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Current Drug Targets

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ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

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Mini-Review Article

Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle

Author(s): Saumya Kapoor, Deep Rohan Chatterjee, Moumita Ghosh Chowdhury, Rudradip Das and Amit Shard*

Volume 24, Issue 6, 2023

Published on: 02 May, 2023

Page: [464 - 483] Pages: 20

DOI: 10.2174/1389450124666230330103126

Price: $65

Abstract

Pyruvate kinase M2 (PKM2) has surfaced as a potential target for anti-cancer therapy. PKM2 is known to be overexpressed in the tumor cells and is a critical metabolic conduit in supplying the augmented bioenergetic demands of the recalcitrant cancer cells. The presence of PKM2 in structurally diverse tetrameric as well as dimeric forms has opened new avenues to design novel modulators. It is also a truism to state that drug discovery has advanced significantly from various computational techniques like molecular docking, virtual screening, molecular dynamics, and pharmacophore mapping. The present review focuses on the role of computational tools in exploring novel modulators of PKM2. The structural features of various isoforms of PKM2 have been discussed along with reported modulators. An extensive analysis of the structure-based and ligand- based in silico methods aimed at PKM2 modulation has been conducted with an in-depth review of the literature. The role of advanced tools like QSAR and quantum mechanics has been established with a brief discussion of future perspectives.

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