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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Short Communication

Acyclic Aldehydo Sugars: 1,3-dimethyl-4,5-diamino Uracil as Recoverable Carbonyl Protecting Group

Author(s): D. Fuentes-Rios, M. Doña, J.M. López-Romero* and R. Rico

Volume 21, Issue 2, 2024

Published on: 13 September, 2023

Page: [213 - 215] Pages: 3

DOI: 10.2174/1570178620666230901101009

Price: $65

Abstract

1,3-dimethyl-4,5-diaminouracil has been used as an efficient protecting group for the carbonyl moiety in sugars by the formation of the imine group. The protection reaction is carried out under mild conditions, the yields are quantitative in most of the cases, and the protecting group is completely recovered and reused. After per-acetylation, deprotection is accomplished at room temperature with aqueous formic acid to produce acyclic acetylated sugars in good global yield.

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