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Current Drug Safety

Editor-in-Chief

ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Research Article

Cutaneous Adverse Drug Reactions: Regional Experience of a Global Challenge

Author(s): Behzad Bushehri, Akbar Mokhtarpoor, Ehsan Bahrami and Adel Ghorani-Azam*

Volume 19, Issue 1, 2024

Published on: 10 April, 2023

Page: [117 - 122] Pages: 6

DOI: 10.2174/1574886318666230303085538

Price: $65

Abstract

Background: Adverse drug reactions (ADR) are considered any harmful and unintended side effects associated with the use of a drug at the usual therapeutic dose, in which skin is involved in most cases. Therefore, the availability of epidemiological information on reactions, reaction patterns, and their causative drugs can be helpful in timely diagnosis and necessary measures, such as caution in prescribing causative drugs to prevent these types of reactions.

Methods: In this retrospective descriptive study, the archived files of patients with dermatoses due to ADR referred to Taleghani University Hospital, Urmia, Iran, during 2015-2020 were studied. Patterns and frequency of skin reactions, demographic data, and the frequency of chronic comorbidities were identified.

Results: A total of 50 patients with drug-induced skin rash were found, of which 14 were male (28%) and 36 were female (72%). Skin rashes were most frequently found in patients aged 31-40 years. In 76% of patients, there was at least one chronic underlying disease. The most common reaction pattern was maculopapular rash (44%), and the most common causative drugs were antiepileptic drugs (34%) and antibiotics (22%). Mortality was found in 4 cases, which was due to antibiotics and antiepileptic drugs that caused toxic SJS/TEN and erythroderma. The hospital stays were highest in SJS and lowest in a maculopapular rash.

Conclusion: Knowledge about the epidemiology and the frequency of adverse drug reactions may be helpful in increasing the awareness of physicians for correct and rational drug prescriptions, which can reduce unnecessary hospital referrals and treatment costs.

