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Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Case Report

Exertional Dyspnea; Just an Untrained Child? Two Case Reports Analyzing the Role of Lung Function Testing

Author(s): Domenico Paolo La Regina, Enrica Mancino, Elio Iovine, Mattia Spatuzzo, Fabrizio Virgili, Luigi Matera, Raffaella Nenna and Fabio Midulla*

Volume 19, Issue 4, 2023

Published on: 04 October, 2023

Page: [268 - 272] Pages: 5

DOI: 10.2174/1573398X19666230823094353

Price: $65

Abstract

Background: Dyspnea is a common symptom that afflicts many patients with pulmonary disease and may be the primary manifestation of not only lung disease but also myocardial dysfunction, anemia, neuromuscular disorders, obesity, etc. Dyspnea can be induced by physical activity, which is referred to as exercise-induced dyspnea (EID). It can be caused by various etiologies, sometimes concomitant. In pediatrics, the three most common causes of exertional dyspnea are exercise-induced bronchoconstriction, inducible laryngeal obstruction, and being physically untrained.

Case Presentation: We report two cases of adolescents who developed EID and their management approach. The first patient had an inducible laryngeal obstruction (EILO), while the second had an exercise-induced bronchoconstriction (EIB).

Discussion: The diagnosis of EIB is based on clinical symptoms (e.g., exercise-related symptoms of dyspnea, cough, or wheezing) and lung function testing (LFT). This test shows a reversible airflow limitation in response to exercise. A decrease in FEV1 ≥ 10% is considered positive. A major goal is to ensure that patients with EIB continue physical activity. Therapy is based on non-pharmacologic and pharmacologic measures.

Conclusion: Our aim is to add our experience to the available knowledge on the diagnosis of EID. In conclusion, when faced with a child with exertional dyspnea, before declaring that he is not trained, it is always necessary to collect an accurate medical history, examination and carry out LFT, excluding pathologies of the upper and lower respiratory tract, such as EILO and EIB.

Am J Respir Crit Care Med Parshall M.B. 185 435 2012 10.1164/rccm.201111-2042ST Parshall M.B.; Schwartzstein R.M.; Adams L.; Banzett R.B.; Manning H.L.; Bourbeau J.; Calverley P.M.; Gift A.G.; Harver A.; Lareau S.C.; Mahler D.A.; Meek P.M.; O’Donnell D.E.; An official American Thoracic Society statement: Update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med 2012,185(4),435-452 Eur Arch Otorhinolaryngol Liyanagedara S. 274 1781 2017 10.1007/s00405-016-4338-1 Liyanagedara S.; McLeod R.; Elhassan H.A.; Exercise induced laryngeal obstruction: A review of diagnosis and management. Eur Arch Otorhinolaryngol 2017,274(4),1781-1789 Eur Arch Otorhinolaryngol Christensen P.M. 268 1313 2011 10.1007/s00405-011-1612-0 Christensen P.M.; Thomsen S.F.; Rasmussen N.; Backer V.; Exercise-induced laryngeal obstructions: Prevalence and symptoms in the general public. Eur Arch Otorhinolaryngol 2011,268(9),1313-1319 Paediatr Respir Rev Røksund O.D. 21 86 2017 Røksund O.D.; Heimdal J.H.; Clemm H.; Vollsæter M.; Halvorsen T.; Exercise inducible laryngeal obstruction: Diagnostics and management. Paediatr Respir Rev 2017,21,86-94 Eur Respir J Halvorsen T. 50 1602221 2017 10.1183/13993003.02221-2016 Halvorsen T.; Walsted E.S.; Bucca C.; Bush A.; Cantarella G.; Friedrich G.; Herth F.J.F.; Hull J.H.; Jung H.; Maat R.; Nordang L.; Remacle M.; Rasmussen N.; Wilson J.A.; Heimdal J.H.; Inducible laryngeal obstruction: An official joint european respiratory society and european laryngological society statement. Eur Respir J 2017,50(3),1602221 Pediatr Pulmonol Olin J.T. 52 813 2017 10.1002/ppul.23634 Olin J.T.; Deardorff E.H.; Fan E.M.; Johnston K.L.; Keever V.L.; Moore C.M.; Bender B.G.; Therapeutic laryngoscopy during exercise: A novel non-surgical therapy for refractory EILO. Pediatr Pulmonol 2017,52(6),813-819 Acta Otolaryngol Norlander K. 135 1152 2015 Norlander K.; Johansson H.; Jansson C.; Nordvall L.; Nordang L.; Surgical treatment is effective in severe cases of exercise-induced laryngeal obstruction: A follow-up study. Acta Otolaryngol 2015,135(11),1152-1159 J Allergy Clin Immunol Weiler J.M. 138 1292 2016 10.1016/j.jaci.2016.05.029 Weiler J.M.; Brannan J.D.; Randolph C.C.; Hallstrand T.S.; Parsons J.; Silvers W.; Storms W.; Zeiger J.; Bernstein D.I.; Blessing-Moore J.; Greenhawt M.; Khan D.; Lang D.; Nicklas R.A.; Oppenheimer J.; Portnoy J.M.; Schuller D.E.; Tilles S.A.; Wallace D.; Exercise-induced bronchoconstriction update—2016. J Allergy Clin Immunol 2016,138(5),1292-1295.e36 J Allergy Clin Immunol Weiler J.M. 119 1349 2007 10.1016/j.jaci.2007.02.041 Weiler J.M.; Bonini S.; Coifman R.; Craig T.; Delgado L.; Capão-Filipe M.; Passali D.; Randolph C.; Storms W.; American academy of allergy, asthma and immunology work group report: Exercise-induced asthma. J Allergy Clin Immunol 2007,119(6),1349-1358 Ann Allergy Asthma Immunol Pongdee T. 110 311 2013 10.1016/j.anai.2013.02.002 Pongdee T.; Li J.T.; Exercise-induced bronchoconstriction. Ann Allergy Asthma Immunol 2013,110(5),311-315 Eur J Respir Dis Anderson S.D. 67 20 1985 Anderson S.D.; Schoeffel R.E.; Black J.L.; Daviskas E.; Airway cooling as the stimulus to exercise-induced asthma--a re-evaluation. Eur J Respir Dis 1985,67(1),20-30 Am J Respir Crit Care Med Freed A.N. 159 1101 1999 10.1164/ajrccm.159.4.9802072 Freed A.N.; Davis M.S.; Hyperventilation with dry air increases airway surface fluid osmolality in canine peripheral airways. Am J Respir Crit Care Med 1999,159(4),1101-1107 Am J Respir Crit Care Med Parsons J.P. 187 1016 2013 10.1164/rccm.201303-0437ST Parsons J.P.; Hallstrand T.S.; Mastronarde J.G.; Kaminsky D.A.; Rundell K.W.; Hull J.H.; Storms W.W.; Weiler J.M.; Cheek F.M.; Wilson K.C.; Anderson S.D.; An official American Thoracic Society clinical practice guideline: Exercise-induced bronchoconstriction. Am J Respir Crit Care Med 2013,187(9),1016-1027 Allergy Millqvist E. 50 225 1995 10.1111/j.1398-9995.1995.tb01138.x Millqvist E.; Bake B.; Bengtsson U.; Löwhagen O.; A breathing filter exchanging heat and moisture prevents asthma induced by cold air. Allergy 1995,50(3),225-228 J Allergy Clin Immunol Pract Greiwe J. 8 2542 2020 10.1016/j.jaip.2020.05.020 Greiwe J.; Cooke A.; Nanda A.; Epstein S.Z.; Wasan A.N.; Shepard K.V.; Capão-Filipe M.; Nish A.; Rubin M.; Gregory K.L.; Dass K.; Blessing-Moore J.; Randolph C.; Work group report: Perspectives in diagnosis and management of exercise-induced bronchoconstriction in athletes. J Allergy Clin Immunol Pract 2020,8(8),2542-2555 Am J Respir Crit Care Med Inman M.D. 153 65 1996 10.1164/ajrccm.153.1.8542164 Inman M.D.; O’Byrne P.M.; The effect of regular inhaled albuterol on exercise-induced bronchoconstriction. Am J Respir Crit Care Med 1996,153(1),65-69 Cochrane Database Syst Rev Bonini M. CD003564 2013 Bonini M.; Di Mambro C.; Calderon M.A.; Compalati E.; Schünemann H.; Durham S.; Canonica G.W.; Beta-agonists for exercise-induced asthma. Cochrane Database Syst Rev 2013(10),CD003564 Thorax Lazarinis N. 69 130 2014 10.1136/thoraxjnl-2013-203557 Lazarinis N.; Jørgensen L.; Ekström T.; Bjermer L.; Dahlén B.; Pullerits T.; Hedlin G.; Carlsen K.H.; Larsson K.; Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction. Thorax 2014,69(2),130-136

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