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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Research Article

Synthesis and Molecular Docking Study of Some New Thiazole-coumarin Molecular Hybrids as Antibacterial Agents

Author(s): Jehan Y. Al-Humaidi, Sobhi M. Gomha*, Fathy M. Abdelrazek, Hassan M. Abdel-aziz and Aboubakr H. Abdelmonsef

Volume 21, Issue 6, 2024

Published on: 09 August, 2023

Page: [810 - 821] Pages: 12

DOI: 10.2174/1570179420666230707142817

Price: $65

Abstract

Background: The emergence of drug-resistant bacteria and multidrug-resistant diseases, both of which are associated with high mortality, has posed a serious global health issue. Thiazoles and coumarins were reported as antimicrobial agents.

Objective: This research paper aims to describe the synthesis of some novel thiazole derivatives bearing a coumarin residue as antibacterial agents.

Methods: The thiazole - coumarin hybrids were synthesized starting from the condensation of 3- acetyl coumarin (1) hydrazine carbothioamide (2) or thisemicarbazide then reacting the resulting products with different p-substituted phenacyl bromides (4a-e), hydrazonoyl chlorides (8a-e), and (11). In vitro antibacterial activity was studied in this work. In addition, molecular docking studies for the new compounds have also been carried out to investigate the binding mode of actions against the target DNA gyrase B.

Results: Some of the newly synthesized compounds such as compounds 10b, 7, and 6b showed pronounced activities against Gram (+ve) and Gram (-ve) bacteria compared to a reference antibacterial agent. Compounds 10b, 7, and 6b exhibited the best binding affinity against the target.

Conclusion: We could obtain a series of precious hitherto unknown thiazole derivatives with varied antibacterial activities from cheap laboratory-available starting material following rather simple environmentally friendly techniques avoiding the use of hazardous or heavy metal-containing catalysts.

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