.; Saini, S.S.; Schmid-Grendelmeier, P.; Sekerel, B.E.; Siebenhaar, F.; Siiskonen, H.; Soria, A.; Staubach-Renz, P.; Stingeni, L.; Sussman, G.; Szegedi, A.; Thomsen, S.F.; Vadasz, Z.; Vestergaard, C.; Wedi, B.; Zhao, Z.; Maurer, M. The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy, 2022, 77(3), 734-766.
[http://dx.doi.org/10.1111/all.15090] [PMID: 34536239]
[49]
Sánchez, J.; Diez, S.; Cardona, R. Clinical control of CSU with antihistamines allows for tolerance of nsaid-exacerbated cutaneous disease. J. Allergy Clin. Immunol. Pract., 2020, 8(10), 3577-3583.e1.
[http://dx.doi.org/10.1016/j.jaip.2020.06.057] [PMID: 32673879]
[50]
Pérez, C.; Sánchez-Borges, M.; Capriles, E. Pretreatment with montelukast blocks NSAID-induced urticaria and angioedema. J. Allergy Clin. Immunol., 2001, 108(6), 1060-1061.
[http://dx.doi.org/10.1067/mai.2001.120275] [PMID: 11742290]
[51]
Asero, R. Etoricoxib challenge in patients with chronic urticaria with NSAID intolerance. Clin. Exp. Derma-tol., 2007, 32, 661-663,5.
[http://dx.doi.org/10.1111/j.1365-2230.2007.02464.x]
[52]
Zembowicz, A.; Mastalerz, L.; Setkowicz, M.; Radziszewski, W.; Szczeklik, A. Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs. Arch. Dermatol., 2003, 139(12), 1577-1582.
[http://dx.doi.org/10.1001/archderm.139.12.1577] [PMID: 14676074]
[53]
Setkowicz, M.; Mastalerz, L.; Podolec-Rubis, M.; Sanak, M.; Szczeklik, A. Clinical course and urinary eicosanoids in patients with aspirin-induced urticaria followed up for 4 years. J. Allergy Clin. Immunol., 2009, 123(1), 174-178.
[http://dx.doi.org/10.1016/j.jaci.2008.09.005] [PMID: 18842291]
[54]
Quiralte, J.; Blanco, C.; Castillo, R.; Delgado, J.; Carrillo, T. Intolerance to nonsteroidal antiinflammatory drugs: Results of controlled drug challenges in 98 patients. J. Allergy Clin. Immunol., 1996, 98(3), 678-685.
[http://dx.doi.org/10.1016/S0091-6749(96)70102-1] [PMID: 8828546]
[55]
Doña, I.; Blanca-López, N.; Jagemann, L.R.; Torres, M.J.; Rondón, C.; Campo, P.; Gómez, A.I.; Fernández, J.; Laguna, J.J.; Rosado, A.; Blanca, M.; Canto, G. Response to a selective COX-2 inhibitor in patients with urticaria/angioedema induced by nonsteroidal anti-inflammatory drugs. Allergy, 2011, 66(11), 1428-1433.
[http://dx.doi.org/10.1111/j.1398-9995.2011.02684.x] [PMID: 21834936]
[56]
Nettis, E.; Di Paola, R.; Ferrannini, A.; Tursi, A. Meloxicam in hypersensitivity to NSAIDs. Allergy, 2001, 56(8), 803-804.
[http://dx.doi.org/10.1034/j.1398-9995.2001.056008803.x] [PMID: 11488693]
[57]
Asero, R. Intolerance to nonsteroidal anti-inflammatory drugs might precede by years the onset of chronic urticaria. J. Allergy Clin. Immunol., 2003, 111(5), 1095-1098.
[http://dx.doi.org/10.1067/mai.2003.1444] [PMID: 12743575]
[58]
Doña, I.; Blanca-López, N.; Torres, M.J.; Gómez, F.; Fernández, J.; Zambonino, M.A.; Monteseirín, F.J.; Canto, G.; Blanca, M.; Cornejo-García, J.A. NSAID-induced urticaria/angioedema does not evolve into chronic urticaria: A 12-year follow-up study. Allergy, 2014, 69(4), 438-444.
[http://dx.doi.org/10.1111/all.12335] [PMID: 24372026]
[59]
Doña, I.; Barrionuevo, E.; Salas, M.; Cornejo-García, J.A.; Perkins, J.R.; Bogas, G.; Prieto, A.; Torres, M.J. Natural evolution in patients with nonsteroidal anti-inflammatory drug-induced urticaria/angioedema. Allergy, 2017, 72(9), 1346-1355.
[http://dx.doi.org/10.1111/all.13147] [PMID: 28226401]
[60]
Klar, H.; Sotošek, N.; Šelb, J.; Košnik, M. Selective hypersensitivity to a single nonsteroidal anti-inflammatory drug. Acta Dermatovenerol. Alp. Panonica Adriat., 2019, 28(3), 97-101.
[http://dx.doi.org/10.15570/actaapa.2019.25] [PMID: 31545385]
[61]
Pérez-Sánchez, N.; Doña, I.; Bogas, G.; Salas, M.; Testera, A.; Cornejo-García, J.A.; Torres, M.J. Evaluation of subjects experiencing allergic reactions to non-steroidal anti-inflammatory drugs: Clinical characteristics and drugs involved. Front. Pharmacol., 2020, 11, 503.
[http://dx.doi.org/10.3389/fphar.2020.00503] [PMID: 32425774]
[62]
Kowalski, M.L.; Bienkiewicz, B.; Woszczek, G.; Iwaszkiewicz, J.; Poniatowska, M. Diagnosis of pyrazolone drug sensitivity: Clinical history versus skin testing and in vitro testing. Allergy Asthma Proc., 1999, 20(6), 347-352.
[http://dx.doi.org/10.2500/108854199778251799] [PMID: 10624489]
[63]
Fernández, T.D.; Torres, M.J.; Blanca-López, N.; Rodríguez-Bada, J.L.; Gomez, E.; Canto, G.; Mayorga, C.; Blanca, M. Negativization rates of IgE radioimmunoassay and basophil activation test in immediate reactions to penicillins. Allergy, 2009, 64(2), 242-248.
[http://dx.doi.org/10.1111/j.1398-9995.2008.01713.x] [PMID: 19178404]
[64]
Kvedariene, V.; Kamey, S.; Ryckwaert, Y.; Rongier, M.; Bousquet, J.; Demoly, P.; Arnoux, B. Diagnosis of neuromuscular blocking agent hypersensitivity reactions using cytofluorimetric analysis of basophils. Allergy, 2006, 61(3), 311-315.
[http://dx.doi.org/10.1111/j.1398-9995.2006.00978.x] [PMID: 16436139]
[65]
Gómez, E.; Blanca-Lopez, N.; Torres, M.J.; Requena, G.; Rondon, C.; Canto, G.; Blanca, M.; Mayorga, C. Immunoglobulin E-mediated immediate allergic reactions to dipyrone: Value of basophil activation test in the identification of patients. Clin. Exp. Allergy, 2009, 39(8), 1217-1224.
[http://dx.doi.org/10.1111/j.1365-2222.2009.03237.x] [PMID: 19400910]
[66]
Kowalski, M.L.; Makowska, J.S. Seven steps to the diagnosis of NSAIDs hypersensitivity: How to apply a new classification in real practice? Allergy Asthma Immunol. Res., 2015, 7(4), 312-320.
[http://dx.doi.org/10.4168/aair.2015.7.4.312] [PMID: 25749768]
[67]
Wöhrl, S. NSAID hypersensitivity - recommendations for diagnostic work up and patient management. Allergo J. Int., 2018, 27(4), 114-121.
[http://dx.doi.org/10.1007/s40629-018-0064-0] [PMID: 29974031]
[68]
Walters, K.M.; Woessner, K.M. An overview of nonsteroidal antiinflammatory drug reactions. Immunol. Allergy Clin. North Am., 2016, 36(4), 625-641.
[http://dx.doi.org/10.1016/j.iac.2016.06.001] [PMID: 27712759]
[69]
Yeung, W.Y.W.; Park, H.S. Update on the management of nonsteroidal anti-inflammatory drug hypersensitivity. Yonsei Med. J., 2020, 61(1), 4-14.
[http://dx.doi.org/10.3349/ymj.2020.61.1.4] [PMID: 31887794]
[70]
Kerr, A.; Ferguson, J. Photoallergic contact dermatitis. Photodermatol. Photoimmunol. Photomed., 2010, 26(2), 56-65.
[http://dx.doi.org/10.1111/j.1600-0781.2010.00494.x] [PMID: 20415735]
[71]
Brockow, K.; Garvey, L.H.; Aberer, W.; Atanaskovic-Markovic, M.; Barbaud, A.; Bilo, M.B.; Bircher, A.; Blanca, M.; Bonadonna, B.; Campi, P.; Castro, E.; Cernadas, J.R.; Chiriac, A.M.; Demoly, P.; Grosber, M.; Gooi, J.; Lombardo, C.; Mertes, P.M.; Mosbech, H.; Nasser, S.; Pagani, M.; Ring, J.; Romano, A.; Scherer, K.; Schnyder, B.; Testi, S.; Torres, M.; Trautmann, A.; Terreehorst, I. Skin test concentrations for systemically administered drugs -- an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy, 2013, 68(6), 702-712.
[http://dx.doi.org/10.1111/all.12142] [PMID: 23617635]
[72]
Branicka, O.; Rogala, B.; Glück, J. Eosinophil/neutrophil/platelet-to-lymphocyte ratios in various types of immediate hypersensitivity to NSAIDs: A preliminary study. Int. Arch. Allergy Immunol., 2020, 181(10), 774-782.
[http://dx.doi.org/10.1159/000509116] [PMID: 32814336]
[73]
Blanca-Lopez, N.; J Torres, M.; Doña, I.; Campo, P.; Rondón, C.; Seoane Reula, M.E.; Salas, M.; Canto, G.; Blanca, M. Value of the clinical history in the diagnosis of urticaria/angioedema induced by NSAIDs with cross-intolerance. Clin. Exp. Allergy, 2013, 43(1), 85-91.
[http://dx.doi.org/10.1111/cea.12013] [PMID: 23278883]
[74]
Viola, M.; Rumi, G.; Valluzzi, R.L.; Gaeta, F.; Caruso, C.; Romano, A. Assessing potential determinants of positive provocation tests in subjects with NSAID hypersensitivity. Clin. Exp. Allergy, 2011, 41(1), 96-103.
[http://dx.doi.org/10.1111/j.1365-2222.2010.03648.x] [PMID: 21155909]
[75]
Li, L.; Bensko, J.; Buchheit, K.; Saff, R.R.; Laidlaw, T.M. Safety, outcomes, and recommendations for two-step outpatient nonsteroidal anti-inflammatory drug challenges. J. Allergy Clin. Immunol. Pract., 2022, 10(5), 1286-1292.e2.
[http://dx.doi.org/10.1016/j.jaip.2021.11.006] [PMID: 34800703]
[76]
Sánchez-Borges, M.; Park, H.S. NSAID hypersensitivity. J. Allergy Clin. Immunol. Pract., 2019, 7(2), 746-747.
[http://dx.doi.org/10.1016/j.jaip.2018.10.037] [PMID: 30717875]
[77]
Niżankowska-Mogilnicka, E.; Bochenek, G.; Mastalerz, L.; Swierczyńska, M.; Picado, C.; Scadding, G.; Kowalski, M.L.; Setkowicz, M.; Ring, J.; Brockow, K.; Bachert, C.; Wöhrl, S.; Dahlén, B.; Szczeklik, A. EAACI/GA2LEN guideline: Aspirin provocation tests for diagnosis of aspirin hypersensitivity. Allergy, 2007, 62(10), 1111-1118.
[http://dx.doi.org/10.1111/j.1398-9995.2007.01409.x] [PMID: 17521312]
[78]
Messaad, D.; Sahla, H.; Benahmed, S.; Godard, P.; Bousquet, J.; Demoly, P. Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction. Ann. Intern. Med., 2004, 140(12), 1001-1006.
[http://dx.doi.org/10.7326/0003-4819-140-12-200406150-00009] [PMID: 15197017]
[79]
Schubert, B.; Grosse Perdekamp, M.T.; Pfeuffer, P.; Raith, P.; Bröcker, E.B.; Trautmann, A. Nonsteroidal anti-inflammatory drug hypersensitivity: Fable or reality? Eur. J. Dermatol., 2005, 15(3), 164-167.
[PMID: 15908299]
[80]
Torres, M.J.; Barrionuevo, E.; Kowalski, M.; Blanca, M. Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs. Immunol. Allergy Clin. North Am., 2014, 34(3), 507-524, vii-viii.
[http://dx.doi.org/10.1016/j.iac.2014.04.001] [PMID: 25017675]
[81]
Rutkowski, K.; Nasser, S.M.; Ewan, P.W. Paracetamol hypersensitivity: Clinical features, mechanism and role of specific IgE. Int. Arch. Allergy Immunol., 2012, 159(1), 60-64.
[http://dx.doi.org/10.1159/000335213] [PMID: 22555261]
[82]
Zedlitz, S.; Linzbach, L.; Kaufmann, R.; Boehncke, W.H. Reproducible identification of the causative drug of a fixed drug eruption by oral provocation and lesional patch testing. Contact Dermat., 2002, 46(6), 352-353.
[http://dx.doi.org/10.1034/j.1600-0536.2002.460606.x] [PMID: 12190624]
[83]
Pichler, W.J.; Tilch, J. The lymphocyte transformation test in the diagnosis of drug hypersensitivity. Allergy, 2004, 59(8), 809-820.
[http://dx.doi.org/10.1111/j.1398-9995.2004.00547.x] [PMID: 15230812]
[84]
Cornejo-Garcia, J.A.; Blanca-López, N.; Doña, I.; Andreu, I.; Agúndez, J.A.; Carballo, M.; Blanca, M.; Canto, M.G. Hypersensitivity reactions to non-steroidal anti-inflammatory drugs. Curr. Drug Metab., 2009, 10(9), 971-980.
[http://dx.doi.org/10.2174/138920009790711841] [PMID: 20214589]
[85]
Settipane, R.A.; Schrank, P.J.; Simon, R.A.; Mathison, D.A.; Christiansen, S.C.; Stevenson, D.D. Prevalence of cross-sensitivity with acetaminophen in aspirin-sensitive asthmatic subjects. J. Allergy Clin. Immunol., 1995, 96(4), 480-485.
[http://dx.doi.org/10.1016/S0091-6749(95)70290-3] [PMID: 7560658]
[86]
Asero, R. Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders. Ann. Allergy Asthma Immunol., 1999, 82(6), 554-558.
[http://dx.doi.org/10.1016/S1081-1206(10)63166-3] [PMID: 10400483]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy