Login Register Cart 0
Generic placeholder image

Current Chemical Biology

Editor-in-Chief

ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

Medicinal, Pharmacological and Biochemical Progress on the Study of Genus Helianthemum: A Review

Author(s): Soumia Mouffouk*, Chaima Mouffouk, Sara Mouffouk and Hamada Haba

Volume 17, Issue 3, 2023

Published on: 29 March, 2023

Page: [147 - 159] Pages: 13

DOI: 10.2174/2212796817666230227112835

Price: $65

Abstract

The genus Helianthemum from the Cistaceae family includes about 110 plants, which are well known for their wide therapeutic uses and interesting pharmacological activities. To the best of our knowledge, there are no previous comprehensive and critical reviews on the therapeutic applications, chemical composition, and biological properties of this genus. In this context, the present paper describes a systematic mini-review on the traditional use, phytochemical composition, and pharmacological properties of species belonging to the genus Helianthemum. For this, more than 75 papers covering the period from 1970 to 2022 were collected and analyzed to achieve this review. From 110 species of the genus Helianthemum, only 22 species were studied. Helianthemum species are widely used in folk medicine for the treatment of respiratory, hepatic, renal, psychiatric, and inflammatory diseases. According to the collected information, species from this genus have several pharmacological properties linked to their rich chemical composition, particularly in phenolic compounds and flavonoids. In fact, Helianthemum plants have antioxidant, antimicrobial, anti-inflammatory, analgesic, antidiabetic, insecticide, anticancer, antiulcer, larvicide, chemo, and hepatoprotective activities, justifying their various uses in traditional medicine. Despite the intense use of Helianthemum species in traditional human and veterinary medicine, few studies were conducted on the phytochemical composition and pharmacological activities of the plants constituting this genus. In fact, until now, the emphasis has only been on twenty-two species and the work carried out was not explanatory, especially for certain species. So it will be interesting to broaden the spectrum of the tested biological activities, especially for endemic species in order to understand the possible modes of action and to confirm the toxicity of certain species.

Next »
Graphical Abstract

[1]
Jamshidi-Kia, F.; Lorigooini, Z.; Amini-Khoei, H. Medicinal plants: Past history and future perspective. J. Herbmed. Pharmacol, 2018, 7(1), 1-7.
[http://dx.doi.org/10.15171/jhp.2018.01]
[2]
Shakya, A.K. Medicinal plants: Future source of new drugs. Int. J. Herb. Med., 2016, 4(4), 59-64.
[3]
Mabberley, DJ The plant-book: A portable dictionary of the vascular plants.Mabberley Cambridge university press: New York, NY, 1997, 858, 10011-4211.
[4]
Raynaud, C. Contribution to the study of certain species of the genus “Helianthemum” sect.” Helianthemum”: preliminary note. An. Jardin Bot Mad., 1984, 41(2), 303-311.
[5]
Quézel, P; Santa, S. New flora of Algeria and southern desert regions. Centre National de la recherche scientifique: Paris,France, , 1962, 1962-1170.
[6]
Sánchez-Gómez, P.; Jiménez, J.F.; Vera, J.B. Helianthemum motae (Cistaceae), a new species from southeastern Spain. Ann. Bot. Fenn., 2011, 48(1), 49-56.
[http://dx.doi.org/10.5735/085.048.0107]
[7]
Wafa, N.; Sofiane, G. In vitro antioxidant and anti-inflammatory activities valorisation of tannin crude extract of helianthemum helian-themoïdes (desf.) grosser. J. Drug Deliv. Ther., 2020, 10(1-s), 135-139.
[http://dx.doi.org/10.22270/jddt.v10i1-s.3884]
[8]
Djemam, N.; Lassed, S.; Gül, F.; Altun, M.; Monteiro, M.; Menezes-Pinto, D.; Benayache, S.; Benayache, F.; Zama, D.; Demirtas, I.; Morato, M. Characterization of ethyl acetate and n-butanol extracts of Cymbopogon schoenanthus and Helianthemum lippii and their ef-fect on the smooth muscle of the rat distal colon. J. Ethnopharmacol., 2020, 252, 112613.
[http://dx.doi.org/10.1016/j.jep.2020.112613] [PMID: 31981748]
[9]
Djebbari, R.; Zama, D. The protective effect of plant extracts Helianthemum confertum and Helianthemum ruficomum against the toxicity induced by Doxorubicin., PhD dissertation. University of Constantine, 2017.
[10]
Baldemir, A.; Gökşen, N.; Ildız, N.; Karatoprak, G.Ş.; Koşar, M. phytochemical profile and biological activities of Helianthemum canum l. baumg. from Turkey. Chem. Biodivers., 2017, 14(7), e1700052.
[http://dx.doi.org/10.1002/cbdv.201700052] [PMID: 28306206]
[11]
Alsabri, S.G.; Rmeli, N.B.; Zetrini, A.A.; Mohamed, S.B.; Meshri, M.I.; Aburas, K.M. Phytochemical, anti-oxidant, anti-microbial, anti-inflammatory and anti-ulcer properties of Helianthemum lippii. J. Pharmacogn. Phytochem., 2013, 2(2), 86-96.
[12]
Bensaber, S.M.; Mrema, I.A.; Jaeda, M.I.; Gbaj, A.M. Cytotoxic activity of Helianthemum lippii. Libyan J Med Res., 2014, 8, 92-94.
[13]
Hamza, N.; Berke, B.; Umar, A.; Cheze, C.; Gin, H.; Moore, N. A review of Algerian medicinal plants used in the treatment of diabetes. J. Ethnopharmacol., 2019, 238, 111841.
[http://dx.doi.org/10.1016/j.jep.2019.111841] [PMID: 30959140]
[14]
Lakhdari, W.; Dehliz, A.; Acheuk, F.; Mlik, R.; Hammi, H.; Doumandji-Mitiche, B. Ethnobotanical study of some plants used in tradi-tional medicine in the region of Oued Righ (Algerian Sahara). J Med Plants Stud., 2016, 4(2), 204-211.
[15]
Sher, H.; Aldosari, A. Ethnobotanical survey on plants of veterinary importance around Al-Riyadh (Saudi Arabia). Afr. J. Pharm. Pharmacol., 2013, 7(21), 1404-1410.
[http://dx.doi.org/10.5897/AJPP2012.2177]
[16]
Volpato, G.; Puri, R.K. Dormancy and revitalization: The fate of ethnobotanical knowledge of camel forage among Sahrawi nomads and refugees of Western Sahara. Ethnobot. Res. Appl., 2014, 12, 183-210.
[http://dx.doi.org/10.17348/era.12.0.183-210]
[17]
El Rhaffari, L.; Zaid, A. Practice of phytotherapy in the south-east of Morocco (Tafilalet): Empirical knowledge for a renovated pharma-copoeia. Sour. Know. Med. Fut., 2002, 1, 293-318.
[18]
Barbosa, E.; Calzada, F.; Campos, R. Antigiardial activity of methanolic extracts from Helianthemum glomeratum Lag. and Rubus coriifo-lius Focke in suckling mice CD-1. J. Ethnopharmacol., 2006, 108(3), 395-397.
[http://dx.doi.org/10.1016/j.jep.2006.05.026] [PMID: 16824716]
[19]
Calzada, F.; Alanís, A.D. Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum. Phytother. Res., 2007, 21(1), 78-80.
[http://dx.doi.org/10.1002/ptr.2031] [PMID: 17094176]
[20]
Meckes, M.; Calzada, F.; Tapia-Contreras, A.; Cedillo-Rivera, R. Antiprotozoal properties of Helianthemum glomeratum. Phytother. Res., 1999, 13(2), 102-105.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199903)13:2<102:AID-PTR408>3.0.CO;2-#] [PMID: 10190180]
[21]
Meckes, M.; Torres, J.; Calzada, F.; Rivera, J.; Camorlinga, M.; Lemus, H.; Rodríguez, G. Antibacterial properties of Helianthemum glomeratum, a plant used in Maya traditional medicine to treat diarrhoea. Phytother. Res., 1997, 11(2), 128-131.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199703)11:2<128:AID-PTR55>3.0.CO;2-N]
[22]
Benítez, G.; González-Tejero, M.R.; Molero-Mesa, J. Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): Ethnopharmacological synthesis. J. Ethnopharmacol., 2010, 129(1), 87-105.
[http://dx.doi.org/10.1016/j.jep.2010.02.016] [PMID: 20226847]
[23]
Rubio-Moraga, Á.; Argandoña, J.; Mota, B.; Pérez, J.; Verde, A.; Fajardo, J.; Gómez-Navarro, J.; Castillo-López, R.; Ahrazem, O.; Gómez-Gómez, L. Screening for polyphenols, antioxidant and antimicrobial activitiesof extracts from eleven Helianthemum taxa (Cista-ceae) used in folk medicine in south-eastern Spain. J. Ethnopharmacol., 2013, 148(1), 287-296.
[http://dx.doi.org/10.1016/j.jep.2013.04.028] [PMID: 23615124]
[24]
Palici, I.F.; Liktor-Busa, E.; Zupkó, I.; Touzard, B.; Chaieb, M.; Urbán, E.; Hohmann, J. Study of in vitro antimicrobial and antiprolifera-tive activities of selected Saharan plants. Acta Biol. Hung., 2015, 66(4), 385-394.
[http://dx.doi.org/10.1556/018.66.2015.4.3] [PMID: 26616371]
[25]
Pirvu, L.; Nicu, I. Polyphenols content, antioxidant and antimicrobial activity of ethanol extracts from the aerial part of Rock Rose (Heli-anthemum nummularium) species. J. Agric. Sci. Technol. A, 2017, 7, 61-67.
[26]
Kujawska, M.; Klepacki, P.; Łuczaj, Ł. Fischer’s Plants in folk beliefs and customs: a previously unknown contribution to the ethnobot-any of the Polish-Lithuanian-Belarusian borderland. J. Ethnobiol. Ethnomed., 2017, 13(1), 20.
[http://dx.doi.org/10.1186/s13002-017-0149-8] [PMID: 28335791]
[27]
Fajardo, J.; Verde, A.; Rivera, D.; Obón, C. Plants in the popular culture of the province of Albacete. Serie I--Estudios; Institute of Alba-cete Studies “Don Juan Manuel” of the Hon; Albacete Provincial Council, 2000, pp. 1-264.
[28]
Verde, A; de Castro, O; Rivera Nuñez, D. Etnobotánica en las sierras de Segura y Alcaraz. Instituto de estudios albacetenses de la Excma. Diputación de Albacete,, 1998, 343-347.
[29]
Fernández Ocaña, A.M. Estudio etnobotánico en el Parque Natural de las Sierras de Cazorla, Segura y Las Villas. Investigación química de un grupo de especies interesantes. Doctoral thesis. University of Jaen, Jaen. 2000.
[30]
Pardo de Santayana, M.; Blanco, E.; Morales, R. Plants known as té in Spain: An ethno-pharmaco-botanical review. J. Ethnopharmacol., 2005, 98(1-2), 1-19.
[http://dx.doi.org/10.1016/j.jep.2004.11.003] [PMID: 15763359]
[31]
Rigat, M.; Bonet, M.À.; Garcia, S.; Garnatje, T.; Vallès, J. Studies on pharmaceutical ethnobotany in the high river Ter valley (Pyrenees, Catalonia, Iberian Peninsula). J. Ethnopharmacol., 2007, 113(2), 267-277.
[http://dx.doi.org/10.1016/j.jep.2007.06.004] [PMID: 17656056]
[32]
Alzetrini, A.A.; Mohamed, S.A.; Alsabri, S.J.; Elkilany, A.A.; Sherif, F.M.; Gbaj, A.M. Helianthemum virgatum has analgesiclike effect in mice. Libyan J Med Res, 2009, 5(2), 1-3.
[33]
Díez, J.; Manjón, J.L.; Martin, F. Molecular phylogeny of the mycorrhizal desert truffles (Terfezia and Tirmania), host specificity and edaphic tolerance. Mycologia, 2002, 94(2), 247-259.
[http://dx.doi.org/10.1080/15572536.2003.11833230] [PMID: 21156494]
[34]
Amina, H.; Maher, G.; Neffati, M. Micropropagation of Helianthemum lippii L. var Sessiliforuim (Cistaceae) an important pastoral plant of North African arid areas. Afr. J. Biotechnol., 2013, 12(46), 6468-6473.
[http://dx.doi.org/10.5897/AJB2013.12023]
[35]
Le Floc’h, E. Contribution to an ethnobotanical study of the Tunisian flora; Ministry of Higher Education and Scientific Research, 1983.
[36]
Durand, M. Une ostéopathie atrophique chez le chameau: le kraff. Bull Acad Vét., 1958, 31, 159-160.
[37]
Bellakhdar, J.; La, P.; Marocaine, T. Ancient Arab medicine and popular knowledge. The Traditional Pharmacopoeia; Ibis Press: Paris, France, 1997.
[38]
Benhammou, N. Antioxidant activity of extracts of phenolic compounds from ten medicinal plants from western and southwestern Alge-ria. PHD dissertation. University of Tlemcen, 2012.
[39]
Alsabri, S.G.; Zetrini, A.E.; Ermeli, N.B.; Mohamed, S.B.; Bensaber, S.M.; Hermann, A. Study of eight medicinal plants for antioxidant activities. J. Chem. Pharm. Res., 2012, 4(8), 4028-4031.
[40]
Atef, C.; Anouar, F.; El-Hadda, A.; Azzedine, C. Phytochemicals study, antioxidant and antimicrobial activities of Helianthemum lippii (L.) pers. in different stages of growth (somatic, flowering and fruiting). World J. Pharm. Pharm. Sci., 2015, 4, 338-349.
[41]
Mohammed, F.S.; Kına, E.; Sevindik, M.; Doğan, M.; Pehlivan, M. Antioxidant and antimicrobial activities of ethanol extract of Helian-themum salicifolium (Cistaceae). Indian J. Nat. Prod. Resour., 2021, 12(3), 459-462.
[42]
Lai̇b, I.; Djahra, A.B. Phytochemical investigation of Helianthemum lippii l. aerial Dum.Cours part and evaluation for its antioxidant activities. Int. J. Second. Metabol., 2022, 9(2), 229-237.
[http://dx.doi.org/10.21448/ijsm.999518]
[43]
Sassi, A.B.; Harzallah-Skhiri, F.; Aouni, M. Investigation of some medicinal plants from Tunisia for antimicrobial activities. Pharm. Biol., 2007, 45(5), 421-428.
[http://dx.doi.org/10.1080/13880200701215406]
[44]
Benabdelaziz, I.; Marcourt, L.; Benkhaled, M.; Wolfender, J.L.; Haba, H. Antioxidant and antibacterial activities and polyphenolic con-stituents of Helianthemum sessiliflorum Pers. Nat. Prod. Res., 2017, 31(6), 686-690.
[http://dx.doi.org/10.1080/14786419.2016.1209669] [PMID: 27417554]
[45]
Plescia, F.; Venturella, F.; D’Anneo, A.; Catania, V.; Gargano, M.L.; Polito, G. Phytochemical-rich extracts of Helianthemum lippii possess antimicrobial, anticancer, and anti-biofilm activities. Plant Biosyst., 2022, 3, 1-11.
[http://dx.doi.org/10.1080/11263504.2022.2048274]
[46]
Badria, F.A.; Hetta, M.H.; Sarhan, R.M.; Ezz El-Din, M.H. Lethal effects of Helianthemum lippii (L.) on Acanthamoeba castellanii cysts in vitro. Korean J. Parasitol., 2014, 52(3), 243-249.
[http://dx.doi.org/10.3347/kjp.2014.52.3.243] [PMID: 25031463]
[47]
Corradi, E.; Abbet, C.; Gafner, F.; Hamburger, M.; Potterat, O. Screening of alpine plant extracts as protective agents against UV-induced skin damage. Planta Med., 2013, 79(13), PC3.
[http://dx.doi.org/10.1055/s-0033-1351997]
[48]
Hininger-Favier, I.; Marcourt, L.; Boucherle, B.; Agostini, M.; Gao, B.; Hybertson, B.M.; Bose, S.K.; McCord, J.M.; Millery, A.; Rome, M.; Ferreira Queiroz, E.; Wolfender, J.L.; Gallet, C.; Boumendjel, A. Phytochemical and biological investigation of Helianthemum num-mularium, a high-altitude growing alpine plant overrepresented in ungulates diets. Planta Med., 2020, 86(16), 1185-1190.
[http://dx.doi.org/10.1055/a-1197-2898] [PMID: 32645735]
[49]
Ben Jannet, H. H-Skhiri, F.; Mighri, Z.; Simmonds, M.S.J.; Blaney, W.M. Antifeedant activity of plant extracts and of new natural di-glyceride compounds isolated from Ajuga pseudoiva leaves against Spodoptera littoralis larvae. Ind. Crops Prod., 2001, 14(3), 213-222.
[http://dx.doi.org/10.1016/S0926-6690(01)00086-3]
[50]
Bouzergoune, F.; Bitam, F.; Aberkane, M.C.; Mosset, P.; Fetha, M.N.H.; Boudjar, H.; Aberkane, A. Preliminary phytochemical and anti-microbial activity investigations on the aerial parts of Helianthemum kahiricum. Chem. Nat. Compd., 2013, 49(4), 751-752.
[http://dx.doi.org/10.1007/s10600-013-0729-3]
[51]
Alsabri, S.G.; Ebsaim, M.A.; Mohamed, S.S.; Omer, N.H.; Ghnan, N.S.; Edawdi, S.A. Antiulcer property of Libyan Helianthemum ka-hiricum plant. J. Pharmacogn. Phytochem., 2014, 2(5), 80-84.
[52]
Djeridane, A.; Hamdi, A.; Bensania, W.; Cheifa, K.; Lakhdari, I.; Yousfi, M. The in vitro evaluation of antioxidative activity, α-glucosidase and α-amylase enzyme inhibitory of natural phenolic extracts. Diabetes Metab. Syndr., 2015, 9(4), 324-331.
[http://dx.doi.org/10.1016/j.dsx.2013.10.007] [PMID: 25470628]
[53]
Terfassi, S.; Dauvergne, X.; Cérantola, S.; Lemoine, C.; Bensouici, C.; Fadila, B. First report on phytochemical investigation, antioxidant and antidiabetic activities of Helianthemum getulum. Nat. Prod. Res., 2022, 36(11), 2806-2813.
[PMID: 34044679]
[54]
Calzada, F.; Alanis, A.D.; Meckes, M.; Tapia-Contreras, A.; Cedillo-Rivera, R. in vitro susceptibility of Entamoeba histolytica and Giar-dia lamblia to some medicinal plants used by the people of Southern Mexico. Phytother. Res., 1998, 12(1), 70-72.
[http://dx.doi.org/10.1002/(SICI)1099-1573(19980201)12:1<70:AID-PTR189>3.0.CO;2-V]
[55]
Meckes, M.; Villarreal, M.L.; Tortoriello, J.; Berlin, B.; Berlin, E.A. A microbiological evaluation of medicinal plants used by the Maya people of Southern Mexico. Phytother. Res., 1995, 9(4), 244-250.
[http://dx.doi.org/10.1002/ptr.2650090403]
[56]
Meckes, M.; David-Rivera, A.D.; Nava-Aguilar, V.; Jimenez, A. Activity of some Mexican medicinal plant extracts on carrageenan-induced rat paw edema. Phytomedicine, 2004, 11(5), 446-451.
[http://dx.doi.org/10.1016/j.phymed.2003.06.002] [PMID: 15330501]
[57]
Chemam, Y.; Benayache, S.; Marchioni, E.; Zhao, M.; Mosset, P.; Benayache, F. On-line screening, isolation and identification of antiox-idant compounds of Helianthemum ruficomum. Molecules, 2017, 22(2), 239.
[http://dx.doi.org/10.3390/molecules22020239] [PMID: 28208718]
[58]
Djebbari, R.; Chemam, Y.; Amrani, A.; Lassed, S.; Boubekri, N.B.; Zama, D. in vitro antioxidant activities of n-butanol extract of Helian-themum confertum. Int. J. Phytomed., 2015, 7(1), 119-122.
[59]
Pascual-Villalobos, M.J.; Robledo, A. Anti-insect activity of plant extracts from the wild flora in southeastern Spain. Biochem. Syst. Ecol., 1999, 27(1), 1-10.
[http://dx.doi.org/10.1016/S0305-1978(98)00051-9]
[60]
Tian, L.; Yang, J.; Liu, Q.; Gao, W.F. On fungistasis of the extracts from Helianthemum ordosicum for pathogenic germs of plants; J Tianjin Normal Univ., 2007, p. 1.
[61]
Tian, L.; Liu, Q. Nematicidal activity of extracts of Helianthemum ordosicum against Bursaphelenchus xylophilus. Guangxi Zhi Wu, 2008, (6), 32.
[62]
Yang, W.S.; Tian, L.; Liu, Q. Toxicity of the extract from helianthemum ordosicum against plutella xylostella; J Inner Mong Norm Univ., 2007, p. 2.
[63]
Sokmen, A.; Jones, B.M.; Erturk, M. The in vitro antibacterial activity of Turkish medicinal plants. J. Ethnopharmacol., 1999, 67(1), 79-86.
[http://dx.doi.org/10.1016/S0378-8741(98)00189-5] [PMID: 10616963]
[64]
Tawaha, K.; Alali, F.; Gharaibeh, M.; Mohammad, M.; Elelimat, T. Antioxidant activity and total phenolic content of selected Jordanian plant species. Food Chem., 2007, 104(4), 1372-1378.
[http://dx.doi.org/10.1016/j.foodchem.2007.01.064]
[65]
Hudaib, M.; Mohammad, M.K.; Issa, A.Y.; Aburjai, T.A.; Bustanji, Y.K.; Tawaha, K.A.; Assaf, A.M.; Alali, F.Q. Xanthine oxidase in-hibitory activity of the methanolic extracts of selected Jordanian medicinal plants. Pharmacogn. Mag., 2011, 7(28), 320-324.
[http://dx.doi.org/10.4103/0973-1296.90413] [PMID: 22262935]
[66]
Boutlelis, D.A.; Mounia, B.; Salah, B.; Hakim, B.; Rebiai, A.; Laib, I. Bio-synthesis of Zinc nanoparticle using Helianthemum lippii L. extract and improving in rats their hepatoprotective effects against carbon tetrachloride induced liver damage. Ann. Rom. Soc. Cell Biol., 2022, 26(01), 1949-1963.
[67]
Sova, M.; Saso, L. Natural sources, pharmacokinetics, biological activities and health benefits of hydroxycinnamic acids and their me-tabolites. Nutrients, 2020, 12(8), 2190.
[http://dx.doi.org/10.3390/nu12082190] [PMID: 32717940]
[68]
Manuja, R.; Sachdeva, S.; Jain, A.; Chaudhary, J. A comprehensive review on biological activities of p-hydroxy benzoic acid and its derivatives. Int. J. Pharm. Sci. Rev. Res., 2013, 22(2), 109-115.
[69]
Ibrahim, O.H.M.; Al-Qurashi, A.D.; Asiry, K.A.; Mousa, M.A.A.; Alhakamy, N.A.; Abo-Elyousr, K.A.M. Investigation of potential in vitro anticancer and antimicrobial activities of Balanites aegyptiaca (l.) Delile fruit extract and its phytochemical components. Plants, 2022, 11(19), 2621.
[http://dx.doi.org/10.3390/plants11192621] [PMID: 36235487]
[70]
Kargutkar, S.; Brijesh, S. Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus. Inflammopharmacology, 2018, 26(2), 469-477.
[http://dx.doi.org/10.1007/s10787-017-0379-3] [PMID: 28766086]
[71]
Babu, S.; Jayaraman, S. An update on β-sitosterol: A potential herbal nutraceutical for diabetic management. Biomed. Pharmacother., 2020, 131, 110702.
[http://dx.doi.org/10.1016/j.biopha.2020.110702] [PMID: 32882583]
[72]
El Omari, N.; Jaouadi, I.; Lahyaoui, M.; Benali, T.; Taha, D.; Bakrim, S.; El Menyiy, N.; El Kamari, F.; Zengin, G.; Bangar, S.P.; Lorenzo, J.M.; Gallo, M.; Montesano, D.; Bouyahya, A. Natural sources, pharmacological properties, and health benefits of daucosterol: Versatili-ty of actions. Appl. Sci., 2022, 12(12), 5779.
[http://dx.doi.org/10.3390/app12125779]
[73]
Bae, J.; Kim, N.; Shin, Y.; Kim, S.Y.; Kim, Y.J. Activity of catechins and their applications. Biomed. Dermatol., 2020, 4(1), 8.
[http://dx.doi.org/10.1186/s41702-020-0057-8]
[74]
Bernatova, I. Biological activities of (−)-epicatechin and (−)-epicatechin-containing foods: Focus on cardiovascular and neuropsycholog-ical health. Biotechnol. Adv., 2018, 36(3), 666-681.
[http://dx.doi.org/10.1016/j.biotechadv.2018.01.009] [PMID: 29355598]
[75]
Braicu, C.; Pilecki, V.; Balacescu, O.; Irimie, A.; Berindan Neagoe, I. The relationships between biological activities and structure of fla-van-3-ols. Int. J. Mol. Sci., 2011, 12(12), 9342-9353.
[http://dx.doi.org/10.3390/ijms12129342] [PMID: 22272136]
[76]
Yun, J.; Woo, E.R.; Lee, D.G. Effect of isoquercitrin on membrane dynamics and apoptosis-like death in Escherichia coli. Biochim. Biophys. Acta Biomembr., 2018, 1860(2), 357-363.
[http://dx.doi.org/10.1016/j.bbamem.2017.11.008] [PMID: 29155212]
[77]
Riaz, A; Rasul, A; Hussain, G; Zahoor, MK; Jabeen, F; Subhani, Z; Younis, T; Ali, M; Sarfraz, I; Selamoglu, Z Astragalin: A bioactive phytochemical with potential therapeutic activities. Adv.Pharmacol. Sci, 2018, 2018.
[http://dx.doi.org/10.1155/2018/9794625]
[78]
Luhata, L.P.; Luhata, W.G. Tiliroside: Biosynthesis, bioactivity and structure activity relationship (SAR)-A review. J. Phytopharmacol., 2017, 6(6), 343-348.
[http://dx.doi.org/10.31254/phyto.2017.6607]
[79]
Kim, J.K.; Park, S.U. Quercetin and its role in biological functions: An updated review. EXCLI J., 2018, 17, 856-863.
[http://dx.doi.org/10.17179/excli2018-1538] [PMID: 30233284]
[80]
Al-Dhabi, N.A.; Arasu, M.V.; Park, C.H.; Park, S.U. An up-to-date review of rutin and its biological and pharmacological activities. EXCLI J., 2015, 14, 59-63.
[http://dx.doi.org/10.17179/excli2014-663] [PMID: 26535031]
[81]
Bangar, S.P.; Chaudhary, V.; Sharma, N.; Bansal, V.; Ozogul, F.; Lorenzo, J.M. Kaempferol: A flavonoid with wider biological activities and its applications. Crit. Rev. Food Sci. Nutr., 2022, 1-25.
[http://dx.doi.org/10.1080/10408398.2022.2067121] [PMID: 35468008]
[82]
Yu, S.; Guo, Q.; Jia, T.; Zhang, X.; Guo, D.; Jia, Y.; Li, J.; Sun, J. Mechanism of action of nicotiflorin from Tricyrtis maculata in the treatment of acute myocardial infarction: From network pharmacology to experimental pharmacology. Drug Des. Devel. Ther., 2021, 15, 2179-2191.
[http://dx.doi.org/10.2147/DDDT.S302617] [PMID: 34079221]
[83]
Zbidi, H.; Salido, S.; Altarejos, J.; Perez-Bonilla, M.; Bartegi, A.; Rosado, J.A.; Salido, G.M. Olive tree wood phenolic compounds with human platelet antiaggregant properties. Blood Cells Mol. Dis., 2009, 42(3), 279-285.
[http://dx.doi.org/10.1016/j.bcmd.2009.01.001] [PMID: 19195914]
[84]
Mahmoud, S.Y.; Alshammari, S.O. Bioactive compounds of methanolic extract of Helianthemum lippii grows in Hafr Al-Batin region, northeastern Saudi Arabia. Acta Fytotech. Zootech., 2022, 25(1), 60-66.
[http://dx.doi.org/10.15414/afz.2022.25.01.60-66]
[85]
Benabdelaziz, I.; Haba, H.; Lavaud, C.; Harakat, D.; Benkhaled, M. Lignans and other constituents from Helianthemum sessiliflorum Pers. Rec. Nat. Prod., 2015, 9(3), 342.
[86]
Javidnia, K.; Nasiri, A.; Miri, R.; Jamalian, A. Composition of the essential oil of Helianthemum kahiricum Del. from Iran. J. Essent. Oil Res., 2007, 19(1), 52-53.
[http://dx.doi.org/10.1080/10412905.2007.9699230]
[87]
Calzada, F.; Lopéz, R.; Meckes, M.; Cedillo-Rivera, R. Flavonoids of the aerial parts of Helianthemum glomeratum. Int. J. Pharmacol., 1995, 33(4), 351-352.
[88]
Calzada, F.; Meckes, M.; Cedillo-Rivera, R. Antiamoebic and antigiardial activity of plant flavonoids. Planta Med., 1999, 65(1), 78-80.
[http://dx.doi.org/10.1055/s-2006-960445] [PMID: 10083850]
[89]
Barroso, F.G.; Martínez, T.F.; Paz, T.; Parra, A.; Alarcón, F.J. Tannin content of grazing plants of southern Spanish arid lands. J. Arid Environ., 2001, 49(2), 301-314.
[http://dx.doi.org/10.1006/jare.2000.0770]
[90]
Gökşena, N.; Demircib, B.; Baldemirc, A.; Koşara, M. Essential oil composition of Helianthemum canum (L.) Baumg. (Cistaceae) grow-ing in Turkey. Asian Soc Pharmacog., 2017, 1(1), 5-10.
[91]
Wang, QH Chemical constituents of Helianthemum ordosicum. Chinese Trad Herb Drug, 2014, 2607-2610.
[92]
Wang, Q.; Wu, R.; Wu, J.; Dai, N.; Han, N. A new alkaloid from Helianthemum ordosicum. Magn. Reson. Chem., 2015, 53(4), 314-316.
[http://dx.doi.org/10.1002/mrc.4194] [PMID: 25501342]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy