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Current Organocatalysis

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ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

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Review Article

Organocatalyzed Synthesis of Anti-tubercular Agents

Author(s): Sunil Sharma, Kavita Singh, Rakhi Yadav, Ramesh Kumar and Ram Sagar*

Volume 11, Issue 2, 2024

Published on: 18 October, 2023

Page: [95 - 115] Pages: 21

DOI: 10.2174/2213337210666230901141841

Price: $65

Abstract

This review highlights synthetic developments of anti-tubercular agents by using organocatalysts. Organocatalysts-mediated synthesis is environmentally benign and highly compatible with aqueous-solvent systems, and such catalysts are attractive because of their inexpensive cost, low toxicity, good air and moisture stability and follow many principles of green chemistry. Numerous anti-tuberculosis agents have been synthesized utilizing organocatalysts and tested for their in vivo and in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv pathogens. The inhibitory concentrations of the reported compounds were compared with the standard reference drugs in order to evaluate their inhibition potency.

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