Login Register Cart 0
Generic placeholder image

Current Alzheimer Research

Editor-in-Chief

ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Digital Intervention for the Management of Alzheimer’s Disease

Author(s): Namish Manchanda, Akanksha Aggarwal, Sonal Setya* and Sushama Talegaonkar*

Volume 19, Issue 14, 2022

Published on: 13 February, 2023

Page: [909 - 932] Pages: 24

DOI: 10.2174/1567205020666230206124155

Price: $65

Abstract

Alzheimer’s disease (AD) is a progressive, multifactorial, chronic, neurodegenerative disease with high prevalence and limited therapeutic options, making it a global health crisis. Being the most common cause of dementia, AD erodes the cognitive, functional, and social abilities of the individual and causes escalating medical and psychosocial needs. As yet, this disorder has no cure and current treatment options are palliative in nature. There is an urgent need for novel therapy to address this pressing challenge. Digital therapeutics (Dtx) is one such novel therapy that is gaining popularity globally. Dtx provides evidence based therapeutic interventions driven by internet and software, employing tools such as mobile devices, computers, videogames, apps, sensors, virtual reality aiding in the prevention, management, and treatment of ailments like neurological abnormalities and chronic diseases. Dtx acts as a supportive tool for the optimization of patient care, individualized treatment and improved health outcomes. Dtx uses visual, sound and other non-invasive approaches for instanceconsistent therapy, reminiscence therapy, computerised cognitive training, semantic and phonological assistance devices, wearables and computer-assisted rehabilitation environment to find applications in Alzheimer's disease for improving memory, cognition, functional abilities and managing motor symptom. A few of the Dtx-based tools employed in AD include "Memory Matters", "AlzSense", "Alzheimer Assistant", "smart robotic dog", "Immersive virtual reality (iVR)" and the most current gamma stimulation. The purpose of this review article is to summarize the current trends in digital health in AD and explore the benefits, challenges, and impediments of using Dtx as an adjunctive therapy for the management of AD.

« Previous Next »
[1]
Impairment MC. 2022 Alzheimer’s disease facts and figures. Alzheimers Dement 2022; 18(4): 700-89.
[http://dx.doi.org/10.1002/alz.12638] [PMID: 35289055]
[2]
Reitz C, Brayne C, Mayeux R. Epidemiology of Alzheimer disease. Nat Rev Neurol 2011; 7(3): 137-52.
[http://dx.doi.org/10.1038/nrneurol.2011.2] [PMID: 21304480]
[3]
Xiao LD, Wang J, He GP, De Bellis A, Verbeeck J, Kyriazopoulos H. Family caregiver challenges in dementia care in Australia and China: A critical perspective. BMC Geriatr 2014; 14(1): 6.
[http://dx.doi.org/10.1186/1471-2318-14-6] [PMID: 24456381]
[4]
Kazhungil F, Velayudhan R, Kumar M, Thazhe MR. A comparative study of caregiver burden in late-onset depression and Alzheimer’s disease. Psychogeriatrics 2016; 16(3): 209-15.
[http://dx.doi.org/10.1111/psyg.12141] [PMID: 27148797]
[5]
Yu H, Wang X, He R, Liang R, Zhou L. Measuring the caregiver burden of caring for community-residing people with Alzheimer’s Disease. PLoS One 2015; 10(7): e0132168.
[http://dx.doi.org/10.1371/journal.pone.0132168] [PMID: 26154626]
[6]
Dunkin JJ, Anderson-Hanley C. Dementia caregiver burden: A review of the literature and guidelines for assessment and intervention. Neurology 1998; 51(S1): S53-60.
[http://dx.doi.org/10.1212/WNL.51.1_Suppl_1.S53] [PMID: 9674763]
[7]
Max W, Webber P, Fox P. Alzheimer’s disease. J Aging Health 1995; 7(2): 179-99.
[http://dx.doi.org/10.1177/089826439500700202] [PMID: 10172777]
[8]
Haley WE, West CAC, Wadley VG, et al. Psychological, social, and health impact of caregiving: A comparison of Black and White dementia family caregivers and noncaregivers. Psychol Aging 1995; 10(4): 540-52.
[http://dx.doi.org/10.1037/0882-7974.10.4.540] [PMID: 8749581]
[9]
Srinivas P. Diagnosis and management of Alzheimer’s disease - an update. Med J Malaysia 1999; 54(4): 541-9.
[PMID: 11072482]
[10]
Perez-Nievas BG, Stein TD, Tai HC, et al. Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology. Brain 2013; 136(8): 2510-26.
[http://dx.doi.org/10.1093/brain/awt171] [PMID: 23824488]
[11]
Koca E. Taşkapilioğlu O, Bakar M. Caregiver burden in different stages of alzheimer’s disease. Noro Psikiyatri Arsivi 2017; 54(1): 82-6.
[http://dx.doi.org/10.5152/npa.2017.11304] [PMID: 28566965]
[12]
Kratzsch T, Peters J, Frölich L. Etiology and pathogenesis of Alzheimer dementia. Wien Med Wochenschr 2002; 152(3-4): 72-6.
[http://dx.doi.org/10.1046/j.1563-258x.2002.01127.x] [PMID: 11925775]
[13]
Blaikie L, Kay G, Maciel P, Kong TLP. Experimental modelling of Alzheimer’s disease for therapeutic screening. Eur J Med Chem 2022; 5(April): 100044.
[http://dx.doi.org/10.1016/j.ejmcr.2022.100044]
[14]
Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer’s disease. Trends Pharmacol Sci 1991; 12(10): 383-8.
[http://dx.doi.org/10.1016/0165-6147(91)90609-V] [PMID: 1763432]
[15]
Behl T, Kaur I, Sehgal A, et al. “Aducanumab” making a comeback in Alzheimer’s disease: An old wine in a new bottle. Biomed Pharmacother 2022; 148: 112746.
[http://dx.doi.org/10.1016/j.biopha.2022.112746] [PMID: 35231697]
[16]
Murphy MP, LeVine H III. Alzheimer’s disease and the amyloid-beta peptide. J Alzheimers Dis 2010; 19(1): 311-23.
[http://dx.doi.org/10.3233/JAD-2010-1221] [PMID: 20061647]
[17]
Carter CJ. Alzheimer’s disease plaques and tangles: Cemeteries of a Pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction. Neurochem Int 2011; 58(3): 301-20.
[http://dx.doi.org/10.1016/j.neuint.2010.12.003] [PMID: 21167244]
[18]
Barage SH, Sonawane KD. Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer’s disease. Neuropeptides 2015; 52: 1-18.
[http://dx.doi.org/10.1016/j.npep.2015.06.008] [PMID: 26149638]
[19]
Kametani F, Hasegawa M. Reconsideration of amyloid hypothesis and tau hypothesis in alzheimer’s disease. Front Neurosci 2018; 12: 25.
[http://dx.doi.org/10.3389/fnins.2018.00025] [PMID: 29440986]
[20]
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci 1986; 83(13): 4913-7.
[http://dx.doi.org/10.1073/pnas.83.13.4913] [PMID: 3088567]
[21]
Butterfield DA, Lauderback CM. Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: Potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic Biol Med 2002; 32(11): 1050-60.
[http://dx.doi.org/10.1016/S0891-5849(02)00794-3] [PMID: 12031889]
[22]
Crews L, Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer’s disease. Hum Mol Genet 2010; 19(R1): R12-20.
[http://dx.doi.org/10.1093/hmg/ddq160] [PMID: 20413653]
[23]
Bloom GS. Amyloid-β and Tau. JAMA Neurol 2014; 71(4): 505-8.
[http://dx.doi.org/10.1001/jamaneurol.2013.5847] [PMID: 24493463]
[24]
Thal DR, Fändrich M. Protein aggregation in Alzheimer’s disease: Aβ and τ and their potential roles in the pathogenesis of AD. Acta Neuropathol 2015; 129(2): 163-5.
[http://dx.doi.org/10.1007/s00401-015-1387-2] [PMID: 25600324]
[25]
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science 2002; 297(5580): 353-6.
[http://dx.doi.org/10.1126/science.1072994] [PMID: 12130773]
[26]
Savelieff MG, Lee S, Liu Y, Lim MH. Untangling amyloid-β tau, and metals in Alzheimer’s disease. ACS Chem Biol 2013; 8(5): 856-65.
[http://dx.doi.org/10.1021/cb400080f] [PMID: 23506614]
[27]
Querfurth HW, LaFerla FM. Alzheimer’s Disease. N Engl J Med 2010; 362(4): 329-44.
[http://dx.doi.org/10.1056/NEJMra0909142] [PMID: 20107219]
[28]
Meda L, Cassatella MA, Szendrei GI, et al. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 1995; 374(6523): 647-50.
[http://dx.doi.org/10.1038/374647a0] [PMID: 7715705]
[29]
Yamamoto M, Kiyota T, Horiba M, et al. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol 2007; 170(2): 680-92.
[http://dx.doi.org/10.2353/ajpath.2007.060378] [PMID: 17255335]
[30]
Rossi F, Bianchini E. Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes. Biochem Biophys Res Commun 1996; 225(2): 474-8.
[http://dx.doi.org/10.1006/bbrc.1996.1197] [PMID: 8753786]
[31]
Francis PT. The interplay of neurotransmitters in Alzheimer’s disease. CNS Spectr 2005; 10(S18): 6-9.
[http://dx.doi.org/10.1017/S1092852900014164] [PMID: 16273023]
[32]
Kale MB, Bajaj K, Umare M, et al. Exercise and nutraceuticals: Eminent approach for diabetic neuropathy. Curr Mol Pharmacol 2022; 15(1): 108-28.
[PMID: 34191703]
[33]
Chen ZR, Huang JB, Yang SL, Hong FF. Role of cholinergic signaling in Alzheimer’s disease. Molecules 2022; 27(6): 1816.
[http://dx.doi.org/10.3390/molecules27061816] [PMID: 35335180]
[34]
John OO, Amarachi IS, Chinazom AP, Adaeze E, Kale MB, Umare MD. Phytotherapy: A promising approach for the treatment of Alzheimer’s disease. Pharmacol Res 2022; 2(2021): 100030.
[http://dx.doi.org/10.1016/j.prmcm.2021.100030]
[35]
de la Monte SM, Tong M. Brain metabolic dysfunction at the core of Alzheimer’s disease. Biochem Pharmacol 2014; 88(4): 548-59.
[http://dx.doi.org/10.1016/j.bcp.2013.12.012] [PMID: 24380887]
[36]
Pugazhenthi S. Chapter eight - metabolic syndrome and the cellular phase of Alzheimer’s disease. Molecular Biology of Aging. Academic Press 2017; pp. 243-58.
[37]
Kshirsagar V, Thingore C, Juvekar A. Insulin resistance: A connecting link between Alzheimer’s disease and metabolic disorder. Metab Brain Dis 2021; 36(1): 67-83.
[http://dx.doi.org/10.1007/s11011-020-00622-2] [PMID: 32986168]
[38]
Reisberg B, Doody R, Stöffler A, Schmitt F, Ferris S, Möbius HJ. Memantine in moderate-to-severe Alzheimer’s disease. N Engl J Med 2003; 348(14): 1333-41.
[http://dx.doi.org/10.1056/NEJMoa013128] [PMID: 12672860]
[39]
Esang M, Gupta M. Aducanumab as a novel treatment for alzheimer’s disease: A decade of hope, controversies, and the future. Cureus 2021; 13(8): e17591.
[http://dx.doi.org/10.7759/cureus.17591] [PMID: 34646644]
[40]
Nguyen TT, Giau VV, Vo TK. Current advances in transdermal delivery of drugs for Alzheimer’s disease. Indian J Pharmacol 2017; 49(2): 145-54.
[PMID: 28706327]
[41]
Nguyen TT, Nguyen TTD, Nguyen TKO, Vo TK, Vo VG. Advances in developing therapeutic strategies for Alzheimer’s disease. Biomed Pharmacother 2021; 139(March): 111623.
[http://dx.doi.org/10.1016/j.biopha.2021.111623] [PMID: 33915504]
[42]
Batta A, Khirasaria R, Singh V. Exploring digital therapeutics: The next paradigm of modern health-care industry. Perspect Clin Res 2020; 11(2): 54-8.
[http://dx.doi.org/10.4103/picr.PICR_89_19] [PMID: 32670828]
[43]
Chung JY. Digital therapeutics and clinical pharmacology. Transl Clin Pharmacol 2019; 27(1): 6-11.
[http://dx.doi.org/10.12793/tcp.2019.27.1.6] [PMID: 32055575]
[44]
Fairburn CG, Patel V. The impact of digital technology on psychological treatments and their dissemination. Behav Res Ther 2017; 88: 19-25.
[http://dx.doi.org/10.1016/j.brat.2016.08.012] [PMID: 28110672]
[45]
Katz R, Mesfin T, Barr K. Lessons from a community-based mHealth diabetes self-management program: “it’s not just about the cell phone”. J Health Commun 2012; 17(S1): 67-72.
[http://dx.doi.org/10.1080/10810730.2012.650613] [PMID: 22548601]
[46]
Quinn CC, Clough SS, Minor JM, Lender D, Okafor MC, Gruber-Baldini A. WellDoc mobile diabetes management randomized controlled trial: Change in clinical and behavioral outcomes and patient and physician satisfaction. Diabetes Technol Ther 2008; 10(3): 160-8.
[http://dx.doi.org/10.1089/dia.2008.0283] [PMID: 18473689]
[47]
Luderer H, Chiodo L, Wilson A, et al. Patient engagement with a game-based digital therapeutic for the treatment of opioid use disorder: Protocol for a randomized controlled open-label, decentralized trial. JMIR Res Protoc 2022; 11(1): e32759.
[http://dx.doi.org/10.2196/32759] [PMID: 35080499]
[48]
Sverdlov O, van Dam J, Hannesdottir K, Thornton-Wells T. Digital therapeutics: An integral component of digital innovation in drug development. Clin Pharmacol Ther 2018; 104(1): 72-80.
[http://dx.doi.org/10.1002/cpt.1036] [PMID: 29377057]
[49]
Kvedar JC, Fogel AL, Elenko E, Zohar D. Digital medicine’s March on chronic disease. Nat Biotechnol 2016; 34(3): 239-46.
[http://dx.doi.org/10.1038/nbt.3495] [PMID: 26963544]
[50]
Cho CH, Lee HJ. Could digital therapeutics be a game changer in psychiatry? Psychiatry Investig 2019; 16(2): 97-8.
[http://dx.doi.org/10.30773/pi.2019.01.20] [PMID: 30808114]
[51]
Digital Therapeutics Alliance. Available from: https://dtxalliance.org/join-dta/application/
[52]
Dang A, Arora D, Rane P. Role of digital therapeutics and the changing future of healthcare. J Family Med Prim Care 2020; 9(5): 2207-13.
[http://dx.doi.org/10.4103/jfmpc.jfmpc_105_20] [PMID: 32754475]
[53]
Capobianco E. On digital therapeutics. Front Digit Humanit 2015; 10: 2.
[http://dx.doi.org/10.3389/fdigh.2015.00006]
[54]
Panayi ND, Mars MM, Burd R. The promise of digital (mobile) health in cancer prevention and treatment. Future Oncol 2013; 9(5): 613-7.
[http://dx.doi.org/10.2217/fon.13.42] [PMID: 23647287]
[55]
Plowman RS, Peters-Strickland T, Savage GM. Digital medicines: Clinical review on the safety of tablets with sensors. Expert Opin Drug Saf 2018; 17(9): 849-52.
[http://dx.doi.org/10.1080/14740338.2018.1508447] [PMID: 30073875]
[56]
Huh KY, Oh J, Lee S, Yu KS. Clinical evaluation of digital therapeutics: Present and future. Healthc Inform Res 2022; 28(3): 188-97.
[http://dx.doi.org/10.4258/hir.2022.28.3.188] [PMID: 35982593]
[57]
Mesko B. Győrffy Z. The rise of the empowered physician in the digital health era: Viewpoint. J Med Internet Res 2019; 21(3): e12490.
[http://dx.doi.org/10.2196/12490] [PMID: 30912758]
[58]
Hong JS, Wasden C, Han DH. Introduction of digital therapeutics. Comput Methods Programs Biomed 2021; 209: 106319.
[http://dx.doi.org/10.1016/j.cmpb.2021.106319] [PMID: 34364181]
[59]
Afra P, Bruggers CS, Sweney M, et al. Mobile software as a medical device (SaMD) for the treatment of epilepsy: Development of digital therapeutics comprising behavioral and music-based interventions for neurological disorders. Front Hum Neurosci 2018; 12: 171.
[http://dx.doi.org/10.3389/fnhum.2018.00171] [PMID: 29780310]
[60]
Catalani C, Farese C. Can digital therapeutics revolutionize medicine? ideo 2019. Available from: https://www.ideo.com/journal/can-digital-therapeutics-revolutionize-medicine
[61]
Joyce M, Leclerc K. Digital therapeutics: Preparing for takeoff. 2018. Available from: https://www.mckinsey.com/industries/pharmaceuticals-and-medical-products/our-insights/digital-therapeutics-preparing-for-takeoff
[62]
Marková H, Laczó J, Andel R, Hort J. Vlček K. Perspective taking abilities in amnestic mild cognitive impairment and Alzheimer’s disease. Behav Brain Res 2015; 281: 229-38.
[http://dx.doi.org/10.1016/j.bbr.2014.12.033] [PMID: 25541035]
[63]
Mukherjee S. FDA approves first addiction treatment mobile app Fortune. 2017. Available from: https://fortune.com/2017/09/14/fda-alcohol-marijuana-cocaine-mobile-app/
[64]
Moore A, Preece A, Sharma R, et al. A randomised controlled trial of the effect of a connected inhaler system on medication adherence in uncontrolled asthmatic patients. Eur Respir J 2021; 57(6): 2003103.
[http://dx.doi.org/10.1183/13993003.03103-2020] [PMID: 33334936]
[65]
Kagen S, Garland A. Asthma and allergy mobile apps in 2018. Curr Allergy Asthma Rep 2019; 19(1): 6.
[http://dx.doi.org/10.1007/s11882-019-0840-z] [PMID: 30712150]
[66]
Maher R, Caulfield B. A novel externally applied neuromuscular stimulator for the treatment of stress urinary incontinence in women-a pilot study. Neuromodulation 2012; 25: 16.
[PMID: 23009698]
[67]
Javanbakht M, Mashayekhi A, Monga A, Atkinson J, Branagan-Harris M. Economic analysis of electrical muscle stimulator with multipath technology for the treatment of stress urinary incontinence: A UK-based cost-utility analysis. J Med Econ 2020; 23(9): 1004-15.
[http://dx.doi.org/10.1080/13696998.2020.1776298] [PMID: 32468884]
[68]
Erten Uyumaz B, Feijs L, Hu J. A review of digital cognitive behavioral therapy for insomnia (cbt-i apps): Are they designed for engagement? Int J Environ Res Public Health 2021; 18(6): 2929.
[http://dx.doi.org/10.3390/ijerph18062929] [PMID: 33809308]
[69]
Meyer B, Berger T, Caspar F, Beevers CG, Andersson G, Weiss M. Effectiveness of a novel integrative online treatment for depression (Deprexis): Randomized controlled trial. J Med Internet Res 2009; 11(2): e15.
[http://dx.doi.org/10.2196/jmir.1151] [PMID: 19632969]
[70]
Page R, Shankar R, McLean BN, Hanna J, Newman C. Digital care in epilepsy: A conceptual framework for technological therapies. Front Neurol 2018; 9: 99.
[http://dx.doi.org/10.3389/fneur.2018.00099] [PMID: 29551988]
[71]
DiIorio C, Escoffery C, McCarty F, et al. Evaluation of WebEase: An epilepsy self-management Web site. Health Educ Res 2008; 24(2): 185-97.
[http://dx.doi.org/10.1093/her/cyn012] [PMID: 18682382]
[72]
García-Betances RI, Jiménez-Mixco V, Arredondo MT, Cabrera-Umpiérrez MF. Using virtual reality for cognitive training of the elderly. Am J Alzheimers Dis Other Demen 2015; 30(1): 49-54.
[http://dx.doi.org/10.1177/1533317514545866] [PMID: 25107931]
[73]
Torous J, Roberts LW. Needed innovation in digital health and smartphone applications for mental health. JAMA Psychiatry 2017; 74(5): 437-8.
[http://dx.doi.org/10.1001/jamapsychiatry.2017.0262] [PMID: 28384700]
[74]
Anderson JN, Krukowski RA, Paladino AJ, et al. THRIVE intervention development: Using participatory action research principles to guide a Health app-based intervention to improve oncology care. J Hosp Manag Health Policy 2020; 5: 5.
[http://dx.doi.org/10.21037/jhmhp-20-103] [PMID: 34308256]
[75]
Espie CA, Kyle SD, Williams C, et al. A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application. Sleep 2012; 35(6): 769-81.
[http://dx.doi.org/10.5665/sleep.1872] [PMID: 22654196]
[76]
Anthes E. Mental health: There’s an app for that. Nature 2016; 532(7597): 20-3.
[http://dx.doi.org/10.1038/532020a] [PMID: 27078548]
[77]
Cliffe B, Croker A, Denne M, Smith J, Stallard P. Digital cognitive behavioral therapy for insomnia for adolescents with mental health problems: Feasibility open trial. JMIR Ment Health 2020; 7(3): e14842.
[http://dx.doi.org/10.2196/14842] [PMID: 32134720]
[78]
Modi AC, Mara CA, Schmidt M, et al. Epilepsy journey: A proof of concept trial of a Web‐based executive functioning intervention for adolescents with epilepsy. Epilepsia 2019; 60(9): 1895-907.
[http://dx.doi.org/10.1111/epi.16317] [PMID: 31423591]
[79]
Alzamanan MZ, Lim KS, Akmar IM, Abdul GN. Self-management apps for people with epilepsy: systematic analysis. JMIR Mhealth Uhealth 2021; 9(5): e22489.
[http://dx.doi.org/10.2196/22489] [PMID: 34047709]
[80]
Patterson V. The development of a smartphone application to help manage epilepsy in resource-limited settings. Seizure 2020; 79: 69-74.
[http://dx.doi.org/10.1016/j.seizure.2020.03.020] [PMID: 32417687]
[81]
Bayoumy K, Gaber M, Elshafeey A, et al. Smart wearable devices in cardiovascular care: Where we are and how to move forward. Nat Rev Cardiol 2021; 18(8): 581-99.
[http://dx.doi.org/10.1038/s41569-021-00522-7] [PMID: 33664502]
[82]
Brinkmann BH, Karoly PJ, Nurse ES, et al. Seizure diaries and forecasting with wearables: Epilepsy monitoring outside the clinic. Front Neurol 2021; 12: 690404.
[http://dx.doi.org/10.3389/fneur.2021.690404] [PMID: 34326807]
[83]
Onorati F, Regalia G, Caborni C, et al. Prospective study of a multimodal convulsive seizure detection wearable system on pediatric and adult patients in the epilepsy monitoring unit. Front Neurol 2021; 12: 724904.
[http://dx.doi.org/10.3389/fneur.2021.724904] [PMID: 34489858]
[84]
Marusic U, Verghese J, Mahoney JR. Does cognitive training improve mobility, enhance cognition, and promote neural activation? Front Aging Neurosci 2022; 14(May): 845825.
[http://dx.doi.org/10.3389/fnagi.2022.845825] [PMID: 35677205]
[85]
Tacchino A, Pedullà L, Bonzano L, et al. A new app for at-home cognitive training: Description and pilot testing on patients with multiple sclerosis. JMIR Mhealth Uhealth 2015; 3(3): e85.
[http://dx.doi.org/10.2196/mhealth.4269] [PMID: 26323749]
[86]
Marcelle ET, Ho EJ, Kaplan MS, Adler LA, Castellanos FX, Milham MP. Cogmed working memory training presents unique implementation challenges in adults with ADHD. Front Psychiatry 2018; 9: 388.
[http://dx.doi.org/10.3389/fpsyt.2018.00388] [PMID: 30210370]
[87]
Thompson CK, Choy JJ, Holland A, Cole R. Sentactics®: Computer-automated treatment of underlying forms. Aphasiology 2010; 24(10): 1242-66.
[http://dx.doi.org/10.1080/02687030903474255] [PMID: 21170283]
[88]
Filoteo JV, Cox EM, Split M, Gross M, Culjat M, Keene D. Evaluation of reminx as a behavioral intervention for mild to moderate dementia. IEEE Eng Med Biol Soc Annu Int Conf 2018. 2018: 3314-7.
[http://dx.doi.org/10.1109/EMBC.2018.8513049]
[89]
Cuevas PEG, Davidson PM, Mejilla JL, Rodney TW. Reminiscence therapy for older adults with Alzheimer’s disease: A literature review. Int J Ment Health Nurs 2020; 29(3): 364-71.
[http://dx.doi.org/10.1111/inm.12692] [PMID: 31984570]
[90]
Yen HY, Lin LJ. A systematic review of reminiscence therapy for older adults in Taiwan. J Nurs Res 2018; 26(2): 138-50.
[http://dx.doi.org/10.1097/jnr.0000000000000233] [PMID: 29016468]
[91]
Boulay M, Benveniste S, Boespflug S, Jouvelot P, Rigaud AS. A pilot usability study of MINWii, a music therapy game for demented patients. Technol Health Care 2011; 19(4): 233-46.
[http://dx.doi.org/10.3233/THC-2011-0628] [PMID: 21849735]
[92]
Garcia-Agundez A, Folkerts AK, Konrad R, et al. Recent advances in rehabilitation for Parkinson’s disease with exergames: A systematic review. J Neuroeng Rehabil 2019; 16(1): 17.
[http://dx.doi.org/10.1186/s12984-019-0492-1] [PMID: 30696453]
[93]
Robert P, Manera V, Derreumaux A, et al. Efficacy of a web app for cognitive training (MeMo) regarding cognitive and behavioral performance in people with neurocognitive disorders: Randomized controlled trial. J Med Internet Res 2020; 22(3): e17167.
[http://dx.doi.org/10.2196/17167] [PMID: 32159519]
[94]
Mc Carthy M, Schueler P. Editorial: Can digital technology advance the development of treatments for Alzheimer’s Disease? J Prev Alzheimers Dis 2019; 6(4): 217-20.
[PMID: 31686090]
[95]
Topol E. Digital medicine: Empowering both patients and clinicians. Lancet 2016; 388(10046): 740-1.
[http://dx.doi.org/10.1016/S0140-6736(16)31355-1] [PMID: 27560260]
[96]
Choi MJ, Kim H, Nah HW, Kang DW. Digital therapeutics: Emerging new therapy for neurologic deficits after stroke. J Stroke 2019; 21(3): 242-58.
[http://dx.doi.org/10.5853/jos.2019.01963] [PMID: 31587534]
[97]
Firth J, Siddiqi N, Koyanagi A, et al. The lancet psychiatry commission: A blueprint for protecting physical health in people with mental illness. Lancet Psychiatry 2019; 6(8): 675-712.
[http://dx.doi.org/10.1016/S2215-0366(19)30132-4] [PMID: 31324560]
[98]
Arigo D, Jake-Schoffman DE, Wolin K, Beckjord E, Hekler EB, Pagoto SL. The history and future of digital health in the field of behavioral medicine. J Behav Med 2019; 42(1): 67-83.
[http://dx.doi.org/10.1007/s10865-018-9966-z] [PMID: 30825090]
[99]
Chen TJ, Li LJ, Chen PY. The effects of reminiscence therapy on depressive symptoms of Chinese elderly: study protocol of a randomized controlled trial. BMC Psychiatry 2012; 12: 189.
[http://dx.doi.org/10.1186/1471-244X-12-189] [PMID: 23126676]
[100]
Huang HC, Chen YT, Chen PY, et al. Reminiscence therapy improves cognitive functions and reduces depressive symptoms in elderly people with dementia: A meta-analysis of randomized controlled trials. J Am Med Dir Assoc 2015; 16(12): 1087-94.
[http://dx.doi.org/10.1016/j.jamda.2015.07.010] [PMID: 26341034]
[101]
Peng X-D, Huang C-Q, Chen L-J, Lu Z-C. Cognitive behavioural therapy and reminiscence techniques for the treatment of depression in the elderly: A systematic review. J Int Med Res 2009; 37(4): 975-82.
[http://dx.doi.org/10.1177/147323000903700401] [PMID: 19761679]
[102]
Simon JD. Past trends and Future prospects. Columbia J World Bus 1982; 68: 1-8.
[103]
Lee HJ. Digital therapeutics in pain medicine. Korean J Pain 2021; 34(3): 247-9.
[http://dx.doi.org/10.3344/kjp.2021.34.3.247] [PMID: 34193631]
[104]
Badawy SM, Radovic A. Digital approaches to remote pediatric health care delivery during the COVID-19 pandemic: Existing evidence and a call for further research. JMIR Pediatr Parent 2020; 3(1): e20049.
[http://dx.doi.org/10.2196/20049] [PMID: 32540841]
[105]
Rodriguez-Villa E, Rauseo-Ricupero N, Camacho E, Wisniewski H, Keshavan M, Torous J. The digital clinic: Implementing technology and augmenting care for mental health. Gen Hosp Psychiatry 2020; 66: 59-66.
[http://dx.doi.org/10.1016/j.genhosppsych.2020.06.009] [PMID: 32688094]
[106]
Torous J, Myrick KJ, Rauseo-Ricupero N, Firth J. Digital mental health and COVID-19: Using technology today to accelerate the curve on access and quality tomorrow. JMIR Ment Health 2020; 7(3): e18848.
[http://dx.doi.org/10.2196/18848]
[107]
Read S, Comas-Herrera A, Grundy E. Social isolation and memory decline in later-life. J Gerontol B Psychol Sci Soc Sci 2020; 75(2): 367-76.
[http://dx.doi.org/10.1093/geronb/gbz152] [PMID: 31781769]
[108]
Maharani A, Pendleton N, Leroi I. Hearing impairment, loneliness, social isolation, and cognitive function: Longitudinal analysis using English Longitudinal Study on ageing. Am J Geriatr Psychiatry 2019; 2(12): 1348-56.
[http://dx.doi.org/10.1016/j.jagp.2019.07.010] [PMID: 31402088]
[109]
Shankar A, Rafnsson SB, Steptoe A. Longitudinal associations between social connections and subjective wellbeing in the English Longitudinal Study of Ageing. Psychol Health 2015; 30(6): 686-98.
[http://dx.doi.org/10.1080/08870446.2014.979823] [PMID: 25350585]
[110]
Quail Z, Bolton L, Massey K. Digital delivery of non-pharmacological intervention programmes for people living with dementia during the COVID-19 pandemic. BMJ Case Rep 2021; 14(6): e242550.
[http://dx.doi.org/10.1136/bcr-2021-242550] [PMID: 34140328]
[111]
Fotis T. Digital health and perioperative care. J Perioper Pract 2017; 27(6): 126-8.
[http://dx.doi.org/10.1177/175045891702700601] [PMID: 29239200]
[112]
Dockendorf MF, Hansen BJ, Bateman KP, Moyer M, Shah JK, Shipley LA. Digitally enabled, patient‐centric clinical trials: Shifting the drug development paradigm. Clin Transl Sci 2021; 14(2): 445-59.
[http://dx.doi.org/10.1111/cts.12910] [PMID: 33048475]
[113]
Shah N, Adusumalli S. Nudges and the meaningful adoption of digital health. Per Med 2020; 429-33.
[http://dx.doi.org/10.2217/pme-2020-0071]
[114]
Rassi-Cruz M, Valente F, Caniza MV. Digital therapeutics and the need for regulation: How to develop products that are innovative, patient-centric and safe. Diabetol Metab Syndr 2022; 14(1): 48.
[http://dx.doi.org/10.1186/s13098-022-00818-9] [PMID: 35365189]
[115]
Khosla S, Tepie MF, Nagy MJ, et al. The alignment of real-world evidence and digital health: Realising the opportunity. Ther Innov Regul Sci 2021; 55(4): 889-98.
[http://dx.doi.org/10.1007/s43441-021-00288-7] [PMID: 33914297]
[116]
Patel NA, Butte AJ. Characteristics and challenges of the clinical pipeline of digital therapeutics. NPJ Digit Med 2020; 3(1): 159.
[http://dx.doi.org/10.1038/s41746-020-00370-8] [PMID: 33311567]
[117]
Santo K, Redfern J. Digital health innovations to improve cardiovascular disease care. Curr Atheroscler Rep 2020; 22(12): 71.
[http://dx.doi.org/10.1007/s11883-020-00889-x] [PMID: 33009975]
[118]
Redfern J. Can older adults benefit from smart devices, wearables, and other digital health options to enhance cardiac rehabilitation? Clin Geriatr Med 2019; 35(4): 489-97.
[http://dx.doi.org/10.1016/j.cger.2019.07.004] [PMID: 31543180]
[119]
Ellis TD, Earhart GM. Digital therapeutics in parkinson’s disease: Practical applications and future potential. J Parkinsons Dis 2021; 11(S1): S95-S101.
[http://dx.doi.org/10.3233/JPD-202407] [PMID: 33646177]
[120]
Hwang TJ, Kesselheim AS. Leveraging novel and existing pathways to approve new therapeutics to treat serious drug-resistant infections. Am J Law Med 2016; 42(2-3): 429-50.
[http://dx.doi.org/10.1177/0098858816658275] [PMID: 29086648]
[121]
Lupton D, Jutel A. ‘It’s like having a physician in your pocket!’ A critical analysis of self-diagnosis smartphone apps. Soc Sci Med 2015; 133: 128-35.
[http://dx.doi.org/10.1016/j.socscimed.2015.04.004] [PMID: 25864149]
[122]
Hollis C, Morriss R, Martin J, Amani S, Cotton R, Denis M. Technological innovations in mental healthcare: Harnessing the digital revolution. Br J Psychiatry 2015; 206(4): 263-5.
[http://dx.doi.org/10.1192/bjp.bp.113.142612] [PMID: 25833865]
[123]
Bucci S, Schwannauer M, Berry N. The digital revolution and its impact on mental health care. Psychol Psychother 2019; 92(2): 277-97.
[http://dx.doi.org/10.1111/papt.12222] [PMID: 30924316]
[124]
Kothare PA, Jadhav PR, Gupta P, Harrelson JC, Dickmann L. Harnessing the potential of emerging digital health and biological sampling technologies for clinical drug development: Promise to reality. Clin Pharmacol Ther 2018; 104(6): 1125-35.
[http://dx.doi.org/10.1002/cpt.1100] [PMID: 29696625]
[125]
Catarinella FS, Bos WH. Digital health assessment in rheumatology: Current and future possibilities. Clin Exp Rheumatol 2016; 34(S5): S2-4.
[PMID: 27762198]
[126]
Patel S, Saunders KEA. Apps and wearables in the monitoring of mental health disorders. Br J Hosp Med 2018; 79(12): 672-5.
[http://dx.doi.org/10.12968/hmed.2018.79.12.672] [PMID: 30526097]
[127]
Scales K, Zimmerman S, Miller SJ. Evidence-based nonpharmacological practices to address behavioral and psychological symptoms of dementia. Gerontologist 2018; 58(S1): S88-S102.
[http://dx.doi.org/10.1093/geront/gnx167] [PMID: 29361069]
[128]
Gitlin LN, Winter L, Dennis MP, Hodgson N, Hauck WW. A biobehavioral home-based intervention and the well-being of patients with dementia and their caregivers: the COPE randomized trial. JAMA 2010; 304(9): 983-91.
[http://dx.doi.org/10.1001/jama.2010.1253] [PMID: 20810376]
[129]
Gitlin LN, Marx K, Piersol CV, et al. Effects of the tailored activity program (TAP) on dementia-related symptoms, health events and caregiver wellbeing: A randomized controlled trial. BMC Geriatr 2021; 21(1): 581.
[http://dx.doi.org/10.1186/s12877-021-02511-4] [PMID: 34670502]
[130]
Gitlin LN, Winter L, Dennis MP, Hodgson N, Hauck WW. Targeting and managing behavioral symptoms in individuals with dementia: A randomized trial of a nonpharmacological intervention. J Am Geriatr Soc 2010; 58(8): 1465-74.
[http://dx.doi.org/10.1111/j.1532-5415.2010.02971.x] [PMID: 20662955]
[131]
Teri L, Gibbons LE, McCurry SM, et al. Exercise plus behavioral management in patients with Alzheimer disease: A randomized controlled trial. JAMA 2003; 290(15): 2015-22.
[http://dx.doi.org/10.1001/jama.290.15.2015] [PMID: 14559955]
[132]
Fabrizio C, Termine A, Caltagirone C, Sancesario G. Artificial intelligence for alzheimer’s disease: Promise or challenge? Diagnostics 2021; 11(8): 1473.
[http://dx.doi.org/10.3390/diagnostics11081473] [PMID: 34441407]
[133]
Seo Y, Jang H, Lee H. Potential applications of artificial intelligence in clinical trials for alzheimer’s disease. Life 2022; 12(2): 275.
[http://dx.doi.org/10.3390/life12020275] [PMID: 35207561]
[134]
Mishra R, Li B. The application of artificial intelligence in the genetic study of alzheimer’s disease. Aging Dis 2020; 11(6): 1567-84.
[http://dx.doi.org/10.14336/AD.2020.0312] [PMID: 33269107]
[135]
Leurent C, Ehlers MD. Digital technologies for cognitive assessment to accelerate drug development in Alzheimer’s disease. Clin Pharmacol Ther 2015; 98(5): 475-6.
[http://dx.doi.org/10.1002/cpt.212] [PMID: 26272508]
[136]
Khan F, Granville N, Malkani R, Chathampally Y. Health-related quality of life improvements in systemic lupus erythematosus derived from a digital therapeutic plus tele-health coaching intervention: Randomized controlled pilot trial. J Med Internet Res 2020; 22(10): e23868.
