Abstract
Depression, or major depressive disorder, is a mental illness that significantly affects psychosocial functioning and reduces the quality of one’s life. The annual incidence of depression throughout the globe is around 6%. The disorder should be diagnosed at a particular stage for the treatment to be designed. Biomarkers can help to do so with objective pieces of evidence. Various biomarkers like Imaging biomarkers, Molecular biomarkers, Transcriptomic biomarkers, Genetic biomarkers, Neuroendocrine, and Inflammatory biomarkers can be used to diagnose depression. The use of digital sensors has also been reported recently for the determination of depression. This review summarizes various biomarkers to diagnose depression. Further recent updates and related clinical trials are included.
Graphical Abstract
[http://dx.doi.org/10.1146/annurev-publhealth-031912-114409] [PMID: 23514317]
[http://dx.doi.org/10.1186/1741-7015-9-90]
[http://dx.doi.org/10.1016/S0140-6736(18)31948-2] [PMID: 30396512]
[http://dx.doi.org/10.1016/S0140-6736(21)02143-7] [PMID: 34634250]
[http://dx.doi.org/10.1038/nrdp.2016.65]
[http://dx.doi.org/10.1111/cns.12835] [PMID: 29508560]
[http://dx.doi.org/10.1602/neurorx.1.2.182] [PMID: 15717018]
[http://dx.doi.org/10.3390/ijms22041758] [PMID: 33578758]
[http://dx.doi.org/10.1016/j.jad.2017.07.001] [PMID: 28709695]
[http://dx.doi.org/10.1016/j.neubiorev.2016.02.011] [PMID: 26906761]
[http://dx.doi.org/10.1007/978-3-030-15950-4_35] [PMID: 31347073]
[http://dx.doi.org/10.30773/pi.2019.07.25.2] [PMID: 31550875]
[http://dx.doi.org/10.1016/j.biopsych.2007.07.009] [PMID: 17884017]
[http://dx.doi.org/10.1002/da.22049] [PMID: 23526784]
[http://dx.doi.org/10.2967/jnumed.117.189654] [PMID: 28935838]
[http://dx.doi.org/10.1016/j.ajp.2016.02.003] [PMID: 27208445]
[http://dx.doi.org/10.1016/j.jad.2012.03.026] [PMID: 22682101]
[http://dx.doi.org/10.1016/j.jad.2015.04.010] [PMID: 25913539]
[http://dx.doi.org/10.1088/1741-2552/ab0093] [PMID: 30669122]
[http://dx.doi.org/10.1038/s41398-018-0239-y] [PMID: 30181587]
[http://dx.doi.org/10.1016/j.biopsych.2011.07.016] [PMID: 21937023]
[http://dx.doi.org/10.1016/j.pnpbp.2009.09.015] [PMID: 19778568]
[http://dx.doi.org/10.1016/j.jad.2014.05.051] [PMID: 25082110]
[http://dx.doi.org/10.1038/ng.2250] [PMID: 22504417]
[http://dx.doi.org/10.1038/npp.2015.77] [PMID: 25781268]
[http://dx.doi.org/10.1073/pnas.1000446107] [PMID: 20534464]
[http://dx.doi.org/10.1016/j.biopsych.2011.10.035] [PMID: 22177602]
[http://dx.doi.org/10.3389/fpsyt.2019.00703] [PMID: 31632306]
[http://dx.doi.org/10.1073/pnas.0812686106] [PMID: 19171889]
[http://dx.doi.org/10.1186/s13244-020-00872-9] [PMID: 32500316]
[http://dx.doi.org/10.1177/009286150704100504]
[http://dx.doi.org/10.1007/978-3-319-53889-1_11] [PMID: 28523548]
[http://dx.doi.org/10.1371/journal.pone.0121975] [PMID: 25763923]
[http://dx.doi.org/10.1038/nrn3879] [PMID: 25790865]
[http://dx.doi.org/10.1371/journal.pone.0033201] [PMID: 22427989]
[http://dx.doi.org/10.1371/journal.pone.0063648] [PMID: 23704927]
[http://dx.doi.org/10.1016/j.jpsychires.2016.07.012] [PMID: 27468165]
[http://dx.doi.org/10.1371/journal.pone.0086469] [PMID: 24475125]
[http://dx.doi.org/10.1186/1471-2202-11-14]
[http://dx.doi.org/10.1371/journal.pone.0093388] [PMID: 24676134]
[http://dx.doi.org/10.12659/MSM.899372] [PMID: 28039689]
[http://dx.doi.org/10.1002/brb3.711] [PMID: 28638716]
[http://dx.doi.org/10.1016/j.pharmthera.2018.01.010] [PMID: 29406246]
[http://dx.doi.org/10.2217/bmm-2016-0130] [PMID: 27404501]
[http://dx.doi.org/10.1016/j.ebiom.2021.103337]
[http://dx.doi.org/10.1016/j.ebiom.2021.103569] [PMID: 34521053]
[http://dx.doi.org/10.1373/clinchem.2009.123752] [PMID: 19498050]
[http://dx.doi.org/10.1007/7854_2011_197] [PMID: 22294088]
[http://dx.doi.org/10.1001/archpsyc.64.3.327] [PMID: 17339521]
[http://dx.doi.org/10.1002/dneu.20758] [PMID: 20186711]
[http://dx.doi.org/10.1016/j.pnpbp.2013.04.009] [PMID: 23602950]
[http://dx.doi.org/10.1016/j.pharep.2015.10.006] [PMID: 26922551]
[http://dx.doi.org/10.3389/fpsyg.2018.02201] [PMID: 30524332]
[http://dx.doi.org/10.1192/bjp.113.504.1237] [PMID: 4169954]
[http://dx.doi.org/10.1007/s00213-015-4093-9]
[http://dx.doi.org/10.1038/sj.npp.1300992]
[http://dx.doi.org/10.1002/da.20642] [PMID: 19960531]
[http://dx.doi.org/10.1523/JNEUROSCI.17-21-08451.1997] [PMID: 9334417]
[http://dx.doi.org/10.1038/sj.npp.1300459]
[http://dx.doi.org/10.1177/0891988712455236] [PMID: 22859701]
[http://dx.doi.org/10.1016/j.cobeha.2018.01.024] [PMID: 29503842]
[http://dx.doi.org/10.1001/jamapsychiatry.2019.0864] [PMID: 31066876]
[http://dx.doi.org/10.1093/ijnp/pyx056] [PMID: 29106542]
[http://dx.doi.org/10.1038/nn.2274]
[http://dx.doi.org/10.3389/fncel.2019.00087] [PMID: 30914923]
[http://dx.doi.org/10.1038/s41380-018-0219-x] [PMID: 30120418]
[http://dx.doi.org/10.3390/ijms21207777] [PMID: 33096634]
[http://dx.doi.org/10.2147/NDT.S5700] [PMID: 19721723]
[http://dx.doi.org/10.1016/j.biopsych.2012.07.009] [PMID: 22901293]
[http://dx.doi.org/10.1016/j.jpsychires.2013.04.008] [PMID: 23684549]
[http://dx.doi.org/10.1016/j.pnpbp.2006.12.011]
[http://dx.doi.org/10.1007/s00702-010-0452-1] [PMID: 20690032]
[http://dx.doi.org/10.1016/j.neuron.2012.08.037] [PMID: 23040813]
[http://dx.doi.org/10.1016/j.brainresbull.2006.04.008] [PMID: 16861106]
[http://dx.doi.org/10.1038/mp.2010.44]
[http://dx.doi.org/10.1073/pnas.0406788101] [PMID: 15483108]
[http://dx.doi.org/10.1126/stke.118pe19] [PMID: 18460680]
[http://dx.doi.org/10.1007/s11920-017-0803-9] [PMID: 28608123]
[http://dx.doi.org/10.1007/s11920-010-0150-6]
[http://dx.doi.org/10.1038/nrn3229] [PMID: 22510887]
[http://dx.doi.org/10.4088/JCP.11r07237] [PMID: 22579150]
[http://dx.doi.org/10.1016/S1673-8527(08)60099-5] [PMID: 19302968]
[http://dx.doi.org/10.1016/j.mito.2020.06.004] [PMID: 32544465]
[http://dx.doi.org/10.1016/B978-0-12-813176-3.00026-2]
[http://dx.doi.org/10.1101/gad.1346005] [PMID: 16166375]
[http://dx.doi.org/10.1186/s12888-017-1308-0] [PMID: 28438147]
[http://dx.doi.org/10.1016/j.neubiorev.2015.05.007] [PMID: 25999120]
[http://dx.doi.org/10.1038/mp.2013.151]
[http://dx.doi.org/10.1192/bjp.bp.115.180653] [PMID: 27908897]
[http://dx.doi.org/10.1002/gps.3796] [PMID: 22410877]
[http://dx.doi.org/10.1016/j.psyneuen.2015.05.005] [PMID: 26036452]
[http://dx.doi.org/10.1007/978-0-585-37970-8_2] [PMID: 10442165]
[http://dx.doi.org/10.1016/j.pnpbp.2007.03.004] [PMID: 17433516]
[http://dx.doi.org/10.1097/YCO.0b013e328315a561] [PMID: 19122532]
[http://dx.doi.org/10.1007/s11011-008-9118-1] [PMID: 19085093]
[http://dx.doi.org/10.1111/acps.12698] [PMID: 28122130]
[http://dx.doi.org/10.1186/1741-7015-11-28] [PMID: 23384232]
[http://dx.doi.org/10.2174/13894501113149990154] [PMID: 23531160]
[http://dx.doi.org/10.1007/s10802-013-9740-1] [PMID: 23553496]
[http://dx.doi.org/10.1016/j.pnpbp.2010.05.014] [PMID: 20493228]
[http://dx.doi.org/10.12659/MSM.889853] [PMID: 24457625]
[http://dx.doi.org/10.1016/j.jad.2012.01.016] [PMID: 22331023]
[http://dx.doi.org/10.12740/PP/76863] [PMID: 30218560]
[http://dx.doi.org/10.1016/j.jpsychires.2020.12.029] [PMID: 33388702]
[http://dx.doi.org/10.1038/s41598-019-56341-x] [PMID: 31875008]
[http://dx.doi.org/10.2147/VHRM.S30378] [PMID: 23386789]
[http://dx.doi.org/10.7150/ijms.13800] [PMID: 26816492]
[http://dx.doi.org/10.1016/j.coph.2007.10.010] [PMID: 18032111]
[http://dx.doi.org/10.1016/j.psyneuen.2014.11.013] [PMID: 25459900]
[http://dx.doi.org/10.2337/dc12-1442] [PMID: 23349152]
[http://dx.doi.org/10.2337/diacare.23.7.934] [PMID: 10895843]
[http://dx.doi.org/10.3389/fpsyt.2021.640741] [PMID: 34025472]
[http://dx.doi.org/10.1038/s41746-019-0078-0]
[http://dx.doi.org/10.3389/fnins.2017.00370] [PMID: 28701915]
[http://dx.doi.org/10.1016/j.ddtec.2016.07.004] [PMID: 27986220]
[http://dx.doi.org/10.3389/fncom.2016.00137] [PMID: 28066224]
[http://dx.doi.org/10.2196/12814]
[http://dx.doi.org/10.1038/s41398-020-00893-4]
[http://dx.doi.org/10.1145/2661806.2661809]
[http://dx.doi.org/10.1038/npp.2011.151] [PMID: 21814182]
[http://dx.doi.org/10.1016/j.nicl.2013.08.016] [PMID: 24273717]
[http://dx.doi.org/10.1016/j.biopsych.2019.07.010] [PMID: 31561859]
[http://dx.doi.org/10.1038/s41380-018-0252-9]
[http://dx.doi.org/10.1503/jpn.150177] [PMID: 27327561]
[http://dx.doi.org/10.1016/S0006-3223(99)00284-X] [PMID: 10745050]
[http://dx.doi.org/10.1007/s00213-016-4364-0] [PMID: 27356518]
[http://dx.doi.org/10.1016/j.biopsych.2008.05.005] [PMID: 18571629]
[http://dx.doi.org/10.1016/j.jad.2007.07.024] [PMID: 17727958]
[http://dx.doi.org/10.1016/j.jad.2003.07.002] [PMID: 15183598]
[http://dx.doi.org/10.1016/j.psyneuen.2007.04.010] [PMID: 17560728]
[http://dx.doi.org/10.4306/pi.2014.11.2.167] [PMID: 24843372]
[http://dx.doi.org/10.1016/j.clinbiochem.2009.02.020] [PMID: 19272368]
[http://dx.doi.org/10.3389/fpsyt.2019.00030] [PMID: 30792669]
[http://dx.doi.org/10.1007/s12035-017-0632-1]
[http://dx.doi.org/10.1038/mp.2012.144] [PMID: 23089630]
[http://dx.doi.org/10.1007/s00213-002-1148-5]
[http://dx.doi.org/10.1371/journal.pone.0125855] [PMID: 25946463]
[http://dx.doi.org/10.1016/j.bbr.2021.113185] [PMID: 33617903]
[http://dx.doi.org/10.1002/ddr.21332] [PMID: 27539538]