Login Register Cart 0
Generic placeholder image

Pharmaceutical Nanotechnology

Editor-in-Chief

ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

The Effect of Curcumin Nanoparticles on Paracetamol-induced Liver Injury in Male Wistar Rats

Author(s): Irma Putri Damayanti*, Neni Susilaningsih, Trilaksana Nugroho, Suhartono Suhartono, Suryono Suryono, Hardhono Susanto, Ari Suwondo and Endang Mahati

Volume 11, Issue 5, 2023

Published on: 08 June, 2023

Page: [493 - 503] Pages: 11

DOI: 10.2174/2211738511666230601105536

Price: $65

Abstract

Introduction: Curcumin is a naturally occurring compound that has antioxidant properties, acts as a hepatoprotective, and lowers lipid peroxidation. However, curcumin's low solubility and bioavailability are its primary drawbacks and prevent its use as a therapeutic agent. In this study, curcumin nanoparticles will be created using the ultrasonic-assisted extraction method, and their effectiveness against paracetamol-induced changes in ALT, AST, SOD, MDA, and TNF-α will be compared to that of pure curcumin.

Purpose: This study aimed to determine the hepatoprotective effect of curcumin nanoparticles in paracetamol- induced rats as a model for liver injury.

Methods: Thirty-six male Wistar rats, aged 6 to 8 weeks, with a minimum weight of 120 grams, were used in an experimental laboratory investigation with a post-test-only group design. Rats in each group received 100 mg/kgBW pure curcumin, 100 mg/kgBW curcumin nanoparticles, and 50 mg/kgBW curcumin nanoparticles for 7 days before paracetamol induction. On day 8, 300 mg/kgBW of paracetamol was intraperitoneally injected to cause liver damage. One of the groups received NAC as an antidote 10 hours after paracetamol induction. Detection of ALT and AST using a Chemistry Analyzer. ELISA approach for the detection of SOD, MDA, and TNF-α. The Roenigk score was calculated by two examiners after the liver histopathology preparations were stained using the Hematoxylin-Eosin method. Post hoc analyses were performed after the One Way Annova and Kruskal Wallis tests to examine the data.

Results: According to PSA results, the smallest formula that formed curcumin nanoparticles (10.2 nm) was 8 g of curcumin formula mixed with a mixture of Tween 20 4.5 ml, Kolliphor EL 1.5 ml, Propylene Glycol 1.5 ml, and Capryol 90 1 ml for 21 minutes using an ultrasonic process. MDA and TNF-α levels, as well as the liver's histological Roenigk score, were significantly lower in the 100 mg/kgBB pure curcumin group (C100) when compared to the model group (model). The levels of AST, MDA, TNF-α, and the liver histopathology score were significantly lower in the 100 mg/kgBB (NC100) and 50 mg/kgBB (NC50) curcumin nanoparticle groups compared to the model group (model) and pure curcumin group (C100) (p< 0.05).

Conclusion: Curcumin nanoparticles showed better hepatoprotective ability than pure curcumin.

