Login Register Cart 0
Generic placeholder image

Current Pediatric Reviews

Editor-in-Chief

ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
General Research Article

Seroprevalence of ToRCH Pathogens among Children Admitted to a Tertiary Care Hospital in Eastern India for Cataract Surgery and Cochlear Transplantation

Author(s): Abhilipsa Patra, Sucheta Parija, Pradipta K. Parida, Sanjay Kumar Behera and Amit Ghosh*

Volume 20, Issue 3, 2024

Published on: 27 February, 2023

Page: [365 - 369] Pages: 5

DOI: 10.2174/1573396319666230210094333

Price: $65

Abstract

Aims: The study aims to investigate the presence of TORCH infections in a child with bilateral cataracts and deafness and report the ToRCH-serology screening profile (Toxoplasma gondii (TOX), rubella (RV), cytomegalovirus (CMV), and herpes simplex virus (HSV-I/II)) in pediatric cataract and deafness.

Methods: Cases that had a clear clinical history of congenital cataracts and congenital deafness were included in the study. The study population consisted of 18 bilateral cataracts and 12 bilateral deafness child who was admitted to AIIMS Bhubaneswar for cataract surgery and cochlear implantation, respectively. Sera of all children were tested qualitatively and quantitatively for IgG/IgM-antibodies against ToRCH agents in a sequential manner.

Results: Anti-IgG antibodies against the torch panel were detected in all cataract and deafness patients. Anti-CMV IgG was detected in 17 of 18 bilateral cataract children and 11 of 12 bilateral deaf children. The rates of anti-CMV IgG antibody positivity were significantly higher. In the cataract group, 94.44% and in the deafness group, 91.66% of the patient was Anti-CMV IgG positive. Besides this, 77.7 % of the patient from the cataract group and 75% from the deafness group was anti- RV IgG antibody positive. In bilateral cataract patients, IgG-alone seropositive cases were mostly attributed to CMV (94.44%; 17/18), followed by RV (77.70%; 14/18), HSV-I (27.70%; 5/18), TOX (27.70%; 5/18), and HSV-II (16.60%; 3/18). In bilateral deafness patients, the spectrum of IgG alone seropositive cases was almost the same except for TOX (0/12).

Conclusion: The current study recommends interpreting ToRCH-screening in pediatric cataracts and deafness with caution. Interpretation should include both serial qualitative and quantitative assays in tandem with clinical correlation to minimize diagnostic errors. The sero-clinical-positivity needs to be tested in older children who might pose a threat to the spread of infection.

« Previous Next »
Graphical Abstract

[1]
Leung KKY, Hon KL, Yeung A, Leung AKC, Man E. Congenital infections in Hong Kong: An overview of TORCH. Hong Kong Med J 2020; 26(2): 127-38.
[http://dx.doi.org/10.12809/hkmj198287] [PMID: 32245914]
[2]
Wang Y, Li S, Ma N, et al. The association of ToRCH infection and congenital malformations: A prospective study in China. Eur J Obstet Gynecol Reprod Biol 2019; 240: 336-40.
[http://dx.doi.org/10.1016/j.ejogrb.2019.04.042] [PMID: 31382146]
[3]
Neu N, Duchon J, Zachariah P. TORCH infections. Clin Perinatol 2015; 42(1): 77-103.
[http://dx.doi.org/10.1016/j.clp.2014.11.001] [PMID: 25677998]
[4]
Dhakal R, Gajurel K, Pomares C, Talucod J, Press CJ, Montoya JG. Significance of a positive toxoplasma immunoglobulin m test result in the United States. J Clin Microbiol 2015; 53(11): 3601-5.
[http://dx.doi.org/10.1128/JCM.01663-15] [PMID: 26354818]
[5]
Prince HE, Lapé-Nixon M. Role of cytomegalovirus (CMV) IgG avidity testing in diagnosing primary CMV infection during pregnancy. Clin Vaccine Immunol 2014; 21(10): 1377-84.
[http://dx.doi.org/10.1128/CVI.00487-14] [PMID: 25165026]
[6]
Shakeel T, Dasgupta S, Roy R. ToRCH-screening in pediatric cataract revisited: A North Indian tertiary care centre study. Indian J Ophthalmol 2020; 68(5): 769-75.
[http://dx.doi.org/10.4103/ijo.IJO_1141_19] [PMID: 32317443]
[7]
Mets MB, Chhabra MS. Eye manifestations of intrauterine infections and their impact on childhood blindness. Surv Ophthalmol 2008; 53(2): 95-111.
[http://dx.doi.org/10.1016/j.survophthal.2007.12.003] [PMID: 18348876]
[8]
Chacon Fonseca I, Wong J, Mireskandari K, Chitayat D. Newborn with bilateral congenital cataracts: Never forget congenital rubella syndrome. Paediatr Child Health 2020; 25(2): 72-6.
[http://dx.doi.org/10.1093/pch/pxz005] [PMID: 33390742]
[9]
Vasavada AR, Vasavada SA, Bobrova N, et al. Outcomes of pediatric cataract surgery in anterior persistent fetal vasculature. J Cataract Refract Surg 2012; 38(5): 849-57.
[http://dx.doi.org/10.1016/j.jcrs.2011.11.045] [PMID: 22520309]
[10]
Dandona R, Dandona L. Review of findings of the Andhra Pradesh eye disease study: Policy implications for eye-care services. Indian J Ophthalmol 2001; 49(4): 215-34.
[PMID: 12930114]
[11]
Sahu SK, Pradhan SK, Nayak LM. Seroprevalence of TORCH infection among pregnant women. Int J Community Med Public Health 2019; 6(5): 2189-94.
[http://dx.doi.org/10.18203/2394-6040.ijcmph20191842]
[12]
Lu B, Yang Y. Detection of TORCH pathogens in children with congenital cataracts. Exp Ther Med 2016; 12(2): 1159-64.
[http://dx.doi.org/10.3892/etm.2016.3348] [PMID: 27446337]
[13]
Fung JC, Tilton RC. TORCH serologies and specific IgM antibody determination in acquired and congenital infections. Ann Clin Lab Sci 1985; 15(3): 204-11.
[PMID: 2986514]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy