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Current HIV Research

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ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

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Research Article

Survival of Persons Living With HIV/AIDS: A Multicentric Study From India

Author(s): Sanjeev Sinha*, Sameer Abdul Samad, Garima Bansal, Saurav Verma, Shashikala Anant Sangle, Subhasish Kamal Guha, Neetu Rajput, Ravindra Mohan Pandey, Sanjay Ranjan, Sonali Salvi, Sanjay Mundhe, Monika More, Dolanchampa Modak, Kalpana Datta, S.K. Kabra, Rakesh Lodha, Neeraj Nischal and Bimal Kumar Das

Volume 21, Issue 1, 2023

Published on: 22 February, 2023

Page: [81 - 87] Pages: 7

DOI: 10.2174/1570162X21666230123151639

Price: $65

Abstract

Background: It has been more than 17 years since the introduction of free ART in India. At this point, it would be prudent to look at the factors associated with the survival of persons living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLHA) who are already enrolled in the ART program.

Methods: PLHAs enrolled from antiretroviral therapy (ART) centers located in three different cities in India – Delhi, Pune and Kolkata, and were followed up at six monthly intervals monitoring the WHO stage, CD4 counts, complete blood counts, and liver and kidney function tests, for a duration of three years.

Results and Discussion: The incidence of mortality among HIV/AIDS patients on ART was 5.0 per 1000 patient-years (21/1410, 1.4%). Age at initiation of ART, being above 35 years, was the only significant predictor of mortality (log-rank p = 0.018). Multivariable analysis showed a significant association of an unfavourable outcome (defined as mortality or development of opportunistic infection during follow-up) with male gender (adjusted odds ratio (AOR) = 5.26, p = <0.01) and being unmarried at ART initiation (AOR = 1.39, p = 0.005).

Conclusion: The survival of PLHA with good adherence to ART is independent of the WHO stage or CD4 counts at the initiation of ART. Initiation of ART after 35 years of age was a significant predictor of mortality.

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