Login Register Cart 0
Generic placeholder image

Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Perspective

Natural Compounds Synthesis: A Perspective of Modern Chemistry

Author(s): Aurelio Ortiz and Estibaliz Sansinenea*

Volume 21, Issue 1, 2024

Published on: 15 August, 2023

Page: [2 - 6] Pages: 5

DOI: 10.2174/1570178620666230717112233

Price: $65

Abstract

Natural products have been created by nature and are derived from organisms such as plants or microorganisms. The natural compounds are isolated from natural sources in very small quantities, making it difficult for the form to achieve the compounds' good yields. The last is relevant for doing biological essays and chemical structure elucidation. Besides, they have diverse chemical structures, which have inspired organic chemists to do their organic synthesis. It is important to construct a strategy based on a well-designed retrosynthesis. The reproducibility of the selected methodology, the yields of the compounds of each step and stereoselectivity or diastereoselectivity of the reactions that are being used are the main key points to guarantee the success of a natural compound synthesis. Modern technologies can be the solution. In this review, we try to compile in the form of a critic perspective the most modern techniques that organic chemists are applying for the synthesis of complex natural compounds.

« Previous Next »
Graphical Abstract

[1]
Kumar, K.; Waldmann, H. Angew. Chem. Int. Ed., 2009, 48(18), 3224-3242.
[http://dx.doi.org/10.1002/anie.200803437] [PMID: 19267376]
[2]
Baran, P.S. J. Am. Chem. Soc., 2018, 140(14), 4751-4755.
[http://dx.doi.org/10.1021/jacs.8b02266] [PMID: 29635919]
[3]
Truax, N.J.; Romo, D. Nat. Prod. Rep., 2020, 37(11), 1436-1453.
[http://dx.doi.org/10.1039/D0NP00048E] [PMID: 33104139]
[4]
Maier, M.E. Org. Biomol. Chem., 2015, 13(19), 5302-5343.
[http://dx.doi.org/10.1039/C5OB00169B] [PMID: 25829247]
[5]
Majhi, S. Volume 2 Synthesis of Bioactive Scaffolds; Sharma, K.R.; Banerjee, B., Eds.; De Gruyter: Berlin, Boston, 2022, pp. 259-286.
[http://dx.doi.org/10.1515/9783110797428-007]
[6]
Williams, R.M. J. Org. Chem., 2011, 76(11), 4221-4259.
[http://dx.doi.org/10.1021/jo2003693] [PMID: 21438619]
[7]
Kolb, H.C.; Finn, M.G.; Sharpless, K.B. Angew. Chem. Int. Ed., 2001, 40(11), 2004-2021.
[http://dx.doi.org/10.1002/1521-3773(20010601)40:11<2004:AID-ANIE2004>3.0.CO;2-5] [PMID: 11433435]
[8]
Devaraj, N.K.; Finn, M.G. Chem. Rev., 2021, 121(12), 6697-6698.
[http://dx.doi.org/10.1021/acs.chemrev.1c00469] [PMID: 34157843]
[9]
Zhang, X.; Zhang, S.; Zhao, S.; Wang, X.; Liu, B.; Xu, H. Front Chem., 2021, 9, 774977.
[http://dx.doi.org/10.3389/fchem.2021.774977] [PMID: 34869223]
[10]
2022. Available from: https://www.nobelprize.org/prizes/chemistry/2022/summary
[11]
Medina-Franco, J.L. Biomolecules, 2021, 11(5), 630.
[http://dx.doi.org/10.3390/biom11050630] [PMID: 33922650]
[12]
Chen, Y. Kirchmair. J. Mol. Inform., 2020, 39(12), 2000171.
[http://dx.doi.org/10.1002/minf.202000171] [PMID: 32725781]
[13]
Saldívar-González, F.I.; Aldas-Bulos, V.D.; Medina-Franco, J.L.; Plisson, F. Chem. Sci. (Camb.), 2022, 13(6), 1526-1546.
[http://dx.doi.org/10.1039/D1SC04471K] [PMID: 35282622]
[14]
Sansinenea, E.; Ortiz, A. Curr. Org. Synth., 2022, 19(1), 148-165.
[http://dx.doi.org/10.2174/1570179418666210728145206] [PMID: 35139783]
[15]
Grondal, C.; Jeanty, M.; Enders, D. Nat. Chem., 2010, 2(3), 167-178.
[http://dx.doi.org/10.1038/nchem.539] [PMID: 21124474]
[16]
Han, B.; He, X.H.; Liu, Y.Q.; He, G.; Peng, C.; Li, J.L. Chem. Soc. Rev., 2021, 50(3), 1522-1586.
[http://dx.doi.org/10.1039/D0CS00196A] [PMID: 33496291]
[17]
Roddan, R.; Carter, E.M.; Thair, B.; Hailes, H.C. Nat. Prod. Rep., 2022, 39(7), 1375-1382.
[http://dx.doi.org/10.1039/D2NP00008C] [PMID: 35343542]
[18]
Vanable, E.P.; Habgood, L.G.; Patrone, J.D. Molecules, 2022, 27(19), 6373.
[http://dx.doi.org/10.3390/molecules27196373] [PMID: 36234909]
[19]
Chakrabarty, S.; Romero, E.O.; Pyser, J.B.; Yazarians, J.A.; Narayan, A.R.H. Acc. Chem. Res., 2021, 54(6), 1374-1384.
[http://dx.doi.org/10.1021/acs.accounts.0c00810] [PMID: 33600149]
[20]
Osipyan, A.; Sapegin, A.; Novikov, A.S.; Krasavin, M. J. Org. Chem., 2018, 83(17), 9707-9717.
[http://dx.doi.org/10.1021/acs.joc.8b01210] [PMID: 30101583]
[21]
Reutskaya, E.; Osipyan, A.; Sapegin, A.; Novikov, A.S.; Krasavin, M. J. Org. Chem., 2019, 84(4), 1693-1705.
[http://dx.doi.org/10.1021/acs.joc.8b02805] [PMID: 30566355]
[22]
Guranova, N.I.; Dar’in, D.; Kantin, G.; Novikov, A.S.; Bakulina, O.; Krasavin, M. J. Org. Chem., 2019, 84(7), 4534-4542.
[http://dx.doi.org/10.1021/acs.joc.9b00245] [PMID: 30816715]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy