Abstract
This review presents current strategies of using titanium and zirconium reagents to achieve umpolung of carbonyl and imine functionalities. The reactions of organometallic compounds, including those that are equivalent to acyl anions, α-amino carbanions, α-hydroxy carbanions, and homoenolates, are among the most powerful methods to form carbon-carbon bonds. The remarkable chemoselectivity, regioselectivity, and stereoselectivity observed in many cases once more demonstrate great synthetic application of organotitanium and organozirconium compounds.
Keywords: reagents, titanium, zirconium, Umpolung Reactions, organometallic compounds, chemoselectivity, stereoselectivity
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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