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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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General Review Article

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review

Author(s): Sahar Golpour Hamedani, Makan Pourmasoumi, Gholamreza Askari*, Mohammad Bagherniya, Thozhukat Sathyapalan and Amirhossein Sahebkar*

Volume 31, Issue 20, 2024

Published on: 22 June, 2023

Page: [2944 - 2954] Pages: 11

DOI: 10.2174/0929867330666230413093409

Price: $65

Abstract

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs.

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