Molecular modeling of kappa opioid receptor-Gi protein recognition

Title:Molecular modeling of kappa opioid receptor-Gi protein recognition

Volume: 7 Issue: 6

Author(s): Xuhu Wan, Huang Xiao-Qin, Zhou De-He, Jiang Hua-Liang, Feng Ya-Ping, Chen Kai-Xian and Chi Zhi-Qiang

Affiliation:

Abstract: This work theoretically studied the mechanism involved in recognition of Gi protein and kappa opioid receptor with shape matching method. We used the human kappa opioid receptor model docking with dynorphin A(l- 8)(HKOR_DYN) to mimic the active form of HKOR. The modeling results suggested the cluster formed by A4, AS, AG and 86 in the alpha subunit of Gi protein (Gai) might be the binding core with intercellular solvent face of HKOR and some residues of the intracellular loops play an important role in Gi protein coupling.

Cite this article as:

Wan Xuhu, Xiao-Qin Huang, De-He Zhou, Hua-Liang Jiang, Ya-Ping Feng, Kai-Xian Chen and Zhi-Qiang Chi, Molecular modeling of kappa opioid receptor-Gi protein recognition, Protein & Peptide Letters 2000; 7 (6) . https://dx.doi.org/10.2174/092986650706221208095737