« Previous Next »
Graphical Abstract

Animated Abstract
[1]
Jayaraman T, Lee YY, Chan WK, Mahadeva S. Epidemiological differences of common liver conditions between asia and the west. JGH Open 2020; 4(3): 332-9.
[http://dx.doi.org/10.1002/jgh3.12275] [PMID: 32514433]
[2]
Cinthya SE, Pradipta IS, Abdulah R. Administration of drug induce liver injury to the inpatients with liver disease. Indones J Clin Pharm 2012; 1(2): 4-9.
[3]
Du K, Ramachandran A, Jaeschke H. Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. Redox Biol 2016; 10: 148-56.
[http://dx.doi.org/10.1016/j.redox.2016.10.001] [PMID: 27744120]
[4]
McGill MR, Williams CD, Xie Y, Ramachandran A, Jaeschke H. Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol 2012; 264(3): 387-94.
[http://dx.doi.org/10.1016/j.taap.2012.08.015] [PMID: 22980195]
[5]
Ramachandran A, Jaeschke H. Acetaminophen hepatotoxicity. Semin Liver Dis 2019; 39(2): 221-34.
[http://dx.doi.org/10.1055/s-0039-1679919] [PMID: 30849782]
[6]
Kheradpezhouh E, Panjehshahin MR, Miri R, et al. Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with n-acetyl cysteine. Eur J Pharmacol 2010; 628(1-3): 274-81.
[http://dx.doi.org/10.1016/j.ejphar.2009.11.027] [PMID: 19919835]
[7]
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: Lessons learned from clinical trials. AAPS J 2013; 15(1): 195-218.
[http://dx.doi.org/10.1208/s12248-012-9432-8] [PMID: 23143785]
[8]
Tung BT, Hai NT, Son PK. Hepatoprotective effect of phytosome curcumin against paracetamol-induced liver toxicity in mice. Braz J Pharm Sci 2017; 53(1): 1-13.
[http://dx.doi.org/10.1590/s2175-97902017000116136]
[9]
Granados-Castro LF, Rodríguez-Rangel DS, Fernández-Rojas B, et al. Curcumin prevents paracetamol-induced liver mitochondrial alterations. J Pharm Pharmacol 2016; 68(2): 245-56.
[http://dx.doi.org/10.1111/jphp.12501] [PMID: 26773315]
[10]
Salimi A, Kheiripour N, Fathi Jouzdani A, Ghasemi H, Soleimani Asl S, Ghafouri-Khosrowshahi A, et al. Nanocurcumin improves lipid status, oxidative stress, and function of the liver in aluminium phosphide-induced toxicity: Cellular and molecular mechanisms. Biomed Res Int 2022; 2022.
[11]
Haryuna TSH, Purba AHW, Farhat F, Alviandi W. The antiapoptotic effect of curcumin in the fibroblast of the cochlea in an ototoxic rat model. Iran J Otorhinolaryngol 2018; 30(100): 247-53.
[PMID: 30245978]
[12]
Loganes C, Lega S, Bramuzzo M, et al. Curcumin anti-apoptotic action in a model of intestinal epithelial inflammatory damage. Nutrients 2017; 9(6): 578.
[http://dx.doi.org/10.3390/nu9060578] [PMID: 28587282]
[13]
Barzegar A, Moosavi-Movahedi AA. Intracellular ros protection efficiency and free radical-scavenging activity of curcumin. PLoS One 2011; 6(10): e26012.
[http://dx.doi.org/10.1371/journal.pone.0026012] [PMID: 22016801]
[14]
Singh U, Barik A, Singh BG, Priyadarsini KI. Reactions of reactive oxygen species (ROS) with curcumin analogues: Structure–activity relationship. Free Radic Res 2011; 45(3): 317-25.
[http://dx.doi.org/10.3109/10715762.2010.532493] [PMID: 21034358]
[15]
Moratilla-Rivera I, Sánchez M, Valdés-González JA, Gómez-Serranillos MP. Natural products as modulators of nrf2 signaling pathway in neuroprotection. Int J Mol Sci 2023; 24(4): 3748.
[http://dx.doi.org/10.3390/ijms24043748] [PMID: 36835155]
[16]
Ghareghomi S, Rahban M, Moosavi-Movahedi Z, Habibi-Rezaei M, Saso L, Moosavi-Movahedi AA. The potential role of curcumin in modulating the master antioxidant pathway in diabetic hypoxia-induced complications. Molecules 2021; 26(24): 7658.
[http://dx.doi.org/10.3390/molecules26247658] [PMID: 34946740]
[17]
Yousef MI, Omar SAM, El-Guendi MI, Abdelmegid LA. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 2010; 48(11): 3246-61.
[http://dx.doi.org/10.1016/j.fct.2010.08.034] [PMID: 20804811]
[18]
Bulku E, Stohs SJ, Cicero L, Brooks T, Halley H, Ray SD. Curcumin exposure modulates multiple pro-apoptotic and anti-apoptotic signaling pathways to antagonize acetaminophen-induced toxicity. Curr Neurovasc Res 2012; 9(1): 58-71.
[http://dx.doi.org/10.2174/156720212799297083] [PMID: 22272768]
[19]
Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol 2007; 595: 127-48.
[http://dx.doi.org/10.1007/978-0-387-46401-5_4] [PMID: 17569208]
[20]
Alizadeh M, Kheirouri S. Curcumin reduces malondialdehyde and improves antioxidants in humans with diseased conditions: a comprehensive meta-analysis of randomized controlled trials. Biomedicine 2019; 9(4): 23.
[http://dx.doi.org/10.1051/bmdcn/2019090423] [PMID: 31724938]
[21]
Somanawat K, Thong-Ngam D, Klaikeaw N. Curcumin attenuated paracetamol overdose induced hepatitis. World J Gastroenterol 2013; 19(12): 1962-7.
[http://dx.doi.org/10.3748/wjg.v19.i12.1962] [PMID: 23569342]
[22]
Zendedel E, Butler AE, Atkin SL, Sahebkar A. Impact of curcumin on sirtuins: A review. J Cell Biochem 2018; 119(12): 10291-300.
[http://dx.doi.org/10.1002/jcb.27371] [PMID: 30145851]
[23]
Miao Y, Zhao S, Gao Y, et al. Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling. Brain Res Bull 2016; 121: 9-15.
[http://dx.doi.org/10.1016/j.brainresbull.2015.11.019] [PMID: 26639783]
[24]
Nie H, Hong Y, Lu X, et al. SIRT2 mediates oxidative stress-induced apoptosis of differentiated PC12 cells. Neuroreport 2014; 25(11): 838-42.
[http://dx.doi.org/10.1097/WNR.0000000000000192] [PMID: 24922350]
[25]
Ungurianu A, Zanfirescu A. Margină D. regulation of gene expression through food—curcumin as a sirtuin activity modulator. Plants 2022; 11(13): 1741.
[http://dx.doi.org/10.3390/plants11131741] [PMID: 35807694]
[26]
Xie YL, Chu JG, Jian XM, et al. Curcumin attenuates lipopolysaccharide/d -galactosamine-induced acute liver injury by activating nrf2 nuclear translocation and inhibiting nf-kb activation. Biomed Pharmacother 2017; 91: 70-7.
[http://dx.doi.org/10.1016/j.biopha.2017.04.070] [PMID: 28448872]
[27]
Li W, Jiang L, Lu X, Liu X, Ling M. Curcumin protects radiation-induced liver damage in rats through the nf-κb signaling pathway. BMC Complementary Medicine and Therapies 2021; 21(1): 10.
[http://dx.doi.org/10.1186/s12906-020-03182-1] [PMID: 33386071]
[28]
Soliman MM, Nassan MA, Ismail TA. Immunohistochemical and molecular study on the protective effect of curcumin against hepatic toxicity induced by paracetamol in wistar rats. BMC Complement Altern Med 2014; 14(1): 457.
[http://dx.doi.org/10.1186/1472-6882-14-457] [PMID: 25432491]
[29]
Dogaru G, Bulboaca AE, Gheban D, Boarescu PM, Rus V, Festila D, et al. Effect of liposomal curcumin on acetaminophen hepatotoxicity by down-regulation of oxidative stress and matrix metalloproteinases 2020.
[http://dx.doi.org/10.21873/invivo.11809]
[30]
Toden S, Goel A. The holy grail of curcumin and its efficacy in various diseases: Is bioavailability truly a big concern? J Restor Med 2017; 6(1): 27-36.
[http://dx.doi.org/10.14200/jrm.2017.6.0101] [PMID: 30899605]
[31]
Farghaly HS, Hussein MA. Protective effect of curcumin against paracetamol-induced liver damage. Aust J Basic Appl Sci 2010; 5(712): 143966.
[32]
Sahebkar A, Cicero AFG, Simental-Mendía LE, Aggarwal BB, Gupta SC. Curcumin downregulates human tumor necrosis factor-α levels: a systematic review and meta-analysis ofrandomized controlled trials. Pharmacol Res 2016; 107: 234-42.
[http://dx.doi.org/10.1016/j.phrs.2016.03.026] [PMID: 27025786]
[33]
Kheradpezhouh E, Barritt GJ, Rychkov GY. Curcumin inhibits activation of trpm2 channels in rat hepatocytes. Redox Biol 2016; 7(7): 1-7.
[http://dx.doi.org/10.1016/j.redox.2015.11.001] [PMID: 26609559]
[34]
Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: A comprehensive update. J Clin Transl Hepatol 2016; 4(2): 131-42.
[PMID: 27350943]
[35]
Jaeschke H, Akakpo JY, Umbaugh DS, Ramachandran A. Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure. Toxicol Sci 2020; 174(2): 159-67.
[http://dx.doi.org/10.1093/toxsci/kfaa002] [PMID: 31926003]
[36]
Marinda FD. Hepatoprotective effect of curcumin in chronic hepatitis. J Major 2014; 3(7): 52-6.
[37]
Chiew AL, Gluud C, Brok J, Buckley NA. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev 2018; 2(2): CD003328.
[PMID: 29473717]
[38]
Licata A, Minissale MG. Stankevičiūtė S, et al. N-acetylcysteine for preventing acetaminophen-induced liver injury: A comprehensive review. Front Pharmacol 2022; 13: 828565.
[http://dx.doi.org/10.3389/fphar.2022.828565] [PMID: 36034775]
[39]
Tenório MCS, Graciliano NG, Moura FA, Oliveira ACM, Goulart MOF. N-acetylcysteine (Nac): Impacts on human health. Antioxidants 2021; 10(6): 967.
[http://dx.doi.org/10.3390/antiox10060967] [PMID: 34208683]
[40]
Tsikas D, Mikuteit M. N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations. Amino Acids 2022; 54(9): 1251-60.
[http://dx.doi.org/10.1007/s00726-022-03185-x] [PMID: 35829920]
[41]
Ezeriņa D, Takano Y, Hanaoka K, Urano Y, Dick TP. N-Acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and Sulfane sulfur production. Cell Chem Biol 2018; 25(4): 447-459.e4.
[http://dx.doi.org/10.1016/j.chembiol.2018.01.011] [PMID: 29429900]
[42]
Guo J, Cao X, Hu X, Li S, Wang J. The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats. BMC Pharmacol Toxicol 2020; 21(1): 62.
[http://dx.doi.org/10.1186/s40360-020-00440-3] [PMID: 32811563]
[43]
Ben-Shachar R, Chen Y, Luo S, Hartman C, Reed M, Nijhout HF. The biochemistry of acetaminophen hepatotoxicity and rescue: A mathematical model. Theor Biol Med Model 2012; 9(1): 55.
[http://dx.doi.org/10.1186/1742-4682-9-55] [PMID: 23249634]
[44]
James LP, McCullough SS, Lamps LW, Hinson JA. Effect of n-acetylcysteine on acetaminophen toxicity in mice: Relationship to reactive nitrogen and cytokine formation. Toxicol Sci 2003; 75(2): 458-67.
[http://dx.doi.org/10.1093/toxsci/kfg181] [PMID: 12883092]
[45]
Saito C, Zwingmann C, Jaeschke H. Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and n-acetylcysteine. Hepatology 2010; 51(1): 246-54.
[http://dx.doi.org/10.1002/hep.23267] [PMID: 19821517]
[46]
Vigyan Kendra K, Preeti Kumari I, Kumar Maurya Scholar R, Kumar V, Kumar Verma R, Kumari P, et al. Medicinal properties of turmeric (Curcuma longa L.): A review. ~ 1354 ~. Int J Chem Stud 2018; 6(4): 1354-7.
[47]
Gera M, Sharma N, Ghosh M, et al. Nanoformulations of curcumin: an emerging paradigm for improved remedial application. Oncotarget 2017; 8(39): 66680-98.
[http://dx.doi.org/10.18632/oncotarget.19164] [PMID: 29029547]
[48]
Liu W, Zhai Y, Heng X, Che FY, Chen W, Sun D, et al. Oral bioavailability of curcumin: Problems and advancements. J Drug Target 2016 Sep; 24(8): 694-702.
[http://dx.doi.org/10.3109/1061186X.2016.1157883]
[49]
Chopra H, Dey PS, Das D, et al. Curcumin nanoparticles as promising therapeutic agents for drug targets. Molecules 2021; 26(16): 4998.
[http://dx.doi.org/10.3390/molecules26164998] [PMID: 34443593]
[50]
Chen Y, Lu Y, Lee RJ, Xiang G. Nano encapsulated curcumin: and its potential for biomedical applications. Int J Nanomedicine 2020; 15: 3099-120.
[http://dx.doi.org/10.2147/IJN.S210320] [PMID: 32431504]
[51]
Dei Cas M, Ghidoni R. Dietary curcumin: Correlation between bioavailability and health potential. Nutrients 2019; 11(9): 2147.
[http://dx.doi.org/10.3390/nu11092147] [PMID: 31500361]
[52]
