The specificity of enteropeptidase relative to the chimeric proteins and trypsinogen processing

Title:The specificity of enteropeptidase relative to the chimeric proteins and trypsinogen processing

Volume: 7 Issue: 1

Author(s): Elena Shibanova, Sergey Alexandrov and Ariatolii Miroshnikov

Affiliation:

Abstract: The limited proteolysis by enteropeptidase of the recombinant chimeric proteins incorporating the linker (Asp)4- Lys was studied. The resistant to the hydrolysis chimeric proteins was shown to be the competitive inhibitors in re­ lation to the effectively splitting chimeric proteins and to the low molecular intermediates of the linker, but not of the trypsinogen processing. The linker was shown to be defined the binding of the protein substrates by enzyme only, rather than the efficiency, determined by the C-terminal component of enzyme specificity.

Cite this article as:

Shibanova Elena, Alexandrov Sergey and Miroshnikov Ariatolii, The specificity of enteropeptidase relative to the chimeric proteins and trypsinogen processing, Protein & Peptide Letters 2000; 7 (1) . https://dx.doi.org/10.2174/092986650701221205155643

DOI https://dx.doi.org/10.2174/092986650701221205155643	Print ISSN 0929-8665
Publisher Name Bentham Science Publisher	Online ISSN 1875-5305