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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Mini-Review Article

Anilinopyrimidines: A Review Exploring Synthetic Approaches and Biological Activity

Author(s): Shilpi Pathak*, Rahul Pandey and Neetu Agrawal

Volume 20, Issue 10, 2023

Published on: 08 June, 2023

Page: [931 - 944] Pages: 14

DOI: 10.2174/1570178620666230525140626

Price: $65

Abstract

Anilinopyrimidines have a wide range of biological activities, including antibacterial, antifungal, and anticancer effects. They have a wide range of uses and opportunities due to their varied experimental preparation and study activities. This creates a lot of interest, experiments and analytical analyses are still being conducted to understand their medicinal chemistry better. According to their effects, which can include antifungal and antibacterial, anticancer or antitumor, and other properties, anilinopyrimidines are categorized in this review. In conclusion, it is critical to base the design of new anilinopyrimidine derivatives and the creation of novel synthesis methodologies on the most recent information discovered through recent research. This review intends to shed light on advancements in the synthetic and biological activity of analogs of anilinopyrimidines.

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[1]
Fritz, R.; Lanen, C.; Chapeland-Leclerc, F.; Leroux, P. Pestic. Biochem. Physiol., 2003, 77(2), 54-65.
[http://dx.doi.org/10.1016/S0048-3575(03)00094-4]
[2]
Leroux, P. Agronomie, 1994, 14(8), 541-554.
[http://dx.doi.org/10.1051/agro:19940806]
[3]
Sheina, E.S.; Shestakova, T.S.; Deev, S.L.; Khalymbadzha, I.A.; Slepukhin, P.A.; Eltsov, O.S.; Novikov, A.S.; Shevyrin, V.A.; Charushin, V.N.; Chupakhin, O.N. Chem. Asian J., 2023, 18(5), e202201306.
[http://dx.doi.org/10.1002/asia.202201306] [PMID: 36662627]
[4]
Fedotov, V.V.; Valieva, M.I.; Taniya, O.S.; Aminov, S.V.; Kharitonov, M.A.; Novikov, A.S.; Kopchuk, D.S.; Slepukhin, P.A.; Zyryanov, G.V.; Ulomsky, E.N.; Rusinov, V.L.; Charushin, V.N. Molecules, 2022, 27(22), 8029.
[http://dx.doi.org/10.3390/molecules27228029] [PMID: 36432130]
[5]
Dubovtsev, A.Y.; Zvereva, V.V.; Shcherbakov, N.V.; Dar’in, D.V.; Novikov, A.S.; Kukushkin, V.Y. Org. Biomol. Chem., 2021, 19(20), 4577-4584.
[http://dx.doi.org/10.1039/D1OB00513H] [PMID: 33954321]
[6]
Taniya, O.S.; Fedotov, V.V.; Novikov, A.S.; Sadieva, L.K.; Krinochkin, A.P.; Kovalev, I.S.; Kopchuk, D.S.; Zyryanov, G.V.; Liu, Y.; Ulomsky, E.N.; Rusinov, V.L.; Charushin, V.N. Dyes Pigments, 2022, 204, 110405.
[http://dx.doi.org/10.1016/j.dyepig.2022.110405]
[7]
Kumari, S.; Kumar, R.; Mazumder, A. Lett. Org. Chem., 2022, 19, 689-704.
[http://dx.doi.org/10.2174/1570178619666211231110106]
[8]
Miura, I.; Kamakura, T.; Maeno, S.; Hayashi, S. Pestic. Biochem. Physiol., 1994, 48, 222-228.
[http://dx.doi.org/10.1006/pest.1994.1023]
[9]
Cabras, P.; Angioni, A.; Garau, V.L.; Melis, M.; Pirisi, F.M.; Minelli, E.V.; Cabitza, F.; Cubeddu, M. J. Agric. Food Chem., 1997, 45(7), 2708-2710.
[http://dx.doi.org/10.1021/jf960939x]
[10]
Agrawal, N.; Bhardwaj, A. Chem. Biol. Drug Des., 2022, 100(3), 346-363.
[http://dx.doi.org/10.1111/cbdd.14094] [PMID: 35610776]
[11]
Yadav, P.; Shah, K. Chem. Biol. Drug Des., 2022, 99(5), 758-768.
[http://dx.doi.org/10.1111/cbdd.14026] [PMID: 35152554]
[12]
Yadav, P.; Shah, K. Bioorg. Chem., 2021, 109, 104639.
[http://dx.doi.org/10.1016/j.bioorg.2021.104639] [PMID: 33618829]
[13]
Vaidya, A.; Pathak, D.; Shah, K. Chem. Biol. Drug Des., 2021, 97(3), 572-591.
[http://dx.doi.org/10.1111/cbdd.13795] [PMID: 32946168]
[14]
Waechter, F.; Weber, E.; Hertner, T.; May-Hertl, U. In: Hayes'Handbook of Pesticide Toxicology; Third Edition, 2010, pp. 1903-1913.
[15]
McQuilken, M.P.; Thomson, J. Pest Manag. Sci., 2008, 64(7), 748-754.
[http://dx.doi.org/10.1002/ps.1552] [PMID: 18286666]
[16]
Sapp, M.; Ertunç, T.; Bringmann, I.; Schäffer, A.; Schmidt, B. Pest Manag. Sci., 2004, 60(1), 65-74.
[http://dx.doi.org/10.1002/ps.787] [PMID: 14727743]
[17]
Schocken, M.J.; Mao, J.; Schabacker, D.J. J. Agric. Food Chem., 1997, 45(9), 3647-3651.
[http://dx.doi.org/10.1021/jf970298l]
[18]
Mosbach, A.; Edel, D.; Farmer, A.D.; Widdison, S.; Barchietto, T.; Dietrich, R.A.; Corran, A.; Scalliet, G. Front. Microbiol., 2017, 8, 2361.
[http://dx.doi.org/10.3389/fmicb.2017.02361] [PMID: 29250050]
[19]
Milling, R.J.; Richardson, C. J. Pestic. Sci., 1995, 45(1), 43-48.
[http://dx.doi.org/10.1002/ps.2780450107]
[20]
AboulWafa, O.M; Daabees, H.M.G.; Badawi, W.A. Bioorg. Chem., 2020, 99, 103798.
[http://dx.doi.org/10.1016/j.bioorg.2020.103798] [PMID: 32247112]
[21]
Hubele, A. Crop Prot., 1994, 13.
[22]
Kanetis, L.; Förster, H.; Jones, C.A.; Borkovich, K.A.; Adaskaveg, J.E. Phytopathology, 2008, 98(2), 205-214.
[http://dx.doi.org/10.1094/PHYTO-98-2-0205] [PMID: 18943197]
[23]
Nagata, T.; Masuda, K.; Maeno, S.; Miura, I. Pest Manag. Sci., 2004, 60(4), 399-407.
[http://dx.doi.org/10.1002/ps.828] [PMID: 15119603]
[24]
Fritz, R.; Lanen, C.; Colas, V.; Leroux, P. Pestic. Sci., 1997, 49(1), 40-46.
[http://dx.doi.org/10.1002/(SICI)1096-9063(199701)49:1<40:AID-PS470>3.0.CO;2-Y]
[25]
Paszewski, A.; Prazmo, W.; Nadolska, J.; Regulski, M. J. Gen. Microbiol., 1984, 130(5), 1113-1121.
[PMID: 6381643]
[26]
Liang, X.; Liu, X.; Dong, F.; Xu, J.; Qin, D.; Li, Y.; Tian, Y.; Zhang, Y.; Han, Y.; Zheng, Y. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess., 2013, 30(4), 713-721.
[http://dx.doi.org/10.1080/19440049.2013.768777] [PMID: 23410121]
[27]
Latorre, B.A.; Spadaro, I.; Rioja, M.E. Crop Prot., 2002, 21(10), 957-961.
[http://dx.doi.org/10.1016/S0261-2194(02)00074-1]
[28]
Ali, A.; Aster, S.D.; Graham, D.W.; Patel, G.F.; Taylor, G.E.; Tolman, R.L.; Painter, R.E.; Silver, L.L.; Young, K.; Ellsworth, K.; Geissler, W.; Harris, G.S. Bioorg. Med. Chem. Lett., 2001, 11(16), 2185-2188.
[http://dx.doi.org/10.1016/S0960-894X(01)00407-3] [PMID: 11514166]
[29]
Crombie, A.L.; Sum, F.W.; Powell, D.W.; Hopper, D.W.; Torres, N.; Berger, D.M.; Zhang, Y.; Gavriil, M.; Sadler, T.M.; Arndt, K. Bioorg. Med. Chem. Lett., 2010, 20(12), 3821-3825.
[http://dx.doi.org/10.1016/j.bmcl.2010.04.022] [PMID: 20471256]
[30]
Cumming, J.G.; McKenzie, C.L.; Bowden, S.G.; Campbell, D.; Masters, D.J.; Breed, J.; Jewsbury, P.J. Bioorg. Med. Chem. Lett., 2004, 14(21), 5389-5394.
[http://dx.doi.org/10.1016/j.bmcl.2004.08.007] [PMID: 15454232]
[31]
Han, C.; Huang, Z.; Zheng, C.; Wan, L.; Lai, Y.; Peng, S.; Ding, K.; Ji, H.; Zhang, Y. Eur. J. Med. Chem., 2013, 66, 82-90.
[http://dx.doi.org/10.1016/j.ejmech.2013.05.026] [PMID: 23792318]
[32]
Liu, M.; Wang, S.; Clampit, J.E.; Gum, R.J.; Haasch, D.L.; Rondinone, C.M.; Trevillyan, J.M.; Abad-Zapatero, C.; Fry, E.H.; Sham, H.L.; Liu, G. Bioorg. Med. Chem. Lett., 2007, 17(3), 668-672.
[http://dx.doi.org/10.1016/j.bmcl.2006.10.093] [PMID: 17107797]
[33]
Suzuki, N.; Shiota, T.; Watanabe, F.; Haga, N.; Murashi, T.; Ohara, T.; Matsuo, K.; Omori, N.; Yari, H.; Dohi, K.; Inoue, M.; Iguchi, M.; Sentou, J.; Wada, T. Bioorg. Med. Chem. Lett., 2012, 22(1), 456-460.
[http://dx.doi.org/10.1016/j.bmcl.2011.10.103] [PMID: 22101132]
[34]
Romu, A.A.; Lei, Z.; Zhou, B.; Chen, Z.S.; Korlipara, V. Bioorg. Med. Chem. Lett., 2017, 27(21), 4832-4837.
[http://dx.doi.org/10.1016/j.bmcl.2017.09.048] [PMID: 28974338]
[35]
Han, C.; Huang, Z.; Zheng, C.; Wan, L.; Zhang, L.; Peng, S.; Ding, K.; Ji, H.; Tian, J.; Zhang, Y. J. Med. Chem., 2013, 56(11), 4738-4748.
[http://dx.doi.org/10.1021/jm400463q] [PMID: 23668441]
[36]
Zhan, Z.; Ai, J.; Liu, Q.; Ji, Y.; Chen, T.; Xu, Y.; Geng, M.; Duan, W. ACS Med. Chem. Lett., 2014, 5(6), 673-678.
[http://dx.doi.org/10.1021/ml500066m] [PMID: 24944742]
[37]
Yang, J.; Chai, B.; Li, H.; Li, Z.; Liu, C. ACS Symposium Series, 2015, 1204, pp. 163-173.
[http://dx.doi.org/ 10.1021/bk-2015-1204.ch012]
[38]
Jo, J.; Kim, S.H.; Kim, H.; Jeong, M.; Kwak, J.H.; Taek Han, Y.; Jeong, J.Y.; Jung, Y.S.; Yun, H. Bioorg. Med. Chem. Lett., 2019, 29(1), 62-65.
[http://dx.doi.org/10.1016/j.bmcl.2018.11.010] [PMID: 30447889]
[39]
Han, C.; Wan, L.; Ji, H.; Ding, K.; Huang, Z.; Lai, Y.; Peng, S.; Zhang, Y. Eur. J. Med. Chem., 2014, 77, 75-83.
[http://dx.doi.org/10.1016/j.ejmech.2014.02.032] [PMID: 24607591]
[40]
Gandin, V.; Ferrarese, A.; Dalla Via, M.; Marzano, C.; Chilin, A.; Marzaro, G. Sci. Rep., 2015, 5(1), 16750.
[http://dx.doi.org/10.1038/srep16750] [PMID: 26568452]
[41]
Suzuki, N.; Shiota, T.; Watanabe, F.; Haga, N.; Murashi, T.; Ohara, T.; Matsuo, K.; Oomori, N.; Yari, H.; Dohi, K.; Inoue, M.; Iguchi, M.; Sentou, J.; Wada, T. Bioorg. Med. Chem. Lett., 2011, 21(6), 1601-1606.
[http://dx.doi.org/10.1016/j.bmcl.2011.01.119] [PMID: 21334203]
[42]
Abdulrahman, H.L.; Uzairu, A.; Uba, S. Beni. Suef Univ. J. Basic Appl. Sci., 2020, 9(1), 13.
[http://dx.doi.org/10.1186/s43088-020-00041-3]
[43]
Waly, M.A.; Bader-Eldien, E.T.; Aboudobarah, M.E.; Aboumosalam, E.S.T. Med. Chem. Res., 2013, 22(11), 5267-5273.
[http://dx.doi.org/10.1007/s00044-013-0535-2]
[44]
Liu, C.; Cui, Z.; Yan, X.; Qi, Z.; Ji, M.; Li, X. Molecules, 2016, 21(7), 828.
[http://dx.doi.org/10.3390/molecules21070828] [PMID: 27347910]
[45]
Forster, B.; Staub, T. Crop Prot., 1996, 15(6), 529-537.
[http://dx.doi.org/10.1016/0261-2194(96)00021-X]

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