Flory S, Sus N, Haas K, et al. Increasing post‐digestive solubility of curcumin is the most successful strategy to improve its oral bioavailability: A randomized cross‐over trial in healthy adults and In Vitro bioaccessibility experiments. Mol Nutr Food Res 2021; 65(24): 2100613.
[http://dx.doi.org/10.1002/mnfr.202100613] [PMID: 34665507]
[53]
Gupta T, Singh J, Kaur S, Sandhu S, Singh G, Kaur IP. Enhancing bioavailability and stability of curcumin using solid lipid nanoparticles (CLEN): A covenant for its effectiveness. Front Bioeng Biotechnol 2020; 8: 879.
[http://dx.doi.org/10.3389/fbioe.2020.00879] [PMID: 33178666]
[54]
Bayet-Robert M, Kwiatowski F, Leheurteur M, et al. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol Ther 2010; 9(1): 8-14.
[http://dx.doi.org/10.4161/cbt.9.1.10392] [PMID: 19901561]
[55]
He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest 2011; 29(3): 208-13.
[http://dx.doi.org/10.3109/07357907.2010.550592] [PMID: 21314329]
[56]
Dhillon N, Aggarwal BB, Newman RA, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008; 14(14): 4491-9.
[http://dx.doi.org/10.1158/1078-0432.CCR-08-0024] [PMID: 18628464]
[57]
Ma Z, Wang N, He H, Tang X. Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. J Control Release 2019; 316: 359-80.
[http://dx.doi.org/10.1016/j.jconrel.2019.10.053] [PMID: 31682912]
[58]
Sasaki H, Sunagawa Y, Takahashi K, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull 2011; 34(5): 660-5.
[http://dx.doi.org/10.1248/bpb.34.660] [PMID: 21532153]
[59]
Józsa L, Vasvári G, Sinka D, et al. Enhanced antioxidant and anti-inflammatory effects of self-nano and microemulsifying drug delivery systems containing curcumin. Molecules 2022; 27(19): 6652.
[http://dx.doi.org/10.3390/molecules27196652] [PMID: 36235189]
[60]
Karthikeyan A, Senthil N, Min T, Lu J, Mircioiu C, Paciello F, et al. Nanocurcumin: A Promising Candidate for Therapeutic Applications. Front Pharmacol 2020; 11: 487.
[http://dx.doi.org/10.3389/fphar.2020.00487] [PMID: 32425772]
[61]
Mauludin R, Al-Hakim NA, Fidrianny I, Anggadiredja K. Effect of Banana (Musa sp.) Peels Extract in Nanoemulsion Dosage Forms for the Improvement of Memory: In Vitro & In Vivo Studies. Pharm Nanotechnol 2022; 10(4): 299-309.
[http://dx.doi.org/10.2174/2211738510666220422135519] [PMID: 35466890]
[62]
Steinborn B, Lächelt U. Metal-organic Nanopharmaceuticals. Pharm Nanotechnol 2020; 8(3): 163-90.
[http://dx.doi.org/10.2174/2211738508666200421113215] [PMID: 32316907]
[63]
Sumantri IB. Ismayadi, Mustanti LF. The Potency of Wound Healing of Nanogel-containing Mikania micrantha Leaves Extract in Hyperglycemic Rats. Pharm Nanotechnol 2021; 9(5): 339-46.
[http://dx.doi.org/10.2174/2211738509666211209164105] [PMID: 34886791]
[64]
Powers KW, Palazuelos M, Moudgil BM, Roberts SM. Characterization of the size, shape, and state of dispersion of nanoparticles for toxicological studies. Nanotoxicology 2007; 1(1): 42-51.
[http://dx.doi.org/10.1080/17435390701314902]
[65]
Champion JA, Walker A, Mitragotri S. Role of particle size in phagocytosis of polymeric microspheres. Pharm Res 2008; 25(8): 1815-21.
[http://dx.doi.org/10.1007/s11095-008-9562-y] [PMID: 18373181]
[66]
Sharma G, Valenta DT, Altman Y, et al. Polymer particle shape independently influences binding and internalization by macrophages. J Control Release 2010; 147(3): 408-12.
[http://dx.doi.org/10.1016/j.jconrel.2010.07.116] [PMID: 20691741]
[67]
Gratton SEA, Ropp PA, Pohlhaus PD, et al. The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci USA 2008; 105(33): 11613-8.
[http://dx.doi.org/10.1073/pnas.0801763105] [PMID: 18697944]
[68]
Setthacheewakul S, Mahattanadul S, Phadoongsombut N, Pichayakorn W, Wiwattanapatapee R. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm 2010; 76(3): 475-85.
[http://dx.doi.org/10.1016/j.ejpb.2010.07.011] [PMID: 20659556]
[69]
Zhao F, Zhao Y, Liu Y, Chang X, Chen C, Zhao Y. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small 2011; 7(10): 1322-37.
[http://dx.doi.org/10.1002/smll.201100001] [PMID: 21520409]
[70]
Jazayeri-Tehrani SA, Rezayat SM, Mansouri S, et al. Nano-curcumin improves glucose indices, lipids, inflammation, and Nesfatin in overweight and obese patients with non-alcoholic fatty liver disease (NAFLD): a double-blind randomized placebo-controlled clinical trial. Nutr Metab 2019; 16(1): 8.
[http://dx.doi.org/10.1186/s12986-019-0331-1] [PMID: 30705687]
[71]
Marslin G, Prakash J, Qi S, Franklin G. Oral delivery of curcumin polymeric nanoparticles ameliorates CCl4-induced subacute hepatotoxicity in wistar rats. Polymers 2018; 10(5): 541.
[http://dx.doi.org/10.3390/polym10050541] [PMID: 30966575]
[72]
Boarescu I, Boarescu PM, Pop RM, et al. Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation. Biomedicines 2021; 10(1): 61.
[http://dx.doi.org/10.3390/biomedicines10010061] [PMID: 35052741]
[73]
Boarescu PM, Boarescu I. Bocșan IC, et al. Curcumin Nanoparticles Protect against Isoproterenol Induced Myocardial Infarction by Alleviating Myocardial Tissue Oxidative Stress, Electrocardiogram, and Biological Changes. Molecules 2019; 24(15): 2802.
[http://dx.doi.org/10.3390/molecules24152802] [PMID: 31374848]
[74]
Asadirad A, Nashibi R, Khodadadi A, et al. Antiinflammatory potential of nano‐curcumin as an alternative therapeutic agent for the treatment of mild‐to‐moderate hospitalized COVID‐19 patients in a placebo‐controlled clinical trial. Phytother Res 2022; 36(2): 1023-31.
[http://dx.doi.org/10.1002/ptr.7375] [PMID: 35040210]
[75]
Boarescu PM, Boarescu I. Bocșan IC, et al. Antioxidant and anti-inflammatory effects of curcumin nanoparticles on drug-induced acute myocardial infarction in diabetic rats. Antioxidants 2019; 8(10): 504.
[http://dx.doi.org/10.3390/antiox8100504] [PMID: 31652638]
[76]
Potphode ND, Daunde JA, Desai SS, Walvekar MV. Nano-curcumin: A potent enhancer of body antioxidant system in diabetic mice. Int J Phytomed 2018; 10(3): 162.
[http://dx.doi.org/10.5138/09750185.2271]
[77]
Ilavenil S, Al-Dhabi N, Srigopalram S, et al. Acetaminophen induced hepatotoxicity in Wistar rats - A proteomic approach. Molecules 2016; 21(2): 161.
[http://dx.doi.org/10.3390/molecules21020161] [PMID: 26828476]
[78]
Xiao Y, Chen X, Yang L, et al. Preparation and oral bioavailability study of curcuminoid-loaded microemulsion. J Agric Food Chem 2013; 61(15): 3654-60.
[http://dx.doi.org/10.1021/jf400002x] [PMID: 23451842]
[79]
Rajalakshmi N, Dhivya S. A Review on the preparation methods of Curcumin Nanoparticles. PharmaTutor 2018; 6(9): 6-10.
[http://dx.doi.org/10.29161/PT.v6.i9.2018.6]
[80]
Thilakarathna RCN, Madhusankha GDMP. Impact of ultra-sonication on gelation process in dairy products incorporated with polysaccharides. Food Nutr Sci 2020; 11(5): 327-35.
[http://dx.doi.org/10.4236/fns.2020.115024]
[81]
Singla M, Sit N. Application of ultrasound in combination with other technologies in food processing: A review. Ultrason Sonochem 2021; 73: 105506.
[http://dx.doi.org/10.1016/j.ultsonch.2021.105506] [PMID: 33714087]
[82]
Suryono S, Hadiyanto H, Yasin M, Widyowati R, Muniroh M, Amalia A. Effect of frequency, temperature, and time of sonication on xanton content of mangosteen (Garcinia mangostana L.) peel extract through ultrasound assisted extraction. NASA 2019; 125: 25006.
[83]
Health, Research Ethics Committee, the Ministry of Health R, Indonesia.. National Guidelines on Health Research Ethics. Jakarta: the Ministry of Health, Republic of Indonesia 2011.
[84]
Retnam L, Chatikavanij P, Kunjara P, et al. Laws, Regulations, Guidelines and Standards for Animal Care and Use for Scientific Purposes in the Countries of Singapore, Thailand, Indonesia, Malaysia, and India. ILAR J 2017; 57(3): 312-23.
[http://dx.doi.org/10.1093/ilar/ilw038] [PMID: 29117407]
[85]
Zabihi F, Yang M, Leng Y, Zhao Y. PLGA–HPMC nanoparticles prepared by a modified supercritical anti-solvent technique for the controlled release of insulin. J Supercrit Fluids 2015; (99): 15-22.
[86]
Aragon G, Younossi ZM. When and how to evaluate mildly elevated liver enzymes in apparently healthy patients. Cleve Clin J Med 2010; 77(3): 195-204.
[http://dx.doi.org/10.3949/ccjm.77a.09064] [PMID: 20200170]
[87]
Patel HV. Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in Wistar rats Hepatoprotective Activity of Some Plants Extract Against Paracetamol Induced Hepatotoxicity in Rats. J Herb Med Toxicol 2014; 4: 2.
[88]
Atia MM, Abdel-Tawab HS, Mostafa AM, Mobarak SA. Nanocurcumin and curcumin prevent N, N′-methylenebisacrylamide-induced liver damage and promotion of hepatic cancer cell growth. Sci Rep 2022; 12(1): 8319.
[http://dx.doi.org/10.1038/s41598-022-12406-y] [PMID: 35585174]
[89]
Moradi kelardeh B, Azarbayjani M, Peeri M, Matinhomaee H. Effect of curcumin supplementation and resistance training in patients with nonalcoholic fatty liver disease. Faslnamah-i Giyahan-i Daruyi 2016; 15(60): 161-72.
[90]
Yallapu MM, Jaggi M, Chauhan SC. Poly(β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells. Macromol Biosci 2010; 10(10): 1141-51.
[http://dx.doi.org/10.1002/mabi.201000084] [PMID: 20572274]
[91]
Mohamed Ibrahim R, El Zahraa Ali Abd Elaal F, Zaki S. Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats. International Journal of Food Science and Biotechnology 2019; 4(3): 64.
[http://dx.doi.org/10.11648/j.ijfsb.20190403.12]
[92]
Meshkibaf MH, Maleknia M, Noroozi S. Effect of curcumin on gene expression and protein level of methionine sulfoxide reductase A (MSRA), SOD, CAT and GPx in Freund’s adjuvant inflammation-induced male rats. J Inflamm Res 2019; 12: 241-9.
[http://dx.doi.org/10.2147/JIR.S212577] [PMID: 31564949]
[93]
Zukowski P, Maciejczyk M, Matczuk J, Kurek K, Waszkiel D, Zendzian-Piotrowska M, et al. Effect of N-acetylcysteine on antioxidant defense, oxidative modification, and salivary gland function in a rat model of insulin resistance. Oxid Med Cell Longev 2018; 2018.
[94]
Sahebkar A, Serban MC, Ursoniu S, Banach M. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. J Funct Foods 2015; 18: 898-909.
[http://dx.doi.org/10.1016/j.jff.2015.01.005]
[95]
Mohajer A, Ghayour-Mobarhan M, Parizadeh SMR, Tavallaie S, Rajabian M, Sahebkar A. Effects of supplementation with curcuminoids on serum copper and zinc concentrations and superoxide dismutase enzyme activity in obese subjects. Trace Elem Electrolytes 2015; 32(1): 16-21.
[http://dx.doi.org/10.5414/TEX01363]
[96]
Ali BH, Marrif H, Noureldayem SA, Bakheit AO, Blunden G. Some biological properties of curcumin: A review. Nat Prod Commun 2006; 1(6): 1934578X0600100.
[http://dx.doi.org/10.1177/1934578X0600100613]
[97]
Urošević M, Nikolić L, Gajić I, Nikolić V, Dinić A, Miljković V. Curcumin: Biological activities and modern pharmaceutical forms. Antibiotics 2022; 11(2): 135.
[http://dx.doi.org/10.3390/antibiotics11020135] [PMID: 35203738]
[98]
Raghavendar R. Kotha Devanand L.Luthria. Curcumin: Biological, pharmaceutical, nutraceutical and analytical aspects. Molecules 2019; 24: 58-66.
[99]
García-Niño WR, Pedraza-Chaverrí J. Protective effect of curcumin against heavy metals-induced liver damage. Food Chem Toxicol 2014; 69(April): 182-201.
[http://dx.doi.org/10.1016/j.fct.2014.04.016] [PMID: 24751969]
[100]
