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Current Drug Metabolism

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ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

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Mini-Review Article

Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials

Author(s): Xueping Xie, Wenjuan Ma, Yuxi Zhan, Qifeng Zhang, Chaowei Wang* and Huiyong Zhu*

Volume 24, Issue 5, 2023

Published on: 15 June, 2023

Page: [315 - 326] Pages: 12

DOI: 10.2174/1389200224666230601091346

Price: $65

Abstract

Nucleic acid strands can be synthesized into various nucleic acid-based nanomaterials (NANs) through strict base pairing. The self-assembled NANs are programmable, intelligent, biocompatible, non-immunogenic, and non-cytotoxic. With the rapid development of nanotechnology, the application of NANs in the biomedical fields, such as drug delivery and biological sensing, has attracted wide attention. However, the stability of NANs is often affected by the cation concentrations, enzymatic degradation, and organic solvents. This susceptibility to degradation is one of the most important factors that have restricted the application of NANs. NANs can be denatured or degraded under conditions of low cation concentrations, enzymatic presence, and organic solvents. To deal with this issue, a lot of methods have been attempted to improve the stability of NANs, including artificial nucleic acids, modification with specific groups, encapsulation with protective structures, etc. In this review, we summarized the relevant methods to have a deeper understanding of the stability of NANs.

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