A Review on the Mechanism and Structure-activity Relationship of
Resveratrol Heteroaryl Analogues

Yijun      Xiang; Yao      Xu; Jiaxin      Li; Jingyi      Jiang; Yanjie      Wang; Xiaoshun      Li; Wenbin      Ai; Pengbing      Mi; Zehua      Yang; Zitong      Zheng
doi:10.2174/1386207326666230713125512
Abstract

Resveratrol is one of the most interesting naturally-occurring nonflavonoid phenolic compounds with various biological activities, such as anticancer, neuroprotection, antibacterial, and anti-inflammatory. However, there is no clinical usage of resveratrol due to either its poor activity or poor pharmacokinetic properties. Heteroarenes-modified resveratrol is one pathway to improve its biological activities and bioavailability, and form more modification sites. In this review, we present the progress of heteroaryl analogues of resveratrol with promising biological activities in the latest five years, ranging from the synthesis to the structure-activity relationship and mechanism of actions. Finally, introducing heteroarenes into resveratrol is an effective strategy, which focuses on the selectivity of structure-activity relationship in vivo.
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DOI https://dx.doi.org/10.2174/1386207326666230713125512	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402
Combinatorial Chemistry & High Throughput Screening

A Review on the Mechanism and Structure-activity Relationship of Resveratrol Heteroaryl Analogues

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