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Recent Patents on Biotechnology

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ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Research Article

The Patent Landscape of Polyhydroxyalkanoates Production by Algae and Cyanobacteria

Author(s): Dielle Pierotti Procópio, Letícia Oliveira Bispo Cardoso, Bruna Bacaro Borrego, Louise Hase Gracioso, Claudio Augusto Oller Nascimento, Elen Aquino Perpetuo, Cassius Vinicius Stevani and Renato Sanches Freire*

Volume 17, Issue 3, 2023

Published on: 11 January, 2023

Page: [271 - 288] Pages: 18

DOI: 10.2174/1872208317666221207145011

Price: $65

Abstract

Background: As global awareness regarding climate change and environmental pollution outcomes arise, eco-friendly and negative emission technologies emerge.

Methods: In this scenario, polyhydroxyalkanoate (PHA)-accumulating microorganisms play an important role in the transition from the petrochemical-based non-biodegradable polymer to renewable, eco-friendly, and biocompatible materials. More specifically, CO2 can be converted to biopolymers through photosynthesis by cyanobacteria and algae, posing as a promising technology for renewable material, CO2, and petroleum-dependence mitigations. However, although many microorganisms can accumulate PHA intracellularly, limitations persist, such as the elevated cost and limited market availability.

Results: Herein is presented a patent-based mapping on technological trends of PHAs production, including its production by microalgae and cyanobacteria using the Questel Orbit Intelligence software (version 1.9.8) in complement with the Espacenet Patent Search database.

Conclusion: The inquiry on PHAs retrieved 34,243 patents filed since 1912, whereas 156 are related to their specific production by photosynthetic microorganisms, evidencing a prospective market for intellectual property.

Graphical Abstract

[1]
Afreen R, Tyagi S, Singh GP, Singh M. Challenges and perspectives of polyhydroxyalkanoate production from microalgae/cyanobacteria and bacteria as microbial factories: An assessment of hybrid biological system. Front Bioengin Biotechnol 2021; 9: 624885.
[http://dx.doi.org/10.3389/fbioe.2021.624885]
[2]
Mathuriya AS, Yakhmi JV. Polyhydroxyalkanoates: Biodegradable Plastics and Their Applications. In: Martínez L, Kharissova O, Kharisov B, Eds. Handbook of Ecomaterials. Cham: Springer 2017; pp. 1-29.
[http://dx.doi.org/10.1007/978-3-319-48281-1_84-1]
[3]
Kumar M, Rathour R, Singh R, et al. Bacterial polyhydroxyalkanoates: Opportunities, challenges, and prospects. J Clean Prod 2020; 121500.
[http://dx.doi.org/10.1016/j.jclepro.2020.121500]
[4]
Carpine R, Olivieri G, Hellingwerf KJ, Pollio A, Marzocchella A. Industrial production of poly-β-hydroxybutyrate from CO2: Can cyanobacteria meet this challenge? Processes 2020; 8(3): 323.
[http://dx.doi.org/10.3390/pr8030323]
[5]
Marichelvam MK, Jawaid M, Asim M. Corn and rice starch-based bio-plastics as alternative packaging materials. Fibers 2019; 7(4): 32.
[http://dx.doi.org/10.3390/fib7040032]
[6]
Anjum M, Miandad R, Waqas M, et al. Solid waste management in Saudi Arabia. Appl Agric Biotechnol 2016; 2016(1): 13-26.
[7]
Byrom D. Polymer synthesis by microorganisms: Technology and economics. Trends Biotechnol 1987; 5(9): 246-50.
[http://dx.doi.org/10.1016/0167-7799(87)90100-4]
[8]
Brandl H, Gross RA, Lenz RW, Fuller RC. Plastics from bacteria and for bacteria: Poly(β-hydroxyal-] kanoates) as natural, biocompatible, and biodegradable polyesters. Adv Biochem Eng Biotechnol 1990; 41: 77-93.
[http://dx.doi.org/10.1007/BFb0010232] [PMID: 2126418]
[9]
Dawes EA, Senior PJ. The role and regulation of energy reserve polymers in micro-organisms. Adv Microb Physiol 1973; 10(C): 135-266.
[http://dx.doi.org/10.1016/S0065-2911(08)60088-0] [PMID: 4594739]
[10]
Madison LL, Huisman GW. Metabolic engineering of poly(3-hydroxyalkanoates): From DNA to plastic. Microbiol Mol Biol Rev 1999; 63(1): 21-53.
[http://dx.doi.org/10.1128/MMBR.63.1.21-53.1999] [PMID: 10066830]
[11]
Shrivastav A, Kim HY, Kim YR. Advances in the applications of polyhydroxyalkanoate nanoparticles for novel drug delivery system. BioMed Res Int 2013; 2013: 1-12.
[http://dx.doi.org/10.1155/2013/581684] [PMID: 23984383]
[12]
Lee SY. Bacterial polyhydroxyalkanoates. Biotechnol Bioeng 1996; 49(1): 1-14.
[http://dx.doi.org/10.1002/(SICI)1097-0290(19960105)49:1<1::AID-BIT1>3.0.CO;2-P] [PMID: 18623547]
[13]
Utsunomia C, Ren Q, Zinn M. Poly (4-Hydroxybutyrate). Front Bioeng Biotechnol 2020; 8(April): 257.
[http://dx.doi.org/10.3389/fbioe.2020.00257] [PMID: 32318554]
[14]
Wu Q, Wang Y, Chen GQ. Medical application of microbial biopolyesters polyhydroxyalkanoates. Artif Cells Blood Substit Immobil Biotechnol 2009; 37(1): 1-12.
[http://dx.doi.org/10.1080/10731190802664429] [PMID: 19132638]
[15]
Koller M, Braunegg G. Advanced approaches to produce polyhydroxyalkanoate (PHA) biopolyesters in a sustainable and economic fashion. EuroBiotech Journal 2018; 2(2): 89-103.
[http://dx.doi.org/10.2478/ebtj-2018-0013]
[16]
Aslan AKHN, Ali MDM, Morad NA, Tamunaidu P. Polyhydroxyalkanoates Production from Waste Biomass. IOP Conference Series: Earth and Environmental Science Institute of Physics Publishing, 2016; Vol. 36: p. 012040.
[17]
Bugnicourt E, Cinelli P, Lazzeri A, Alvarez V. Polyhydroxyalkanoate (PHA): Review of synthesis, characteristics, processing and potential applications in packaging. eXPRESS Polymer Letters 2014; 8(11): 791-808.
[http://dx.doi.org/10.3144/expresspolymlett.2014.82]
[18]
Carpine R, Olivieri G, Hellingwerf K, Pollio A, Marzocchella A. Cyanobacterial Route to Produce Poly-β-Hydroxybutyrate. Chem Eng Trans 2015; 43: 1-6.
[http://dx.doi.org/10.3303/CET1543049]
[19]
Kamravamanesh D, Kovacs T, Pflügl S, et al. Increased poly-β-hydroxybutyrate production from carbon dioxide in randomly mutated cells of cyanobacterial strain Synechocystis sp. PCC 6714: Mutant generation and characterization. Bioresour Technol 2018; 266: 34-44.
[http://dx.doi.org/10.1016/j.biortech.2018.06.057] [PMID: 29957289]
[20]
Elvers D, Song CH, Steinbüchel A, Leker J. Technology trends in biodegradable polymers: Evidence from patent analysis. Polym Rev 2016; 56(4): 584-606.
[http://dx.doi.org/10.1080/15583724.2015.1125918]
[21]
Zinn M, Witholt B, Egli T. Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate. Adv Drug Deliv Rev 2001; 53(1): 5-21.
[http://dx.doi.org/10.1016/S0169-409X(01)00218-6]
[22]
Yao YC, Zhan XY, Zhang J, et al. Specific drug targeting system based on polyhydroxyalkanoate granule binding protein phap fused with targeted cell ligands. Biomaterials 2008; 29(36): 4823-30.
[http://dx.doi.org/10.1016/j.biomaterials.2008.09.008]
[23]
Shum-Tim D, Stock U, Hrkach J, et al. Tissue engineering of autologous aorta using a new biodegradable polymer. Ann Thorac Surg 1999; 68(6): 2298-304.
[http://dx.doi.org/10.1016/S0003-4975(99)01055-3] [PMID: 10617020]
[24]
Cyras VP, Commisso MS, Mauri AN, Vázquez A. Biodegradable double-layer films based on biological resources: Polyhydroxybutyrate and cellulose. J Appl Polym Sci 2007; 106(2): 749-56.
[http://dx.doi.org/10.1002/app.26663]
[25]
Cyras VP, Soledad CM, Analía V. Biocomposites based on renewable resource: Acetylated and non acetylated cellulose cardboard coated with polyhydroxybutyrate. Polymer 2009; 50(26): 6274-80.
[http://dx.doi.org/10.1016/j.polymer.2009.10.065]
[26]
Dagnon KL, Thellen C, Ratto JA, D’Souza NA. Physical and thermal analysis of the degradation of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) coated paper in a constructed soil medium. J Polym Environ 2010; 18(4): 510-22.
[http://dx.doi.org/10.1007/s10924-010-0231-y]
[27]
Weiner R. Biopolymers from marine prokaryotes. Trends Biotechnol 1997; 15(10): 390-4.
[http://dx.doi.org/10.1016/S0167-7799(97)01099-8] [PMID: 9351283]
[28]
Tharanathan RN. Biodegradable films and composite coatings: Past, present and future. Trends Food Sci Technol 2003; 14(3): 71-8.
[http://dx.doi.org/10.1016/S0924-2244(02)00280-7]
[29]
Li L, Huang W, Wang B, Wei W, Gu Q, Chen P. Properties and structure of polylactide/poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PLA/PHBV) blend fibers. Polymer 2015; 68: 183-94.
[http://dx.doi.org/10.1016/j.polymer.2015.05.024]
[30]
Hufenus R, Reifler FA, Maniura-Weber K, Spierings A, Zinn M. Biodegradable bicomponent fibers from renewable sources: Melt-spinning of poly(lactic acid) and Poly[(3-hydroxybutyrate)-co-(3-hydroxyvalerate)]. Macromol Mater Eng 2012; 297(1): 75-84.
[http://dx.doi.org/10.1002/mame.201100063]
[31]
Gordeyev SA, Nekrasov YP, Shilton SJ. Processing of gel-spun poly(?-hydroxybutyrate) fibers. J Appl Polym Sci 2001; 81(9): 2260-4.
[http://dx.doi.org/10.1002/app.1665]
[32]
Voĭnova ON, Kalacheva GS, Grodnitskaia ID, Volova TG. Microbial polymers as a degradable carrier for pesticide delivery. Prikl Biokhim Mikrobiol 2009; 45(4): 427-31.
[PMID: 19764611]
[33]
Grillo R, Pereira AES, de Melo NFS, et al. Controlled release system for ametryn using polymer microspheres: Preparation, characterization and release kinetics in water. J Hazard Mater 2011; 186(2-3): 1645-51.
[http://dx.doi.org/10.1016/j.jhazmat.2010.12.044] [PMID: 21215514]
[34]
Zhang X, Wei C, He Q, Ren Y. Enrichment of chlorobenzene and o-nitrochlorobenzene on biomimetic adsorbent prepared by poly-3-hydroxybutyrate (PHB). J Hazard Mater 2010; 177(1-3): 508-15.
[http://dx.doi.org/10.1016/j.jhazmat.2009.12.062] [PMID: 20060220]
[35]
Boyandin AN, Zhila NO, Kiselev EG, Volova TG. Constructing slow-release formulations of metribuzin based on degradable poly(3-Hydroxybutyrate). J Agric Food Chem 2016; 64(28): 5625-32.
[36]
Defoirdt T, Sorgeloos P, Bossier P. Alternatives to antibiotics for the control of bacterial disease in aquaculture. Curr Opin Microbiol 2011; 14(3): 251-8.
[http://dx.doi.org/10.1016/j.mib.2011.03.004] [PMID: 21489864]
[37]
Chen Q, Xiao S, Zhang R, Guo F, Wang K, Zhu H. Spindle-like hierarchical carbon structure grown from polyhydroxyalkanoate/ferrocene/chloroform precursor. Carbon 2016; 103: 346-51.
[http://dx.doi.org/10.1016/j.carbon.2016.03.028]
[38]
Li WR, Xie XB, Shi QS, Zeng HY. Ou- Yang YS, Chen YBen. Antibacterial activity and mechanism of silver nanoparticles on Escherichia Coli. Appl Microbiol Biotechnol 2010; 85(4): 1115-22.
[http://dx.doi.org/10.1007/s00253-009-2159-5] [PMID: 19669753]
[39]
Phukon P, Saikia JP, Konwar BK. Enhancing the stability of colloidal silver nanoparticles using polyhydroxyalkanoates (PHA) from Bacillus circulans (MTCC 8167) isolated from crude oil contaminated soil. Colloids Surf B Biointerfaces 2011; 86(2): 314-8.
[http://dx.doi.org/10.1016/j.colsurfb.2011.04.014] [PMID: 21565473]
[40]
Zhang X, Luo R, Wang Z, Deng Y, Chen GQ. Application of (R)-3-hydroxyalkanoate methyl esters derived from microbial polyhydroxyalkanoates as novel biofuels. Biomacromolecules 2009; 10(4): 707-11.
[http://dx.doi.org/10.1021/bm801424e] [PMID: 19249855]
[41]
Wang SY, Wang Z, Liu MM, Xu Y, Zhang XJ, Chen GQ. Properties of a new gasoline oxygenate blend component: 3-Hydroxybutyrate methyl ester produced from bacterial poly-3-hydroxybutyrate. Biomass Bioenergy 2010; 34(8): 1216-22.
[http://dx.doi.org/10.1016/j.biombioe.2010.03.020]
[42]
Verlinden RAJ, Hill DJ, Kenward MA, Williams CD, Radecka I. Bacterial synthesis of biodegradable polyhydroxyalkanoates. J Appl Microbiol 2007; 1437-49.
[http://dx.doi.org/10.1111/j.1365-2672.2007.03335.x]
[43]
Sharma L, Kumar Singh A, Panda B, Mallick N. Process optimization for poly-β-hydroxybutyrate production in a nitrogen fixing cyanobacterium, Nostoc muscorum using response surface methodology. Bioresour Technol 2007; 98(5): 987-93.
[http://dx.doi.org/10.1016/j.biortech.2006.04.016] [PMID: 16765593]
[44]
Martins RG, Gonçalves IS, Morais MG, Costa JAV. New technologies from the bioworld: Selection of biopolymer-producing microalgae. Polímeros 2017; 27(4): 285-9.
[http://dx.doi.org/10.1590/0104-1428.2375]
[45]
Ciesielski S, Mozejko J, Pisutpaisal N. Plant oils as promising substrates for polyhydroxyalkanoates production. J Cleaner Prod 2015; 106: 408-21.
[http://dx.doi.org/10.1016/j.jclepro.2014.09.040]
[46]
Vermaas WF. Modified cyanobacteria. US patent US8753840B2, 2007.

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