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[1]
Mustafa SS, Ostrov D, Yerly D. Severe cutaneous adverse drug reactions: Presentation, risk factors, and management. Curr Allergy Asthma Rep 2018; 18(4): 26.
[http://dx.doi.org/10.1007/s11882-018-0778-6] [PMID: 29574562]
[2]
Ferner RE. Adverse drug reactions in dermatology. Clin Exp Dermatol 2015; 40(2): 105-10.
[http://dx.doi.org/10.1111/ced.12572] [PMID: 25622648]
[3]
Gerogianni K, Tsezou A, Dimas K. Drug-induced skin adverse reactions: The role of pharmacogenomics in their prevention. Mol Diagn Ther 2018; 22(3): 297-314.
[http://dx.doi.org/10.1007/s40291-018-0330-3] [PMID: 29564734]
[4]
a) Farshchian M, Ansar A, Zamanian A, Rahmatpour-Rokni G, Kimyai-Asadi A, Farshchian M. Drug-induced skin reactions: A 2-year study. Clin Cosmet Investig Dermatol 2015; 8: 53-6.
[PMID: 25709487];
b) Szatkowski J, Schwartz RA. Acute generalized exanthematous pustulosis (AGEP): A review and update. J Am Acad Dermatol 2015; 73(5): 843-8.
[http://dx.doi.org/10.1016/j.jaad.2015.07.017] [PMID: 26354880]
[5]
Hoetzenecker W, Nägeli M, Mehra ET, et al. Adverse cutaneous drug eruptions: Current understanding. Semin Immunopathol 2016; 38(1): 75-86.
[http://dx.doi.org/10.1007/s00281-015-0540-2] [PMID: 26553194]
[6]
Tuchinda P, Chularojanamontri L, Sukakul T, et al. Cutaneous adverse drug reactions in the elderly: A retrospective analysis in Thailand. Drugs Aging 2014; 31(11): 815-24.
[http://dx.doi.org/10.1007/s40266-014-0209-x] [PMID: 25193784]
[7]
a) Alomar MJ. Factors affecting the development of adverse drug reactions (Review article). Saudi Pharm J 2014; 22(2): 83-94.
[http://dx.doi.org/10.1016/j.jsps.2013.02.003] [PMID: 24648818];
b) Ghorani-Azam A, Balali-Mood M, Riahi-Zanjani B, Darchini-Maragheh E, Sadeghi M. Acute phenobarbital poisoning for the management of seizures in newborns and children; A systematic literature review. CNS Neurol Disord Drug Targets 2021; 20(2): 174-80.
[http://dx.doi.org/10.2174/1871527319666201207205916] [PMID: 33290203]
[8]
Riahi-Zanjani B, Delirrad M, Fazeli-Bakhtiyari R, et al. Hematological consequences of valproic acid in pediatric patients: A systematic review with a mechanistic approach. CNS Neurol Disord Drug Targets 2022; 21(4): 316-25.
[http://dx.doi.org/10.2174/1871527320666210811162345] [PMID: 34382515]
[9]
White RW, Wang S, Pant A, et al. Early identification of adverse drug reactions from search log data. J Biomed Inform 2016; 59: 42-8.
[http://dx.doi.org/10.1016/j.jbi.2015.11.005] [PMID: 26610385]
[10]
Rademaker M, Oakley A, Duffill MB. Cutaneous adverse drug reactions in a hospital setting. J Eur Acad Dermatol Venereol 1995; 5(1): S166.
[http://dx.doi.org/10.1016/0926-9959(95)96455-H] [PMID: 7753511]
[11]
Chopra D, Sharma V, Kapoor R, Dwivedi S. An observational study of cutaneous adverse drug reactions in a teaching hospital. Int J Clin Pharm 2015; 37(6): 996-9.
[http://dx.doi.org/10.1007/s11096-015-0161-9] [PMID: 26238222]
[12]
Zhao J, Hu L, Zhang L, Zhou M, Gao L, Cheng L. Causative drugs for drug-induced cutaneous reactions in central China: A 608-case analysis. An Bras Dermatol 2019; 94(6): 664-70.
[http://dx.doi.org/10.1016/j.abd.2019.01.007] [PMID: 31789251]
[13]
Büyüköztürk S, Kekik Ç, Gökyiğit AZ, et al. Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population. Eur Ann Allergy Clin Immunol 2018; 50(1): 36-41.
[http://dx.doi.org/10.23822/EurAnnACI.1764-1489.23] [PMID: 29350020]
[14]
Latha S, Choon SE. Incidence of cutaneous adverse drug reactions among medical inpatients of Sultanah Aminah Hospital Johor Bahru. Med J Malaysia 2017; 72(3): 151-6.
[PMID: 28733562]
[15]
Bhattacharya S. The facts about penicillin allergy: A review. J Adv Pharm Technol Res 2010; 1(1): 11-7.
[PMID: 22247826]
[16]
a) Careta MF, Delgado L, Patriota R. Report of allergic reaction after application of botulinum toxin. Aesthet Surg J 2015; 35(5): NP102-5.
[http://dx.doi.org/10.1093/asj/sju105] [PMID: 26063836];
b) Rosenfield LK, Kardassakis DG, Tsia KA, Stayner G. The first case report of a systemic allergy to on a botulinum toxina (botox) in a healthy patient. Aesthet Surg J 2014; 34(5): 766-8.
[http://dx.doi.org/10.1177/1090820X14532648] [PMID: 24847156]
[17]
Modi A, Desai M, Shah S, Shah B. Analysis of cutaneous adverse drug reactions reported at the regional ADR monitoring center. Indian J Dermatol 2019; 64(3): 250.
[http://dx.doi.org/10.4103/ijd.IJD_682_16] [PMID: 31148872]
[18]
Patel T, Thakkar S, Sharma DC. Cutaneous adverse drug reactions in Indian population: A systematic review. Indian Dermatol Online J 2014; 5(6)(Suppl 2): 76.
[http://dx.doi.org/10.4103/2229-5178.146165] [PMID: 25593813]

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