Abstract
The use of ''smart materials,'' or ''stimulus responsive'' materials, has proven useful in a variety of fields, including tissue engineering and medication delivery. Many factors, including temperature, pH, redox state, light, and magnetic fields, are being studied for their potential to affect a material's properties, interactions, structure, and/or dimensions. New tissue engineering and drug delivery methods are made possible by the ability of living systems to respond to both external stimuli and their own internal signals) for example, materials composed of stimuliresponsive polymers that self assemble or undergo phase transitions or morphology transformation. The researcher examines the potential of smart materials as controlled drug release vehicles in tissue engineering, aiming to enable the localized regeneration of injured tissue by delivering precisely dosed drugs at precisely timed intervals.
Graphical Abstract
[http://dx.doi.org/10.1016/j.molmed.2018.08.004] [PMID: 30213702]
[http://dx.doi.org/10.1016/j.jconrel.2018.01.021] [PMID: 29407678]
[http://dx.doi.org/10.1016/j.carbpol.2017.02.105] [PMID: 28385221]
[http://dx.doi.org/10.1016/j.colsurfb.2018.05.015] [PMID: 29751344]
[http://dx.doi.org/10.1021/acsami.6b00291] [PMID: 27043006]
[http://dx.doi.org/10.1021/acscentsci.6b00371] [PMID: 28386594]
[http://dx.doi.org/10.1016/j.actbio.2017.11.003]
[http://dx.doi.org/10.1016/j.msec.2017.04.022] [PMID: 28531977]
[http://dx.doi.org/10.1016/j.micromeso.2016.08.034]
[http://dx.doi.org/10.1039/C2BM00136E] [PMID: 32481797]
[http://dx.doi.org/10.1146/annurev-bioeng-060418-052324] [PMID: 30857392]
[http://dx.doi.org/10.1039/C7MH00373K]
[http://dx.doi.org/10.3390/molecules21111580] [PMID: 27879635]
[http://dx.doi.org/10.3390/molecules21111585] [PMID: 27879628]
[http://dx.doi.org/10.3390/jfb2040355] [PMID: 24956449]
[http://dx.doi.org/10.2174/1381612825666191007163152] [PMID: 31589116]
[http://dx.doi.org/10.1002/mame.202000130]
[http://dx.doi.org/10.1590/s1679-45082017rb4024] [PMID: 29091160]
[http://dx.doi.org/10.1007/978-3-319-11355-5_1]
[http://dx.doi.org/10.1038/nprot.2016.123] [PMID: 27583639]
[http://dx.doi.org/10.1038/nmat3776] [PMID: 24150417]
[http://dx.doi.org/10.1039/c3py21118e]
[http://dx.doi.org/10.1186/s12951-018-0398-2] [PMID: 30243297]
[http://dx.doi.org/10.1016/j.copbio.2013.03.011] [PMID: 23578463]
[http://dx.doi.org/10.1016/j.actbio.2015.07.010] [PMID: 26162587]
[http://dx.doi.org/10.1007/s10439-010-9977-6] [PMID: 20198510]
[http://dx.doi.org/10.1016/j.colsurfb.2015.08.043] [PMID: 26355812]
[http://dx.doi.org/10.1002/adma.201802084] [PMID: 30294947]
[http://dx.doi.org/10.1088/1361-6463/ab0532]
[http://dx.doi.org/10.1002/adfm.201909045]
[http://dx.doi.org/10.1039/C6PY01872F]
[http://dx.doi.org/10.1039/C6RA25340G]
[http://dx.doi.org/10.1163/092050610X545049] [PMID: 22133349]
[http://dx.doi.org/10.1021/acsami.6b10491] [PMID: 27704757]
[http://dx.doi.org/10.1021/acsami.8b10001] [PMID: 30028125]
[http://dx.doi.org/10.1016/j.eurpolymj.2017.12.004]
[http://dx.doi.org/10.1002/wnan.1389] [PMID: 26762467]
[http://dx.doi.org/10.1007/s12274-018-2198-2]
[http://dx.doi.org/10.1002/mabi.200900297] [PMID: 20014197]
[http://dx.doi.org/10.3390/polym3031215]
[http://dx.doi.org/10.1016/j.msec.2019.04.069] [PMID: 31147031]
[http://dx.doi.org/10.1016/j.eurpolymj.2019.05.024]
[http://dx.doi.org/10.1088/2515-7639/ab1af5]
[http://dx.doi.org/10.1016/j.chempr.2018.07.002]
[http://dx.doi.org/10.1016/j.actbio.2019.05.018] [PMID: 31096042]
[http://dx.doi.org/10.1039/C1LC20859D] [PMID: 22105780]
[http://dx.doi.org/10.1039/C4BM00448E] [PMID: 26221932]
[http://dx.doi.org/10.1002/jbm.a.35638] [PMID: 26707893]
[http://dx.doi.org/10.1002/adma.201303233] [PMID: 24741694]
[http://dx.doi.org/10.1016/j.jvs.2009.12.028] [PMID: 20223627]
[http://dx.doi.org/10.1590/S1516-14392000000300006]
[http://dx.doi.org/10.1016/S0169-409X(01)00240-X] [PMID: 11755704]
[http://dx.doi.org/10.1016/j.biomaterials.2012.04.050] [PMID: 22681979]
[http://dx.doi.org/10.1002/(SICI)1099-1581(199805)9:5<282::AID-PAT755>3.0.CO;2-N]
[http://dx.doi.org/10.1201/9781315369488]
[http://dx.doi.org/10.1039/D1MA00193K]
[http://dx.doi.org/10.1002/app.31675]
[http://dx.doi.org/10.1007/978-3-319-76573-0_18-1]
[http://dx.doi.org/10.1201/9781420007329]
[http://dx.doi.org/10.1002/pi.2196]
[http://dx.doi.org/10.1021/ma302522x] [PMID: 24496435]
[http://dx.doi.org/10.1007/s13233-013-1051-4]
[http://dx.doi.org/10.1201/9781439894156]
[http://dx.doi.org/10.1016/j.ijbiomac.2016.04.071] [PMID: 27126169]
[http://dx.doi.org/10.1039/C7PY02014G]
[http://dx.doi.org/10.5772/38852]
[http://dx.doi.org/10.1007/978-4-431-54400-5_2]
[http://dx.doi.org/10.1016/j.addr.2008.02.004] [PMID: 18406491]
[http://dx.doi.org/10.1016/j.progpolymsci.2006.03.001]
[http://dx.doi.org/10.1016/j.actbio.2017.11.016] [PMID: 29128530]
[http://dx.doi.org/10.1016/j.addma.2019.02.012]
[http://dx.doi.org/10.4155/tde.14.38] [PMID: 25090282]
[http://dx.doi.org/10.1007/s13233-011-0308-z]
[http://dx.doi.org/10.1039/C8BM01246F] [PMID: 30648168]
[http://dx.doi.org/10.1016/B978-0-08-101997-9.00017-5]
[http://dx.doi.org/10.3390/pharmaceutics11120671] [PMID: 31835628]
[http://dx.doi.org/10.1021/acsami.7b13176] [PMID: 29260543]
[http://dx.doi.org/10.2144/btn-2018-0083] [PMID: 30730212]
[http://dx.doi.org/10.1089/ten.2005.11.1768] [PMID: 16411822]
[http://dx.doi.org/10.1021/acs.langmuir.6b03051] [PMID: 27668306]
[http://dx.doi.org/10.1021/la502131h] [PMID: 25149436]
[http://dx.doi.org/10.1021/bm401670t] [PMID: 24432713]
[http://dx.doi.org/10.1016/j.actbio.2017.11.020] [PMID: 29128540]
[http://dx.doi.org/10.1016/j.biomaterials.2018.07.038]
[http://dx.doi.org/10.1016/j.actbio.2018.01.042] [PMID: 29454158]
[http://dx.doi.org/10.1016/j.biomaterials.2015.08.028] [PMID: 26318816]
[http://dx.doi.org/10.1088/1758-5090/aa6265] [PMID: 28229956]
[http://dx.doi.org/10.1021/acsami.7b04552] [PMID: 28603958]
[http://dx.doi.org/10.21315/tlsr2018.29.2.9]
[http://dx.doi.org/10.1038/natrevmats.2017.87]
[http://dx.doi.org/10.7150/thno.4847] [PMID: 23139729]
[http://dx.doi.org/10.1039/B9PY00300B]
[http://dx.doi.org/10.1002/adma.201502843] [PMID: 26389516]
[http://dx.doi.org/10.4155/tde-2016-0060] [PMID: 28088880]
[http://dx.doi.org/10.1039/C1CS15179G] [PMID: 22008710]
[http://dx.doi.org/10.1002/cphc.201500897] [PMID: 26593975]
[http://dx.doi.org/10.1039/C3RA47370H]
[http://dx.doi.org/10.4103/0975-7406.130965] [PMID: 25035633]
[http://dx.doi.org/10.15171/apb.2017.002] [PMID: 28507932]
[http://dx.doi.org/10.1021/acs.langmuir.8b03241] [PMID: 30346771]
[http://dx.doi.org/10.1002/adma.201503799] [PMID: 27578301]
[http://dx.doi.org/10.1016/j.eurpolymj.2015.04.001]
[http://dx.doi.org/10.1016/j.bej.2017.12.012]
[http://dx.doi.org/10.1016/j.biomaterials.2015.04.011] [PMID: 25956194]
[http://dx.doi.org/10.1016/j.msec.2013.12.006] [PMID: 24433909]
[http://dx.doi.org/10.1016/j.actbio.2017.11.009] [PMID: 29127064]
[http://dx.doi.org/10.1039/C5TB00757G] [PMID: 32262717]
[http://dx.doi.org/10.1038/mtna.2013.46] [PMID: 23982190]
[http://dx.doi.org/10.1158/0008-5472.CAN-08-3021] [PMID: 19351852]
[http://dx.doi.org/10.1016/j.jconrel.2014.11.010] [PMID: 25445692]
[http://dx.doi.org/10.1364/BOE.7.000442] [PMID: 26977353]
[http://dx.doi.org/10.1002/jctb.1468]
[http://dx.doi.org/10.1016/S0142-9612(02)00175-8] [PMID: 12219820]
[http://dx.doi.org/10.1021/acsmacrolett.7b00714] [PMID: 35650929]
[http://dx.doi.org/10.1002/chem.201801051] [PMID: 29578259]
[http://dx.doi.org/10.1039/C8BM00019K] [PMID: 29528057]
[http://dx.doi.org/10.1038/ncomms13088] [PMID: 27708265]
[http://dx.doi.org/10.3390/cancers13051164] [PMID: 33803133]
[http://dx.doi.org/10.1021/acsami.7b18302] [PMID: 29430919]
[http://dx.doi.org/10.1016/j.actbio.2016.12.004] [PMID: 28088668]
[http://dx.doi.org/10.1021/acs.langmuir.5b01878] [PMID: 26149326]
[http://dx.doi.org/10.1016/j.ajps.2015.11.123]
[http://dx.doi.org/10.1021/acsomega.6b00079] [PMID: 27656689]
[http://dx.doi.org/10.1002/pi.5170]
[http://dx.doi.org/10.1039/C4CC02216E] [PMID: 24849317]
[http://dx.doi.org/10.1039/c4py00564c]
[http://dx.doi.org/10.1007/s12274-016-1097-7]
[http://dx.doi.org/10.1039/c1sm00011j]
[http://dx.doi.org/10.1021/acsami.6b11043] [PMID: 27709887]
[http://dx.doi.org/10.1021/acsami.7b01016] [PMID: 28304158]
[http://dx.doi.org/10.1002/adfm.201909049]
[http://dx.doi.org/10.1039/D0NR02552F] [PMID: 32567640]
[http://dx.doi.org/10.1002/advs.201903783] [PMID: 32328436]
[http://dx.doi.org/10.1126/science.aaq1144] [PMID: 29439241]
[http://dx.doi.org/10.1038/s41467-019-10847-0] [PMID: 31253798]
[http://dx.doi.org/10.1002/anie.201911025] [PMID: 31544993]
[http://dx.doi.org/10.1007/s00289-019-02772-5]
[http://dx.doi.org/10.1039/C5CC08617E] [PMID: 26558317]
[http://dx.doi.org/10.3390/ani11020460] [PMID: 33572472]
[http://dx.doi.org/10.1002/adma.201603612] [PMID: 27966826]
[http://dx.doi.org/10.21577/0103-5053.20190074]
[http://dx.doi.org/10.2217/nnm.14.126] [PMID: 25343351]
[http://dx.doi.org/10.3390/gels1020135] [PMID: 30674170]
[http://dx.doi.org/10.1021/la802155a] [PMID: 18847290]
[http://dx.doi.org/10.1016/j.jcis.2009.11.016] [PMID: 20022022]
[http://dx.doi.org/10.1088/1748-6041/10/4/045002] [PMID: 26154495]
[http://dx.doi.org/10.1016/j.colsurfb.2017.05.046] [PMID: 28551573]
[http://dx.doi.org/10.1039/C5BM00268K] [PMID: 26456625]
[http://dx.doi.org/10.1080/09205063.2018.1519987] [PMID: 30183550]
[http://dx.doi.org/10.1039/C4PY01750A]
[http://dx.doi.org/10.1038/s41392-017-0004-3] [PMID: 29560283]
[http://dx.doi.org/10.1039/C3PY01192E]
[http://dx.doi.org/10.1039/C6CS00196C] [PMID: 27156979]
[http://dx.doi.org/10.1016/j.jorganchem.2016.10.041]
[http://dx.doi.org/10.1007/s42114-017-0009-y]
[http://dx.doi.org/10.1002/adma.201601613] [PMID: 27488822]
[http://dx.doi.org/10.1038/ncomms1521] [PMID: 22027591]
[http://dx.doi.org/10.1038/srep02811] [PMID: 24091865]
[http://dx.doi.org/10.1021/acs.chemmater.7b03635]
[http://dx.doi.org/10.1002/wnan.1527]
[http://dx.doi.org/10.1016/j.polymer.2016.09.039]
[http://dx.doi.org/10.3762/bjoc.14.190] [PMID: 30202469]
[http://dx.doi.org/10.1021/la404349w] [PMID: 24417726]
[http://dx.doi.org/10.1021/ja1027452] [PMID: 20681712]
[http://dx.doi.org/10.1016/j.progpolymsci.2018.01.001] [PMID: 29983457]
[PMID: 28699530]
[http://dx.doi.org/10.1016/j.jconrel.2010.03.023] [PMID: 20359512]
[http://dx.doi.org/10.4103/1673-5374.235303] [PMID: 30106059]
[http://dx.doi.org/10.1016/j.actbio.2017.08.045] [PMID: 28865991]
[http://dx.doi.org/10.1039/C4TB00142G] [PMID: 32261732]
[http://dx.doi.org/10.1039/C8TB00782A] [PMID: 32254411]
[http://dx.doi.org/10.1016/j.actbio.2014.02.015] [PMID: 24556448]
[http://dx.doi.org/10.1016/j.bprint.2018.e00035]
[http://dx.doi.org/10.1016/j.bbagen.2015.01.020] [PMID: 25662071]
[http://dx.doi.org/10.1038/s41598-017-03992-3] [PMID: 28642614]
[http://dx.doi.org/10.2147/IJN.S92031] [PMID: 26730191]
[http://dx.doi.org/10.1038/ncomms3208] [PMID: 23896756]
[http://dx.doi.org/10.1021/nn305559j] [PMID: 23363247]
[http://dx.doi.org/10.1016/j.cclet.2018.08.007]
[http://dx.doi.org/10.1007/s10529-013-1259-6] [PMID: 23801114]
[http://dx.doi.org/10.1016/j.colsurfb.2018.11.003] [PMID: 30439640]
[http://dx.doi.org/10.1016/j.cis.2013.09.006] [PMID: 24139510]
[http://dx.doi.org/10.1016/j.bjbas.2017.05.008]
[http://dx.doi.org/10.1016/j.jmmm.2016.05.019]
[http://dx.doi.org/10.1016/j.surfin.2018.11.005]
[http://dx.doi.org/10.1016/j.cjche.2017.05.017]
[http://dx.doi.org/10.1016/j.jsamd.2018.07.002]
[http://dx.doi.org/10.1002/9783527803255]
[http://dx.doi.org/10.1039/C4NR03150D] [PMID: 25327219]
[http://dx.doi.org/10.1021/cr068445e] [PMID: 18543879]
[http://dx.doi.org/10.1002/btm2.10014] [PMID: 29313015]
[http://dx.doi.org/10.1002/mabi.201500440] [PMID: 26891447]