Multiple Natural Polymers in Drug and Gene Delivery Systems

Zhengfa      Jiang; Zongmian      Song; Chen      Cao; Miaoheng      Yan; Zhendong      Liu; Xingbo      Cheng; Hongbo      Wang; Qingnan      Wang; Hongjian      Liu; Songfeng      Chen
doi:10.2174/0929867330666230316094540
Abstract

Natural polymers are organic compounds produced by living organisms. In nature, they exist in three main forms, including proteins, polysaccharides, and nucleic acids. In recent years, with the continuous research on drug and gene delivery systems, scholars have found that natural polymers have promising applications in drug and gene delivery systems due to their excellent properties such as biocompatibility, biodegradability, low immunogenicity, and easy modification. However, since the structure, physicochemical properties, pharmacological properties and biological characteristics of biopolymer molecules have not yet been entirely understood, further studies are required before large-scale clinical application. This review focuses on recent advances in the representative natural polymers such as proteins (albumin, collagen, elastin), polysaccharides (chitosan, alginate, cellulose) and nucleic acids. We introduce the characteristics of various types of natural polymers, and further outline the characterization methods and delivery forms of these natural polymers. Finally, we discuss possible challenges for natural polymers in subsequent experimental studies and clinical applications. It provides an important strategy for the clinical application of natural polymers in drug and gene delivery systems.
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DOI https://dx.doi.org/10.2174/0929867330666230316094540	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

Multiple Natural Polymers in Drug and Gene Delivery Systems

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