Masuda T, Maekawa T, Hidaka K, Bando H, Takeda Y, Yamaguchi H. Chemical studies on antioxidant mechanism of curcumin: analysis of oxidative coupling products from curcumin and linoleate. J Agric Food Chem 2001; 49(5): 2539-47.
[http://dx.doi.org/10.1021/jf001442x] [PMID: 11368633]
[101]
Mehta J, Rayalam S, Wang X. Cytoprotective effects of natural compounds against oxidative stress. Antioxidants 2018; 7(10): 147.
[http://dx.doi.org/10.3390/antiox7100147] [PMID: 30347819]
[102]
Lee JH, Song MY, Song EK, et al. Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway. Diabetes 2009; 58(2): 344-51.
[http://dx.doi.org/10.2337/db07-1795] [PMID: 19008341]
[103]
Zhang M, Tang J, Li Y, et al. Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1α/SIRT3 pathway involved. Chem Biol Interact 2017; 277: 168-75.
[http://dx.doi.org/10.1016/j.cbi.2017.09.018] [PMID: 28951138]
[104]
Keskin-Aktan A, Akbulut KG, Yazici-Mutlu Ç, Sonugur G, Ocal M, Akbulut H. The effects of melatonin and curcumin on the expression of SIRT2, Bcl-2 and Bax in the hippocampus of adult rats. Brain Res Bull 2018; 137: 306-10.
[http://dx.doi.org/10.1016/j.brainresbull.2018.01.006] [PMID: 29325994]
[105]
Calzoni E, Cesaretti A, Polchi A, Di Michele A, Tancini B, Emiliani C. Biocompatible polymer nanoparticles for drug delivery applications in cancer and neurodegenerative disorder therapies. J Funct Biomater 2019; 10(1): 4.
[http://dx.doi.org/10.3390/jfb10010004] [PMID: 30626094]
[106]
Rachmawati H, Shaal LA, Müller RH, Keck CM. Development of curcumin nanocrystal: physical aspects. J Pharm Sci 2013; 102(1): 204-14.
[http://dx.doi.org/10.1002/jps.23335] [PMID: 23047816]
[107]
Cheng CY, Mruk DD. The blood-testis barrier and its implications for male contraception. Pharmacol Rev 2012; 64(1): 16-64.
[http://dx.doi.org/10.1124/pr.110.002790] [PMID: 22039149]
[108]
Isaacson D, Mueller JL. JCN SS. Article R. Cytokines and the junction restructuring events during spermatogenesis in the testis: An emerging new concept of regulation. Cytokine Growth Factor Rev 2009; 20(4): 329-38.
[http://dx.doi.org/10.1016/j.cytogfr.2009.07.007] [PMID: 19651533]
[109]
Wong EWP, Mruk DD, Lee WM, Cheng CY. Regulation of blood–testis barrier dynamics by TGF-β3 is a Cdc42-dependent protein trafficking event. Proc Natl Acad Sci 2010; 107(25): 11399-404.
[http://dx.doi.org/10.1073/pnas.1001077107] [PMID: 20534521]
[110]
Hamidie RDR, Patriasih R, Sulastri A. Potential of nanocurcumin on cytokine storm through decreased IL-6 and TNF-α expression. Malaysian J Med Heal Sci 2021; 17: 115-9.
[111]
Li G, Chen JB, Wang C, et al. Curcumin protects against acetaminophen-induced apoptosis in hepatic injury. World J Gastroenterol 2013; 19(42): 7440-6.
[http://dx.doi.org/10.3748/wjg.v19.i42.7440] [PMID: 24259976]
[112]
Lee DE, Lee SJ, Kim SJ, Lee HS, Kwon OS. Curcumin ameliorates nonalcoholic fatty liver disease through inhibition of O-GlcNAcylation. Nutrients 2019; 11(11): 2702.
[http://dx.doi.org/10.3390/nu11112702] [PMID: 31717261]
[113]
Li J, Niu R, Dong L, Gao L, Zhang J, Zheng Y, et al. Nanoencapsulation of curcumin and its protective effects against CCl 4 - induced hepatotoxicity in Mice. J Nanomater 2019; 2019.
[114]
El-Desoky GE, Wabaidur SM, AlOthman ZA, Habila MA. Evaluation of Nano‐curcumin effects against Tartrazine‐induced abnormalities in liver and kidney histology and other biochemical parameters. Food Sci Nutr 2022; 10(5): 1344-56.
[http://dx.doi.org/10.1002/fsn3.2790] [PMID: 35592283]
[115]
Panzarini E, Mariano S, Tacconi S, Carata E, Tata AM, Dini L. Novel therapeutic delivery of nanocurcumin in central nervous system related disorders. Nanomaterials. MDPI AG. 2021; 11: pp. 1-30.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy