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Pharmaceutical Nanotechnology

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ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

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Review Article

Targeted Approach to Enhance the Solubility of Weakly Soluble Drugs by Nanocrystal Technology

Author(s): Sangam Rana, Deepali Tomar*, Peeyush Kaushik, Prerna Sharma, Nidhi Rani* and Kumar Guarve

Volume 11, Issue 5, 2023

Published on: 08 June, 2023

Page: [425 - 432] Pages: 8

DOI: 10.2174/2211738511666230504115640

Price: $65

Abstract

About 90% of the newly discovered drugs are poorly soluble in water, to overcome this problem, nanocrystal technology is used. Nanocrystal technology is a modern technique that is specially used to increase the solubility of less soluble drugs. Production of a nanocrystal on a large scale can be done by techniques like homogenization (high-pressure), precipitation, and milling methods. Using this technique, saturation solubility, the adhesiveness of a drug molecule to the surface cell, and the dissolution velocity is enhanced. This technology is better than the traditional method because it provides certain other benefits like increased drug loading capability, fantastic reproducibility of oral retention, further developed proportionality of portion bioavailability and expanded patient compliance. This audit makes sense of the various kinds of techniques for the arrangement of nanocrystals, benefits, drawbacks, a system of solvency improvement, clinical applications, and future imminent. This review article also provides further guidelines for studies about nanocrystal technology.

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[1]
Gigliobianco M, Casadidio C, Censi R, Di Martino P. Nanocrystals of poorly soluble drugs: Drug bioavailability and physicochemical stability. Pharmaceutics 2018; 10(3): 134.
[http://dx.doi.org/10.3390/pharmaceutics10030134] [PMID: 30134537]
[2]
Bhuyan B, Rajak P, Nath L. Nanocrystal technology and drug delivery. World J Pharm Res 2014; 3: 2940-71.
[3]
Jarvis M, Krishnan V, Mitragotri S. Nanocrystals: A perspective on translational research and clinical studies. Bioeng Transl Med 2019; 4(1): 5-16.
[http://dx.doi.org/10.1002/btm2.10122] [PMID: 30680314]
[4]
Junghanns JU, Müller RH. Nanocrystal technology, drug delivery and clinical applications. Int J Nanomedicine 2008; 3(3): 295-309.
[PMID: 18990939]
[5]
Sajanlal PR, Sreeprasad TS, Samal AK, Pradeep T. Anisotropic nanomaterials: Structure, growth, assembly, and functions. Nano Rev 2011; 2(1): 5883.
[http://dx.doi.org/10.3402/nano.v2i0.5883] [PMID: 22110867]
[6]
Available from: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/nanocrystal
[7]
Joshi K, Chandra A, Jain K, Talegaonkar S. Nanocrystalization: An emerging technology to enhance the bioavailability of poorly soluble drugs. Pharm Nanotechnol 2019; 7(4): 259-78.
[http://dx.doi.org/10.2174/2211738507666190405182524] [PMID: 30961518]
[8]
Junyaprasert VB, Morakul B. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian J Pharm Sci 2015; 10(1): 13-23.
[9]
Gao L, Liu G, Ma J, et al. Application of drug nanocrystal technologies on oral drug delivery of poorly soluble drugs. Pharm Res 2013; 30(2): 307-24.
[http://dx.doi.org/10.1007/s11095-012-0889-z] [PMID: 23073665]
[10]
Zhou Y, Du J, Wang L, Wang Y. Nanocrystals technology for improving bioavailability of poorly soluble drugs: A mini-review. J Nanosci Nanotechnol 2017; 17(1): 18-28.
[http://dx.doi.org/10.1166/jnn.2017.13108] [PMID: 29616786]
[11]
Shah R, Eldridge D, Palombo E, Harding I. Optimisation and stability assessment of solid lipid nanoparticles using particle size and zeta potential. J Physiol Sci 2014; 25(1): 59-75.
[12]
Mourdikoudis S, Pallares RM, Thanh NTK. Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties. Nanoscale 2018; 10(27): 12871-934.
[http://dx.doi.org/10.1039/C8NR02278J] [PMID: 29926865]
[13]
Gülsün T, Gürsoy RN, Öner L. Nanocrystal technology for oral delivery of poorly water-soluble drugs. Fabad J Pharm Sci 2009; 34(1): 55.
[14]
Shankar SJ. A review on the role of nanocrystals and nanosuspensions in drug delivery systems. Int J Appl Pharm 2020; 12(1): 10-6.
[15]
Salazar J, Müller RH, Möschwitzer JP. Combinative particle size reduction technologies for the production of drug nanocrystals. J Pharm 2014; 2014: 1-14.
[http://dx.doi.org/10.1155/2014/265754] [PMID: 26556191]
[16]
de Waard H, Frijlink HW, Hinrichs WLJ. Bottom-up preparation techniques for nanocrystals of lipophilic drugs. Pharm Res 2011; 28(5): 1220-3.
[http://dx.doi.org/10.1007/s11095-010-0323-3] [PMID: 21086152]
[17]
Sinha B, Müller RH, Möschwitzer JP. Bottom-up approaches for preparing drug nanocrystals: Formulations and factors affecting particle size. Int J Pharm 2013; 453(1): 126-41.
[http://dx.doi.org/10.1016/j.ijpharm.2013.01.019] [PMID: 23333709]
[18]
Mu RH. Manufacturing of nanoparticles by milling and homogenization techniques. In: Nanoparticle technology for drug delivery. (1st edition.). Boca Raton Florida: CRC Press 2006; pp. 45-76.
[19]
Moribe K, Ueda K, Limwikrant W, Higashi K, Yamamoto K. Nano-sized crystalline drug production by milling technology. Curr Pharm Des 2013; 19(35): 6246-58.
[http://dx.doi.org/10.2174/1381612811319350003] [PMID: 23470002]
[20]
Sharma OP, Patel V. Nanocrystal for ocular drug delivery: Hope or hype. Drug Deliv Transl Res 2016; 6(4): 399-413.
[21]
Abid N, Khan AM, Shujait S, et al. Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: A review. Adv Colloid Interface Sci 2022; 300: 102597.
[http://dx.doi.org/10.1016/j.cis.2021.102597] [PMID: 34979471]
[22]
Singh JP, Kumar M, Sharma A, Pandey G, Chae KH, Lee S. Bottom-up and top-down approaches for MgO. In: Sonochemical Reactions. London, UK: IntechOpen 2020; p. 91182.
[23]
Hoshyar N, Gray S, Han H, Bao G. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction. Nanomedicine 2016; 11(6): 673-92.
[http://dx.doi.org/10.2217/nnm.16.5] [PMID: 27003448]
[24]
Longmire M, Choyke PL, Kobayashi H. Clearance properties of nano-sized particles and molecules as imaging agents: Considerations and caveats. Nanomedicine 2008; 3(5): 703-17.
[http://dx.doi.org/10.2217/17435889.3.5.703]
[25]
Malamatari M, Taylor KM, Malamataris S, Douroumis D. Pharmaceutical nanocrystals: Production by wet milling and applications. Drug Discov Today 2018; 23(3): 534-47.
[26]
Bansal S, Bansal M. Nanocrystals: Current strategies and trends. Int j res pharm. Biomed Res 2012; 3(1): 407-19.
[27]
Nagarwal C, Kumar R, Dhanawat R, Das M, Pandit NK, Cdd JJ. Nanocrystal technology in the delivery of poorly soluble drugs: An overview. Curr Drug Deliv 2011; 8(4): 398-406.
[http://dx.doi.org/10.2174/156720111795767988]
[28]
Pawar VK, Singh Y, Meher JG, Gupta S, Chourasia MKJ, Jo CR. Engineered nanocrystal technology: In-vivo fate, targeting and applications in drug delivery. J Control Release 2014; 183: 51-66.
[http://dx.doi.org/10.1016/j.jconrel.2014.03.030]
[29]
Sawant SV, Kadam D, Jadhav D, Sankpal S. Drug nanocrystals: Novel technique for delivery of poorly soluble drugs. Int J Sci Innov Dis 2011; 1(3): 1-15.

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