[http://dx.doi.org/10.2196/23868] [PMID: 33079070]
[137]
Kim E, Baskys A, Law AV, Roosan MR, Li Y, Roosan D. Scoping review: the empowerment of Alzheimer’s Disease caregivers with mHealth applications. NPJ Digit Med 2021; 4(1): 131.
[http://dx.doi.org/10.1038/s41746-021-00506-4] [PMID: 34493819]
[138]
Stutzel MC, Fillipo M, Sztajnberg A, Brittes A, da Motta LB. SMAI - mobile system for elderly monitoring. IEEE Int Conf Serious Games Appl Heal 2016; 2016: 1-8.
[139]
Oliveira R, Barreto A, Cardoso A, Duarte C, Sousa F. Environment-aware system for alzheimer’s patients. Int Conf Wireless Mobile Commun Healthcare 2014; 2014: 8-11.
[http://dx.doi.org/10.4108/icst.mobihealth.2014.257523]
[140]
Cho S, Lee JH, Kim IK, Kim MG, Sik KY, Lee E. The educational and supportive mobile application for caregivers of dementia people. Stud Health Technol Inform 2016; 225: 1045-6.
[PMID: 27332475]
[141]
Vergara JA, Ramírez YM, Camargo JE. A pervasive and ubiquitous mobile health application for tracking people with disabilities. Comput Colombian Conf 2015. 2015: 206-13.
[http://dx.doi.org/10.1109/ColumbianCC.2015.7333433]
[142]
Kong APH. Conducting cognitive exercises for early dementia with the use of apps on ipads. Comm Disord Q 2015; 36(2): 102-6.
[http://dx.doi.org/10.1177/1525740114544026]
[143]
Ghanem AS. A mobile cloud-based system for Alzheimer’ s disease. Int Conf Innov Intell Informatics. Comput Tech 2018; 2018: 1-5.
[144]
Thorpe JR, Rønn-Andersen KVH. Bień P, Özkil AG, Forchhammer BH, Maier AM. Pervasive assistive technology for people with dementia: A UCD case. Healthc Technol Lett 2016; 3(4): 297-302.
[http://dx.doi.org/10.1049/htl.2016.0057] [PMID: 28008366]
[145]
Tyack C, Camic PM, Heron MJ, Hulbert S. Viewing art on a tablet computer: A well-being intervention for people with dementia and their caregivers. J Appl Gerontol 2017; 36(7): 864-94.
[http://dx.doi.org/10.1177/0733464815617287] [PMID: 26675353]
[146]
Wohlfahrt-Laymann J, Hermens H, Villalonga C, Vollenbroek-Hutten M, Banos O. MobileCogniTracker. J Ambient Intell Humaniz Comput 2019; 10(6): 2143-60.
[http://dx.doi.org/10.1007/s12652-018-0827-y]
[147]
Burleson W, Lozano C, Ravishankar V, Lee J, Mahoney D. An assistive technology system that provides personalized dressing support for people living with dementia: Capability study. JMIR Med Inform 2018; 6(2): e21.
[http://dx.doi.org/10.2196/medinform.5587] [PMID: 29716885]
[148]
Bayen E, Jacquemot J, Netscher G, Agrawal P, Tabb Noyce L, Bayen A. Reduction in fall rate in dementia managed care through video incident review: Pilot study. J Med Internet Res 2017; 19(10): e339.
[http://dx.doi.org/10.2196/jmir.8095] [PMID: 29042342]
[149]
Surendran D, Rohinia M. BLE bluetooth beacon based solution to monitor egress of alzheimer’s disease sufferers from indoors. Procedia Comput Sci 2019; 165: 591-7.
[http://dx.doi.org/10.1016/j.procs.2020.01.053]
[150]
Docking RE, Lane M, Schofield PA. Usability testing of the iphone app to improve pain assessment for older adults with cognitive impairment (Prehospital Setting): A qualitative study. Pain Med 2018; 19(6): 1121-31.
[http://dx.doi.org/10.1093/pm/pnx028] [PMID: 28340247]
[151]
Atee M, Hoti K, Hughes JD. A technical note on the PainChekTM system: A web portal and mobile medical device for assessing pain in people with dementia. Front Aging Neurosci 2018; 10: 117.
[http://dx.doi.org/10.3389/fnagi.2018.00117] [PMID: 29946251]
[152]
Armstrong N, Nugent C, Moore G, Finlay D. Using smartphones to address the needs of persons with Alzheimer’s disease. Ann Telecommun 2010; 65(9): 485-95.
[http://dx.doi.org/10.1007/s12243-010-0165-3]
[153]
Kerkhof YJF, Bergsma A, Graff MJL, Dröes RM. Selecting apps for people with mild dementia: Identifying user requirements for apps enabling meaningful activities and self-management. J Rehabil Assist Technol Eng 2017; 4: 2055668317710593.
[http://dx.doi.org/10.1177/2055668317710593] [PMID: 31186930]
[154]
Lindqvist E, PerssonVasiliou A, Hwang AS, et al. The contrasting role of technology as both supportive and hindering in the everyday lives of people with mild cognitive deficits: A focus group study. BMC Geriatr 2018; 18(1): 185.
[http://dx.doi.org/10.1186/s12877-018-0879-z] [PMID: 30119653]
[155]
Grossman MR, Zak DK, Zelinski EM. Mobile apps for caregivers of older adults: Quantitative content analysis. JMIR Mhealth Uhealth 2018; 6(7): e162.
[PMID: 30061093]
[156]
McCREADIE C. Tinker A. The acceptability of assistive technology to older people. Ageing Soc 2005; 25(1): 91-110.
[http://dx.doi.org/10.1017/S0144686X0400248X]
[157]
Nirjon S, Emi IA, Mondol MAS, Salekin A, Stankovic JA. MOBI-COG: A mobile application for instant screening of dementia using the mini-cog test. Proc Wireless Health 2014; 2014: 2668889.
[http://dx.doi.org/10.1145/2668883.2668889]
[158]
Sindi S, Calov E, Fokkens J, et al. The CAIDE dementia risk score app: The development of an evidence‐based mobile application to predict the risk of dementia. Alzheimers Dement 2015; 1(3): 328-33.
[http://dx.doi.org/10.1016/j.dadm.2015.06.005] [PMID: 27239514]
[159]
Shibata D, Wakamiya S, Ito K, Miyabe M, Kinoshita A, Aramaki E. VocabChecker: Measuring language abilities for detecting early stage dementia. Proc Int Conf Intell User Interfaces Compan 2018; 24: 1-2.
[http://dx.doi.org/10.1145/3180308.3180332]
[160]
Welsh D, Morrissey K, Foley S, McNaney R, Salis C, McCarthy J. Ticket to Talk: Supporting conversation between young people and people with dementia through digital media. Proc CHI Conf Human Factors Comput Sys 2018 2018; 3173949.
[http://dx.doi.org/10.1145/3173574.3173949]
[161]
Yousaf K, Mehmood Z, Saba T, et al. Mobile-health applications for the efficient delivery of health care facility to People with Dementia (PwD) and support to their carers: A survey. BioMed Res Int 2019; 2019: 7151475.
[http://dx.doi.org/10.1155/2019/7151475] [PMID: 31032361]
[162]
Gates NJ, Rutjes AWS, Di Nisio M, et al. Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life. Cochrane Libr 2019; 3(3): CD012277.
[http://dx.doi.org/10.1002/14651858.CD012277.pub2] [PMID: 30864187]
[163]
Peeters G, Black IL, Gomersall SR, et al. Behaviour change techniques in computerized cognitive training for cognitively healthy older adults: a systematic review. Neuropsychol Rev 2022; 2022: 0123456789.
[http://dx.doi.org/10.1007/s11065-022-09537-4] [PMID: 35157209]
[164]
Orgeta V, McDonald KR, Poliakoff E, Hindle JV, Clare L, Leroi I. Cognitive training interventions for dementia and mild cognitive impairment in Parkinson’s disease. Cochrane Libr 2020; 2020(2): CD011961.
[http://dx.doi.org/10.1002/14651858.CD011961.pub2] [PMID: 32101639]
[165]
Hafdi M, Hoevenaar-Blom MP, Richard E. Multi-domain interventions for the prevention of dementia and cognitive decline. Cochrane Database Syst Rev 2021; 11(11): CD013572.
[PMID: 34748207]
[166]
Alvarez F. New signals in multimedia systems and applications behavior analysis through multimodal sensing for care of Parkinson’s and Alzheimer’s Patients IEEE 2018; 2018: 1-2.
[167]
Fardoun HM, Mashat AA, Ramirez CJ. Recognition of familiar people with a mobile cloud architecture for Alzheimer patients. Disabil Rehabil 2015; 3(4): 398-402.
[http://dx.doi.org/10.3109/0963828820151025992]
[168]
Hofmann M, Rösler A, Schwarz W, et al. Interactive computer-training as a therapeutic tool in Alzheimer’s disease. Compr Psychiatry 2003; 44(3): 213-9.
[http://dx.doi.org/10.1016/S0010-440X(03)00006-3] [PMID: 12764709]
[169]
Hofmann M, Hock C, Müller-Spahn F. Computer-based cognitive training in Alzheimer’s disease patients. Ann N Y Acad Sci 1996; 777(1): 249-54.
[http://dx.doi.org/10.1111/j.1749-6632.1996.tb34427.x] [PMID: 8624093]
[170]
Cavallo F, Aquilano M, Arvati M. An ambient assisted living approach in designing domiciliary services combined with innovative technologies for patients with Alzheimer’s disease: A case study. Am J Alzheimers Dis Other Demen 2015; 30(1): 69-77.
[http://dx.doi.org/10.1177/1533317514539724] [PMID: 24951634]
[171]
Fiatarone Singh MA, Gates N, Saigal N, et al. The Study of Mental and Resistance Training (SMART) study—resistance training and/or cognitive training in mild cognitive impairment: A randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc 2014; 15(12): 873-80.
[http://dx.doi.org/10.1016/j.jamda.2014.09.010] [PMID: 25444575]
[172]
Shimada H, Makizako H, Doi T, et al. Effects of combined physical and cognitive exercises on cognition and mobility in patients with mild cognitive impairment: A randomized clinical trial. J Am Med Dir Assoc 2018; 19(7): 584-91.
[http://dx.doi.org/10.1016/j.jamda.2017.09.019] [PMID: 29153754]
[173]
Marshall J, Caute A, Chadd K, et al. Technology-enhanced writing therapy for people with aphasia: Results of a quasi-randomized waitlist controlled study. Int J Lang Commun Disord 2019; 54(2): 203-20.
[http://dx.doi.org/10.1111/1460-6984.12391] [PMID: 29749112]
[174]
Gold M, Amatniek J, Carrillo MC, et al. Digital technologies as biomarkers, clinical outcomes assessment, and recruitment tools in Alzheimer’s disease clinical trials. Alzheimers Dement (N Y) 2018; 4(1): 234-42.
[http://dx.doi.org/10.1016/j.trci.2018.04.003] [PMID: 29955666]
[175]
Astell AJ, Smith SK, Potter S, Preston-Jones E. Computer Interactive Reminiscence and Conversation Aid groups—Delivering cognitive stimulation with technology. Alzheimers Dement (N Y) 2018; 4(1): 481-7.
[http://dx.doi.org/10.1016/j.trci.2018.08.003] [PMID: 30258977]
[176]
Moon S, Park K. The effect of digital reminiscence therapy on people with dementia: A pilot randomized controlled trial. BMC Geriatr 2020; 20(1): 166.
[http://dx.doi.org/10.1186/s12877-020-01563-2] [PMID: 32375661]
[177]
Austin PD, Craig A, Middleton JW, et al. The short-term effects of head-mounted virtual-reality on neuropathic pain intensity in people with spinal cord injury pain: a randomised cross-over pilot study. Spinal Cord 2021; 59(7): 738-46.
[http://dx.doi.org/10.1038/s41393-020-00569-2] [PMID: 33077900]
[178]
Choi MJ, Kim H, Nah H-W, Kang D-W, Choi SK, Yelton B. Immersive virtual reality reminiscence reduces anxiety in the oldest-old without causing serious side effects: A single-center, pilot, and randomized crossover study. J Alzheimers Dis 2021; 3(1): 1502-8.
[http://dx.doi.org/10.1016/j.jamda.2019.06.026]
[179]
Arellano Y. Level up  The use of video games in healthcare. DePaul J Health Care Law 2022; 23(1): 25.
[180]
West GL, Zendel BR, Konishi K, et al. Playing Super Mario 64 increases hippocampal grey matter in older adults. PLoS One 2017; 12(12): e0187779.
[http://dx.doi.org/10.1371/journal.pone.0187779] [PMID: 29211727]
[181]
Perrochon A, Borel B, Istrate D, Compagnat M, Daviet JC. Exercise-based games interventions at home in individuals with a neurological disease: A systematic review and meta-analysis. Ann Phys Rehabil Med 2019; 62(5): 366-78.
[http://dx.doi.org/10.1016/j.rehab.2019.04.004] [PMID: 31078706]
[182]
Chen Y, Zhang Y, Guo Z, Bao D, Zhou J. Comparison between the effects of exergame intervention and traditional physical training on improving balance and fall prevention in healthy older adults: A systematic review and meta-analysis. J Neuroeng Rehabil 2021; 18(1): 164.
[http://dx.doi.org/10.1186/s12984-021-00917-0] [PMID: 34819097]
[183]
Fang Q, Ghanouni P, Anderson SE, et al. Effects of Exergaming on Balance of Healthy Older Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Games Health J 2020; 9(1): 11-23.
[http://dx.doi.org/10.1089/g4h.2019.0016] [PMID: 31800322]
[184]
Zhang J, Luximon Y, Pang MYC, Wang H. Effectiveness of exergaming-based interventions for mobility and balance performance in older adults with Parkinson’s disease: systematic review and meta-analysis of randomised controlled trials. Age Ageing 2022; 51(8): afac175.
[http://dx.doi.org/10.1093/ageing/afac175] [PMID: 35930726]
[185]
Elena P, Demetris S, Christina M, Marios P. Differences between exergaming rehabilitation and conventional physiotherapy on quality of life in parkinson’s disease: A systematic review and meta-analysis. Front Neurol 2021; 12: 683385.
[http://dx.doi.org/10.3389/fneur.2021.683385] [PMID: 34434157]
[186]
Buyle M, Jung Y, Pavlou M, Gonzalez SC, Bamiou DE. The role of motivation factors in exergame interventions for fall prevention in older adults: A systematic review and meta-analysis. Front Neurol 2022; 13: 903673.
[http://dx.doi.org/10.3389/fneur.2022.903673] [PMID: 35989930]
[187]
Kendrick D, Kumar A, Carpenter H, et al. Exercise for reducing fear of falling in older people living in the community. Cochrane Libr 2014; 2015(10): CD009848.
[http://dx.doi.org/10.1002/14651858.CD009848.pub2] [PMID: 25432016]
[188]
Swinnen N, Vandenbulcke M, de Bruin ED, et al. The efficacy of exergaming in people with major neurocognitive disorder residing in long-term care facilities: A pilot randomized controlled trial. Alzheimers Res Ther 2021; 13(1): 70.
[http://dx.doi.org/10.1186/s13195-021-00806-7] [PMID: 33785077]
[189]
Swinnen N, Vandenbulcke M, Vancampfort D. Exergames in people with major neurocognitive disorder: A systematic review. Disabil Rehabil Assist Technol 2022; 17(4): 376-89.
[http://dx.doi.org/10.1080/17483107.2020.1785566] [PMID: 32697614]
[190]
Karssemeijer EGA, Aaronson JA, Bossers WJR, Donders R, Olde Rikkert MGM, Kessels RPC. The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial. Alzheimers Res Ther 2019; 11(1): 3.
[http://dx.doi.org/10.1186/s13195-018-0454-z] [PMID: 30611286]
[191]
Zhao Y, Feng H, Wu X, et al. Effectiveness of exergaming in improving cognitive and physical function in people with mild cognitive impairment or dementia: Systematic review. JMIR Serious Games 2020; 8(2): e16841.
[http://dx.doi.org/10.2196/16841] [PMID: 32602841]
[192]
van Santen J, Dröes RM, Holstege M, et al. Effects of exergaming in people with dementia: results of a systematic literature review. J Alzheimers Dis 2018; 63(2): 741-60.
[http://dx.doi.org/10.3233/JAD-170667] [PMID: 29689716]
[193]
Daley AJ. Can exergaming contribute to improving physical activity levels and health outcomes in children? Pediatrics 2009; 124(2): 763-71.
[http://dx.doi.org/10.1542/peds.2008-2357] [PMID: 19596728]
[194]
Ben-Sadoun G, Manera V, Alvarez J, Sacco G, Robert P. Recommendations for the design of serious games in neurodegenerative diseases. Front Aging Neurosci 2018; 10(FEB): 13.
[http://dx.doi.org/10.3389/fnagi.2018.00013] [PMID: 29456501]
[195]
Ben-Sadoun G, Sacco G, Manera V, et al. Physical and cognitive stimulation using an exergame in subjects with normal aging, mild and moderate cognitive impairment. J Alzheimers Dis 2016; 53(4): 1299-314.
[http://dx.doi.org/10.3233/JAD-160268] [PMID: 27372645]
[196]
Carabeo CGG, Dalida CMM, Padilla EMZ, Rodrigo MMT. Stroke patient rehabilitation. Simul Gaming 2014; 45(2): 151-66.
[http://dx.doi.org/10.1177/1046878114531102]
[197]
Manera V, Petit PD, Derreumaux A, et al. ‘Kitchen and cooking,’ a serious game for mild cognitive impairment and Alzheimer’s disease: A pilot study. Front Aging Neurosci 2015; 7: 24.
[PMID: 25852542]
[198]
Ozdogar AT, Baba C, Kahraman T, et al. Effects and safety of exergaming in persons with multiple sclerosis during corticosteroid treatment: A pilot study. Mult Scler Relat Disord 2022; 63: 103823.
[http://dx.doi.org/10.1016/j.msard.2022.103823] [PMID: 35523062]
[199]
Ozdogar AT, Ertekin O, Kahraman T, Yigit P, Ozakbas S. Effect of video-based exergaming on arm and cognitive function in persons with multiple sclerosis: A randomized controlled trial. Mult Scler Relat Disord 2020; 40: 101966.
[http://dx.doi.org/10.1016/j.msard.2020.101966] [PMID: 32045868]
[200]
Spooner D, Pachana N. Ecological validity in neuropsychological assessment: A case for greater consideration in research with neurologically intact populations. Arch Clin Neuropsychol 2006; 21(4): 327-37.
[http://dx.doi.org/10.1016/j.acn.2006.04.004] [PMID: 16769198]
[201]
Campbell Z, Zakzanis KK, Jovanovski D, Joordens S, Mraz R, Graham SJ. Utilizing virtual reality to improve the ecological validity of clinical neuropsychology: an fMRI case study elucidating the neural basis of planning by comparing the tower of london with a three-dimensional navigation task. Appl Neuropsychol 2009; 16(4): 295-306.
[http://dx.doi.org/10.1080/09084280903297891]
[202]
Tarnanas I, Schlee W, Tsolaki M, Müri R, Mosimann U, Nef T. Ecological validity of virtual reality daily living activities screening for early dementia: Longitudinal study. JMIR Serious Games 2013; 1(1): e2778.
[http://dx.doi.org/10.2196/20049]
[203]
Parsons TD. Ecological validity in virtual reality-based neuropsychological assessment. Encyclopedia of Information Science and Technology. 2014; pp. 1006-15.
[http://dx.doi.org/10.4018/978-1-4666-5888-2.ch095]
[204]
Ellis SR. What are virtual environments? IEEE Comput Graph Appl 1994; 14(1): 17-22.
[http://dx.doi.org/10.1109/38.250914] [PMID: 7757252]
[205]
Rizzo AA, Buckwalter JG, McGee JS, et al. Virtual environments for assessing and rehabilitating cognitive/functional performance a review of projects at the USC integrated media systems center. Presence 2001; 10(4): 359-74.
[http://dx.doi.org/10.1162/1054746011470226]
[206]
Maria TS, Jessica H, Albert AR. Virtual reality and neuropsychology: upgrading the current tools. J Head Trauma Rehabil 2002; 17(5): 378-94.
[http://dx.doi.org/10.1097/00001199-200210000-00002]
[207]
Rizzo AS, Kim GJ. A SWOT analysis of the field of virtual reality rehabilitation and therapy. Presence 2005; 14(2): 119-46.
[http://dx.doi.org/10.1162/1054746053967094]
[208]
Coyle H, Traynor V, Solowij N. Computerized and virtual reality cognitive training for individuals at high risk of cognitive decline: Systematic review of the literature. Am J Geriatr Psychiatry 2015; 23(4): 335-59.
[http://dx.doi.org/10.1016/j.jagp.2014.04.009] [PMID: 24998488]
[209]
Lesk VE, Wan Shamsuddin SN, Walters ER, Ugail H. Using a virtual environment to assess cognition in the elderly. Virtual Real 2014; 18(4): 271-9.
[http://dx.doi.org/10.1007/s10055-014-0252-2]
[210]
Shah LBI, Torres S, Kannusamy P, Chng CML, He HG, Klainin-Yobas P. Efficacy of the virtual reality-based stress management program on stress-related variables in people with mood disorders: the feasibility study. Arch Psychiatr Nurs 2015; 29(1): 6-13.
[http://dx.doi.org/10.1016/j.apnu.2014.09.003] [PMID: 25634868]
[211]
Hartanto D, Kampmann IL, Morina N, Emmelkamp PGM, Neerincx MA, Brinkman WP. Controlling social stress in virtual reality environments. PLoS One 2014; 9(3): e92804.
[http://dx.doi.org/10.1371/journal.pone.0092804] [PMID: 24671006]
[212]
Fornells-Ambrojo M, Freeman D, Slater M, Swapp D, Antley A, Barker C. How do people with persecutory delusions evaluate threat in a controlled social environment? A qualitative study using virtual reality. Behav Cogn Psychother 2015; 43(1): 89-107.
[http://dx.doi.org/10.1017/S1352465813000830] [PMID: 24103196]
[213]
Meyerbröker K, Emmelkamp PMG. Virtual reality exposure therapy in anxiety disorders: A systematic review of process-and-outcome studies. Depress Anxiety 2010; 27(10): 933-44.
[http://dx.doi.org/10.1002/da.20734] [PMID: 20734361]
[214]
Paliokas I, Tsakiris A, Vidalis A, Tzovaras D. Sense of presence and metacognition enhancement in virtual reality exposure therapy in the treatment of social phobias and the fear of flying. In: Shumaker R, Lackey S, Eds.; Virtual, Augmented and Mixed Reality Applications of Virtual and Augmented Reality VAMR 2014. Lecture Notes in Computer Science. Springer: Cham 2014; 8526.
[http://dx.doi.org/10.1007/978-3-319-07464-1_30]
[215]
Gregg L, Tarrier N. Virtual reality in mental health. Soc Psychiatry Psychiatr Epidemiol 2007; 42(5): 343-54.
[http://dx.doi.org/10.1007/s00127-007-0173-4]
[216]
Riva G. Virtual reality in psychotherapy: review. Cyberpsychol Behav 2005; 8(3): 220-30.
[http://dx.doi.org/10.1089/cpb.2005.8.220] [PMID: 15971972]
[217]
McCann RA, Armstrong CM, Skopp NA, et al. Virtual reality exposure therapy for the treatment of anxiety disorders: An evaluation of research quality. J Anxiety Disord 2014; 28(6): 625-31.
[http://dx.doi.org/10.1016/j.janxdis.2014.05.010] [PMID: 25093964]
[218]
da Costa RMEM, de Carvalho LAV. The acceptance of virtual reality devices for cognitive rehabilitation: A report of positive results with schizophrenia. Comput Methods Programs Biomed 2004; 73(3): 173-82.
[http://dx.doi.org/10.1016/S0169-2607(03)00066-X] [PMID: 14980398]
[219]
Baus O, Bouchard S. Moving from virtual reality exposure-based therapy to augmented reality exposure-based therapy: A review. Front Hum Neurosci 2014; 8: 112.
[http://dx.doi.org/10.3389/fnhum.2014.00112] [PMID: 24624073]
[220]
Slobounov SM, Ray W, Johnson B, Slobounov E, Newell KM. Modulation of cortical activity in 2D versus 3D virtual reality environments: An EEG study. Int J Psychophysiol 2015; 95(3): 254-60.
[http://dx.doi.org/10.1016/j.ijpsycho.2014.11.003] [PMID: 25448267]
[221]
Riva G. Virtual reality as assessment tool in psychology. Stud Health Technol Inform 1997; 44: 71-9.
[PMID: 10175344]
[222]
Weniger G, Ruhleder M, Lange C, Wolf S, Irle E. Egocentric and allocentric memory as assessed by virtual reality in individuals with amnestic mild cognitive impairment. Neuropsychologia 2011; 49(3): 518-27.
[http://dx.doi.org/10.1016/j.neuropsychologia.2010.12.031] [PMID: 21185847]
[223]
Serino S, Cipresso P, Morganti F, Riva G. The role of egocentric and allocentric abilities in Alzheimer’s disease: A systematic review. Ageing Res Rev 2014; 16(1): 32-44.
[http://dx.doi.org/10.1016/j.arr.2014.04.004] [PMID: 24943907]
[224]
Cotelli M, Manenti R, Zanetti O, Miniussi C. Non-pharmacological intervention for memory decline. Front Hum Neurosci 2012; 6(0): 46.
[PMID: 22408614]
[225]
Ma M, Zheng H. Virtual reality and serious games in healthcare. Stud Comput Intell 2011; 337: 169-92.
[http://dx.doi.org/10.1007/978-3-642-17824-5_9]
[226]
Nichols S, Patel H. Health and safety implications of virtual reality: a review of empirical evidence. Appl Ergon 2002; 33(3): 251-71.
[http://dx.doi.org/10.1016/S0003-6870(02)00020-0] [PMID: 12164509]
[227]
Kalová E. Vlček K, Jarolímová E, Bureš J. Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer’s disease: corresponding results in real space tests and computer tests. Behav Brain Res 2005; 159(2): 175-86.
[http://dx.doi.org/10.1016/j.bbr.2004.10.016] [PMID: 15817181]
[228]
Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J. Video game training enhances cognitive control in older adults. Nat 2013; 501(7465): 97-101.
[http://dx.doi.org/10.1038/nature12486]
[229]
Yeh SC, Chen YC, Tsai CF, Rizzo A. An innovative virtual reality system for mild cognitive impairment: Diagnosis and evaluation. IEEE-EMBS Conf Biomed Eng Sci IECBES 2012; 2012: 23-7.
[http://dx.doi.org/10.1109/IECBES.2012.6498023]
[230]
Burgess N, Trinkler I, King J, Kennedy A, Cipolotti L. Impaired allocentric spatial memory underlying topographical disorientation. Rev Neurosci 2006; 17(1-2): 239-51.
[http://dx.doi.org/10.1515/REVNEURO.2006.17.1-2.239] [PMID: 16703955]
[231]
Optale G, Urgesi C, Busato V, et al. Controlling memory impairment in elderly adults using virtual reality memory training: A randomized controlled pilot study. Neurorehabil Neural Repair 2010; 24(4): 348-57.
[http://dx.doi.org/10.1177/1545968309353328] [PMID: 19934445]
[232]
Bellassen V, Iglói K, de Souza LC, Dubois B, Rondi-Reig L. Temporal order memory assessed during spatiotemporal navigation as a behavioral cognitive marker for differential Alzheimer’s disease diagnosis. J Neurosci 2012; 32(6): 1942-52.
[http://dx.doi.org/10.1523/JNEUROSCI.4556-11.2012] [PMID: 22323707]
[233]
Serino S, Riva G. How different spatial representations interact in virtual environments: The role of mental frame syncing. Cogn Process 2015; 16(2): 191-201.
[http://dx.doi.org/10.1007/s10339-015-0646-4]
[234]
Nedelska Z, Andel R, Laczó J, et al. Spatial navigation impairment is proportional to right hippocampal volume. Proc Natl Acad Sci 2012; 109(7): 2590-4.
[http://dx.doi.org/10.1073/pnas.1121588109] [PMID: 22308496]
[235]
Hort J, Laczó J, Vyhnálek M, Bojar M, Bureš J, Vlček K. Spatial navigation deficit in amnestic mild cognitive impairment. Proc Natl Acad Sci 2007; 104(10): 4042-7.
[http://dx.doi.org/10.1073/pnas.0611314104] [PMID: 17360474]
[236]
Cushman LA, Stein K, Duffy CJ. Detecting navigational deficits in cognitive aging and Alzheimer disease using virtual reality. Neurology 2008; 71(12): 888-95.
[http://dx.doi.org/10.1212/01.wnl.0000326262.67613.fe] [PMID: 18794491]
[237]
Benoit M, Guerchouche R, Petit PD, et al. Is it possible to use highly realistic virtual reality in the elderly? A feasibility study with image-based rendering. Neuropsychiatr Dis Treat 2015; 11: 557-63.
[PMID: 25834437]
[238]
Seidl U, Lueken U, Thomann PA, Geider J, Schröder J. Autobiographical memory deficits in Alzheimer’s disease. J Alzheimers Dis 2011; 27(3): 567-74.
[http://dx.doi.org/10.3233/JAD-2011-110014] [PMID: 21841262]
[239]
García-Betances RI, Arredondo WMT, Fico G, Cabrera-Umpiérrez MF. A succinct overview of virtual reality technology use in Alzheimer’s disease. Front Aging Neurosci 2015; 7: 80.
[PMID: 26029101]
[240]
Zaidan AA, Zaidan BB, Qahtan MY, Albahri OS, Albahri AS, Alaa M. A survey on communication components for IoT-based technologies in smart homes. Telecomm Syst 2018; 69(1): 1-25.
[http://dx.doi.org/10.1007/s11235-018-0430-8]
[241]
Oskouei RJ, Mousavilou Z, Bakhtiari Z, Jalbani KB. IoT-based healthcare support system for alzheimer’s patients. Wirel Commun Mob Comput 2020; 2020: 8822598.
[http://dx.doi.org/10.1155/2020/8822598]
[242]
Vermesan O, Friess P, Woysch G, Guillemin P, Gusmeroli S, Sundmaeker H. Europe’s IoT Strategic Research Agenda. In: Ian GS, Ovidiu V, Peter F, Anthony F, Eds. The Internet of Things 2012 New Horizons. River Publisher 2012; pp. 22-107.
[243]
Seelye A, Hagler S, Mattek N, et al. Computer mouse movement patterns: A potential marker of mild cognitive impairment. Alzheimers Dement 2015; 1(4): 472-80.
[http://dx.doi.org/10.1016/j.dadm.2015.09.006] [PMID: 26878035]
[244]
Shaikh AA, Gupta NS, Khan ADM, Artist HT. Android and internet of things (IoT) based Alzheimer care/rehabilitation system to monitor and progress patient health condition. Int J Innov Res Comput Commun Eng 2017; 5(3): 5531-9.
[245]
Sindhu B, Shravani NR, Rao KJP, Yashaswini HY, Nayana CG. Real-time health and security monitoring device for dementia affected elders. Int J Eng Res Technol 2018; 6(13): 1-5.
[246]
Ishii H, Kimino K, Aljehani M, Ohe N, Inoue M. An early detection system for dementia using the M2 M/IoT platform. Procedia Comput Sci 2016; 96: 1332-40.
[http://dx.doi.org/10.1016/j.procs.2016.08.178]
[247]
Shende DK, Madrewar S, Bhongade S, Dugade S. Dementia patient activity monitoring and fall detection using iot for elderly. Int J Trend Sci Res Dev 2019; 3(4): 363-7.
[http://dx.doi.org/10.31142/ijtsrd23656]
[248]
Rudzicz F, Wang R, Begum M, Mihailidis A. Speech interaction with personal assistive robots supporting aging at home for individuals with alzheimer’s disease. ACM Trans Access Comput 2015; 7(2): 1-22.
[http://dx.doi.org/10.1145/2744206]
[249]
Lyu MJ, Yuan SM. Cloud-based smart dog music therapy and pneumonia detection system for reducing the difficulty of caring for patients with dementia. IEEE Access 2020; 8: 20977-90.
[http://dx.doi.org/10.1109/ACCESS.2020.2969482]
[250]
Gillani N, Arslan T. Intelligent sensing technologies for the diagnosis, monitoring and therapy of alzheimer’s disease: A systematic review. Sensors 2021; 21(12): 4249.
[http://dx.doi.org/10.3390/s21124249] [PMID: 34205793]
[251]
Zmily A, Mowafi Y, Mashal E. Study of the usability of spaced retrieval exercise using mobile devices for Alzheimer’s disease rehabilitation. JMIR Mhealth Uhealth 2014; 2(3): e31.
[http://dx.doi.org/10.2196/mhealth.3136]
[252]
Yu F, Mathiason MA, Johnson K, Gaugler JE, Klassen D. Memory matters in dementia: Efficacy of a mobile reminiscing therapy app. Alzheimer’s Dement Transl Res Clin Interv 2019; 5(1): 644-51.
[http://dx.doi.org/10.1016/j.trci.2019.09.002] [PMID: 31720365]
[253]
Moon S, Park K. The effect of digital reminiscence therapy on people with dementia: A pilot randomized controlled trial. BMC Geriatr 2020 May; 20(1): 1-11.
[254]
Aljehani SS, Alhazmi RA, Aloufi SS, Aljehani BD, Abdulrahman R. ICare: Applying iot technology for monitoring Alzheimer’s patients. Int Conf Comput Appl Inf Secur 2018; 2018: 1-6.
[http://dx.doi.org/10.1109/CAIS.2018.8442010]
[255]
Aljojo N, Alotaibi R, Alharbi B, Alshutayri A, Tariq Jamal A, Banjar A. Alzheimer assistant: A mobile application using Machine Learning. Rev Român Inform Autom 2020; 30(4): 7-26.
[http://dx.doi.org/10.33436/v30i4y202001]
[256]
Merilampi S, Koivisto A, Virkki J. Activation game for older adults - Development and initial user experiences. 2018 IEEE 6th Int Conf Serious Games Appl Heal SeGAH. 1-5.
[http://dx.doi.org/10.1109/SeGAH.2018.8401351]
[257]
Øksnebjerg L, Woods B, Waldemar G. Designing the ReACT app to support self-management of people with dementia: an iterative user-involving process. Gerontology 2019; 65(6): 673-85.
[http://dx.doi.org/10.1159/000500445] [PMID: 31266031]
[258]
Stoeckle M, Freund L. A proof of concept personalized music player for persons with alzheimer’s disease. Proc Assoc Inf Sci Technol 2016; 53(1): 1-4.
[http://dx.doi.org/10.1002/pra2.2016.14505301082]
[259]
Lancioni GE, Singh NN, O’Reilly MF, et al. A computer-aided program for helping patients with moderate Alzheimer’s disease engage in verbal reminiscence. Res Dev Disabil 2014; 35(11): 3026-33.
[http://dx.doi.org/10.1016/j.ridd.2014.07.047] [PMID: 25124700]
[260]
Derbring S, Barbos Nordström M, Svenningsson JA, et al. Effects of a digital reminiscing intervention on people with dementia and their care-givers and relatives. Ageing Soc 2021; 2021: 1-18.
[http://dx.doi.org/10.1017/S0144686X21001446]
[261]
İnel Manav A, Simsek N. The effect of reminiscence therapy with internet-based videos on cognitive status and apathy of older people with mild dementia. J Geriatr Psychiatry Neurol 2019; 32(2): 104-3.
[http://dx.doi.org/10.1177/0891988718819864] [PMID: 30612511]
[262]
Kaur PD, Sharma P. IC-SMART: IoTCloud enabled seamless monitoring for Alzheimer diagnosis and rehabilitation system. J Ambient Intell Humaniz Comput 2019; 11(8): 3387-403.
[http://dx.doi.org/10.1007/s12652-019-01534-5]
[263]
Mendoza MB, Bergado CA, De Castro JLB, Siasat RGT. Tracking system for patients with Alzheimer’s disease in a nursing home. IEEE Reg 10 Annu Int Conf Proc 2017. 2017: 2566-70.
[http://dx.doi.org/10.1109/TENCON.2017.8228294]
[264]
Enshaeifar S, Barnaghi P, Skillman S, et al. The internet of things for dementia care. IEEE Internet Comput 2018; 22(1): 8-17.
[http://dx.doi.org/10.1109/MIC.2018.112102418]
[265]
Doniger GM, Beeri MS, Bahar-Fuchs A, et al. Virtual reality‐based cognitive‐motor training for middle‐aged adults at high Alzheimer’s disease risk: A randomized controlled trial. Alzheimers Dement 2018; 4(1): 118-29.
[http://dx.doi.org/10.1016/j.trci.2018.02.005] [PMID: 29955655]
[266]
Bourrelier J, Ryard J, Dion M, Merienne F, Manckoundia P, Mourey F. Use of a virtual environment to engage motor and postural abilities in elderly subjects with and without mild cognitive impairment (MAAMI Project). IRBM 2016; 37(2): 75-80.
[http://dx.doi.org/10.1016/j.irbm.2016.02.007]
[267]
Tominari M, Uozumi R, Becker C, Kinoshita A. Reminiscence therapy using virtual reality technology affects cognitive function and subjective well-being in older adults with dementia. Cogent Psychol 2021; 8(1): 1968991.
[http://dx.doi.org/10.1080/23311908.2021.1968991]
[268]
Chan D, Suk HJ, Jackson BL, et al. Gamma frequency sensory stimulation prevents brain atrophy, improves sleep and memory in probable mild Alzheimer’s patients. Alzheimers Dement 2021; 17(S9): 2-3.
[http://dx.doi.org/10.1002/alz.054218]
[269]
He Q, Colon-Motas KM, Pybus AF, et al. A feasibility trial of gamma sensory flicker for patients with prodromal Alzheimer’s disease. Alzheimers Dement 2021; 7(1): e12178.
[http://dx.doi.org/10.1002/trc2.12178] [PMID: 34027028]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy