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Current Neurovascular Research

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ISSN (Print): 1567-2026
ISSN (Online): 1875-5739

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Research Article

CT Perfusion Alterations in Patients with Symptomatic and Asymptomatic Unilateral Middle Cerebral Artery Severe Stenosis or Occlusion

Author(s): Mengke Ban, Zhigang Zhang, Junyan Yue*, Yuhua He, Zhenfang Guo and Ping Zhang*

Volume 20, Issue 1, 2023

Published on: 15 February, 2023

Page: [62 - 69] Pages: 8

DOI: 10.2174/1567202620666230119122237

Price: $65

Abstract

Objective: To investigate the changes in CT perfusion between symptomatic and asymptomatic patients with unilateral middle cerebral artery severe stenosis or occlusion.

Methods: A total of 64 consecutive patients with unilateral middle cerebral artery severe stenosis or occlusion admitted to the First Affiliated Hospital of Xinxiang Medical College from January 2019 to March 2022 were retrospectively analyzed and divided into the symptomatic group (n = 33), and the asymptomatic group (n = 31). Clinical data of the two groups were collected. Multivariate logistic regression analysis was performed to analyze the factors of symptomatic and asymptomatic MCA stenosis. A t-test was performed to compare the differences in cerebral perfusion parameters between the two groups.

Results: Multivariate logistic regression analysis indicated that glycosylated hemoglobin levels and high-density lipoprotein cholesterol levels were associated with the development of asymptomatic MCA severe stenosis or occlusion (odds ratio = 1.591 and 0.04, respectively). There were significant differences in CBV, MTT, and TTP between symptomatic and asymptomatic groups (p < 0.05). The CBF of the affected side in the symptomatic group was lower than that of the unaffected side (p < 0.05), whereas the asymptomatic group in CBF was not. Compared with the asymptomatic group, the CBF, MTT, and TTP of the affected side were significantly different (p < 0.05). In contrast, the cerebral perfusion parameters of the unaffected side were not significantly different (p > 0.05).

Conclusion: The use of CT perfusion imaging to analyze the alterations in cerebral perfusion parameters in patients with symptomatic and asymptomatic MCA severe stenosis or occlusion was helpful in clinical diagnosis and selecting treatment strategies and judging the development of the disease.

« Previous Next »
[1]
Liebeskind DS, Cotsonis GA, Saver JL, Lynn MJ, Cloft HJ, Chimowitz MI. Collateral circulation in symptomaticintracranial atherosclerosis. J Cereb Blood Flow Metab 2011; 31(5): 1293-301.
[http://dx.doi.org/10.1038/jcbfm.2010.224] [PMID: 21157476]
[2]
Chen K, Wang Y. Chinese experts consensus on endovascular treatment of symptomatic atherosclerotic non-acute intracranial large artery total occlusion 2018. Chin J Stroke 2018; 13: 1166-81.
[3]
Bin P, Bo W. Chinese guidelines for diagnosis and treatment of Acute Ischemic Stroke 2018. Chin J Neurol 2018; 51: 666-82.
[4]
Samuels OB, Joseph GJ, Lynn MJ, Smith HA, Chimowitz MI. A standardized method for measuring intracranial arterial stenosis. AJNR Am J Neuroradiol 2000; 21(4): 643-6.
[PMID: 10782772]
[5]
Tan IYL, Demchuk AM, Hopyan J, et al. CT angiography clot burden score and collateral score: Correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct. AJNR Am J Neuroradiol 2009; 30(3): 525-31.
[http://dx.doi.org/10.3174/ajnr.A1408] [PMID: 19147716]
[6]
Xu YY, Li ML, Gao S, et al. Non-moyamoya vessel network formation along steno-occlusive middle cerebral artery. Neurology 2016; 86(21): 1957-63.
[http://dx.doi.org/10.1212/WNL.0000000000002698] [PMID: 27164677]
[7]
Ge Y, Guo T, Wang Y. Factors influencing collateral circulation after middle cerebral artery stenosis and its research progress. Chin J Geriatr Heart Brain Vessel Dis 2019; 21: 211-3.
[8]
Winklewski PJ, Kaszubowski M, Halena G, et al. Computed tomography indicators of cerebral microperfusion improve long term after carotid stenting in symptomatic patients. Acta Biochim Pol 2019; 66(2): 229-36.
[http://dx.doi.org/10.18388/abp.2018_2793] [PMID: 30957796]
[9]
Major AS, Harrison DG. What fans the fire: Insights into mechanisms of inflammation in atherosclerosis and diabetes mellitus. Circulation 2011; 124(25): 2809-11.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.111.070565] [PMID: 22184043]
[10]
Moreno PR, Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 2004; 44(12): 2293-300.
[http://dx.doi.org/10.1016/j.jacc.2004.07.060] [PMID: 15607389]
[11]
Zhang L, Zalewski A, Liu Y, et al. Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation 2003; 108(4): 472-8.
[http://dx.doi.org/10.1161/01.CIR.0000080378.96063.23] [PMID: 12860917]
[12]
Perségol L, Darabi M, Dauteuille C, et al. Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate. J Lipid Res 2018; 59(1): 25-34.
[http://dx.doi.org/10.1194/jlr.M076927] [PMID: 29150495]
[13]
Tudorache IF, Trusca VG, Gafencu AV, Apolipoprotein E. Apolipoprotein E - A multifunctional protein with implications in various pathologies as a result of its structural features. Comput Struct Biotechnol J 2017; 15: 359-65.
[http://dx.doi.org/10.1016/j.csbj.2017.05.003] [PMID: 28660014]
[14]
Khan AA, Patel J, Desikan S, et al. Asymptomatic carotid artery stenosis is associated with cerebral hypoperfusion. J Vasc Surg 2021; 73(5): 1611-1621.e2.
[http://dx.doi.org/10.1016/j.jvs.2020.10.063] [PMID: 33166609]
[15]
Yang T, Higashino Y, Kataoka H, et al. Correlation between reduction in microvascular transit time after superficial temporal artery–middle cerebral artery bypass surgery for moyamoya disease and the development of postoperative hyperperfusion syndrome. J Neurosurg 2018; 128(5): 1304-10.
[http://dx.doi.org/10.3171/2016.11.JNS162403] [PMID: 28498060]
[16]
Zhang C, Wang Y, Zhao X, et al. Clinical, imaging features and outcome in internal carotid artery versus middle cerebral artery disease. PLoS One 2019; 14(12): e0225906.
[http://dx.doi.org/10.1371/journal.pone.0225906] [PMID: 31805111]
[17]
Lou X, Ma X, Liebeskind DS, et al. Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis. J Cereb Blood Flow Metab 2019; 39(1): 108-17.
[http://dx.doi.org/10.1177/0271678X17725212] [PMID: 28786338]
[18]
Shi SM, Li HM, Zhang ZY, Gao WW, Chen Y, Ma GL. Analysis of cerebral perfusion of leptomeningeal branch and perforating branch of unilateral middle cerebral artery with severe stenosis or occlusion based on multi-delay arterial spin labeling. Zhonghua Yi Xue Za Zhi 2021; 101(23): 1784-90.
[PMID: 34167278]

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